Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse by Guang‐Jie Zhu, Yuhang Huang, Linqing Zhang, Keji Yan, Cui Qiu, Yihan He, Qing Liu, Chengwen Zhu, Matías Morín, Miguel Ángel Moreno‐Pelayo, Min‐Sheng Zhu, Xin Cao, Han Zhou, Xiaoyun Qian, Zhigang Xu, Jie Chen, Xia Gao, Guoqiang Wan

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Cingulin is an RNA-binding protein promoting pancreatic cancer through enhancing importin 7-mediated phospho-ERK nuclear translocation by Yuling Su, Fang Wei, Shu Li, Jiaming Qi, Guohuan Lin, Guantuo Li, Ping Liang, Zhenwei Yang, You Long, Xiaojia Li, Tingting Jiang, Jie He, Weiye Liang, Keping Xie

“…Little is known about cingulin (CGN) in carcinogenesis. In this study, we demonstrated the critical oncogenic role of CGN in PDAC pathogenesis. …”
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Nonmuscle Myosin-2B Regulates Apical Cortical Mechanics, ZO-1 Dynamics and Cell Size in MDCK Epithelial Cells by Marine Maupérin, Niklas Klatt, Thomas Glandorf, Thomas Di Mattia, Isabelle Méan, Andreas Janshoff, Sandra Citi

“…In epithelial cells, nonmuscle myosin-2B (NM2B) shows a cortical localization and is tethered to tight junctions (TJs) and adherens junctions (AJs) by the junctional adaptor proteins cingulin and paracingulin. MDCK cells knock-out (KO) for cingulin show decreased apical membrane cortex stiffness and decreased TJ membrane tortuosity, and the rescue of these phenotypes requires the myosin-binding region of cingulin. …”
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Tight junction proteins in glial tumors development and progression by Jakub Moskal, Slawomir Michalak, Slawomir Michalak

“…Tight junctions are composed of a group of integral membrane proteins, which include the claudin family, tight junction-associated Marvel protein family, junctional adhesion molecule family, and proteins that anchor the cytoskeleton, such as zonula occludens proteins and the cingulin family. Several factors, such as neurotransmitters or cytokines, and processes like ischemia/hypoxia, inflammation, tumorigenesis, phosphorylation/dephosphorylation, ubiquitination, and palmitoylation, regulate tight junction proteins. …”
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A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics by Marine Maupérin, Yuze Sun, Thomas Glandorf, Tabea Anne Oswald, Niklas Klatt, Burkhard Geil, Annick Mutero-Maeda, Isabelle Méan, Lionel Jond, Andreas Janshoff, Jie Yan, Sandra Citi

“…The knock-out of γ-actin also decreases apical membrane stiffness and increases dynamic exchange of the cytoplasmic tight junction proteins like ZO-1 and cingulin, without affecting tight junction organization and barrier function. …”
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Intestinal tight junctions are severely altered in NEC preterm neonates by Amir Bein, Smadar Eventov-Friedman, Dan Arbell, Betty Schwartz

“…Results: The tight junction genes ZO-1, occludin, cingulin and claudin-4 were significantly down regulated in NEC. …”
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Effect of heat stress on ileal epithelial barrier integrity in broilers divergently selected for high- and low-water efficiency by Elizabeth S. Greene, Brooklee Roach, Maria Fernandez Cuadrado, Sara Orlowski, Sami Dridi

“…Cldn4 was increased in the HWE line and decreased by HS. Cingulin (Cgn) gene expression was lower in HWE as compared to LWE and lower in HS as compared to thermoneutral (TN) condition. …”
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