Facilitators and barriers affecting the implementation of e-health for chronic respiratory diseases in remote settings: a qualitative evidence synthesis by Emil Matias Salmi, Francesca Wanda Basile, Faiz Ahmad Khan, Larry Watt, Rinn Song, Else Margreet Bijker

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Development trend of primary healthcare after health reform in China: a longitudinal observational study by Hui Li, Jie Feng, Zuxun Lu, Yanhong Gong, Xuan Zhou, Guopeng Zhang, Xiaoxv Yin, Jianxiong Wu

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Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction by Zheping Chen, Zhenxiang Zuo, Yizheng Zhang, Guoliang Shan, Le Zhang, Moxuan Gong, Yuyang Ye, Yufeng Ma, Yanwu Jin

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Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patients by Chong Zhang, Wenjin Peng, Meng Ning, Weiru Liang, Bin Su, Tingting Guo, Kun Hu, Wei Su, Yi Chen, Yingwu Liu

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Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice by Wanying Cheng, Cenzhu Wang, Meican Ma, Yu Zhou

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Efficiency and safety of HAIC combined with lenvatinib and tislelizumab for advanced hepatocellular carcinoma with high tumor burden: a multicenter propensity score matching analys... by Zhonghua Zhao, Xiongying Jiang, Shiping Wen, Yanzhang Hao

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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

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Development of a Transcultural Social Ethical and Integrated Care Model, for Dependent and Older People Populations at Risk of Exclusion in the Mediterranean Sea Basin (TEC-MED): A... by Ana María Porcel-Gálvez, Elena Fernández-García, Soledad Vázquez-Santiago, Sergio Barrientos-Trigo, María Dolores Mateos-Garcia, Mercedes Bueno-Ferrán, Jalila El Ati, Hajer Aounallah-Skhiri, Marta Lima-Serrano

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The American Society of Pain and Neuroscience (ASPN) Guidelines and Consensus on the Definition, Current Evidence, Clinical Use and Future Applications for Physiologic Closed-Loop... by Pope JE, Deer TR, Sayed D, Antony AB, Bhandal HS, Calodney AK, Chakravarthy K, Costandi S, Diep J, Durbhakula S, Fishman MA, Gilligan C, Goree JH, Guirguis M, Hagedorn JM, Hunter CW, Kallewaard JW, Kapural L, Lam CM, Li S, Mayrsohn B, Nijhuis H, Nikolic S, Petersen EA, Poree LR, Puri SK, Reece DE, Rosen SM, Russo MA, Shah JM, Staats PS, Verrills P, Vu CM, Levy RM, Mekhail N

“…Jason E Pope,1 Timothy Ray Deer,2 Dawood Sayed,3 Ajay B Antony,4 Harjot Singh Bhandal,1 Aaron K Calodney,5 Krishnan Chakravarthy,6 Shrif Costandi,7 Jack Diep,8 Shravani Durbhakula,9 Michael A Fishman,10 Christopher Gilligan,11 Johnathan Heck Goree,12 Maged Guirguis,13 Jonathan Michael Hagedorn,14 Corey William Hunter,15,16 Jan Willem Kallewaard,17,18 Leonardo Kapural,19– 21 Christopher M Lam,3 Sean Li,22 Brian Mayrsohn,23,24 Harold Nijhuis,25 Serge Nikolic,26 Erika A Petersen,27 Lawrence Raymond Poree,28 Shawn K Puri,29 David E Reece,30 Steven Mark Rosen,31 Marc A Russo,32 Jay M Shah,33 Peter Sean Staats,34 Paul Verrills,35 Chau M Vu,1 Robert M Levy,36 Nagy Mekhail37 1Evolve Restorative Center, Santa Rosa, CA, USA; 2Pain Services, The Spine & Nerve Center of the Virginias, Charleston, WV, USA; 3Department of Anesthesiology and Pain Medicine, The University of Kansas Medical Center, Kansas City, KS, USA; 4The Orthopaedic Institute, Gainesville, FL, USA; 5Clinical Research, Precision Spine Care, Tyler, TX, USA; 6Anesthesiology and Pain Medicine, Solaris Research Institute, Wilmington, DE, USA; 7Pain Medicine, Cleveland Clinic, Cleveland, OH, USA; 8Nevada Pain Management, Las Vegas, NV, USA; 9Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA; 10Michael Fishman MD PLLC, Lebanon, PA, USA; 11Robert Wood Johnson University Hospital, New Brunswick, NJ, USA; 12Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 13Interventional Pain Management Department, Ochsner Health System, New Orleans, LA, USA; 14Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA; 15Ainsworth Institute of Pain Management, New York City, NY, USA; 16Physical Medicine & Rehabilitation, Icahn School of Medicine at Mount Sinai Hospital, New York City, NY, USA; 17Amsterdam University Medical Centre, Amsterdam, The Netherlands; 18Rijnstate Hospital, Arnhem, The Netherlands; 19Carolinas Pain Institute, Winston Salem, NC, USA; 20Centers for Clinical Research, Winston Salem, NC, USA; 21Chronic Pain Research Institute, Winston Salem, NC, USA; 22National Spine and Pain Centers, Shrewsbury, NJ, USA; 23Interventional Pain Management, Maywell Health, Plainview, NY, USA; 24Interventional Pain Management, Maywell Health, New York City, NY, USA; 25Anesthesiology, St Antonius Hospital, Nieuwegein, Utrecht, The Netherlands; 26Pain Medicine and Neuromodulation, St Bartholomew’s Hospital, Barts Health NHS Trust, London, UK; 27Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 28Anesthesia- Division of Pain Medicine, University of California, San Francisco, CA, USA; 29Integrated Pain Associates, Killeen, TX, USA; 30Absolute Pain Management, Rockville, MD, USA; 31Delaware Valley Pain and Spine Institute, Trevose, PA, USA; 32School of Biomedical Sciences, University of Newcastle, Newcastle, NSW, Australia; 33Samwell Institute of Pain Management, Colonia, Livingston, and Englewood, NJ, USA; 34National Spine and Pain Centers, Atlantic Beach, FL, USA; 35Metropain, Melbourne, VIC, Australia; 36Neuromodulation: Technology at the Neural Interface, International Neuromodulation Society, Boca Raton, FL, USA; 37Evidence-Based Pain Management Research, Cleveland Clinic, Cleveland, OH, USACorrespondence: Timothy Ray Deer, The Spine and Nerve Center of the Virginias, 400 Court Street, Charleston, WV, 25304, USA, Tel +1 304 347 6141, Email doctdeer@aol.comIntroduction: Neuromodulation has been a staple of treatment for moderate-to-severe chronic refractory pain since the introduction of the first spinal cord stimulator by Norman Shealy in 1967. …”
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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsResearch in context by Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, Dhrusti Patel, Emily Alger, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Johann de Bono, Thomas R. Jeffry Evans, Elizabeth Garrett–Mayer, Robert M. Golub, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Israel Maia, Adrian Mander, Lynley V. Marshall, James Matcham, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Lesley Seymour, Yoshiya Tanaka, Moreno Ursino, Christopher J. Weir, Christina Yap

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Unveiling and validating biomarkers related to the IL-10 family in chronic sinusitis with nasal polyps: insights from transcriptomics and single-cell RNA sequencing analysis by Xinghong Liu, Yi Peng, Ling Guo, Weilan Xiong, Weijiang Liao, Jiangang Fan

“…Ultimately, this work underscores the identification of four IL-10 family-related biomarkers, providing a theoretical foundation for future clinical research in CRSwNP.…”
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Acupuncture Dosage and Its Correlation with Effectiveness in Patients with Chronic Stable Angina: A Systematic Review and Meta-Analysis of Randomized Controlled Trial by Huang D, Li Y, Zheng X, Hu J, Tang H, Yin Y, Wu Z, Kong L

“…Dajun Huang,1,* Yanwei Li,1,* Xiaoyan Zheng,2,3,* Jinming Hu,1 Hanzhang Tang,1 Yongjun Yin,1 Zhou Wu,1 Lingqiu Kong1 1Department of Cardiovascular Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Clinical Research Center for Acupuncture and Moxibustion in Sichuan province, Sichuan JinXin Xinan Women’s and Children’s Hospital, Chengdu, People’s Republic of China; 3Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingqiu Kong; Zhou Wu, Department of Cardiovascular Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Address: No. 39 Shi’er Qiao Road, Chengdu, Sichuan, 610023, People’s Republic of China, Email klq521@163.com; 1209293923@qq.comObjective: This systematic review aimed to compare the efficacy of various acupuncture dosages for Chronic Stable Angina (CSA) using randomized controlled trials (RCTs), addressing the unclear relationship between dosage and effectiveness despite acupuncture’s potential.Methods: We searched eight bibliographic databases from inception to October 31, 2024, evaluating RCTs comparing acupuncture to placebo or standard care for CSA patients, focusing on angina attack frequency as the primary outcome. …”
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The Impact of Hyperoxia on Outcome of Patients Treated with Noninvasive Respiratory Support by Seyhan Pala Cifci, Yasemin Urcan Tapan, Bengu Turemis Erkul, Yusuf Savran, Bilgin Comert

“…The results from the recent clinical researches about hyperoxia indicate that hyperoxia can be related to worse outcomes than expected in some critically ill patients. …”
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Risk of myocardial infarction and heart failure in gout patients: a systematic review and meta-analysis by Panpan Wang, Huanhuan Yang

“…This study adopts a meta-analysis to analyze the risk of MI and HF in gout patients. Methods Clinical research literature related to gout complicated with MI or HF was searched in databases such as PubMed, Embase, Web of Science, Cochrane Library, etc. through computer retrieval before March 2023. …”
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Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics Analysis by Xie H, Wei L, Ruan G, Zhang H, Shi H

“…Hailun Xie,1,* Lishuang Wei,1,* Guotian Ruan,2– 5 Heyang Zhang,2– 5 Hanping Shi1 1Department of Gastrointestinal and Gland Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 2Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 3National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, People’s Republic of China; 5Laboratory for Clinical Medicine, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hanping Shi, Department of Gastrointestinal and Gland Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China, Email shihp@ccmu.edu.cnPurpose: Interleukin-6 (IL-6) is a central factor linking inflammation to cancer. …”
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Safety, Tolerability, and Immunogenicity of the Invaplex_AR-Detox <i>Shigella</i> Vaccine Co-Administered with the dmLT Adjuvant in Dutch and Zambian Adults: Study Protoc... by Geert V. T. Roozen, Nsofwa Sukwa, Masuzyo Chirwa, Jessica A. White, Marcus Estrada, Nicole Maier, Kevin R. Turbyfill, Renee M. Laird, Akamol E. Suvarnapunya, Aicha Sayeh, Flavia D’Alessio, Candice Marion, Laura Pattacini, Marie-Astrid Hoogerwerf, Rajagopal Murugan, Manuela Terrinoni, Jan R. Holmgren, Sodiomon B. Sirima, Sophie Houard, Michelo Simuyandi, Meta Roestenberg

“…Besides strengthening the vaccine pipeline against a major diarrheal disease, another goal of the ShigaPlexIM project is to stimulate capacity building and strengthen global North-South relations in clinical research. Trial registration: EU CT number: 2023-506394-35-02, ClinicalTrials.gov identifier: NCT05961059.…”
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Engineered T cells secreting αB7-H3-αCD3 bispecific engagers for enhanced anti-tumor activity against B7-H3 positive multiple myeloma: a novel therapeutic approach by Punchita Rujirachaivej, Teerapong Siriboonpiputtana, Kornkan Choomee, Kamonlapat Supimon, Thanich Sangsuwannukul, Pucharee Songprakhon, Krissada Natungnuy, Piriya Luangwattananun, Pornpimon Yuti, Mutita Junking, Pa-thai Yenchitsomanus

“…Additional preclinical and clinical research is required to fully assess their therapeutic potential.…”
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Cross-Platform Ecological Momentary Assessment App (JTrack-EMA+): Development and Usability Study by Mehran Sahandi Far, Jona M Fischer, Svea Senge, Robin Rathmakers, Thomas Meissner, Dominik Schneble, Mamaka Narava, Simon B Eickhoff, Juergen Dukart

“…ConclusionsThe JTrack-EMA+ platform prioritizes platform-independent architecture, providing an easy entry point for clinical researchers to deploy EMA in their respective clinical studies. …”
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Development of a core outcome set and core measurement set for kangaroo mother care: a study protocol by Yuan Li, Xia Li, Qiong Chen, Ying Xin Li, Han Mei Peng, Xue Mei Guo, Xiao Wen Li, Yan Ling Hu, Xing Li Wan

“…These discrepancies hinder the inclusion of KMC clinical research in systematic reviews or meta-analyses, reducing its research value, leading to resource wastage and raising concerns about selective reporting biases. …”
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Quantification of Macular Vascular Density Using Optical Coherence Tomography Angiography and Its Relationship with Retinal Thickness in Myopic Eyes of Young Adults by Shiqi Yang, Minwen Zhou, Bing Lu, Pengfei Zhang, Jingke Zhao, Mei Kang, Ruoshi Wang, Fenghua Wang, Xiaodong Sun

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