Observational study protocol: the faecal microbiome in the acute stage of new-onset paediatric type 1 diabetes in an Irish cohort by Eugene Dempsey, Catherine Stanton, Paul Ross, Colin Patrick Hawkes, Aonghus Lavelle, Carol-Anne O’Shea, Elaine Catherine Kennedy, Fiona Catherine Ross

“…Through this initial exploratory study, we aim to identify specific microbial biomarkers which may be used as future interventional targets throughout the various stages of T1D progression.Ethics and dissemination This study has been approved by the Clinical Research Ethics Committee of the Cork Teaching Hospitals. …”
Get full text

From fragmented to integrated healthcare managing hypertension post-stroke: a qualitative study by Hala F. Azhari, Jonathan Hewitt, Martin O'Neill, Alexander Smith, Terence Quinn, Jesse Dawson

Get full text

Burden and trends of dietary iron deficiency in the Middle East and North Africa region, 1990–2021 by Saeid Safiri, Saeid Safiri, Fatemeh Amiri, Nahid Karamzad, Nahid Karamzad, Mark J. M. Sullman, Mark J. M. Sullman, Ali-Asghar Kolahi, Morteza Abdollahi

Get full text

Impact of the Clinical Trials Act 2018 on clinical trial activity in Japan from 2018 to 2020: a retrospective database study using new and conventional Japanese registries by Hiroyuki Taruno, Mari S Oba, Osamu Takizawa, Kayoko Kikuchi, Kazuaki Matsui, Mayumi Shikano

Get full text

Effects of aquatic exercise compared with land-based exercise on the body composition and function of older adults with sarcopenia: protocol for a randomised controlled trial by Na Li, Fang Cheng, Jinfeng Yang, Yuanpeng Liao, PeiJie Sun, Weicheng Yang, Jinqi Yang, Jianxin Ran

Get full text

Does Probability Guided Hysteroscopy Reduce Costs in Women Investigated for Postmenopausal Bleeding? by M. C. Breijer, N. van Hanegem, N. C. M. Visser, R. H. M. Verheijen, B. W. J. Mol, J. M. A. Pijnenborg, B. C. Opmeer, A. Timmermans

Get full text

Normal tissue radioprotection by amifostine via Warburg-type effects by Michael I. Koukourakis, Alexandra Giatromanolaki, Christos E. Zois, Dimitra Kalamida, Stamatia Pouliliou, Ilias V. Karagounis, Tzu-Lan Yeh, Martine I. Abboud, Timothy D. W. Claridge, Christopher J. Schofield, Efthimios Sivridis, Costantinos Simopoulos, Savvas P. Tokmakidis, Adrian L. Harris

“…These findings shed new light on the mechanism of amifostine cytoprotection and encourage clinical research with this agent for the treatment of primary and metastatic liver cancer.…”
Get full text

Three Types of Broadly Reacting Antibodies against Influenza B Viruses Induced by Vaccination with Seasonal Influenza Viruses by Daisuke Hirano, Nobuko Ohshima, Ritsuko Kubota-Koketsu, Ayami Yamasaki, Gene Kurosawa, Yoshinobu Okuno, Shunji Yoshida, Yoshikazu Kurosawa

Get full text

Prescribing Multiple Neurostimulants during Rehabilitation for Severe Brain Injury by Amy A. Herrold, Theresa Louise-Bender Pape, Ann Guernon, Trudy Mallinson, Eileen Collins, Neil Jordan

Get full text

Effect of Intermittent Fasting Diet on Glucose and Lipid Metabolism and Insulin Resistance in Patients with Impaired Glucose and Lipid Metabolism: A Systematic Review and Meta-Anal... by Xiaojie Yuan, Jiping Wang, Shuo Yang, Mei Gao, Lingxia Cao, Xumei Li, Dongxu Hong, Suyan Tian, Chenglin Sun

Get full text

Promoting Physical Activity in the Management of Type 2 Diabetes: A Feasibility Study to Develop Intervention Tools for Delivery of Diabetes‐Specific Education by Daniel Crabtree, Sara Bradley, Jenni Connelly, Lynn Bauermeister, Trish Gorely, Sandra MacRury

“…Results There was a 56% total attrition rate from baseline to 3 months due to COVID‐19 and its impact on clinical research. Around 50% of participants achieved minimum physical activity recommendations at each time point and 22% of participants had accelerometer data at 3 time points. …”
Get full text

Assessment of Knowledge Gaps in Cervical Cancer Screening and HPV Vaccination Among Chinese Women: A Comprehensive Population-Based Study by Huang X, Ruan G, Sun P

“…Xinxin Huang,1 Guanyu Ruan,2 Pengming Sun2 1The Ministry of Health, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian Province, People’s Republic of China; 2Laboratory of Gynecologic Oncology, Fujian Clinical Research Center for Gynecologic Oncology, Fujian Matermity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian Province, People’s Republic of ChinaCorrespondence: Guanyu Ruan; Pengming Sun, Email ruangy_fjsfy@163.com; sunfemy@hotmail.comBackground: While studies on cervical cancer screening (CCS) and human papillomavirus (HPV) vaccine uptake exist in China, few have examined both within populations participating in CCS programs.Methods: This cross-sectional, population-based survey included 37,797 women aged 18– 64 years attending gynecological outpatient clinics. …”
Get full text

Comparison of Maylard and Cherney incisions' outcomes in hysterectomy surgery for benign indications: a double-blind randomized controlled trial by Maryam Vaezi, Roghayeh Zarei, Hosein Azizi

Get full text

Study on the Mechanism of Black Phosphorus Nanosheets Loading Sr2+ Used in Photothermal Antibacterial Treatment by Ma G, Li B, Diao J, Zhang Y, Zhang B, Wu D, Gui H, Zhong J, Zhu H, Zhang D

“…Gaoqiang Ma,1,* Binyang Li,1,* Jiayong Diao,1 Yongzhi Zhang,1 Bing Zhang,1 Dongni Wu,1 Houda Gui,1 Junhao Zhong,1 Hongguang Zhu,2 Dongjiao Zhang1 1Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, People’s Republic of China; 2Department of Stomatology, Weifang People’s Hospital, Weifang, 261000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dongjiao Zhang; Hongguang Zhu, Email djzhang1109@sdu.edu.cn; zhuhongguang9025@126.comPurpose: Bacterial infections seriously affect the health of patients and their incidence is very high. …”
Get full text

Use of 18F-NaF PET in the staging of skeletal metastases of newly diagnosed, high-risk prostate cancer patients: a nationwide cohort study by Christian Torp-Pedersen, Mette Nørgaard, Helle D Zacho, Lars J Petersen, Anna Winther Mogensen, Marie T Pank

Get full text

Liposomal Formulations: A Recent Update by Surendra S. Agrawal, Vrinda Baliga, Vaishali Y. Londhe

“…This review also covers recent preclinical and clinical research showing the therapeutic promise of next-generation liposomal formulations for cancer, infectious diseases, neurological disorders and inflammatory disorders. …”
Get full text

Outcome of Concurrent Occult Hemothorax and Pneumothorax in Trauma Patients Who Required Assisted Ventilation by Ismail Mahmood, Zainab Tawfeek, Ayman El-Menyar, Ahmad Zarour, Ibrahim Afifi, Suresh Kumar, Ruben Peralta, Rifat Latifi, Hassan Al-Thani

Get full text

The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development by Pralay Mukhopadhyay, Hesham A. Abdullah, Joanna B. Opalinska, Prani Paka, Eric Richards, Katja Weisel, Suzanne Trudel, Maria-Victoria Mateos, Meletios Athanasios Dimopoulos, Sagar Lonial

“…The wider implications of the lessons learned for clinical research in RRMM and in earlier treatment settings are discussed.…”
Get full text

Closely Spaced MEG Source Localization and Functional Connectivity Analysis Using a New Prewhitening Invariance of Noise Space Algorithm by Junpeng Zhang, Yuan Cui, Lihua Deng, Ling He, Junran Zhang, Jing Zhang, Qun Zhou, Qi Liu, Zhiguo Zhang

“…Therefore, the proposed PW-INN method is a promising MEG source analysis to provide a high spatial-temporal characterization of cortical activity and connectivity, which is crucial for basic and clinical research of neural plasticity.…”
Get full text

The leishmaniases in Kenya: A scoping review. by Grace Grifferty, Hugh Shirley, Katherine O'Brien, Jason L Hirsch, Adrienne M Orriols, Kiira Lani Amechi, Joshua Lo, Neeharika Chanda, Sarra El Hamzaoui, Jorja Kahn, Samantha V Yap, Kyleigh E Watson, Christina Curran, Amina Atef AbdelAlim, Neeloy Bose, Alissa Link Cilfone, Richard Wamai

“…The most prevalent study types were "epidemiological research" (n = 88, 33%) tied with "clinical research" (n = 88, 33%), then "basic science research" (n = 49, 18%) and "secondary research" (n = 44, 16%).…”
Get full text