Targeting Toll-like receptor 4 and microbiota dysregulation: a new frontier in nonalcoholic fatty liver disease management by K.B. Kvit

“…It encompasses a spectrum of disorders, ranging from simple steatosis to non-alcoholic steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma, often associated with metabolic syndrome and insulin resistance. …”
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Timosin alpha-1 immunomodulating properties by M. V. Mayevskaya

“…Timosin alpha-1 can be applied at immune antineoplastic therapy, in particular in treatment of hepatocellular carcinoma which is related to a final stage of persistent infection of hepatitis B and C viruses, that, as a rule, develops on a background of liver cirrhosis and in Caucasian patients.Conclusion. Timosin alpha-1 is successfully applied in clinical practice in treatment of chronic viral hepatites B and C, as antineoplastic immunomodulating drug and requires further active studies.…”
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Prevalence of Hepatitis C Virus Infection in Cancer Patients: A Cross-sectional Study from Regional Cancer Care Centre, Gujarat, India by Hirenkumar Ashokbhai Patel, Foram Maulin Patel

“…It is one of the major risk factors for acute to chronic liver diseases, such as altered liver functions, chronic hepatitis, cirrhosis, hepatocellular carcinoma and liver failure. …”
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Chronic hepatitis B and risk of kidney involvement by M. V. Mayevskaya, I. N. Tikhonov, V. T. Ivashkin

“…At development of liver cirrhosis (LC) and its decompensation one more aspect of renal disease at CHB arises i.e. risk of hepatorenal syndrome (HRS) of the 1st or 2nd type that is a poor prognostic marker and requires individual therapeutic approach.Conclusion. …”
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Geographic Distribution of HCV Genotypes and Efficacy of Direct-Acting Antivirals in Chronic HCV-Infected Patients in North and Northeast China: A Real-World Multicenter Study by Wencong Li, Jing Liang, Jihong An, Lingdi Liu, Yihui Hou, Lu Li, Wen Zhao, Luyao Cui, Ningning Xue, Zaid Al-Dhamin, Tao Han, Yuemin Nan, Liaoyun Zhang

“…SVR12 was higher in noncirrhosis versus compensated cirrhosis patients (100% vs. 97.09%, p=0.022). No severe drug-related adverse event was observed. …”
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Molecular and serological investigation of hepatitis B virus in patients with acute undifferentiated febrile illness at Tha Song Yang hospital, Tak Province, Thailand by Narin Thippornchai, Anon Sae-Oueng, Akanitt Jittmittraphap, Wang Nguitragool, Pornsawan Leaungwutiwong

“…Abstract Background Hepatitis B virus (HBV) infection is associated with hepatitis, often progressing to liver cirrhosis or cancer, posing a significant public health challenge, particularly in Thailand. …”
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Collagen fibers quantification for liver fibrosis assessment using linear dichroism photoacoustic microscopy by Yang Qiu, Honghui Li, Kun Yu, Jiali Chen, Li Qi, Yinghua Zhao, Liming Nie

“…Liver fibrosis represents a progressive pathological condition that can culminate in severe hepatic dysfunction, potentially advancing to cirrhosis and liver cancer. The extent of liver fibrosis is intrinsically associated with the quantity of collagen fibers. …”
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COVID-19 in Patients with Primary Biliary Cholangitis by М. К. Prashnova, K. L. Raikhelson, N. V. Marchenko, S. M. Zakharenko

“…Between March 2020 and March 2021, 50 patients (34.7 %) suffered COVID-19, with mean age of 58.8 ± 10.7 years, 16 of which were diagnosed with liver cirrhosis. Mild COVID-19 was observed in 34 (68 %) people, moderate course — in 14 (28 %), severe — in 2 (4 %), cases of extremely severe course were not recorded. 12 patients were hospitalized, 8 of which received oxygen therapy due to a decrease in SpO2 < 94 %, there was no need for the use of other methods of oxygen therapy in any case. …”
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Hepatitis B virus hijacks MRE11-RAD50-NBS1 complex to form its minichromosome. by Kaitao Zhao, Jingjing Wang, Zichen Wang, Mengfei Wang, Chen Li, Zaichao Xu, Qiong Zhan, Fangteng Guo, Xiaoming Cheng, Yuchen Xia

“…Chronic hepatitis B virus (HBV) infection can significantly increase the incidence of cirrhosis and liver cancer, and there is no curative treatment. …”
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Development of a Recombinant Cell-Based Indirect Immunofluorescence Assay for the Determination of Autoantibodies against Soluble Liver Antigen in Autoimmune Hepatitis by Christiane Radzimski, Christian Probst, Bianca Teegen, Kristin Rentzsch, Inga Madeleine Blöcker, Cornelia Dähnrich, Wolfgang Schlumberger, Winfried Stöcker, Dimitrios P. Bogdanos, Lars Komorowski

“…The recombinant cells were used in IFA (RC-IFA) to analyze sera from 20 AIH patients with anti-SLA positivity predetermined by ELISA together with 80 controls (20 anti-SLA negative AIH, 15 primary biliary cirrhosis, 15 HCV, and 30 healthy blood donors). Using RC-IFA, anti-SLA was detected in all ELISA positive AIH sera but in none of the controls. …”
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Transient Elastography in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease: A Systemic Review and Meta-Analysis by Changzhou Cai, Xin Song, Xueyang Chen, Weihua Zhou, Qi Jin, Shenghui Chen, Feng Ji

“…In patients with ALD/NAFLD, CAP was feasible for identifying and screening steatosis, and LSM was accurate for diagnosing fibrosis, especially severe fibrosis and cirrhosis.…”
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Preoperative Thrombocytopenia May Predict Poor Surgical Outcome after Extended Hepatectomy by Mohammad Golriz, Omid Ghamarnejad, Elias Khajeh, Mohammadsadegh Sabagh, Markus Mieth, Katrin Hoffmann, Alexis Ulrich, Thilo Hackert, Karl Heinz Weiss, Peter Schirmacher, Markus W. Büchler, Arianeb Mehrabi

“…The aim of this study was to evaluate the predictive potential of platelet counts on the outcome of EH in patients without portal hypertension, splenomegaly, or cirrhosis. Methods. A series of 213 consecutive patients underwent EH (resection of ≥ five liver segments) between 2001 and 2016. …”
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Causal Mediation Analyses for the Natural Course of Hepatitis C: A Prospective Cohort Study by Yi-Ting Huang, Yao-Chun Hsu, Hwai-I Yang, Mei-Hsuan Lee, Tai-Hsuan Lai, Chien-Jen Chen, Yen-Tsung Huang

“…Results: In 18,972 participants with 934 HCV infection, we observed that 54.1% of HCV-induced mortality was mediated by intrahepatic diseases, such as liver cirrhosis and liver cancer, and 45.9% of mortality was mediated by extrahepatic diseases. …”
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Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert Opinion by V. V. Tsukanov, M. F. Osipenko, E. V. Beloborodova, M. A. Livzan, I. B. Khlynov, S. A. Alekseenko, Yu. P. Sivolap, J. L. Tonkikh, A. V. Vasyutin

“…In the treatment of NAFLD, diet and lifestyle modification, weight loss, the use of insulin sensitizers, vitamin E, statins (in the presence of hyperlipidemia) and drugs with metabolic activity are effective.Currently, a point of view is being actively expressed about the synergism of the action of alcohol and the metabolic syndrome on the development of fibrosis, cirrhosis, and hepatocellular carcinoma. The current international consensus recommends a change in the nomenclature of NAFLD and ALD and proposes the terms “metabolically associated steatotic liver disease” and “metabolically associated alcoholic liver disease”.Conclusion. …”
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Refining MR-guided thermal ablation for HCC within the Milan criteria: a decade of clinical outcomes and predictive modeling at a single institution by Fu-Qun Wei, Pei-Shu Huang, Bing Zhang, Rui Guo, Yan Yuan, Jin Chen, Zheng-Yu Lin

“…Poorer outcomes were associated with age ≤ 60 years, tumor size > 2 cm, multiple tumors, cirrhosis, proximity to major vessels, and narrow ablation margins (P < 0.05). …”
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Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease by Sameh Abdelkhalik Ahmed, Amal Selim, Nehad Hawash, Ahmed Khaled Tawfik, Mohamed Yousef, Abdelrahman Kobtan, Rehab Badawi, Sally Elnawasany, Reham Abdelkader Elkhouly, Amr Shaaban Hanafy, Fatma H. Rizk, Loai Mansour, Sherief Abd-Elsalam

“…A total of 100 patients with liver cirrhosis referred for upper endoscopy were enrolled and divided equally in two groups, midazolam plus fentanyl group and propofol plus fentanyl group. …”
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Age-Dependent Effects of Butyl Benzyl Phthalate Exposure on Lipid Metabolism and Hepatic Fibrosis in Mice by Min-Seo Park, Seonhwa Hwang, Hyun-Bon Kang, Minjeong Ha, Juyeon Park, So-Youn Park, Yong-Joo Park, Min-Hi Park

“…In contrast, aged mice exhibited hepatic fibrosis, with increased collagen deposition and upregulation of genes related to fibrosis (Acta2, MMP2, TGF-ß1, and Col1a2), cirrhosis (CXCR4, SOX9, DCN, and MFAP4), and cancer (Bcl2, CDKN2a, c-Myc, and Fn1). …”
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Nursing management for enhanced recovery after liver transplantation in a patient with cavernous transformation of the portal vein (1例成人门静脉海绵样变性患者行肝移植的加速康复护理)... by WANG Ting (王婷), LUO Hongping (罗鸿萍)

“…This paper reviewed the clinical data of a hepatocellular carcinoma (BCLC stage A) patient with hepatitis C virus-related cirrhosis, cavernous transformation of the portal vein and portal hypertension, and summarized the nursing management for enhanced recovery after liver transplantation. …”
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Challenges in Diagnosing Intrahepatic Cholangiolithiasis in a 39-Year-Old Patient by A. K. Guseva, O. N. Sergeyeva, T. P. Nekrasova, O. T. Imaraliev, A. V. Okhlobystin, Y. N. Shirokova, A. S. Ostrovskaya, M. S. Zharkova, A. S. Cherenda, V. T. Ivashkin

“…Primary sclerosing cholangitis is a chronic progressive liver disease characterized by destructive inflammation and fibrosis in the bile ducts, leading to biliary strictures, secondary biliary cirrhosis, portal hypertension and liver failure. Cholangiolithiasis occurs in more than half of cases of primary sclerosing cholangitis and can be both a complication and a cause of secondary sclerosing cholangitis, maintaining inflammation in the ducts and facilitating stone formation. …”
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Assessment of liver fibrosis by acoustic radiation force impulse elastography in rheumatic disease patients on long-term methotrexate treatment by Arindam Nandy Roy, Gayatri Senapathy, Vijay Kumar Bongu, Yarram Ashok Kumar, Syeda Sana Fatima, Regina Lata Thadigiri

“…Three patients had ARFI abnormalities (1: cirrhosis and 2: early stage fibrosis). There was no correlation between the ARFI values / biochemical parameters and the cumulative dose of methotrexate. …”
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