Opioid Therapy for Chronic Nonmalignant Pain by Russell K Portenoy

“…A critical review of the medical literature pertaining to chronic pain, opioid pharmacology and addiction medicine can clarify misconceptions about opioid therapy and provide a foundation for patient selection and drug administration. …”
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Advanced Genetic Testing Comes to the Pain Clinic to Make a Diagnosis of Paroxysmal Extreme Pain Disorder by Ashley Cannon, Svetlana Kurklinsky, Kimberly J. Guthrie, Douglas L. Riegert-Johnson

“…Patients with a personal and family history of chronic pain may benefit from a referral to Medical Genetics. …”
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Psychological Factors Associated with Phantom Limb Pain: A Review of Recent Findings by Xaver Fuchs, Herta Flor, Robin Bekrater-Bodmann

“…Psychological factors have been shown to play an important role in other types of chronic pain, where they are pivotal in the acquisition and maintenance of pain symptoms. …”
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Effects of Flotation-REST on Muscle Tension Pain by Anette Kjellgren, Ulf Sundequist, Torsten Norlander, Trevor Archer

“…Thirty-seven patients (14 men and 23 women) suffering from chronic pain consisting of aching muscles in the neck and back area participated in the study. …”
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Spinal NGF Restores Opioid Sensitivity in Neuropathic Rats: Possible Role of NGF as a Regulator of CCK-Induced Anti-Opioid Effects by Catherine M Cahill, Terence J Coderre

“…These models provide an approach for examining the contribution of central NGF to nociceptive transmission. Chronic pain emanating from a nerve injury is typically refractory to traditional analgesics such as opioids. …”
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The McGill Pain Questionnaire - Japanese Version, Reconsidered: Confirming the Reliability and Validity by Mamoru Hasegawa, Suguru Hattori, Keiji Ishizaki, Shosuke Suzuki, Fumio Goto

“…BACKGROUND: The McGill Pain Questionnaire (MPQ) is one of the most widely used instruments in the world to evaluate patients with chronic pain. However, differences in languages and cultural backgrounds have hindered its standardization in Japan.…”
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Cannabinoids for Pain Management: What is their Role? by Alexander J Clark, Mary E Lynch

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Modifiable factors for irritable bowel syndrome: evidence from Mendelian randomisation approach by Jinling Tang, Zhirong Yang, Shanshan Wu, Feng Sha, Tengfei Lin, Di Liu, Meiling Cao, Yiwen Jiang, Weijie Cao, Fuxiao Li

“…The presence of multisite chronic pain may offer a promising avenue for the concurrent prevention of IBS and its coexisting disorders.…”
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Possible Nonopioid-Mediated Analgesia Produced by Methotrimeprazine in Rats by Perry N Fuchs, Bradley Kerr, Ronald Melzack

“…BACKGROUND: Several reports in the 1960s demonstrated that methotrimeprazine (MTMZ), a phenothiazine derivative, is effective for treating acute and chronic pain. Although MTMZ has received little attention in recent decades, the fact that it derives from a class of drugs usually associated with cognitive and emotional processes, rather than the traditional analgesics, makes it interesting as a potential source of information about the mechanisms of analgesia.…”
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A Short Version of the Pain Anxiety Symptoms Scale (PASS-20): Preliminary Development and Validity by Lance M McCracken, Lara Dhingra

“…BACKGROUND: Research has shown significant relations between fear and avoidance of pain and the suffering and disability of chronic pain. Effective measurement tools have formed the foundation for studying these relations.…”
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Incidence and long-term patient reported outcome measures of patients with radiological cauda equina compression but without clinical features of cauda equina syndrome by Hamzah Alsheikh Soleiman, Mary Solou, Andreas K. Demetriades

“…Despite surgical interventions, chronic pain remains a significant issue. Further research, including multi-centered studies, is warranted to enhance our understanding of this condition and its nuanced subpopulations.…”
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Pain Reconceptualisation after Pain Neurophysiology Education in Adults with Chronic Low Back Pain: A Qualitative Study by Richard King, Victoria Robinson, Helene L. Elliott-Button, James A. Watson, Cormac G. Ryan, Denis J. Martin

“…Pain neurophysiology education (PNE) is an educational intervention for patients with chronic pain. PNE purports to assist patients to reconceptualise their pain away from the biomedical model towards a more biopsychosocial understanding by explaining pain biology. …”
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Treatment Strategies for Chronic Cases by Susan M Lord

“…The challenge to find a treatment strategy for chronic pain after whiplash that completely relieves the condition and prevents its sequelae is reviewed.…”
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Psychiatric Morbidity in Pain Conditions: Results from the Singapore Mental Health Study by Mythily Subramaniam, Janhavi Ajit Vaingankar, Edimansyah Abdin, Siow Ann Chong

“…BACKGROUND: Chronic pain is a common problem among the general population and has been found to be associated with psychiatric disorders in studies based on both clinical samples and epidemiological surveys.…”
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The Role of Controlled Breathing in Pain Management by Maria Wydro, Magdalena Grotowska, Martyna Łukasiewicz, Aleksandra Strawińska

“…Additionally, the combination of DSB and vagus nerve stimulation (VNS) has shown promise in managing chronic pain and improving musculoskeletal pain thresholds. …”
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Cohort profile: the Halland osteoarthritis (HALLOA) cohort–from knee pain to osteoarthritis: a longitudinal observational study in Sweden by Ann Bremander, Maria L E Andersson, S Bergman, Katarina Aili, Emma Haglund

“…It is also important to study the development of chronic pain in OA, to get tools to identify individuals at risk and to be able to offer them treatment.Trial registration number ClinicalTrials.gov (NCT04928170).…”
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Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury by Jeongsoo Han, Minjee Kwon, Myeounghoon Cha, Motomasa Tanioka, Seong-Karp Hong, Sun Joon Bai, Bae Hwan Lee

“…According to recent reports, neural plasticity in the brain including the IC can be induced by nerve injury and may contribute to chronic pain. Continuous active kinase, protein kinase Mζ (PKMζ), has been known to maintain the long-term potentiation. …”
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Antinociceptive and Anti-Inflammatory Activities of Teucrium persicum Boiss. Extract in Mice by Abdolhossein Miri, Javad Sharifi-Rad, Kaveh Tabrizian, Ali Akbar Nasiri

“…Oral gavaged of TPE revealed significant analgesic effect on chronic pain in both formalin test and sciatic nerve ligated animals. …”
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A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain by Wen-Juan Han, Lei Chen, Hai-Bo Wang, Xiang-Zeng Liu, San-Jue Hu, Xiao-Li Sun, Ceng Luo

“…Evidence has accumulated that reactive oxygen species and inflammation play crucial roles in the development of chronic pain, including radicular low back pain. Nonsteroid anti-inflammatory drugs (NSAIDs), for example, salicylic acid, aspirin, provided analgesic effects in various types of pain. …”
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Stem Cells from Human Exfoliated Deciduous Teeth Attenuate Trigeminal Neuralgia in Rats by Xiaofeng Bai, Xuedi Zhang, Chun Wang, Yao Liu, Xuemei Liu, Yu Fan, Xia Zhang

“…Therefore, these results provide preclinical evidence that supports the use of SHED in the treatment of trigeminal neuralgia and potentially other chronic pain conditions.…”
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