DNA Polymerase e - More Than a Polymerase by Helmut Pospiech, Juhani E. Syväoja

“…Alternatively, the two DNA polymerases may be needed to replicate distinct regions depending on chromatin structure. Surprisingly, the essential function of DNA polymerase e does not depend on its catalytic activity, but resides in the nonenzymatic carboxy-terminal domain. …”
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DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer by Nasreddine El Omari, Saad Bakrim, Mohamed Bakha, Abdelaali Balahbib, Abdelhakim Bouyahya, Chrismawan Ardianto, Long Chiau Ming, Hooi Leng Ser

“…This methylation plays an important role in regulating gene expression through direct gene repression or through the control of other epigenetic modifications such as histone modification or chromatin remodeling. DNA methylation is catalyzed by de novo and maintenance DNMT methyltransferase type enzymes and requires the transfer of a methyl group to cytosine to transform it into 5-methyl-cytosine. …”
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DNA methylation, histone acetylation in the regulation of memory and its modulation during aging by Padmanabh Singh, Vijay Paramanik

“…In the present review, we discussed the importance of DNA methylation and histone acetylation on chromatin modifications, regulation of synaptic plasticity gene expression and memory consolidation, and modulation of these epigenetic marks by epigenetic modifiers such as phytochemicals and vitamins. …”
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Preclinical Studies of Chemotherapy Using Histone Deacetylase Inhibitors in Endometrial Cancer by Noriyuki Takai, Hisashi Narahara

“…Furthermore, HDACIs were able to induce the accumulation of acetylated histones in the chromatin of the p21WAF1 gene in human endometrial carcinoma cells. …”
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Heat Shock Protein 70 Neutralizes Apoptosis-Inducing Factor by Guido Kroemer

“…Another example concerns the so-called apoptosis-inducing factor (AIF), another mitochondrial intermembrane protein which can translocate to the nucleus where it induces chromatin condensation and DNA fragmentation[3].…”
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The Histone Modification Code in the Pathogenesis of Autoimmune Diseases by Yasuto Araki, Toshihide Mimura

“…Histone modifications regulate the chromatin states and gene transcription without any change in the DNA sequence, possibly resulting in phenotype alteration in several different cell types. …”
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The immune landscape of fetal chorionic villous tissue in term placenta by Brianna M. Doratt, Heather E. True, Heather E. True, Suhas Sureshchandra, Suhas Sureshchandra, Qi Qiao, Qi Qiao, Monica Rincon, Nicole E. Marshall, Ilhem Messaoudi

“…Additionally, we provide one of the first insights into the chromatin accessibility profile of villous myeloid cells at term. …”
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Longitudinal genetic studies of cognitive characteristics by R. N. Mustafin, A. V. Kazantseva, R. F. Enikeeva, S. B. Malykh, E. K. Khusnutdinova

“…The appropriate correction of epigenetic factors related to environmental differences in cognitive abilities requires to determine the mechanisms of chromatin modifications and variations in DNA methylation. …”
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Fission yeast essential nuclear pore protein Nup211 regulates the expression of genes involved in cytokinesis. by Domenick Kamel, Ayisha Sookdeo, Ayana Ikenouchi, Hualin Zhong

“…Nuclear pore proteins control nucleocytoplasmic transport; however, certain nucleoporins play regulatory roles in activities such as transcription and chromatin organization. The fission yeast basket nucleoporin Nup211 is implicated in mRNA export and is essential for cell viability. …”
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Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies by Silvia Consalvi, Martina Sandoná, Valentina Saccone

“…In particular we focus on the current understanding of the epigenetic networks that regulate differentiation of muscle progenitors by the concerted action of chromatin-modifying enzymes and noncoding RNAs. The novel exciting role of exosome-bound microRNA in mediating epigenetic information transfer is also discussed. …”
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Biochemical Analysis of Histone Succinylation by Atsushi Yokoyama, Shogo Katsura, Akira Sugawara

“…Histone PTMs are regarded as some of the most important, as they can directly regulate gene expression through chromatin reorganization. Recently, histone proteins were found to undergo succinylation, adding to other well-known PTMs such as acetylation, methylation, and phosphorylation. …”
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Revisiting the female germline cell development by Youmei Huang, Yunlong Zhang, Jiahong Yang, Xinpeng Xi, Yanfen Liu, Hanyang Cai, Yuan Qin

“…Recently, more advanced technologies such as whole-mount single-molecule fluorescence in situ hybridization (smFISH), laser-assisted microdissection (LCM), chromatin immunoprecipitation/sequencing, and CRISPR gene editing have provided opportunities to reveal the mechanism of female germline development at different stages. …”
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Midregion PTHrP and Human Breast Cancer Cells by Claudio Luparello

“…In addition, midregion PTHrP appears to be imported in the nucleoplasm of cultured MDA-MB231 cells and in vitro, it can bind chromatin of metaphase spread preparations and also an isolated 20-mer oligonucleotide, thereby appearing endowed with a putative transcription factor–like DNA-binding ability. …”
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Granulocytic Sarcoma of Parotid Gland in a 4-Year-Old Child with Subleukemic AML: A Diagnostic Challenge! by Yashwant Ingale, Tushar Patil, Priyanka Chaudhari, Samapika Routray, Manoj Agrawal

“…Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells having high N : C ratio, coarse chromatin, conspicuous nucleoli, and sometimes angulated nuclei lying in sheets. …”
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Engineering CRISPR for emerging therapeutic applications by Xiaoqi Sun, Zhuang Liu

“…Building on this classic CRISPR–Cas system, the discovery of other diverse CRISPR systems and their further engineering have produced various powerful tools for gene editing and modulation at the genomic, chromatin, and RNA levels. This review summarizes the fundamental knowledge regarding CRISPR–Cas systems and explores the engineering strategies of these versatile systems for novel therapeutic applications. …”
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The Regulation and Functions of Endogenous Retrovirus in Embryo Development and Stem Cell Differentiation by Yangquan Xiang, Hongqing Liang

“…During the course of life, ERVs are associated with multiple aspects of chromatin and transcriptional regulation in development and pathological conditions. …”
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Meiosis-specific stable binding of augmin to acentrosomal spindle poles promotes biased microtubule assembly in oocytes. by Nathalie Colombié, A Agata Głuszek, Ana M Meireles, Hiroyuki Ohkura

“…Here we show that in Drosophila melanogaster oocytes Augmin is dispensable for chromatin-driven assembly of bulk spindle microtubules, but is required for full microtubule assembly near the poles. …”
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Integration of unpaired single cell omics data by deep transfer graph convolutional network. by Yulong Kan, Yunjing Qi, Zhongxiao Zhang, Xikeng Liang, Weihao Wang, Shuilin Jin

“…The rapid advance of large-scale atlas-level single cell RNA sequences and single-cell chromatin accessibility data provide extraordinary avenues to broad and deep insight into complex biological mechanism. …”
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A dual role of Cohesin in DNA DSB repair by Michael Fedkenheuer, Yafang Shang, Seolkyoung Jung, Kevin Fedkenheuer, Solji Park, Davide Mazza, Robin Sebastian, Hiroyuki Nagashima, Dali Zong, Hua Tan, Sushil Kumar Jaiswal, Haiqing Fu, Anthony Cruz, Supriya V. Vartak, Jan Wisniewski, Vittorio Sartorelli, John J. O’Shea, Laura Elnitski, Andre Nussenzweig, Mirit I. Aladjem, Fei-Long Meng, Rafael Casellas

“…Cohesin, a multi-subunit protein complex, plays a crucial role in both chromosome organization and DNA repair by creating architectural loops through chromatin extrusion. However, the mechanisms by which cohesin regulates these distinct processes are not fully understood. …”
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Inhibition of miMOMP-induced SASP to combat age-related disease by Xiaoli Liao, Zhennan Guo, Zhennan Guo, Mouhai He, Yichun Zhang

“…This process is triggered by various stimuli, including oxidative stress, chromatin modifications and oncogene activation, characterized by irreversible cell-cycle arrest, resistance to apoptosis and the induction of a complex senescent associated secretory phenotype (SASP). …”
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