Regional Experience in Improving the Quality and Cost-Effectiveness of Medical Care for Children with Acute Respiratory Pathology in the Rostov Region by Elena A. Besedina, Svetlana G. Piskunova, Alexandra S. Badyan, Eleonora V. Dudnikova, Galina Yu. Barkovskaya

“…CECPP peak indicators came under notice in all observation groups due to high expenses on medications and specifically those not included in clinical practice guidelines, vast amount of unreasonable hospitalizations and diagnostic procedures, expenses on physical therapy (PT), etc. …”
Get full text

Recommendations for the Clinical Development of Medicinal Products for Non-specific Influenza Chemoprophylaxis by A. I. Gubenko, O. Yu. Ivanova

“…When developing preclinical and clinical programmes for medicinal products for influenza prevention, it is necessary, first of all, to take into account the requirements of the national good clinical practice guidelines and the EAEU guidelines for clinical trials in general. …”
Get full text

A novel approach to determining pulmonary valve replacement timing in repaired tetralogy of Fallot patients by Laura Delaney, Andrew Browne, Gruschen R. Veldtman, Sihong Huang

“…Conclusions: Current clinical practice guidelines for timing of PVR in patients with rTOF remains flawed and has since been challenged. …”
Get full text

The effect of a topically-applied cosmetic oil formulation on striae distensae by Beverley Summers, Marlize Lategan

“…The study was performed according to standard good clinical practice guidelines. Methods: The study was conducted among 20 healthy Caucasian women with bilateral abdominal striae. …”
Get full text

Impact of an Early Invasive Strategy versus Conservative Strategy for Unstable Angina and Non-ST Elevation Acute Coronary Syndrome in Patients with Chronic Kidney Disease: A System... by Catriona Shaw, Dorothea Nitsch, Jasmine Lee, Damian Fogarty, Claire C Sharpe

“…<h4>Background</h4>Clinical practice guidelines support an early invasive approach after NSTE-ACS in patients with chronic kidney disease (CKD). …”
Get full text

Evidence summary of lifestyle interventions in adults with metabolic dysfunction-associated steatotic liver disease by Mei-jing Chen, Ying Chen, Jin-qing Lin, Rong Hu, Dun Liu, Jing-yi Chen, Ka Li, Xiao-ying Jiang

“…The available research included clinical decisions, clinical practice guidelines, evidence summaries, systematic evaluation, expert consensus, and expert opinions. …”
Get full text

Mortality of Head and Neck Cancer in China From 1990 to 2019: A Secondary Data Analysis by Zhengxin Zhu, Jiasheng Yuan, Li Fu, Wanqing Zhang, Songtao Liu, Yuehui Liu

“…Continuous monitoring is essential to understand the impact of evolving clinical practice guidelines on the mortality of head and neck cancer.…”
Get full text

Rationale, design and objectives of two phase III, randomised, placebo-controlled studies of GLPG1690, a novel autotaxin inhibitor, in idiopathic pulmonary fibrosis (ISABELA 1 and... by Kevin K Brown, Toby M Maher, Michael Kreuter, David J Lederer, Wim Wuyts, Nadia Verbruggen, Simone Stutvoet, Ann Fieuw, Paul Ford, Walid Abi-Saab, Marlies Wijsenbeek

“…Key secondary endpoints are week 52 composite endpoint of disease progression or all-cause mortality (defined as composite endpoint of first occurrence of ≥10% absolute decline in per cent predicted FVC or all-cause mortality at week 52); time to first respiratory-related hospitalisation until end of study; and week 52 change from baseline in the St George’s Respiratory Questionnaire total score (a quality-of-life measure).Ethics and dissemination Studies will be conducted in accordance with Good Clinical Practice guidelines, Declaration of Helsinki principles, and local ethical and legal requirements. …”
Get full text

Evaluation of Treatment Patterns and Direct Costs Associated with the Management of Neuropathic Pain by Manuel E Machado-Duque, Andres Gaviria-Mendoza, Jorge E Machado-Alba, Natalia Castaño

“…Patients with neuropathic pain in Colombia are being diagnosed late, are using therapeutic agents not recommended as first-line treatment by clinical practice guidelines, and are being treated for short periods of time.…”
Get full text

Nutrition Users’ Guides: an introduction to structured guides to evaluate the nutrition literature by Gordon H Guyatt, Bradley C Johnston, Malgorzata M Bala, Kevin C Klatt, Mary Rozga, Rosa K Hand, Deepa Handu

“…Structured nutrition users’ guides (NUGs) to evaluate common research study designs (ie, randomised trials, cohort studies, systematic reviews and clinical practice guidelines) addressing nutrition questions will help clinicians and their patients, as well as health service workers and policy-makers, use the evidence to make more informed decisions on disease management and prevention. …”
Get full text

Participant Perceptions of Increasing Water Intake in Polycystic Kidney Disease by Sneha Amin, Irene Sangadi, Margaret Allman-Farinelli, Neil Boudville, Imad Haloob, David C.H. Harris, Carmel M. Hawley, David W. Johnson, Vincent W. Lee, Jun Mai, Anna Rangan, Simon D. Roger, Kamal Sud, Eswari Vilayur, Gopala K. Rangan

“…Introduction: Clinical practice guidelines suggest maintaining adequate hydration in people with autosomal dominant polycystic kidney disease (ADPKD). …”
Get full text

Comparison between intratympanic injection of dexamethasone and methylprednisolone in idiopathic sudden sensorineural hearing loss: A randomized clinical trial by Kourosh Eftekharian, Elnaz Najafi, Maryam Amizadeh, Noosheen Mokari, Mohammad Faramarzi, Yalda Izadparast, Yalda Jabbari Moghadam, Ali Eftekharian

“…Three comparisons between the initial and third‐month hearing tests were made to assess the degree of hearing change: (1) pure tone improvement in each individual tone (0.5, 1, 2, 3, and 4 kHz); (2) word‐recognition score improvement; and (3) complete, partial, and no recovery of hearing calculated (as defined by American Academy of Otolaryngology‐Head and Neck Surgery Clinical Practice Guidelines). Results The study was completed with 69 of the 75 patients—34 in the methylprednisolone group and 35 in the dexamethasone group. …”
Get full text

Current guidelines for the management of adrenal incidentalomas in European countries by Julia Ząber, Zuzanna Wyleciał, Patryk Dąbrowski, Marcelina Guzik, Eliza Pyla

“…We also searched current recommendations of The Endocrine Society Clinical Practice Guidelines.   Description of the state of knowledge: Adrenal incidentalomas are asymptomatic adrenal masses detected incidentally during imaging studies performed for unrelated reasons. …”
Get full text

Single center experience with a novel single-branched thoracic stent graft by Theodoros Kratimenos, Dimitra Tachmetzidi Papoutsi, Panagiotis Petaloudis, Nefeli Ntinou, Myrto Papadopoulou, Vasileios Panou, Evaggelia Kalaitzidou, Dimitrios Tomais, Ilias Samiotis, Loukia Alexopoulou-Prounia, Panagiotis Dedeilias, Mihalis Argiriou

“…Abstract Background Thoracic endovascular aortic repair (TEVAR) has been a feasible treatment option since the first stent graft was approved by the FDA in 2005, and is now the recommended method for treating most descending aorta pathology in the current clinical practice guidelines. Indications for TEVAR include descending aorta aneurysms, traumatic aortic injury and pathology that presents as acute aortic syndrome. …”
Get full text

Designing and validating a clinical decision support algorithm for diabetic nephroprotection in older patients by Simon LeClerc, Nicolas Fernandez, Kelley Kilpatrick, Cheryl Sadowski, Noor Alsalemi, Naoual Elftouh, Jean-Philippe Lafrance, Sherilyn Houle

“…Background Older patients with diabetic kidney disease (DKD) often do not receive optimal pharmacological treatment. Current clinical practice guidelines (CPGs) do not incorporate the concept of personalised care. …”
Get full text

Effect of invasive tests during pregnancy on perinatal transmission of hepatitis B infection: a scoping review by Ka Wang Cheung, Tiffany Sin-Tung Au, Ying Rong Li, Zhenyan Han, Zhu Zhang, Mimi Tin Yan Seto

“…We also reviewed 50 international clinical practice guidelines. Most of them did not have recommendations on the management of hepatitis B infected pregnant individuals requiring prenatal or intrapartum invasive tests and significant discrepancies existed among the remaining guidelines. …”
Get full text

Study protocol for a multicentre randomised controlled trial using music prehabilitation to reduce preoperative anxiety before oncological colorectal surgery: the MU-PRIOR trial by Erwin Birnie, Markus Klimek, Johannes Jeekel, Jorrit Gustav Verhoeven, Roos Geensen, Thomas Lodewijk Adriaan Dirven, Willem Jaap Rogier Rietdijk

“…The trial will be carried out following the updated Declaration of Helsinki principles and Good Clinical Practice guidelines. Study results will be published and reported in a peer-reviewed journal according to the Consolidated Standards of Reporting Trials guidelines.Trial registration number NCT05982184.…”
Get full text

THE WAY OF ASSESSING THE ADHERENCE TO MODERN DRUG THERAPY CLINICAL GUIDELINES AIMED AT REDUCING THE RISK OF RECURRENT STROKE (ACCORDING TO THE LIS-2 REGISTER) by A. Yu. Suvorov, S. Yu. Martsevich, N. P. Kutishenko, A. D. Deev, M. L. Ginzburg, A. V. Akimova, E. V. Daniels, N. A. Dmitrieva, L. Yu. Drozdova, N. Yu. Zhuravskaya, O. V. Lerman, Yu. V. Lukina, M. M. Loukianov, V. P. Smirnov, A. V. Fokina

“…The scale evaluation of the quality of therapy for the prevention of recurrent stroke developed in accordance with the modern clinical practice guidelines, as well as the recurrent stroke prevention index (RSPI) for this assessment were elaborated. …”
Get full text

Acute Pain in the African Prehospital Setting: A Scoping Review by Andrit Lourens, Michael McCaul, Romy Parker, Peter Hodkinson

“…Future research is indicated to enable a better understanding of the epidemiology of acute pain and barriers and enablers of acute pain care and to develop evidence-based clinical practice guidelines (CPGs) catering for all EMS systems in Africa. …”
Get full text

Clinical practice outcomes and differential results in maternal and neonatal morbidity among pregnant women in Spain who are candidates for a normal birth: a cross-sectional study by Paula Parás-Bravo, Ana Casteleiro, M Santibanez, Amada Pellico-Lopez, María Paz-Zulueta

“…Furthermore, there were statistically significant differences between the groups according to the type of birth, the need for instrumental birthing methods, the existence of perineal tears, Apgar scores and the requirement for the infant to be admitted to the neonatal intensive care unit.Conclusions Our results suggest a differential clinical practice, in line with the recommendations of the Clinical Practice Guidelines for Care of Normal Birth. Nonetheless, improvements are necessary regarding the care provided to women and infants, as the percentages of episiotomies and caesarean sections are still high when compared with current standards and compared with other reports.…”
Get full text