-
241
The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases
Published 2015-01-01“…The lncRNAs are emerging as an important regulator of biological process, such as chromatin remodeling, gene transcription, protein transport, and trafficking through diverse mechanisms. …”
Get full text
Article -
242
Enigma of Retrotransposon Biology in Mammalian Early Embryos and Embryonic Stem Cells
Published 2018-01-01“…Some other retrotransposons reside in the vicinity of endogenous genes and are capable of regulating nearby genes and cell fate, possibly through providing alternative promoters, regulatory modules, or orchestrating high-order chromatin assembly. In addition, retrotransposons may mediate epigenetic memory, regulate gene expression posttranscriptionally, defend virus infection, and so on. …”
Get full text
Article -
243
A chromosome-level genome assembly of wild silkmoth, Bombyx mandarina
Published 2025-01-01“…., transcriptome-based gene prediction, Assay for Transposase-Accessible Chromatin (ATAC)-seq, and PIWI-interacting RNA (piRNA)-targeted small RNA-seq. …”
Get full text
Article -
244
The role of epigenetics in plant pathogens interactions under the changing environments: A systematic review
Published 2025-03-01“…DNA methylation influences plant immunity by modulating gene expression and chromatin accessibility, while histone modifications, such as acetylation and methylation, enable plants to establish robust defenses by fine-tuning stress-responsive genes. …”
Get full text
Article -
245
Molecular architecture of the altered cortical complexity in autism
Published 2025-01-01“…Partial least squares regression analysis revealed gene sets associated with these cortical complexity changes, enriched for biological functions related to synaptic transmission, synaptic plasticity, mitochondrial dysfunction, and chromatin organization. Cell-specific analyses, protein–protein interaction network analysis and gene temporal expression profiling further elucidated the dynamic molecular landscape associated with these alterations. …”
Get full text
Article -
246
Burkitt Lymphoma Presenting as Unilateral Deafness in an Immunocompetent Patient
Published 2012-01-01“…Examination of the peripheral smear demonstrated the presence of increased circulating blast-like cells of intermediate size, with basophilic cytoplasm and nuclei with open chromatin. MRI of the brain was compatible with hemorrhagic labyrinthitis. …”
Get full text
Article -
247
Regulatory roles of RNA binding proteins in the Hippo pathway
Published 2025-01-01“…It also explores the dynamic interplay between RBPs, non-coding RNAs, TFs, and DNA on chromatin. Additionally, it also outlines future perspectives, including the essential non-canonical functions of RBPs and emerging roles of non-canonical RBPs as transcription factors (TFs) in genes transcription. …”
Get full text
Article -
248
Gastric Endocrine Cell Carcinoma Coexistent with Adenocarcinoma
Published 2013-01-01“…Several biopsied specimens revealed proliferation of small and heterogeneous cancer cells with rich chromatin and fibrous septum with rich vessels at connective tissues, which was confirmed as gastric endocrine cell carcinoma (ECC) on immunostaining with chromogranin and synaptophysin. …”
Get full text
Article -
249
GATA2 participates in protection against hypoxia-induced pulmonary vascular remodeling.
Published 2024-01-01“…Transcript analysis and chromatin immunoprecipitation assays using mouse pulmonary vascular endothelial cells revealed that GATA2 directly regulates the expression of G6pdx (a crucial cytoprotective enzyme) and Bmp4 (a growth factor that mediates vascular homeostasis). …”
Get full text
Article -
250
Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery
Published 2010-01-01“…As a major posttranslational modification, lysine (K) acetylation has received much attention, owing largely to its significant effects on chromatin dynamics and other cellular processes across species. …”
Get full text
Article -
251
Transformation of brain myeloid cell populations by SIV in rhesus macaques revealed by multiomics
Published 2025-01-01“…A unique population of microglia-like cells is found in which the chromatin accessibility of genes diverges from their RNA expression. …”
Get full text
Article -
252
Angioleiomyoma of the uterus presenting as an endometrial polyp: An uncommon occurrence of two cases with a literature review
Published 2024-12-01“…These spindle cells have oval and cigar-shaped nuclei, fine chromatin, and a moderate amount of eosinophilic cytoplasm, resembling smooth muscle cells. …”
Get full text
Article -
253
Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention
Published 2025-01-01“…We find that many transcripts are preferentially enriched within nuclear speckles compared to the nucleoplasm, particularly chromatin- and nucleus-associated transcripts. While total polyadenylated RNA retention increases with nuclear speckle cohesion, the ratios of most mRNA species to each other are constant, indicating non-selective retention. …”
Get full text
Article -
254
Homo Sapiens Chromosomal Location Ontology: A Framework for Genomic Data in Biomedical Knowledge Graphs
Published 2025-01-01“…The utility and performance of HSCLO are demonstrated through a case study involving the integration of high-resolution chromatin interaction data, which reveals significant improvements in query efficiency and data linkage. …”
Get full text
Article -
255
H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy
Published 2010-01-01“…Phosphorylation of H2AX plays a key role in DDR and is required for the assembly of DNA repair proteins at the sites containing damaged chromatin as well as for activation of checkpoints proteins which arrest the cell cycle progression. …”
Get full text
Article -
256
Tumor-initiating and metastasis-initiating cells of clear-cell renal cell carcinoma
Published 2025-02-01“…TICs likely originate from kidney tubule progenitor cells bearing VHL gene inactivation, including chromatin 3p loss. Recent studies also point to the importance of microenvironment reconstituted by the VHL-deficient kidney tubule cells in promoting ccRCC initiation and progression. …”
Get full text
Article -
257
Interplay between Epigenetics and Genetics in Cancer
Published 2013-12-01“…Genomic instability, which occurs through both genetic mechanisms (underlying inheritable phenotypic variations caused by DNA sequence-dependent alterations, such as mutation, deletion, insertion, inversion, translocation, and chromosomal aneuploidy) and epigenomic aberrations (underlying inheritable phenotypic variations caused by DNA sequence-independent alterations caused by a change of chromatin structure, such as DNA methylation and histone modifications), is known to promote tumorigenesis and tumor progression. …”
Get full text
Article -
258
The Polycomb group protein EED is dispensable for the initiation of random X-chromosome inactivation.
Published 2006-05-01“…The Polycomb group (PcG) proteins are thought to silence gene expression by modifying chromatin. The Polycomb repressive complex 2 (PRC2) plays an essential role in mammalian X-chromosome inactivation (XCI), a model system to investigate heritable gene silencing. …”
Get full text
Article -
259
FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic β-Cells
Published 2019-01-01“…Thus, this study indicates that FXR is a critical transcription factor that mediates ADCY8 expression in pancreatic β-cells and has characterized the chromatin modification associated with Adcy8 transcription.…”
Get full text
Article -
260
Cytomorphological traits of fine-needle aspirates of hyalinizing trabecular tumor of the thyroid gland: A brief report
Published 2023-07-01“…The tumor cells exhibited ovoid nuclei, abundant cytoplasm, fine chromatin, nuclear crowding and overlapping, and small nucleoli. …”
Get full text
Article