Why and How to Treat Chronic Hepatitis C by Stephanos J Hadziyannis

“…Chronic hepatitis C (CHC) is a major health problem worldwide, with approximately 200 million affected individuals and a significant rate of progression to end-stage cirrhosis and hepatocellular carcinoma (HCC). If hepatitis C virus (HCV) infection is left untreated in the population, then the number of liver-related deaths will soon double and the need for liver transplantation may increase to five times that seen today. …”
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Current Treatment Approaches to HCC with a Special Consideration to Transplantation by N. Bhardwaj, M. T. P. R. Perera, M. A. Silva

“…It is well known that, in selected, optimized patients, hepatectomy for HCC may be an option, even in patients with underlying cirrhosis. Resectable patients with early HCC and underlying liver disease are however increasingly being considered for transplantation because of potential for better disease-free survival and resolution of underlying liver disease, although this approach is limited by the availability of donor livers, especially in resectable patients. …”
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Efficacy Comparison of Nitazoxanide Combined with Lactulose versus Lactulose Monotherapy in Managing Overt Hepatic Encephalopathy by Taimoor Hafeez Janjua, Amanat Ali, Sameer Ahmed, Sabeen Shakir, Zunera Rashid, Asma Irfan

“…Patient demographics, aetiology of cirrhosis, MELD score, and efficacy of treatment were assessed. …”
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Spontaneous Evisceration, or “Burst Abdomen,” in Patient with Prior Flood Syndrome Surgical Repair by Matthias Barden, Dustin Marinelli, Kirsten Cable

“…A 61-year-old female with prior history of alcoholic cirrhosis and ascites presented to our emergency department with frank evisceration of multiple loops of small bowel from an open anterior abdominal wall dehiscence. …”
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Recent trends in studying of alcohol-induced liver disease by I. I. Komkova, M. S. Zharkova, M. V. Mayevskaya

“…In the studies it was demonstrated, that there is significant difference in death rate of liver cirrhosis between European countries. Disease risk factors include: amount of taken alcohol, its type, frequency of use, female gender, excessive body weight. …”
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Successful case of using suture-mediated system Perclose ProGlide in TAVI by B. M. Todurov, M. B. Todurov, A. V. Khokhlov, M. V. Stan, K. L. Berestova, O. V. Zelenchuk, A. V. Besaga, S. R. Maruniak

“…This clinical case describes the performance of TAVI in a patient with liver cirrhosis, autoimmune hepatitis, coagulopathy, and secondary anemia. …”
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Hepatocellular Carcinoma to the Right Ventricle by George R. Marzouka, Apurva Badheka, Alexis P. Rodriguez, Sandra V. Chaparro

“…We present a case of a 63-year-old man with history of hepatitis C and cirrhosis, which had progressed to HCC. The patient had undergone two prior liver transplantations. …”
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Protective Effect of Vitamin E on Gastric Mucosal Injury in Rats with Biliary Obstruction by Nuh Zafer Cantürk, Zeynep Cantürk, G Özbilim, C Yenisey

“…Fifty rats were divided into three groups. Cirrhosis was induced by bile duct ligation in 40 of 50 rats. …”
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PBC: Animal Models of Cholangiopathies and Possible Endogenous Viral Infections by Masashi Ninomiya, Yoshiyuki Ueno, Tooru Shimosegawa

“…Primary Biliary Cirrhosis (PBC) is considered an autoimmune disease characterized by immune-mediated destruction of the intrahepatic bile ducts and its characteristic serologic marker, the anti-mitochondrial antibody (AMA). …”
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Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma by Hideo Suzuki, Motoyuki Kohjima, Masatake Tanaka, Takeshi Goya, Shinji Itoh, Tomoharu Yoshizumi, Masaki Mori, Mariko Tsuda, Motoi Takahashi, Miho Kurokawa, Koji Imoto, Shigeki Tashiro, Akifumi Kuwano, Masaki Kato, Seiji Okada, Makoto Nakamuta, Yoshihiro Ogawa

“…The metabolic alterations including glycolysis, PPP, TCA cycle, and β-oxidation became more prominent as liver disease progresses from normal, chronic hepatitis, cirrhosis, well-, moderately, and poorly differentiated HCC. …”
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Autoimmune Conditions in 235 Hemochromatosis Probands with HFE C282Y Homozygosity and Their First-Degree Relatives by James C. Barton, J. Clayborn Barton

“…We performed a retrospective study of autoimmune conditions (ACs) in 235 hemochromatosis probands at diagnosis by analyzing age, sex, ACs, history of first-degree family members with ACs (FH), diabetes, heavy ethanol consumption, elevated serum ALT/AST, nonalcoholic fatty liver disease, viral hepatitis, cirrhosis, iron removed to achieve iron depletion (QFe), and positivity for human leukocyte antigen (HLA) haplotypes A∗01, B∗08; A∗02, B∗44; A∗03, B∗07; A∗03, B∗14; and A∗29, B∗44. …”
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Liver Transplantation: Evolving Patient Selection Criteria by Andy S Yu, Aijaz Ahmed, Emmet B Keeffe

“…The development of minimal listing criteria for patients with chronic liver disease based on a specific definition for decompensation of cirrhosis has facilitated the more uniform listing of patients at individual centres across the United States. …”
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A Canadian Isolate of Hepatitis D (delta) Virus by Véronique Poisson, Daniel B Ménard, Éric Frost, Jean-Pierre Perreault

“…HepatitisD(delta) virus (HDV) is an infectious agent that propagates in hepatocytes only in the presence of hepatitis B virus, causing fulminant or chronic hepatitis with liver cirrhosis. HDV is a 36 nm particle that includes a circular RNA genome of 1.7 kilobases with an extensive internal complementary that allows it to fold into a rod-like structure. …”
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Cytokines and HCV-Related Disorders by Poupak Fallahi, Clodoveo Ferri, Silvia Martina Ferrari, Alda Corrado, Domenico Sansonno, Alessandro Antonelli

“…Inability to control infection leads to the recruitment of inflammatory infiltrates into the liver parenchyma by interferon (IFN)-gamma-inducible CXC chemokine ligand (CXCL)-9, -10, and -11 chemokines, which results in sustained liver damage and eventually in liver cirrhosis. The most important systemic HCV-related extrahepatic diseases—mixed cryoglobulinemia, lymphoproliferative disorders, thyroid autoimmune disorders, and type 2 diabetes—are associated with a complex dysregulation of the cytokine/chemokine network, involving proinflammatory and Th1 chemokines. …”
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Multiple Bone Metastases as the First Manifestation of Hepatocellular Carcinoma in Patient with Noncirrhotic Liver by Soo Ya Bae, Hyun Jung Kim, Hyun Ho Oh, Min Kwan Kwon, Jong Ho Lee, Moon Park, Byeong Seok Sohn

“…This case suggests that HCC should be considered as one of differential diagnoses in patient presenting with multiple bone metastases, even in the absence of liver cirrhosis.…”
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Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice by Gilles Willemin, Catherine Roger, Armelle Bauduret, Kaori Minehira

“…Secondly we studied the development of carbon-tetra-chloride- (CCl4-) induced hepatic cirrhosis. After the high-fat diet, both groups developed obesity and hepatic steatosis with a similar degree of hepatic inflammation, suggesting no impact of the knockdown of MHC II on high-fat diet-induced inflammation in mice. …”
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Choice of Allograft in Patients Requiring Intestinal Transplantation: A Critical Review by Genevieve Huard, Thomas Schiano, Jang Moon, Kishore Iyer

“…Thus, patients with cirrhosis or advanced fibrosis should receive a combined allograft, while patients with lower grades of liver fibrosis can usually safely undergo ITx. …”
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The dynamics of a delay model of hepatitis B virus infection with logistic hepatocyte growth by Steffen Eikenberry, Sarah Hews, John D. Nagy, Yang Kuang

“…Chronic HBV affects 350 million people and can lead to death through cirrhosis-inducedliver failure or hepatocellular carcinoma. …”
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Dermatological Disorders following Liver Transplantation: An Update by Dipesh Kumar Yadav, Xue li Bai, Tingbo Liang

“…On the other hand, the vast majority of the nonspecific dermatological lesions linked with cirrhosis improve after removal of diseased liver or due to the immunosuppressant used after LT. …”
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Liver Transplantation in Situs Inversus and Portal Vein Thrombosis (First Case Report in Russia) by M. S. Novruzbekov, O. D. Olisov, V. A. Guliaev, K. N. Lutsyk, K. M. Magomedov, B. I. Kazymov

“…A 32 years-old patient with situs inversus, chronic hepatitis B/D-induced liver cirrhosis and portal vein thrombosis had cadaveric liver transplantation, with the transplant reoriented in abdominal cavity 90° clockwise relative to the median plane. …”
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