Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients by Xiaowen Guo, Yang Qiao, Sijie Yin, Fengqin Luo, Lingmei Yi, Jiajia Chen, Man Lu

“…The pre-registration date was June 20, 2021, and the review approval and official case solicitation began in December 2021; Retrospectively registered) was conducted in accordance with the World Medical Congress Declaration of Helsinki and Good Clinical Practice guidelines. All study subjects provided written informed consent.…”
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Collaborative tailoring of the Reach Out, Stay Strong Essentials (ROSE) program for pregnant veterans in the U.S. Veterans Health Administration: a qualitative case study of contex... by Erin P. Finley, Alison B. Hamilton, Ismelda Canelo, La Shawnta S. Jackson, Rachel Lesser, Rebecca S. Oberman, Julia Yosef, Joya G. Chrystal, Erica H. Fletcher, Bevanne Bean-Mayberry, Tannaz Moin, Melissa M. Farmer, Ariel J. Lang

“…., improving alignment with VA clinical practice guidelines) and adaptations to the implementation approach (e.g., offering training to VA providers beyond the original EMPOWER sites). …”
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Evaluating the Impact of Pharmacotherapy in Augmenting Quit Rates Among Hispanic Adults in an App-Delivered Smoking Cessation Intervention: Secondary Analysis of a Randomized Contr... by Margarita Santiago-Torres, Kristin E Mull, Brianna M Sullivan, Ana Paula Cupertino, Ramzi G Salloum, Matthew Triplette, Michael J Zvolensky, Jonathan B Bricker

“…ObjectiveThis secondary analysis used data from a randomized controlled trial that compared the efficacy of 2 smoking cessation apps, iCanQuit (based on acceptance and commitment therapy) and QuitGuide (following US clinical practice guidelines), to explore the association between pharmacotherapy use and smoking cessation outcomes among the subsample of 173 Hispanic participants who reported on pharmacotherapy use. …”
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Content of Angiogenesis Markers of Insulin-Like Growth Factor-1 and Endostatin in Patients with Acute Myocardial Infarction in the Presence or Absence of Comorbid Obesity by Martovytskyi D., Shelest O., Kravchun P.

“…Obesity was diagnosed according to American association of clinical endocrinologists and American college of endocrinology clinical practice guidelines for comprehensive medical care of patients with obesity, 2016. …”
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Non-invasive ventilation in COVID-19-related acute hypoxemic respiratory failure: a narrative review by Luigi Aronne, Raffaella Pagliaro, Angela Schiattarella, Susan FM Campbell, Maria Vitale, Fabio Perrotta, Klara Komici, Germano Guerra, Andrea Bianco, Filippo Scialò, Vanvitelli - Monaldi COVID Group

“…According to the European Respiratory Society and the American Thoracic Society clinical practice guidelines, NIV is recommended to prevent intubation in hypoxemic acute respiratory failure in patients with community-acquired pneumonia or early acute respiratory distress syndrome without major organ dysfunction. …”
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Improving the management of acute asthma in children through an integrated care pathway: an implementation study protocol by Marta Montejo, Natalia Paniagua, Alvaro Sanchez, Alvaro Sanchez, Mikel Rueda-Etxebarria, Jose I. Pijoan, Jose I. Pijoan, Jose I. Pijoan, Carlos Saiz Hernando, Vanesa Martin, Miguel Angel Vázquez Ronco, Mikel Santiago Burruchaga, Diego García Urabayen, Garbiñe Pérez Llarena, Susana Castelo, Javier Benito

“…IntroductionThis study aims to evaluate the effectiveness and feasibility of the implementation of an Asthma Integrated Care Pathway (AICP) to improve care and reduce variability according to recommended clinical practice guidelines, for children presenting with acute asthma episodes in paediatric primary care, and hospital services including emergency departments.Methods and analysisA cluster quasi-experimental implementation trial with a matched control group will be launched in a regional healthcare service. …”
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Enhancing Safety in Regional Anesthesia: Guidelines from the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI) by Vito Torrano, Salvatore Anastasi, Eleonora Balzani, Enrico Barbara, Astrid Ursula Behr, Mario Bosco, Claudio Buttarelli, Silvia Bruletti, Dario Bugada, Chiara Cadeddu, Gianluca Cappelleri, Luigi Cardia, Salvatore Casarano, Andrea Cortegiani, Floriana D’Ambrosio, Miryam Del Vicario, Andrea Fanelli, Pierfrancesco Fusco, Giuseppe Gazzerro, Daniela Ghisi, Antonino Giarratano, Fabio Gori, Massimiliano Greco, Paolo Angelo Grossi, Alberto Manassero, Gianluca Russo, Salvatore Sardo, Cosimo Savoia, Marco Tescione, Giulia Tinti, Alessandro De Cassai

“…The guidelines presented herein were developed according to the GRADE system (Grading of Recommendations of Assessment Development and Evaluations), in compliance with the methodological manual for the production of clinical practice guidelines published by the National Center for Clinical Excellence, Quality, and Safety of Care, Italian National Institute of Health. …”
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Telmisartan modulates exercise responses in peripheral artery disease: Analyses of skeletal muscle from the TELEX Trial by Kate Kosmac, PhD, Jai K. Joshi, BS, Mary M. McDermott, MD, Jada C. Stewart, BS, Dongxue Zhang, MS, Shujun Xu, MS, Karen J. Ho, MD, Robert Sufit, MD, Luigi Ferrucci, MD, Charlotte A. Peterson, PhD, Ahmed Ismaeel, PhD

“…In participants with PAD randomized to supervised exercise, results suggested that TEL reduced myostatin expression and increased myofiber size, compared with placebo. Clinical practice guidelines recommend angiotensin-converting enzyme inhibitors/angiotensin receptor blockers in patients with hypertension and PAD to reduce cardiovascular events. …”
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Guideline-Directed Medical Therapy in the Management of Cardiovascular Disease: A Cross-sectional Questionnaire-based Study amongst Indian Healthcare Professionals by Prafulla Kerkar, Rajeev Garg, Abhishek Shukla, Viveka Kumar, Akshyaya Pradhan, Arindam Pande, Johan Christopher, Febin Francis, Nitin Zalte, Amarnath Sugumaran

“…Introduction: Guideline-Directed Medical Therapies (GDMT) are evidence-based treatments recommended by clinical practice guidelines for the management of Cardiovascular Diseases (CVDs). …”
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The INfectious DIsease REgistry BIObank (INDI-REBIO): protocol for the design and implementation of a single-centre, prospective registry and biobank in a tertiary care centre in I... by Maurilio Ponzoni, Carmen García, Diana Canetti, Antonella Castagna, Marco Ripa, Paolo Scarpellini, Massimo Locatelli, Simona Bossolasco, Paola Cinque, Angelo Roberto Raccagni, Elena Bruzzesi, Nicola Gianotti, Silvia Nozza, Laura Galli, Vincenzo Spagnuolo, Camilla Muccini, Ilaria Mainardi, Massimo Cernuschi, Francesca Alberton, Benedetta Trentacapilli, Maria Francesca Lucente, Riccardo Lolatto, Martina Strano, Costanza Bertoni, Francesca Sanvito, Tommaso Clemente, Flavia Passini, Chiara Tassan Din, Monica Guffanti, Girolamo Piromalli, Silvia Carletti, Elisa Cantarelli, Cristina Tresoldi, Anna Danise, Raffaele Dell’Acqua, Giovanni Gaiera, Hamid Hasson, Emanuela Messina, Giulia Morsica, Martina Ranzenigo, Caterina Uberti-Foppa, Katia Ruggieri, Viviana Castagna, Gaetana Annicchiarico, Alessandro Baglivi, Liviana Della Torre, Sabrina Bagaglio, Elisabetta Carini, Michele Bellomo, Sara Diotallevi, Flavia Badalucco Ciotta, Chiara Ballabio, Caterina Candela, Gaia Catalano, Chiara Maci, Roberta Monardo, Nicolò Moschetta, Marcella Negri, Rebecka Papaioannu Borjesson, Giacomo Ponta, Alessia Siribelli, Golnaz Torkjazi, Annapia Di Napoli, Floriana Gona, Marco Tonelli, Annunziata Macrì, Enzo Scifo

“…The registry aims to include significant patient numbers across various conditions (among others: bloodstream infections, endovascular infections as infective endocarditis, central nervous system infections, bone and joint infections, multidrug-resistant organisms (MDROs) colonisation, sexually transmitted infections, HIV infection, emerging and re-emerging infectious diseases), enabling comprehensive research on disease evolution, treatment outcomes and the identification of biomarkers.Ethics and dissemination The study adheres to ethical principles outlined by the Helsinki Declaration and Good Clinical Practice guidelines. It has received ethical approval (Comitato Etico CET Lombardia 1, CET 138–2023) and is registered on clinicaltrials.gov (NCT06418048). …”
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CARE Guidelines for Case Reports: Explanation and Elaboration Document. Translation into Russian by David S. Riley, Melissa S. Barber, Gunver S. Kienle, Jeffrey K. Aronson, Tido von Schoen-Angerer, Peter Tugwell, Helmut Kiene, Mark Helfand, Douglas G. Altman, Harold Sox, Paul G. Werthmann, David Moher, Richard A. Rison, Larissa Shamseer, Christian A. Koch, Gordon H. Sun, Patrick Hanaway, Nancy L. Sudak, Marietta Kaszkin-Bettag, James E. Carpenter, Joel J. Gagnier

“…Well-written and transparent case reports (1) reveal early signals of potential benefits, harms, and information on the use of resources; (2) provide information for clinical research and clinical practice guidelines, and (3) inform medical education. …”
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Pulmonary function testing in pediatric allogeneic stem cell transplant recipients to monitor for Bronchiolitis obliterans syndrome: a systematic review by William A. Gower, Maximiliano Tamae-Kakazu, Shivanthan Shanthikumar, Saumini Srinivasan, Erin E. Reardon, Amisha V. Barochia, Edward Charbek, Charlotte Calvo, Pi Chun Cheng, Shailendra Das, Stella M. Davies, Jessica Gross, Ajay Sheshadri, Christoper T. Towe, Samuel B. Goldfarb, Narayan P. Iyer

“…A systematic review evaluating PFT before and after pediatric aHSCT was conducted to inform American Thoracic Society clinical practice guidelines on detection of BOS. Objective To determine the optimal approach to conducting PFT prior to and after pediatric aHSCT. …”
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Advances in diagnostic assays for Clostridioides difficile infection in adults by Dong-ang Liu, Dong-ang Liu, Shiyu Chen, Shiyu Chen, Ruiyao Hu, Ruiyao Hu, Yuting Qiu, Yuting Qiu, Keyi Chen, Keyi Chen, Yue Xu, Yue Xu, Jinghua Yuan, Jinghua Yuan, Xinling Zhang, Xinling Zhang, Xiaoping Li, Xiaoping Li

“…Since publication of a review of the diagnosis of CDI in adults, new clinical diagnostic assays have become available and clinical practice guidelines were updated. This paper presents a comprehensive review of contemporary laboratory diagnostic approaches for CDI in adult patients, with a focus on the utilisation and potential advancements of five sophisticated methodologies, CRISPR in conjunction with nucleic acid amplification tests (NAATs), gene sequencing technology, ultra-high performance liquid chromatography-mass spectrometry, Raman spectroscopy, and real-time cell analysis (RTCA). …”
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Prehospital antibiotics and intravenous fluids for patients with sepsis: protocol for a 2×2 factorial randomised controlled trial by Nick Daneman, Tony Mazzulli, Rob Stenstrom, Gail Klein, Ruxandra Pinto, Lisa Burry, Sheldon Cheskes, Jim Christenson, Damon C. Scales, Anna Rogowsky, Ian R. Drennan, Morgan Hillier, Sandra Jenneson, Philip Moran, Andrew M. Morris, Laurie J. Morrison, Gordon D. Rubenfeld, Christopher W. Seymour, P. Richard Verbeek

“…It will be conducted in accordance with the Declaration of Helsinki, Good Clinical Practice guidelines and regulatory requirements. The final results will be disseminated to participating paramedic services through educational materials, presentations and interactive training. …”
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Participant Perceptions of Increasing Water Intake in Polycystic Kidney Disease by Sneha Amin, Irene Sangadi, Margaret Allman-Farinelli, Neil Boudville, Imad Haloob, David C.H. Harris, Carmel M. Hawley, David W. Johnson, Vincent W. Lee, Jun Mai, Anna Rangan, Simon D. Roger, Kamal Sud, Eswari Vilayur, Gopala K. Rangan

“…Introduction: Clinical practice guidelines suggest maintaining adequate hydration in people with autosomal dominant polycystic kidney disease (ADPKD). …”
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BioKGrapher: Initial evaluation of automated knowledge graph construction from biomedical literature by Henning Schäfer, Ahmad Idrissi-Yaghir, Kamyar Arzideh, Hendrik Damm, Tabea M.G. Pakull, Cynthia S. Schmidt, Mikel Bahn, Georg Lodde, Elisabeth Livingstone, Dirk Schadendorf, Felix Nensa, Peter A. Horn, Christoph M. Friedrich

“…Downstream applications include multi-label document classification using Adapter-infused Transformer models.Results BioKGrapher effectively aligns generated concepts with clinical practice guidelines from the German Guideline Program in Oncology (GGPO), achieving F1-Scores of up to 0.6. …”
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Actions to Improve the Secondary Prevention of Fragility Fractures in Women with Postmenopausal Osteoporosis: A Social Return on Investment (SROI) Study by Olmo-Montes FJ, Caeiro-Rey JR, Peris P, Pérez del Río V, Etxebarria-Foronda Í, Cancio-Trujillo JM, Pareja T, Jódar E, Naranjo A, Moro-Álvarez MJ, García-Goñi M, Vergés J, Maratia S, Campos Tapias I, Prades M, Aceituno S

“…A sensitivity analysis evaluated the returns in worst- and best-case scenarios over three years.Results: Stakeholders agreed on four main actions: 1) establishing fracture liaison services; 2) harmonizing clinical practice guidelines and provide training for healthcare professionals (HCPs); 3) promoting HCPs’ adherence to fracture registries and 4) raising awareness of OP and fragility fractures. …”
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Evaluation and management of incomplete ovarian function suppression in premenopausal breast cancer patients receiving anti-hormone therapy by Ruchi Patel, Elizabeth Weil, Sara Bugamelli, Emma Carroll, Kylie Steinke, Erinn Stockhausen, John Burfeind, Colin Mooney, Janet Retseck, Deepika Sriram, Jutta Deininger, Angela Halbach, Maressa Sweeney, Sailaja Kamaraju, Lubna N. Chaudhary, Yee Chung Cheng

“…The National Comprehensive Cancer Network (NCCN) and the American Society of Clinical Oncology (ASCO) provide recommendations to monitor E2 levels in premenopausal patients on an aromatase inhibitor (AI) due to the concern of incomplete OFS for patients receiving GnRH agonist therapy (Burstein et al. in J Clin Oncol 37(5):423–438, 2019, National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Breast Cancer. Version 2.2024. www.nccn.org ). …”
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Fracturas de cadera osteoporóticas en España. ¿Cómo estamos? Revisión sistemática y metaanálisis de los registros publicados by J.H. Núñez, F. Moreira, M. Surroca, J. Martínez-Peña, M.J. Jiménez-Jiménez, B. Ocrospoma-Flores, P. Castillón, E. Guerra-Farfán

“…Conclusions: Less than half of patients with a hip fracture undergo surgery within 48 hours, despite being recommended by the majority of clinical practice guidelines. Delirium is the most frequently reported postoperative complication, and one in every 5 patients will die within a year after a hip fracture. …”
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[Translated article] Hip fractures in Spain. How are we? Systematic review and meta-analysis of the published registries by J.H. Núñez, F. Moreira, M. Surroca, J. Martínez-Peña, M.J. Jiménez-Jiménez, B. Ocrospoma-Flores, P. Castillón, E. Guerra-Farfán

“…Conclusions: Less than half of patients with a hip fracture undergo surgery within 48 h, despite being recommended by the majority of clinical practice guidelines. Delirium is the most frequently reported postoperative complication, and one in every 5 patients will die within a year after a hip fracture. …”
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