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    Clinical Features and Prognosis of Double-Positive Anti-MDA5 and Anti-CCP Antibodies in Dermatomyositis: A Retrospective Study by Xu X, Zhu L, Li S, Wang G, Ge Y

    Published 2025-02-01
    “…Xiayu Xu,1 Longyang Zhu,2 Sizhao Li,3 Guochun Wang,3 Yongpeng Ge3 1Department of Rheumatology and Immunology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, People’s Republic of China; 2Peking University, China-Japan Friendship School of Clinical Medicine, Beijing, People’s Republic of China; 3Department of Rheumatology, The Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yongpeng Ge, Department of Rheumatology, The Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China, Email gyp2016@163.comObjective: To investigate the clinical features and prognosis of anti-melanoma differentiation-related gene 5 (MDA5) antibody and anti-cyclic citrullinated peptide (CCP) antibody double-positive dermatomyositis (DM) (MDA5+/CCP+ DM).Methods: A retrospective analysis of 264 consecutive cases of MDA5+ DM hospitalized from March 2018 to March 2022, and patients with anti-CCP antibodies were screened out. …”
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    Exploring the Cardioprotective Mechanisms of Ligusticum wallichii in Myocardial Infarction Through Network Pharmacology and Experimental Validation by Yang H, Cao J, Zhou L, Chen J, Tang J, Chen J, Yin L, Xie L, Li J, Luo J

    Published 2025-01-01
    “…Huan Yang,1 Jun Cao,1 Lijie Zhou,1 Jiangchuan Chen,1 Jiaman Tang,1 Jiamei Chen,1 Lengyun Yin,1 Li Xie,2 Jianmin Li,1 Jinwen Luo3 1Department of Pulmonary and Critical Care Medicine, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center For Respiratory Rehabilitation in Hunan Province, Changsha, Hunan, People’s Republic of China; 2Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 3Department of Cardio-Thoracic Surgery, Hunan Children’s Hospital, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Jinwen Luo, Department of Cardio-thoracic Surgery, Hunan Children’s Hospital, Changsha, Hunan, People’s Republic of China, Email Jinwen_luo168@163.com Jianmin Li, Department of Pulmonary and Critical Care Medicine, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, People’s Republic of China, Email Leo780307@sina.comBackground: Myocardial infarction represents a coronary artery ailment with the highest incidence and fatality rates among cardiovascular conditions. …”
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    Thyroid Dysfunction After Intensity-Modulated Radiotherapy and PD⁃1 Inhibitor Treatment for Locally Advanced Nasopharyngeal Carcinoma by Shang K, He Q, Xu X, Luo X, Zhao C, Liu L, Li Z, Li Y, Jin F

    Published 2025-01-01
    “…Kai Shang,1,2,* Qianyong He,1– 3,* Xinyu Xu,2 Xunyan Luo,2 Chaofen Zhao,1,3 Lina Liu,1– 3 Zhuoling Li,1– 3 Yuanyuan Li,1– 3 Feng Jin1,3 1Department of Oncology, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 2School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 3Department of Oncology, the Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Jin, Department of Oncology, the Affiliated Hospital of Guizhou Medical University, 28 Guiyi Street, Guiyang, Guizhou, 550004, People’s Republic of China, Tel +851-86512802, Email tjzlk2023@163.comPurpose: Analyze the incidence and risk factors of thyroid dysfunction in patients with advanced nasopharyngeal carcinoma (LA-NPC) after intensity-modulated radiotherapy (IMRT) and PD⁃1 inhibitor treatment and their relationship with treatment efficacy and prognosis.Methods: Eighty-five LA-NPC patients treated with IMRT and PD-1 inhibitors were retrospectively collected from March 1, 2019, to May 30, 2022. …”
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