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Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone
Published 2025-01-01“…Surprisingly, almost all CG147 strains (99.7%, 1009/1,012) harbor a chromosomal type I-E CRISPR-Cas system, with 41.8% (423/1012) containing an additional plasmid-borne type IV-A3 CRISPR-Cas system, and both target IncF plasmids, e.g., the most prevalent KPC-encoding pKpQIL-like plasmids. …”
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1402
A predictive risk‐scoring model for survival prognosis of multiple myeloma based on gain/amplification of 1q21: Experience in a tertiary hospital in South‐Western China
Published 2024-09-01“…Abstract Background Chromosomal 1q gains and amplifications (+1q21) are frequently observed in patients with newly diagnosed multiple myeloma (NDMM). …”
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1403
Genotype-Phenotype Correlation of G6PD Mutations among Central Thai Children with G6PD Deficiency
Published 2021-01-01“…Only 1 in 27 heterozygous females (3.7%) had G6PD level in the affected male range (9 IU/ml.RBC) which is possibly explained by nonrandom X-chromosome inactivation. The correlation of genotypes, G6PD levels, and clinical phenotypes was not demonstrated in our study in which all of the included G6PD-deficient patients were presented with neonatal hyperbilirubinemia and acute hemolytic anemia, since the genotype-phenotype correlation is normally demonstrated in chronic nonspherocytic hemolytic anemia (CNSHA) G6PD-deficient individuals. …”
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1404
Characterizing executive functioning and associated behaviors in individuals with dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) syndrome
Published 2025-01-01“…IntroductionDYRK1A, a protein kinase located on human chromosome 21, plays a role in postembryonic neuronal development and degeneration. …”
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1405
A novel compound heterozygous mutation in the DYNC2H1 gene in a Chinese family with Jeune syndrome
Published 2025-01-01“…The mutation c.7720G > A, which is a missense mutation, has yet to be reported. Moreover, no chromosomal abnormalities or pathogenic copy number variations (CNVs) were detected in the foetus. …”
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1406
TERTp Mutation and its Prognostic Value in Glioma Patients Under the 2021 WHO Classification: A Real‐World Study
Published 2025-01-01“…Samples were analyzed for TERTp mutation and 59 other gene alterations and chromosome copy number variations. Results A total of 207 patients were included. …”
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1407
E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration
Published 2025-01-01“…Results CNF1 induces the release of reactive oxidizing species and chromosomal instability in non-neoplastic intestinal epithelial cells. …”
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1408
Application of Minimally Invasive Oral Swab Samples for qPCR-Based Sexing in Neognathae Birds
Published 2025-01-01“…This qPCR method assesses variations in gene copy numbers within conserved Z-specific genes such as <i>CHRNA6</i>, <i>DDX4</i>, <i>VPS13A</i>, <i>LPAR1</i>, and <i>TMEM161B</i>, which are absent from the W chromosome. A total of 34 samples were included in this study from the following 17 bird species: domestic pigeon (<i>Columba livia domestica</i>), domestic chicken (<i>Gallus gallus domesticus</i>), domestic goose (<i>Anser anser f domesticus</i>), domestic duck (<i>Anas platyrhynchos domesticus</i>), Mute swan (<i>Cygnus olor</i>), Budgerigar (<i>Melopsittacus undulatus</i>), Lovebird (<i>Agapornis roseicollis</i>), Cockatiel (<i>Nymphicus hollandicus</i>), Red-rumped parrot (<i>Psephotus haematonotus</i>), Rose-ringed parakeet (<i>Psittacula krameri</i>), African grey parrot (<i>Psittacus erithacus</i>), domestic Canary (<i>Serinus canaria forma domestica</i>), Goldfinch (<i>Carduelis carduelis major</i>), Gouldian Finch (<i>Chloebia gouldiae</i>), Red Siskin (<i>Carduelis cucullata</i>), Australian Zebra Finch (<i>Taeniopygia castanotis</i>), and Common buzzard (<i>Buteo buteo</i>). …”
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1409
Roles of the rpoEc-chrR-chrA operon in superoxide tolerance and β-lactam susceptibility of Stenotrophomonas maltophilia
Published 2025-02-01“…Deletion of smlt2375-smlt2367 cluster from the chromosome of KJΔChrR reverted the superoxide tolerance and β-lactam susceptibility to the wild-type level.DiscussionThe rpoEc-chrR pair of S. maltophilia was involved in superoxide tolerance and β-lactam susceptibility. …”
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1410
Effect of miR-144-3p-Targeted Regulation of PTEN on Proliferation, Apoptosis, and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells under Stretch
Published 2022-01-01“…To investigate the effects of miR-144-3p-targeted regulation of phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene on proliferation, apoptosis, and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) under retraction force. …”
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1411
Growth of microbes in competitive lifestyles promotes increased ARGs in soil microbiota: insights based on genetic traits
Published 2025-01-01“…., Pseudomonadaceae was considered to boost the increase of ARGs. It has chromosomally carried kinds of multidrug resistance genes such as mexAB-oprM and mexCD-oprJ could mediate the intrinsic resistance to OTC. …”
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1412
Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81
Published 2024-11-01“…Based on the MICs range of Qs (24–256 mg/L) and FQs (0.24–128 mg/L) breakpoint by EUCAST, we categorized these E. coli isolates into three resistance profiles (I, II, and III) associated with the patterns of chromosomal mutations in the quinolone resistance-determining regions (QRDRs) of gyrA and parC and the plasmid-mediated quinolone resistance encoding genes (PMQRs) detected by PCR-based assay and sequencing; MICs increase in an escalation step according to the co-occurrence of multiple molecular mechanisms. …”
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1413
Whole-Genome Methylation Sequencing Analysis and Functional Verification of LIM-Homeobox Family Genes in Cervical Cancer
Published 2025-01-01“…The DNA methylation level and methylation density on each chromosome varied greatly. As revealed by comparison of methylation before and after radiation in the three patients, 1287, 1261 and 789 differential methylation genes were identified, respectively. 3) Combined with clinical treatment, methylation level difference and correlation enrichment analysis, it was found that LHX2, LHX5 and LHX9 were closely related to the occurrence and development of cervical cancer. …”
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Characterizing tumor biology and immune microenvironment in high-grade serous ovarian cancer via single-cell RNA sequencing: insights for targeted and personalized immunotherapy st...
Published 2025-01-01“…We confirmed the key role of the C2 IGF2+ tumor cell subtype in HGSOC, which was significantly associated with poor prognosis and high levels of chromosomal copy number variations. This subtype was located at the terminal differentiation of the tumor, displaying a higher degree of malignancy and close association with stage IIIC tissue types. …”
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1415
Loss of histone H3K27me3 up-regulates SLC7A11 in diffuse gastric cancer cells
Published 2025-01-01“…RNA sequencing data, data from high-throughput chromosome conformation capture (Hi-C) technology, and publicly available single-cell data were integrated to investigate the target genes regulated by the reprogramming of H3K27me3 modifications in diffuse gastric cancer cells. …”
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1416
Evaluation of wheat products with high flavonoid content: justification of importance of marker-assisted development and production of flavonoid-rich wheat cultivars
Published 2017-11-01“…These two wheat lines have almost similar genomes with the exception of a small part of chromosome 2A, which contains the Pp3/TaMyc1 gene regulating anthocyanin biosynthesis. …”
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1417
Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system
Published 2025-02-01“…Of note, mutations that confer tolerance to antibiotics in Escherichia coli also map to the DNA-binding domain of VapBC encoded by the chromosomally integrated F plasmid. We demonstrate that the tolerance mutations also enhance plasmid stabilization by the same mechanism as VapBL12. …”
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1418
Spatiotemporal and genomic analysis of carbapenem resistance elements in Enterobacterales from hospital inpatients and natural water ecosystems of an Irish city
Published 2025-01-01“…In every isolate, each CEG was surrounded by a gene-specific common genetic environment which constituted part, or all, of a transposable element that was present in both plasmids and the bacterial chromosome. Transposons Tn1999 and Tn4401 were associated with blaOXA-48 and blaKPC-2, respectively, while blaNDM-5 was associated with variable IS26 bound composite transposons, usually containing a class 1 integron.IMPORTANCESince 2018, the Irish National Carbapenemase-Producing Enterobacterales (CPE) Reference Laboratory Service at University Hospital Galway has performed whole-genome sequencing on suspected and confirmed CPE from clinical specimens as well as patient and environmental screening isolates. …”
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Multidisciplinary, multicenter consensus for the care of patients affected with Sturge–Weber syndrome
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