Peripheral blood miRNAs are associated with airflow below threshold in children with asthma by Anshul Tiwari, Brian D. Hobbs, Rinku Sharma, Jiang Li, Alvin T. Kho, Sami Amr, Juan C. Celedón, Scott T. Weiss, Craig P. Hersh, Kelan G. Tantisira, Michael J. McGeachie

“…Poor lung function and airflow issues in childhood are linked to the development of chronic obstructive pulmonary disease (COPD) in adulthood. Methods We analyzed small RNA-Seq data from 365 peripheral whole blood samples from the Genetics of Asthma in Costa Rica Study (GACRS) for association with airflow levels measured by FEV1/FVC. …”
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Physically Meaningful Surrogate Data for COPD by Harry J. Davies, Ghena Hammour, Hongjian Xiao, Patrik Bachtiger, Alexander Larionov, Philip L. Molyneaux, Nicholas S. Peters, Danilo P. Mandic

“…The rapidly increasing prevalence of debilitating breathing disorders, such as chronic obstructive pulmonary disease (COPD), calls for a meaningful integration of artificial intelligence (AI) into respiratory healthcare. …”
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Psychometric Testing of the CHAMPS Questionnaire in French Canadians with COPD by Susanne Mak, Jean Bourbeau, Nancy E. Mayo, Sharon Wood-Dauphinee, Judith E. Soicher

“…Physical activity is an important health behaviour in reducing morbidity and mortality in individuals with chronic obstructive pulmonary disease (COPD). Accurate measurement of the characteristics of physical activity is essential to understanding the impact of COPD on physical activity. …”
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Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma by Katherine J. Baines, Thomas K. Wright, Jodie L. Simpson, Vanessa M. McDonald, Lisa G. Wood, Kristy S. Parsons, Peter A. Wark, Peter G. Gibson

“…The role of β-defensin-1 in asthma and chronic obstructive pulmonary disease (COPD) remains unclear. Methods. …”
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A Single Lung Transplant in a Patient with Fabry Disease: Causality or Far-Fetched? A Case Report by Martina Gaggl, Renate Kain, Peter Jaksch, Dominik Haider, Gerald Mundigler, Till Voigtländer, Raute Sunder-Plassmann, Paulus Rommer, Walter Klepetko, Gere Sunder-Plassmann

“…We report a patient with a diagnosis of chronic obstructive pulmonary disease (COPD) who received a single lung transplant in 2007. …”
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Lung Cancer with Skin and Breast Metastasis: A Case Report and Literature Review by Bikash Bhattarai, Marie Frances Schmidt, Meenakshi Ghosh, Abhisekh Sinha Ray, Saveena Manhas, Vikram Oke, Chidozie Charles Agu, Md. Rawshan Basunia, Danilo Enriquez, Joseph Quist, Catherine Bianchi, Ravi Hans, Saroj Kandel

“…A 48-year-old African American male with a past medical history of poorly differentiated left breast cancer status after modified radical mastectomy (MRM), chronic obstructive pulmonary disease, and smoking (20 pack-years) presents to the ER with progressive shortness of breath on exertion, upper back pain, and weight loss for 2 months in duration. …”
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Risk of pneumonia in patients with isolated minor rib fractures: a nationwide cohort study by Yu-Hsun Wang, Ming-Chih Chou, Sai-Wai Ho, Ying-Hock Teng, Shun-Fa Yang, Han-Wei Yeh, Chao-Bin Yeh

“…This nationwide cohort study investigated the association between IMRFs and the risk of pneumonia in patients with blunt chest traumas.Design Nationwide population-based cohort study.Setting Patients with IMRFs were identified between 2010 and 2011 from the Taiwan National Health Insurance Research Database.Participants Non-traumatic patients were matched through 1:8 propensity-score matching according to age, sex, and comorbidities (namely diabetes, hypertension, cardiovascular disease, asthma and chronic obstructive pulmonary disease (COPD)) with the comparison cohort. …”
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An integrated investigation of mitochondrial genes in COPD reveals the causal effect of NDUFS2 by regulating pulmonary macrophages by Xiaoli Zou, Qiqing Huang, Tutu Kang, Shaoran Shen, Chenxi Cao, Jianqing Wu

“…Abstract Background Despite the increasing body of evidence that mitochondrial activities implicate in chronic obstructive pulmonary disease (COPD), we are still far from a causal-logical and mechanistic understanding of the mitochondrial malfunctions in COPD pathogenesis. …”
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Association between chronic respiratory diseases and frailty in Chinese elderly: a population-based longitudinal study by Ting Yang, Ping He, Dawei Zhu, Dan Guo, Ruoxi Ding, Ke Huang, Yanan Zhao, Xiaolong Guan

“…Specifically, asthma only (HR=1.89, 95% CI: 1.07 to 3.33) and asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) (HR=1.79, 95% CI: 1.19 to 2.69) were associated with a higher risk of frailty among the elderly, while COPD only was not (HR=1.11, 95% CI: 0.73 to 1.65).Conclusion This study shows a significant association between CRDs, particularly asthma only and ACO, and frailty in the elderly. …”
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Environmental burden of disease resulting from long-term nitrogen dioxide exposure in Germany by Paulina Sell, Dietrich Plass, Sarah Kienzler, Hajo Zeeb

“…We first conducted a systematic literature review to identify exposure–response functions (ERFs) which mathematically represent the association between NO2 exposure and the health outcomes: asthma, chronic obstructive pulmonary disease (COPD), type 2 diabetes mellitus (T2DM), ischemic heart disease, lung cancer, stroke, and cardiovascular and respiratory mortality. …”
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Chemical Identification and Antioxidant Screening of Bufei Yishen Formula using an Offline DPPH Ultrahigh-Performance Liquid Chromatography Q-Extractive Orbitrap MS/MS by Jinyan Wu, Bangrong Cai, Ang Zhang, Peng Zhao, Yan Du, Xuefang Liu, Di Zhao, Liu Yang, Xinguang Liu, Jiansheng Li

“…Chronic obstructive pulmonary disease (COPD) has high morbidity and mortality and presents a threat to human health worldwide. …”
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Epigenetic Inhibitors Differentially Impact TGF-β1 Signaling Cascades in COPD Airway Smooth Muscle Cells by Karosham Diren Reddy, Dikaia Xenaki, Ian M. Adcock, Brian G. G. Oliver, Razia Zakarya

“…<b>Background:</b> Chronic obstructive pulmonary disease (COPD) is characterized by progressive and incurable airflow obstruction and chronic inflammation. …”
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Elevated Blood Urea Nitrogen-to-Serum Albumin Ratio as a Factor That Negatively Affects the Mortality of Patients with Hospital-Acquired Pneumonia by Ding-Yun Feng, Yu-Qi Zhou, Xiao-Ling Zou, Mi Zhou, Hai-Ling Yang, Xiao-Xia Chen, Tian-Tuo Zhang

“…This reported mortality identified by the univariate Cox regression analysis is found to have been affected by the following factors: age greater than 70 years, presence of diabetes mellitus and chronic obstructive pulmonary disease, gastric tube intubation, administration of proton-pump inhibitor, blood albumin level less than 30 g/l, elevated neutrophil-to-lymphocyte ratio, antibiotics therapy in the preceding 90 days, intensive care unit (ICU) admission, blood lymphocyte count less than 0.8 × 109/L, elevated blood urea nitrogen/albumin (BUN/ALB) level, and presence of multidrug-resistant (MDR) pathogens. …”
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Prevalence and Economic Impact of Acute Respiratory Failure in the Prehospital Emergency Medical Service of the Madrid Community: Retrospective Cohort Study by Ana María Cintora-Sanz, Cristina Horrillo-García, Víctor Quesada-Cubo, Ana María Pérez-Alonso, Alicia Gutiérrez-Misis

“… Abstract BackgroundChronic obstructive pulmonary disease (COPD), congestive heart failure (CHF), and acute pulmonary edema (APE) are serious illnesses that often require acute care from prehospital emergency medical services (EMSs). …”
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A novel interpretable deep learning model for diagnosis in emergency department dyspnoea patients based on complete data from an entire health care system. by Ellen T Heyman, Awais Ashfaq, Ulf Ekelund, Mattias Ohlsson, Jonas Björk, Ardavan M Khoshnood, Markus Lingman

“…We aimed to design a diagnostic decision support which classifies dyspnoeic ED visits into acute heart failure (AHF), exacerbation of chronic obstructive pulmonary disease (eCOPD), pneumonia and "other diagnoses" by using deep learning and complete, unselected data from an entire regional health care system.…”
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Contemporary Results of Transcatheter Aortic Valve Replacement in Obese Patients by T. Owais, M. El Garhy, P. Lauten, M. Haensig, H. Lapp, P. C. Schulze, T. Kuntze

“…Obese patients showed statistically significant difference in their clinical parameters as having higher incidence of hypertension, diabetes mellitus, pulmonary hypertension, and chronic obstructive pulmonary disease; on the contrary, obese patients were found to be younger than others. …”
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Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] by Céline Heinl, Ines Schadock, Maximilian Wurm, Paul Lucas Wildner, Daniel Butzke, Bettina Bert, Alexandra Bannach-Brown, Matthias Steinfath, Kai Diederich

“…We compare the results with the age and sex of patients in clinical trials focusing on Alzheimer's disease, stroke, type 2 diabetes mellitus, ischemic heart disease, and chronic obstructive pulmonary disease. We also analyze whether the age of the mice used has changed over the past decade. …”
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General medical comorbidities in psychotic disorders in the Finnish SUPER study by Johan Ahti, Tuula Kieseppä, Willehard Haaki, Jaana Suvisaari, Solja Niemelä, Kimmo Suokas, Minna Holm, Asko Wegelius, Olli Kampman, Markku Lähteenvuo, Tiina Paunio, Jari Tiihonen, Jarmo Hietala, Erkki Isometsä

“…Registry-based diagnoses of psychotic disorders and hypertension, diabetes, chronic obstructive pulmonary disease (COPD), cancers, ischemic heart disease, and liver disorders were obtained. …”
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Impact of HACOR Score on Noninvasive Ventilation Failure in Non-COPD Patients with Acute-on-Chronic Respiratory Failure by Min Ding, Xiaoli Han, Linfu Bai, Shicong Huang, Jun Duan

“…A rating scale that takes into account heart rate, acidosis, consciousness, oxygenation, and respiratory rate (the HACOR score) has been used to predict noninvasive ventilation (NIV) failure in patients with chronic obstructive pulmonary disease (COPD). However, the HACOR score has not been used to predict NIV failure in non-COPD patients with acute-on-chronic respiratory failure. …”
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Clinical code usage in UK general practice: a cohort study exploring 18 conditions over 14 years by Christos Grigoroglou, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Salwa S Zghebi, Rosa Parisi, Brian McMillan

“…Objective To assess the diagnostic Read code usage for 18 conditions by examining their frequency and diversity in UK primary care between 2000 and 2013.Design Population-based cohort studySetting 684 UK general practices contributing data to the Clinical Practice Research Datalink (CPRD) GOLD.Participants Patients with clinical codes for at least one of asthma, chronic obstructive pulmonary disease, diabetes, hypertension (HT), coronary heart disease, atrial fibrillation (AF), heart failure, stroke, hypothyroidism, chronic kidney disease, learning disability (LD), depression, dementia, epilepsy, severe mental illness (SMI), osteoarthritis, osteoporosis and cancer.Primary and secondary outcome measures For the frequency ranking of clinical codes, canonical correlation analysis was applied to correlations of clinical code usage of 1, 3 and 5 years. …”
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