Survival impact of centralization and clinical guidelines for soft tissue sarcoma (A prospective and exhaustive population-based cohort). by Olfa Derbel, Pierre Etienne Heudel, Claire Cropet, Pierre Meeus, Gualter Vaz, Pierre Biron, Philippe Cassier, Anne-Valérie Decouvelaere, Dominique Ranchere-Vince, Olivier Collard, Eric De Laroche, Philippe Thiesse, Fadila Farsi, Dominic Cellier, François-Noel Gilly, Jean-Yves Blay, Isabelle Ray-Coquard

“…<h4>Purpose</h4>The outcome of sarcoma has been suggested in retrospective and non-exhaustive studies to be better through management by a multidisciplinary team of experts and adherence to clinical practice guidelines (CPGs). The aim of this prospective and exhaustive population based study was to confirm the impact of adherence to CPGs on survival in patients with localized sarcoma.…”
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Heart rate turbulence in type 2 diabetes mellitus with chronic kidney disease. by Huimin Zhu, You-Fan Peng, Huiping Gu, Xingjing Liu

“…CKD diagnoses were confirmed according to KDIGO Clinical Practice Guidelines.<h4>Results</h4>For HRT parameters, T2DM patients with CKD exhibited a significantly higher turbulence onset (TO) (-0.25 [-1.02, 0.23] vs -0.64 [-1.93 0.10], p = 0.034) and lower turbulence slope (TS) (2.49 [1.27, 4.00] vs 6.20 [2.55, 8.80], p < 0.001) than those without CKD. …”
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Chronic heart failure and the frequency of taking nonsteroidal anti-inflammatory drugs: a register-based study on the possible risks by E. I. Tarlovskaya, Yu. V. Mikhailova

“…Examination and treatment of patients was performed based on current clinical practice guidelines and standards. According to the results of echocardiography, HF with preserved ejection fraction was diagnosed in 70% of patients, HF with mid-range ejection fraction — in 20%, and HF with reduced ejection fraction — in 10%. …”
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Improving type 2 diabetes mellitus management in Ministry of Defense Hospitals in the Kingdom of Saudi Arabia 2018–2021 by Noura Al-Nowaiser, Yasser K Alotaibi, Turki J Al Harbi, Ayla M Tourkmani, Maha Moharram

“…Enrolled hospitals were required to implement an evidence-based change package that included the implementation of diabetes clinical practice guidelines with standardised assessment and care planning tools. …”
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Treatment Patterns of Patients With Pulmonary Hypertension: A Descriptive Study in Colombia by Manuel Machado‐Duque, Andrés Gaviria‐Mendoza, Luis Fernando Valladales‐Restrepo, Manuel Pacheco, Juan Sebastián Franco, María delRosario Forero, Rubiela Suarez, Oscar Peñuela, Jorge E. Machado‐Alba

“…However, current clinical practice guidelines recommend the use of combined therapy. …”
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Predicting mucosal inflammation in IBD patients using patient-reported symptom scores and a faecal calprotectin home test: protocol for a multicentre prospective validation study by Lloyd Brandts, Zlatan Mujagic, M Pierik, Tessa EH Römkens, Laura Janssen, Mariëlle Romberg-Camps, Reinier Cornelis Anthonius van Linschoten, Rachel Louise West, Lennard P L Gilissen

“…The main study outcome is the diagnostic test accuracy of the various patient-reported scores to assess mucosal inflammation in combination with a FC home test.Ethics and dissemination This study is approved by the Medical Research Ethics Committee of azM/UM in Maastricht dated 03 March 2021 (METC 20–085) and is monitored by the Clinical Trial Centre Maastricht according to Good Clinical Practice guidelines. Written informed consent will be obtained from all patients. …”
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Attitudes towards transjugular intrahepatic portosystemic shunt (TIPS) in Australia: a national survey of TIPS centres by Jacob George, Avik Majumdar, Golo Ahlenstiel, Stuart K Roberts, Scott Read, Eric Kalo

“…There is a need for a national consensus clinical practice guidelines to improve access and minimise unwarranted variation. …”
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Intrapleural fibrinolysis and DNase versus video-assisted thoracic surgery (VATS) for the treatment of pleural empyema (FIVERVATS): protocol for a randomised, controlled trial – su... by Najib Rahman, Babu Naidu, Eihab O Bedawi, Zaigham Saghir, Uffe Bodtger, Bo Martin Bibby, Christian B Laursen, Thomas Decker Christensen, Morten Bendixen, Søren Helbo Skaarup, Jens-Ulrik Jensen, Rene Horsleben Petersen, Merete Christensen, Peter Licht, Kirsten Neckelmann, Lars B Møller, Morten Hornemann Borg, Sten Langfeldt, Stefan M W Harders

“…The research project is carried out in accordance with the Helsinki II Declaration, European regulations and Good Clinical Practice Guidelines. The Scientific Ethics Committees for Denmark and the Danish Data Protection Agency have provided permission. …”
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Glimepiride monotherapy versus combination of glimepiride and linagliptin therapy in patients with HNF1A-diabetes: a protocol for a randomised, double-blinded, placebo-controlled t... by Torben Hansen, Tina Vilsbøll, Filip Krag Knop, Alexander Sidelmann Christensen, Heidi Storgaard, Sofie Hædersdal

“…The trial will be carried out and monitored in compliance with Good Clinical Practice guidelines and in accordance with the latest version of the Declaration of Helsinki. …”
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Re-evaluating population-level screening recommendations to address increasing early-onset colorectal cancer rates in Australia: a modelling study☆ by J.-B. Lew, J. Worthington, H. Ge, Q. Luo, E. Feletto, K. Canfell, T. Price

“…These analyses supported the 2023 Clinical practice guidelines for the prevention, early detection and management of colorectal cancer: Population Screening, which led to the NBCSP including people aged 45-49 on an opt-in basis from July 2024.…”
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The prevalence of subclinical atherosclerosis of carotid arteries in patients with calcium pyrophosphate crystal deposition disease and osteoarthritis (pilot study) by M. S. Eliseev, O. V. Zhelyabina, A. M. Novikova, M. N. Chikina, E. I. Markelova, I. G. Kirillova, Yu. O. Korsakova, A. A. Kobriseva

“…McCarty, diagnosis of OA was based on national clinical practice guidelines. We recorded data on smoking, blood pressure level. …”
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Challenges in amphetamine medication availability for individuals with ADHD: a narrative review of the current state of evidence by Mansour M. Alotaibi, Mansour M. Alotaibi, Naif Z. Alrashdi, Naif Z. Alrashdi, Bakriah Alzubaidi, Marzouq K. Almutairi, Sultan A. Alanazi, Anwar B. Almutairi, Mohammed M. Alqahtani, Mohammed M. Alqahtani

“…Policy reports from national institutions highlight persistent barriers to AMPH access, despite their inclusion in recent clinical practice guidelines. Prescription trends suggest significant treatment gaps for AMPH stimulants.ConclusionThe available evidence suggests a likely shortfall in AMPH-based medications. in Saudi Arabia, despite global and local evidence supporting their efficacy. …”
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Improving the management of acute asthma in children through an integrated care pathway: an implementation study protocol by Marta Montejo, Natalia Paniagua, Alvaro Sanchez, Alvaro Sanchez, Mikel Rueda-Etxebarria, Jose I. Pijoan, Jose I. Pijoan, Jose I. Pijoan, Carlos Saiz Hernando, Vanesa Martin, Miguel Angel Vázquez Ronco, Mikel Santiago Burruchaga, Diego García Urabayen, Garbiñe Pérez Llarena, Susana Castelo, Javier Benito

“…IntroductionThis study aims to evaluate the effectiveness and feasibility of the implementation of an Asthma Integrated Care Pathway (AICP) to improve care and reduce variability according to recommended clinical practice guidelines, for children presenting with acute asthma episodes in paediatric primary care, and hospital services including emergency departments.Methods and analysisA cluster quasi-experimental implementation trial with a matched control group will be launched in a regional healthcare service. …”
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Horner syndrome as a complication of ultrasound-guided ablation therapy for thyroid nodules: a scoping review by Tianhao Xie, Tianhao Xie, Yan Fu, Xiaoshi Jin, Xiaoshi Jin, Xiangxiang Ren, Xiangxiang Ren, Jing Zhang, Jing Zhang, Qian Sun, Qian Sun

“…Future prospective studies are needed to clarify incidence rates, long-term prognosis, and refine clinical practice guidelines.…”
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Safety and tolerability of a bevacizumab biosimilar (Effivia®) in adult Mexican patients with cancer: a multicenter, observational, prospective clinical study by Alberto Alfonso Pimentel-Rentería, David Francisco Cantú de León, Eliseo Neftalí De la Cruz, David Suárez, Manuel Rodulfo Segura, José Gustavo Núñez, Livan Delgado-Roche

“…Treatment regimens followed the Clinical Practice Guidelines and the Investigator criteria.ResultsAdult patients (n = 82) were included, 65.8% (n = 54) completed the full 6-cycle treatment, while 34.1% (n = 28) meet the criteria for early discontinuation including disease progression (18.3%), voluntary withdrawal or dropout (7.3%), treatment availability or brand switching (4.9%), and serious adverse events (3.7%). …”
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Phase 2 trial design of BMS-986278, a lysophosphatidic acid receptor 1 (LPA1) antagonist, in patients with idiopathic pulmonary fibrosis (IPF) or progressive fibrotic interstitial... by Jeffrey J Swigris, Toby M Maher, Tamera J Corte, Aryeh Fischer, Hong Xiao, Lisa Lancaster, Takafumi Suda, Xiaojiang Zhan, Jonathan G Goldin, Scott M Palmer, Hideaki Watanabe, Takashi Ogura, Anne Minnich, Giridhar S Tirucherai, Brandon Elpers, R Adam Smith, Edgar D Charles

“…The primary endpoint is rate of change in per cent predicted forced vital capacity from baseline to week 26 in the IPF cohort.Ethics and dissemination This study will be conducted in accordance with Good Clinical Practice guidelines, Declaration of Helsinki principles, and local ethical and legal requirements. …”
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Change from semi‐rigid to soft collars for prehospital management of trauma patients: An observational study by Biswadev Mitra, Stephen Bernard, Cassandra Yankoff, Abha Somesh, Cara Stewart, Christine Koolstra, Carly Talarico, Ziad Nehme, Mark C. Fitzgerald, Peter A. Cameron

“…In 2021, Ambulance Victoria changed clinical practice guidelines to apply soft collars instead of semi‐rigid collars for suspected cervical spine injury. …”
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Efficacy and safety of a new drug formulation, amoxicillin-clavulanate-cineole, for adult lower respiratory tract infections: a nationwide observational study in Morocco by Mohamed Chakib Benjelloun, Youness El Achhab, Youness El Achhab, Chakib Nejjari, Chakib Nejjari, the ORCA Study Group

“…Olipen® 500 mg (amoxicillin 500 mg, clavulanate 62.5 mg, cineole 100 mg) was administered as two sachets, three times daily, for 7–14 days, as per clinical practice guidelines. The primary outcome focused on the clinical recovery and safety as a secondary outcome.ResultsA total of 936 patients were enrolled in the study at the national level. …”
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Patient and physical therapist perspectives on spinal manipulative therapy for low back pain and associated clinical outcomes: protocol for a prospective, single-arm intervention s... by Jason M Beneciuk, Guogen Shan, Joel Bialosky, Jill R Hayes, Katherine E Buzzanca-Fried, Robert Rowe, Sara Cristello, Trent Harrison, Ryan Vickers

“…Multimodal treatment approach of SMT (required during initial three treatment sessions within a 2week period), exercise and education supported by recent clinical practice guidelines will be encouraged for this study.Ethics and dissemination Ethics approval for the study was obtained from the University of Florida Institutional Review Board. …”
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The INfectious DIsease REgistry BIObank (INDI-REBIO): protocol for the design and implementation of a single-centre, prospective registry and biobank in a tertiary care centre in I... by Maurilio Ponzoni, Carmen García, Diana Canetti, Antonella Castagna, Marco Ripa, Paolo Scarpellini, Massimo Locatelli, Simona Bossolasco, Paola Cinque, Angelo Roberto Raccagni, Elena Bruzzesi, Nicola Gianotti, Silvia Nozza, Laura Galli, Vincenzo Spagnuolo, Camilla Muccini, Ilaria Mainardi, Massimo Cernuschi, Francesca Alberton, Benedetta Trentacapilli, Maria Francesca Lucente, Riccardo Lolatto, Martina Strano, Costanza Bertoni, Francesca Sanvito, Tommaso Clemente, Flavia Passini, Chiara Tassan Din, Monica Guffanti, Girolamo Piromalli, Silvia Carletti, Elisa Cantarelli, Cristina Tresoldi, Anna Danise, Raffaele Dell’Acqua, Giovanni Gaiera, Hamid Hasson, Emanuela Messina, Giulia Morsica, Martina Ranzenigo, Caterina Uberti-Foppa, Katia Ruggieri, Viviana Castagna, Gaetana Annicchiarico, Alessandro Baglivi, Liviana Della Torre, Sabrina Bagaglio, Elisabetta Carini, Michele Bellomo, Sara Diotallevi, Flavia Badalucco Ciotta, Chiara Ballabio, Caterina Candela, Gaia Catalano, Chiara Maci, Roberta Monardo, Nicolò Moschetta, Marcella Negri, Rebecka Papaioannu Borjesson, Giacomo Ponta, Alessia Siribelli, Golnaz Torkjazi, Annapia Di Napoli, Floriana Gona, Marco Tonelli, Annunziata Macrì, Enzo Scifo

“…The registry aims to include significant patient numbers across various conditions (among others: bloodstream infections, endovascular infections as infective endocarditis, central nervous system infections, bone and joint infections, multidrug-resistant organisms (MDROs) colonisation, sexually transmitted infections, HIV infection, emerging and re-emerging infectious diseases), enabling comprehensive research on disease evolution, treatment outcomes and the identification of biomarkers.Ethics and dissemination The study adheres to ethical principles outlined by the Helsinki Declaration and Good Clinical Practice guidelines. It has received ethical approval (Comitato Etico CET Lombardia 1, CET 138–2023) and is registered on clinicaltrials.gov (NCT06418048). …”
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