Economic Evaluation of Boceprevir for the Treatment of Patients with Genotype 1 Chronic Hepatitis C Virus Infection in Hungary by Raymond Odhiambo, Jagpreet Chhatwal, Shannon Allen Ferrante, Antoine El Khoury, Elamin Elbasha

“…Model states were fibrosis (F0–F4, defined using METAVIR fibrosis scores), decompensated cirrhosis (DC), hepatocellular carcinoma (HCC), liver transplantation (LT), and liver-related deaths (LD). …”
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Biliary atresia: The profile, management and outcome of patients treated at a tertiary hospital in central South Africa by E Brits, S M le Grange

“…Without intervention, the disease rapidly progresses to liver cirrhosis and fibrosis, with end-stage liver failure and death occurring within the first 3 years of life. …”
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Patient Management in Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus by A. E. Bagriy, A. D. Zubov, M. V. Khomenko, E. S. Mikhailichenko, E. A. Pylaeva, N. A. Khaustova, E. V. Bryukhovetskaya

“…NAFLD is associated with an increased cardiovascular risk (due to association with “metabolic syndrome”) and the risks of liver cirrhosis and hepatocellular carcinoma. Macro- and microvascular complications in T2D comorbidity entail a higher overall mortality. …”
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Histological diagnosis of primary biliary cholangitis in one patient without cholestasis alterations: a case report that escaped guidelines by Matteo Biagi, Elisa Bernasconi, Carmela Cursaro, Enrico Ronconi, Filippo Zanni, Pamela Sighinolfi, Pietro Andreone

“…Primary biliary cholangitis (PBC) is an autoimmune cholangiopathy that affects mainly women and, if untreated, can evolve into biliary cirrhosis. Its prevalence varies worldwide, depending on race, and accounts for 22.27 cases/100,000 habitants in Europe. …”
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Drains vs. no drains following burr-hole evacuation of chronic subdural hematoma by Sajag Gupta

“…Exclusion Criteria: Bilateral chronic subdural haemorrhage on CT scan, recurrent CSDH, patients with  shunt in-situ, patients with bleeding-related conditions (INR > 2.5, BT > 7 min, count of platelets < 60000) or on anticoagulant drugs, patients with severe systemic ailment such as renal failure (Serum Creatinine > 2.5), chronic liver disease (ultrasound shows liver cirrhosis and splenomegaly) and known ischemic heart disease were excluded from this study Materials and Methods: In this study, 100 participants were randomly assigned to two equal groups. …”
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Cirrhotic cardiomyopathy by S. N. Mammayev, A. M. Karimova, T. E. Il’yasova, A. Sh. Khasayev

“…To define cirrhotic cardiomyopathy (CCM), to reveal its pathogenic mechanisms, features of clinical manifestations, to reflect main therapeutic approaches, effect of orthotopic transplantation of liver (OTL) and transjugular portosystemic shunting (TIPS) on the course and prognosis of cardio-vascular disorders at liver cirrhosis (LC).Original positions. Disorder of signal conduction from β-adrenoreceptors, calcium channels receptors, decrease of cardiomyocyte membrane fluidity, increase of nitric oxide and carbon monoxide synthesis, elevation of endocannabinoid system activity and many other changes observed at LC, cause development of complex of structural and functional disorders in myocardium, underlying development of CCM. …”
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Relationship between Serum Ferritin Levels and Sarcopenia in Transfusion-Dependent Thalassemia Patient by Rendra Prasetya Saefudin, Siprianus Ugroseno Yudho Bintoro, Sony Wibisono Mudjanarko, Merlyna Savitri, Lukita Pradhevi, Agustinus Vincent, Michael Austin Pradipta Lusida, Kartika Afrida Fauzia

“…Patients with a Karnofsky score ≤90, who had liver cirrhosis and a history of alcoholism, malignancy, acute infection, HIV, tuberculosis, hepatitis B, hepatitis C, diabetes mellitus, chronic kidney disease, obesity, and stroke were excluded. …”
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Symmetric Lipomatosis Arising in the Tongue Presenting as Macroglossia and Articulatory Disorder by Masanori Kudoh, Ken Omura, Arata Satsukawa, Koshi Matsumoto, Takahide Taguchi, Hiroyuki Harada, Yoshimasa Ishii

“…We report an extremely rare case of SLT arising in an 80-year-old man with a long history of alcoholic liver cirrhosis. He exhibited multiple soft nodular protrusions on the bilateral margin of the tongue presenting as macroglossia for years. …”
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Hepatitis C Worldwide and in Brazil: Silent Epidemic—Data on Disease including Incidence, Transmission, Prevention, and Treatment by Iara Fabricia Kretzer, Andrea do Livramento, Joel da Cunha, Sabrina Gonçalves, Iraci Tosin, Celso Spada, Aricio Treitinger

“…The infection is a leading cause of liver diseases like cirrhosis and hepatocellular carcinoma (HCC); thus, HCV infection constitutes a critical public health problem. …”
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Prediction and Risk Factors for Prognosis of Cirrhotic Patients with Hepatic Encephalopathy by Ying Peng, Qinglin Wei, Yun Liu, Zhenyu Wu, Hongjia Zhang, Hongbo Wu, Jin Chai

“…Patients with liver cirrhosis were retrospectively enrolled. Risk factors were evaluated by multivariate regression analyses. …”
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Evaluation of Small Intestinal Permeability in Patients with Overlap Syndrome (Autoimmune Hepatitis/Primary Biliary Cholangitis) by D. R. Akberova, A. Kh. Odintcova, D. I. Abdulganieva

“…An increased small intestinal permeability was revealed: hepatitis stage — 0.19 [0.13; 0.30] (p &lt; 0.001), liver cirrhosis stage — 0.18 [0.09; 0.30] (p &lt; 0.05) compared with the control group. …”
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Associations between systemic inflammatory biomarkers and metabolic dysfunction associated steatotic liver disease: a cross-sectional study of NHANES 2017–2020 by Xin Qiu, Shuang Shen, Nizhen Jiang, Yifei Feng, Guodong Yang, Donghong Lu

“…Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a primary cause of chronic liver disease, with potential progression to cirrhosis and hepatocellular carcinoma (HCC). Although systemic inflammatory biomarkers are associated with liver diseases, their specific role in MASLD remains unclear. …”
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Biochemical characteristics, genetic variants and treatment outcomes of 55 Chinese cases with neonatal intrahepatic cholestasis caused by citrin deficiency by Juan Li, Jintao Duan, Shuli He, Ying Li, Meifen Wang, Chengjun Deng

“…In long term follow-up, 2 cases developed FTTDCD, 8 cases had special dietary habits, and 1 case died from cirrhosis.ConclusionsNICCD showed more severe impairments in liver, coagulation, and metabolic function than INC. …”
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Alpha Mangostin Inhibits the Proliferation and Activation of Acetaldehyde Induced Hepatic Stellate Cells through TGF-β and ERK 1/2 Pathways by Novriantika Lestari, Melva Louisa, Vivian Soetikno, Averina Geffanie Suwana, Putra Andito Ramadhan, Taufiq Akmal, Wawaimuli Arozal

“…Alcohol-induced fibrosis may develop into cirrhosis, one of the major causes of liver disease mortality. …”
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Chronic Liver Disease in Ethiopia with a Particular Focus on the Etiological Spectrums: A Systematic Review and Meta-Analysis of Observational Studies by Behailu Terefe Tesfaye, Temesgen Mulugeta Feyissa, Azmeraw Bekele Workneh, Esayas Kebede Gudina, Mengist Awoke Yizengaw

“…The keywords “hepatitis, chronic” [Mesh], “end-Stage Liver Disease” [Mesh], “chronic liver disease”, “liver cirrhosis” [Mesh], and “Ethiopia” were used for the searches. …”
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Dysregulation in the microbiota by HBV and HCV infection induces an altered cytokine profile in the pathobiome of infection by Marcos Daniel Mendes Padilha, Francisco Tiago de Vasconcelos Melo, Rogério Valois Laurentino, Andrea Nazaré Monteiro Rangel da Silva, Rosimar Neris Martins Feitosa

“…Viral hepatitis is a public health problem, about 1 million people die due to complications of this viral disease, the etiological agents responsible for inducing cirrhosis and cellular hepatocarcinoma are HBV and HCV, both hepatotropic viruses that cause asymptomatic infection in most cases. …”
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Genotyping of HCV RNA Reveals That 3a Is the Most Prevalent Genotype in Mardan, Pakistan by Sajid Ali, Ayaz Ahmad, Raham Sher Khan, Sanaullah Khan, Muhammad Hamayun, Sumera Afzal Khan, Amjad Iqbal, Abid Ali Khan, Abdul Wadood, Taj Ur Rahman, Ali Hydar Baig

“…The clinical outcomes of patients infected with hepatitis C virus (HCV) range from acute resolving hepatitis to chronic liver diseases such as liver cirrhosis or hepatocellular carcinoma. Identification of the infecting virus genotype is indispensable for the exploration of many aspects of HCV infection, including epidemiology, pathogenesis, and response to antiviral therapy. 1419 individuals were screened for anti-HCV in this study, of which 166 (11.7%) were found reactive by ICT (Immunochromatographic test). …”
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Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways by Ning Liu, Jiao Feng, Xiya Lu, Zhilu Yao, Qing Liu, Yang Lv, Yuru Han, Jingfan Deng, Yingqun Zhou

“…Liver fibrosis is a consequence of wound-healing responses to chronic liver insult and may progress to liver cirrhosis if not controlled. This study investigated the protection against liver fibrosis by isorhamnetin. …”
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The sex differences in diseases progression and prognosis among persons with HIV and HBV coinfection by Rongrong Yang, Qianhui Chen, Fangzhou Jiao, Xingxia Yu, Yong Xiong

“…Furthermore, females had greater CD4+ T lymphocyte counts and a lower prevalence of liver cirrhosis than males throughout the study period. Compared to female, higher incidence of end-stage-liver disease (1.190/100 person-years vs 0.714/100 person-years), higher all-cause mortality (0.440/100 person-years vs 0.148/100 person-years) and higher mortality associated with end-stage-liver diseases (0.273/100 person-years vs 0.074/100 person-years) were found in male. …”
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Co-dynamics of hepatitis B and C viruses under the influence of CTL immunity by A.M. Elaiw, GH.S. Alsaadi, A.A. Raezah, A.D. Hobiny

“…Understanding the cytotoxic T lymphocyte (CTL) immune response against hepatitis B virus (HBV) and hepatitis C virus (HCV) infections is crucial, as these infections can lead to liver cirrhosis and cancer. Mathematical models provide valuable support for biological and medical research by helping to understand the within-host dynamics of single or multiple viral infections and by aiding the development of effective drug therapies. …”
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