The RNA-binding protein Modulo promotes neural stem cell maintenance in Drosophila. by Amalia S Parra, Christopher A Johnston

“…The balance between stem cell self-renewal and neural differentiation is regulated by various cellular machinery, including transcription factors, chromatin remodelers, and RNA-binding proteins. The list of these components remains incomplete, and the mechanisms regulating their function are not fully understood, however. …”
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A Combination of Cell Findings Improves the Accuracy of Voided Urine Cytology by Sachiko Iwai, Mitsuru Kinjo

“…Furthermore, the discriminant analysis revealed that six cellular findings (high nucleus-to-cytoplasm ratio, hyperchromasia, eccentric nuclei, nuclear protrusion, unevenly distributed chromatin, and irregular nuclear shape) showed high accuracy in confirming the diagnosis of HGUC. …”
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Physiological Roles of DNA Double-Strand Breaks by Farhaan A. Khan, Syed O. Ali

“…Under tight spatiotemporal regulation, DSBs serve as a tool for genetic modification, widely used across cellular biology to generate diverse functionalities, ranging from the fundamental upkeep of DNA replication, transcription, and the chromatin landscape to the diversification of immunity and the germline. …”
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Targeting Histone Deacetylases: A Novel Approach in Parkinson’s Disease by Sorabh Sharma, Rajeev Taliyan

“…Indeed, it is becoming increasingly evident that chromatin acetylation status can be impaired during the neurological disease conditions. …”
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Comparative Study of Spermatogenesis and Nucleolar Behavior in Testicular Lobes of Euschistus heros (Heteroptera: Pentatomidae) by Hederson Vinicius de Souza, Mary Massumi Itoyama

“…However, differences regarding the concentration of heteropyknotic chromatin and silver-positive bodies in this lobe deserve attention. …”
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Protocol for semisynthesis of histone H4 with site-specific modifications using irreversible sortase-mediated ligation by Yihang Xiao, Kun Zou, Mingxuan Wu

“…Summary: Post-translational modifications (PTMs) of histone H4 play significant roles in the regulation of chromatin status. Here, we present a protocol for semisynthesis of histone H4 by sortase-mediated ligation (SML). …”
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Finding the Correct Partner: The Meiotic Courtship by Tomás Naranjo

“…Additional movements produced by chromatin conformational changes at early meiosis may also facilitate homologous contacts. …”
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Genome-wide association data reveal a global map of genetic interactions among protein complexes. by Gregory Hannum, Rohith Srivas, Aude Guénolé, Haico van Attikum, Nevan J Krogan, Richard M Karp, Trey Ideker

“…As proof of principle, we use synthetic genetic screens to confirm numerous novel genetic interactions for the INO80 chromatin remodeling complex.…”
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Long Noncoding RNA Regulation of Pluripotency by Alessandro Rosa, Monica Ballarino

“…Recent evidence suggests that a complex network of transcription factors, chromatin regulators, and noncoding RNAs exist in pluripotent cells to regulate the balance between self-renewal and multilineage differentiation. …”
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The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions by Marco Muzi-Falconi, Michele Giannattasio, Marco Foiani, Paolo Plevani

“…However, pol-prim seems to play additional roles in other complex cellular processes, such as the response to DNA damage, telomere maintenance, and the epigenetic control of higher order chromatin assembly.…”
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p63: A Master Regulator at the Crossroads Between Development, Senescence, Aging, and Cancer by Lakshana Sruthi Sadu Murari, Sam Kunkel, Anala Shetty, Addison Bents, Aayush Bhandary, Juan Carlos Rivera-Mulia

“…The p63 protein is a master regulatory transcription factor that plays crucial roles in cell differentiation, adult tissue homeostasis, and chromatin remodeling, and its dysregulation is associated with genetic disorders, physiological and premature aging, and cancer. …”
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Ultrastructural and Molecular Changes in the Developing Small Intestine of the Toad Bufo regularis by S. A. Sakr, G. M. Badawy, H. T. El-Borm

“…These included the appearance of apoptotic bodies/nuclei within the larval epithelium, the presence of macrophages, swollen mitochondria, distorted rough endoplasmic reticulum, chromatin condensation, and irregular nuclear envelop, and the presence of large vacuoles and lysosomes. …”
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Lack of Association Between Partial Y chromosome AZFc-gr/gr Deletions and Male Infertility by Muhsin Jamil Abdulwahid, Mustafa Saber Al-Attar

“…Two pairs of gr/gr primers (sY1291and sY1191) and a primer of Hetero-chromatin sY160-F were used for screening for gr/gr deletion in a single PCR reaction according to EAA and EMQN protocol. …”
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Spatial integration of multi-omics single-cell data with SIMO by Penghui Yang, Kaiyu Jin, Yue Yao, Lijun Jin, Xin Shao, Chengyu Li, Xiaoyan Lu, Xiaohui Fan

“…Unlike previous tools, SIMO not only integrates spatial transcriptomics with single-cell RNA-seq but expands beyond, enabling integration across multiple single-cell modalities, such as chromatin accessibility and DNA methylation, which have not been co-profiled spatially before. …”
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A Novel Heterozygous De Novo MORC2 Missense Variant Causes an Early Onset and Severe Neurodevelopmental Disorder by Daniel Arbide, Nour Elkhateeb, Ewa Goljan, Carolina Perez Gonzalez, Anna Maw, Soo-Mi Park

“…Microrchidia CW-type zinc finger protein 2 (MORC2) is an ATPase-containing nuclear protein which regulates transcription through chromatin remodelling and epigenetic silencing. MORC2 may have a role in the development of neurones, and dominant variants in this gene have recently been linked with disorders including Charcot-Marie-Tooth type 2Z disease, spinal muscular atrophy and, more recently, a neurodevelopmental syndrome consisting of developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy (DIGFAN), presenting with hypotonia, microcephaly, brain atrophy, intellectual disability, hearing loss, faltering growth, and craniofacial dysmorphism. …”
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Functional and Practical Insights Into the Genetic Basis of Takayasu Arteritis by Desiré Casares‐Marfil, Amr H. Sawalha

“…By exploring gene expression and chromatin interaction data, we identified candidate causal genes in TAK, some of them with well‐known functional implications. …”
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Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells by Patrícia S. de Araújo-Souza, Steffi C. H. Hanschke, João P. B. Viola

“…This review will focus on the chromatin status of Ifng promoter in CD8 T cells and possible influences of epigenetic modifications in Ifng gene and conserved noncoding sequences (CNSs) in regulation of IFN-γ production by CD8 T lymphocytes.…”
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Comprehensive genome annotation of Trilocha varians, a new model species of Lepidopteran insects by Jung Lee, Toshiaki Fujimoto, Katsushi Yamaguchi, Shuji Shigenobu, Ken Sahara, Toru Shimada

“…ATAC-seq was also conducted to determine chromatin accessibility across the genome. Finally, piRNA-targeted small RNA-seq revealed T. varians genome harbours 517 piRNA clusters (piCs). …”
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Epigenetics and Breast Cancers by An T. Vo, Richard M. Millis

“…Histone demethylases such as JMJD2B and histone methyltransferases are enzymes which demethylate lysine residues on histones H3 and/or H4. This makes the chromatin accessible for transcription factors and enzymes.…”
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ROLE OF THE MODULATORY MEDIATOR SEROTONIN IN THE INDUCTION OF EPIGENETIC PROCESSES DURING LONG TERM MEMORY FORMATION IN HELIX by L. N. Grinkevich, O. V. Vorobiova

“…They include posttraslational histone modifications, which lead to chromatin remodeling and thereby influences gene expression involved in learning. …”
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