Trajectory of the arterial-alveolar oxygen gradient in COPD for a decade. by Kazuma Nagata, Susumu Sato, Kiyoshi Uemasu, Naoya Tanabe, Atsuyasu Sato, Shigeo Muro, Toyohiro Hirai

“…<h4>Background</h4>Chronic respiratory failure (CRF) is a critical complication in patients with chronic obstructive pulmonary disease (COPD) and is characterized by an increase in the arterial-alveolar oxygen gradient (A-aDO2). …”
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The different response of PM2.5 stimulated nasal epithelial spheroids in control, asthma and COPD groups by Paulina Misiukiewicz-Stępień, Elwira Zajusz-Zubek, Katarzyna Górska, Rafał Krenke, Magdalena Paplińska-Goryca

“…Abstract Background Pathobiology of asthma and chronic obstructive pulmonary disease (COPD) is associated with changes among respiratory epithelium structure and function. …”
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Th1/17-Biased Inflammatory Environment Associated with COPD Alters the Response of Airway Epithelial Cells to Viral and Bacterial Stimuli by Yifan Chen, Rakesh K. Kumar, Paul S. Thomas, Cristan Herbert

“…Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation associated with a Th1/17-biased cytokine environment. …”
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Development of an algorithm impacting COPD care through personalized nutrition and IoT-based monitoring by Prachi Sharma, Mihir Gharia, Devina Aswal, Vishva Trivedi, Bhavnita Soni, Prerna Soni, Devesh Joshi, Dhvni Lalan, Vrushali Athavale, Irfan Shaikh, Koshy Jacob

“…Abstract Background Chronic obstructive pulmonary disease (COPD) is a chronic respiratory condition characterized by high morbidity and mortality rates. …”
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Unmasking health determinants and health outcomes for urban First Nations using respondent-driven sampling by J Smylie, M Firestone, S Maracle, M Spiller, P O'Campo

“…Common chronic diseases included arthritis, hypertension, diabetes and chronic obstructive pulmonary disease and rates of emergency room access were elevated.Conclusions RDS is an effective sampling method in urban Aboriginal contexts as it builds on existing social networks and successfully identified a population-based cohort. …”
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Factors Influencing Postoperative Inpatient Rehabilitation Requirement After Surgical Intervention for Isolated Hip Fracture: A Multicenter Study by Daniel J. Lynch, Andrew Romero, James P. McFadden, Peter Zeblisky, Huazhi Liu, Darwin Ang

“…This cohort had a longer average hospital stay, higher incidence of diabetes, congestive heart failure, chronic renal failure, history of cerebrovascular accident, functionally dependent health status, hypertension, chronic obstructive pulmonary disease, dementia, baseline anticoagulation therapy, and history of myocardial infarction. …”
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Impact of COPD and asthma on in-hospital mortality and management of patients with heart failure in England and Wales: an observational analysis by Claudia Gulea, Rosita Zakeri, Jennifer K Quint, Constantinos Kallis

“…Objective To evaluate the association between having concomitant chronic obstructive pulmonary disease (COPD) or asthma, and in-patient mortality and post-discharge management among patients hospitalised for acute heart failure (HF).Setting Data were obtained from patients enrolled in the National Heart Failure Audit.Participants 217 329 patients hospitalised for HF in England–Wales between March 2012 and 2018.Outcomes In-hospital mortality, referrals to cardiology follow-up and prescriptions for HF medications were compared between patients with comorbid COPD (COPD-HF) or asthma (asthma-HF) versus HF-alone using mixed-effects logistic regression.Results Patients with COPD-HF were more likely to die during hospitalisation, and those with asthma-HF had a reduced likelihood of death, compared with patients who had HF-alone ((adjusted)ORadj, 95% CI: 1.10, 1.06 to 1.14 and ORadj, 95% CI: 0.84, 0.79 to 0.88). …”
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Type II Diabetes Patients under Sildenafil Citrate: Case Series Showing Benefits and a Side Effect by Livia M. Zimmermann, Mauricio S. Baptista, João Paulo Tardivo, Maria A. Pinhal

“…Patient 1, who presented diabetic foot, was treated in the ambulatory, and patient 2, with chronic obstructive pulmonary disease and consequent mild pulmonary hypertension, was treated in the office. …”
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Role of macrophage migration inhibitory factor (MIF) in allergic and endotoxin-induced airway inflammation in mice by M. Korsgren, L. Källström, L. Uller, T. Bjerke, F. Sundler, C. G. A. Persson, O. Korsgren

“…Macrophage migration inhibitory factor (MIF) has recently been forwarded as a critical regulator of inflammatory conditions, and it has been hypothesized that MIF may have a role in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). Hence, we examined effects of MIF immunoneutralization on the development of allergen-induced eosinophilic inflammation as well as on lipopolysaccaride (LPS)-induced neutrophilic inflammation in lungs of mice. …”
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Risk factors for non-benefit of implantable cardioverter defibrillator therapy by Fabienne Kreimer, Marie Lewenhardt, Ibrahim El-Battrawy, Arash Haghikia, Michael Gotzmann

“…Independent risk factors for no-benefit were age ≥ 68 years (HR 4.599, p < 0.001), anemia (HR 2.549, p < 0.001), peripheral artery disease (HR 2.066, p = 0.007), and chronic obstructive pulmonary disease (HR 1.939, p = 0.014). Subgroup analysis by age < 68 years and ≥ 68 years demonstrated that the risk of no-benefit increases with age and comorbidities. …”
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Lipid-lowering drug targets and lung related diseases: a Mendelian randomization study by Haifeng Yu, Xiaofei Zhang, Bian Wen, Shuo Hu, Bin Ni

“…However, long-term inhibition of NPC1L that mimics the use of statin drugs may have contradictory effects on pulmonary edema (OR = 0.508, 95%CI = 0.328–0.786,P = 0.002) and chronic obstructive pulmonary disease (OR = 1.524, 95%CI = 1.099–2.115, P = 0.012). …”
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Respiratory patient experience of measures to reduce risk of COVID-19: findings from a descriptive cross-sectional UK wide survey by Andrew Cumella, Nicholas S Hopkinson, Michael Laffan, Joe Farrington-Douglas, Keir EJ Philip

“…Long-term respiratory conditions reported included asthma (83%), chronic obstructive pulmonary disease (10%), bronchiectasis (4%), interstitial lung disease (2%) and ‘other’ (&lt;1%) (eg, lung cancer and pulmonary endometriosis).Outcome measures Study responses related to impacts on key elements of healthcare, as well as practical, psychological and social consequences related to the COVID-19 pandemic and social distancing measures.Results 45% reported disruptions to care, including cancellations of appointments, investigations, pulmonary rehabilitation, treatment and monitoring. …”
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IL-18 biology in severe asthma by Sarita Thawanaphong, Sarita Thawanaphong, Sarita Thawanaphong, Aswathi Nair, Aswathi Nair, Emily Volfson, Emily Volfson, Parameswaran Nair, Parameswaran Nair, Manali Mukherjee, Manali Mukherjee

“…The role of interleukin-18 (IL-18) and inflammasomes in chronic inflammatory airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), has garnered significant attention in recent years. …”
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Managing Post COVID-19 Patient with Breathlessness by Yen Shen Wong, Muhammad Amin Ibrahim, Mohd Arif Mohd Zim, Mohd Fauzi Abdul Rani

“…We review a case of chronic obstructive pulmonary disease (COPD) patient who developed acute breathlessness post COVID-19 infection, also focusing on the diagnostic approach. …”
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Association between exposure in the cement production industry and non-malignant respiratory effects: a systematic review by Anne Kristin Møller Fell, Karl Christian Nordby

“…Outcomes were restricted to respiratory symptoms, lung function indices, asthma, chronic bronchitis, chronic obstructive pulmonary disease, pneumoconiosis, induced sputum or fraction of exhaled nitric oxide (FeNO) measurements.Participants The studies included exposed cement production workers and non-exposed or low-exposed referents.Primary and secondary outcomes The searches yielded 594 references, and 26 articles were included. …”
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High-resolution mass spectrometry measurement of N-terminal carbamylated hemoglobin as a potential marker for chronic diseases with elevated blood urea levels by Fangjun Chen, Priscilla S.-W. Yeung, Carolyn V. Wong, Ruben Y. Luo

“…Blood samples from healthy individuals, CKD patients, and chronic obstructive pulmonary disease (COPD) patients were analyzed. …”
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Nomograms for Predicting High Hospitalization Costs and Prolonged Stay among Hospitalized Patients with pAECOPD by Nafeisa Dilixiati, Mengyu Lian, Ziliang Hou, Jie Song, Jingjing Yang, Ruiyan Lin, Jinxiang Wang

“…This study aimed to develop nomograms to predict high hospitalization costs and prolonged stays in hospitalized acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients with community-acquired pneumonia (CAP), also known as pAECOPD. …”
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MicroRNA-101-3p Suppresses mTOR and Causes Mitochondrial Fragmentation and Cell Degeneration in COPD by Lei Fang, Xinggang Wang, Ming Zhang, Petra Khan, Michael Tamm, Michael Roth

“…Cigarette smoke is assumed to cause the loss of airway wall structure in chronic obstructive pulmonary disease (COPD) by reducing airway smooth muscle cell (ASMC) function. …”
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Cigarette Smoke Suppresses the Surface Expression of c-kit and FcεRI on Mast Cells by M. E. Givi, B. R. Blokhuis, C. A. Da Silva, I. Adcock, J. Garssen, G. Folkerts, F. A. Redegeld, E. Mortaz

“…Chronic obstructive pulmonary disease (COPD) is a multicomponent disease characterized by emphysema and/or chronic bronchitis. …”
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Cost–consequence analysis of COPD treatment according to NICE and GOLD recommendations compared with current clinical practice in the UK by Jennifer K Quint, Helene Vioix, Toby Capstick, Sue Langham, Jennifer Cook, Antony Wright, Shamika de Silva

“…Objectives The objective of this study was to model the clinical and economic impact of adapting current clinical practice in the management of patients with chronic obstructive pulmonary disease (COPD) to treatment according to national and international guideline recommendations.Design Treatment mapping was undertaken to hypothetically redistribute patients from current clinical practice, representing actual prescribing patterns in the UK, to an alternative recommendation-based treatment scenario, representing prescribing in accordance with either National Institute for Health and Care Excellence (NICE) guidance [NG115] or Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2020 strategy.Setting Primary care practices in the UK (1-year time horizon).Participants Adults with COPD undergoing long-acting inhaler maintenance therapy in the UK (N=1 067,531).Interventions Inhaler maintenance therapy.Outcome measures Costs and clinical outcomes (type of treatment, rates of moderate and/or severe exacerbations, and mild-to-moderate and/or severe pneumonia events) were modelled for the two alternative pathways.Results Compared with current clinical practice, treating patients according to NICE guidance resulted in an estimated annual reduction in expenditure of £46.9 million, and an estimated annual reduction in expenditure of over £43.7 million when patients were treated according to GOLD 2020 strategy. …”
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