Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer by Claudia Duranti, Jessica Iorio, Valeria Manganelli, Giacomo Bagni, Rossella Colasurdo, Tiziano Lottini, Michele Martinelli, Chiara Capitani, Giulia Boso, Franco Nicolas D’Alessandro, Maurizio Sorice, Andrea Becchetti, Roberta Misasi, Tina Garofalo, Annarosa Arcangeli

“…The hERG1/β1 integrin complex in LRs can be dissociated and the downstream signaling pathway can be inhibited by either disrupting LRs through methyl-beta-cyclodextrin (MβCD) or inhibiting cholesterol synthesis by statins. Treatment with a single chain bispecific antibody—scDb-hERG1-β1—specifically targeting the complex significantly potentiates the effects of both MβCD and statins on intracellular signaling. …”
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Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats by Elin Strand, Vegard Lysne, Mari Lausund Grinna, Pavol Bohov, Asbjørn Svardal, Ottar Nygård, Rolf K. Berge, Bodil Bjørndal

“…Treatment with the PPARα agonist was associated with higher liver mass relative to body weight (liver index), lower plasma, and hepatic total cholesterol, as well as lower plasma carnitine and acylcarnitines, compared with control. …”
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Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials by Gofarana Wilar, Cecep Suhandi, Kohji Fukunaga, Masanori Shigeno, Ichiro Kawahata, Rizky Abdulah, Takuya Sasaki

“…Lipid profile parameters, including total cholesterol (SMD: −0.18 mg/dL), LDL-C (SMD: −0.16 mg/dL), and HDL-C (SMD: 0.32 mg/dL), also reduced significantly. …”
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Fabrication and In Vivo Evaluation of In Situ pH-Sensitive Hydrogel of Sonidegib–Invasomes via Intratumoral Delivery for Basal Cell Skin Cancer Management by Maha M. Ghalwash, Amr Gamal Fouad, Nada H. Mohammed, Marwa M. Nagib, Sherif Faysal Abdelfattah Khalil, Amany Belal, Samar F. Miski, Nisreen Khalid Aref Albezrah, Amani Elsayed, Ahmed H. E. Hassan, Eun Joo Roh, Shaimaa El-Housiny

“…Results: Phospholipids (1.72% <i>w</i>/<i>w</i>), cholesterol (0.15% <i>w</i>/<i>w</i>), ethanol (1% <i>v</i>/<i>v</i>), and cineole (1.5% <i>v</i>/<i>v</i>) were shown to be the optimal components in the SDB-invasome formulation. …”
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Effects of Dietary Tea Polyphenols on the Growth, Antioxidant Status, Immune Function, and Intestinal Microbiota of Largemouth Bass (<i>Micropterus salmoides</i>) by Zixin Yang, Qiuwen Su, Jiafa Yang, Zhijun Li, Shanren Lan, Xu Jia, Paihuai Ouyang, Huijuan Tang

“…The levels of total cholesterol (CHO) and low-density lipoprotein (LDL) in the serum significantly decreased with the addition of 0.08% dietary TPs to the diet (<i>p</i> < 0.05). …”
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A Study of Correlation of Adiponectin Levels in Metabolic Syndrome by Apurv Singhal, Vedpal Singh Punia, Akash Bharti, Shaavi Mittal, Praveen Raman Mishra, Prem Kuma

“…In a multivariate analysis, the serum adiponectin content was found to be significantly inversely associated to systolic blood pressure (r=-0.262; p<0.050), BMI (r=-0.288; p<0.050), total cholesterol (r=-0.515; p<0.001), and low-density lipoprotein (r=-0.305; p<0.050) in the study participants. …”
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Growth Performance, Serum Biochemical Profile, Oxidative Status, and Fertility Traits in Male Japanese Quail Fed on Ginger (Zingiber officinale, Roscoe) Essential Oil by Tchoffo Herve, Kana Jean Raphaël, Ngoula Ferdinand, Folack Tiwa Laurine Vitrice, Adoum Gaye, Moussa Mahamat Outman, Ngouozeu Moyo Willy Marvel

“…The serum content in total cholesterol and triglycerides, the liver weight, the serum content in transaminases, and malondialdehyde decreased in treated quails. …”
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Patients with Ankylosing Spondylitis and Low Disease Activity because of Anti-TNF-Alpha Therapy Have Higher TRAIL Levels Than Controls: A Potential Compensatory Effect by Fernanda Genre, Raquel López-Mejías, Javier Rueda-Gotor, José A. Miranda-Filloy, Begoña Ubilla, Beatriz Carnero-López, Natalia Palmou-Fontana, Inés Gómez-Acebo, Ricardo Blanco, Trinitario Pina, Rodrigo Ochoa, Carlos González-Juanatey, Javier Llorca, Miguel A. González-Gay

“…TRAIL levels displayed an inverse correlation with total and LDL cholesterol. We observed an inverse correlation with QUICKI and a marginal association with HOMA-IR. …”
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Exploring the Prevalence and Components of Metabolic Syndrome in Sub-Saharan African Type 2 Diabetes Mellitus Patients: A Systematic Review and Meta-Analysis by Nelson Musilanga, Hussein Nasib, Given Jackson, Frank Shayo, Clarkson Nhanga, Saleh Girukwigomba, Ambokile Mwakibolwa, Samson Henry, Keneth Kijusya, Edgar Msonge

“…Therefore, the current study aimed to determine the weighted pooled prevalence of metabolic syndrome and its components among individuals with type 2 diabetes mellitus in sub-Saharan Africa as defined by the 2004 National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP III 2004) and/or the International Diabetes Federation (IDF) criteria. …”
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Impact of vitamin E and selenium supplementation on growth, reproductive performance, and oxidative stress in dexamethasone-stressed Japanese quail cocks by Ifeanyi Emmanuel Uzochukwu, Luke Chukwudi Ali, Bright Chigozie Amaefule, Chisom C. Okeke, Charles Onochie Osita, Ndubuisi Samuel Machebe, Vesela Yancheva, Dóra Somogyi, Krisztián Nyeste

“…Treatment did not affect blood glucose and cholesterol levels (P ≥ 0.05). Plasma antioxidant assays showed elevated superoxide dismutase and catalase functions and reduced malondialdehyde levels in G3, G4, and G5 compared to G2, indicating reduced oxidative stress. …”
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Enhancing broiler growth and carcass quality: impact of diets enriched with Moringa oleifera leaf powder conjugated with zinc nanoparticles by Mohammed M. El-Abbasy, Ahmed K. Aldhalmi, Elwy A. Ashour, Samar S. Bassiony, Mahmoud Kamal, Abdulmohsen H. Alqhtani, Diaa E. Abou-Kassem, Ahmed A. Elolimy, Mohamed E. Abd El-Hack, Ayman A. Swelum

“…Blood analysis revealed that the ZnNPs-MLPE groups had significantly lower levels of ''total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and alanine transaminase (ALT) compared to the control group. …”
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Association between early dietary patterns and cardiometabolic health at age 8: a confirmatory analysis of the European Childhood Obesity Project by Mariona Gispert-Llauradó, Joaquin Escribano, Natalia Ferré, Veit Grote, Berthold Koletzko, Gina Ambrosini, Elvira Verduci, Dariusz Gruszfeld, Annick Xhonneux, Veronica Luque

“…Triglycerides, HDL cholesterol and insulin resistance index (HOMA-IR) were also categorized as altered versus normal values. …”
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Relationship between stress hyperglycemia ratio and progression of non target coronary lesions: a retrospective cohort study by Shiqi Liu, Ziyang Wu, Gaoliang Yan, Yong Qiao, Yuhan Qin, Dong Wang, Chengchun Tang

“…A hybrid model combining logistic regression and XGBoost yielded the best predictive performance, with an AUC of 0.78 (95% CI: 0.72–0.85), incorporating SHR, number and stenosis severity of non target lesions (NTLs), hypertension and high-density lipoprotein cholesterol (HDL-c). Subgroup analysis showed that elevated SHR was a stronger predictor of NTL progression in non-diabetic patients (OR = 3.76, p = 0.007) compared with diabetic patients (OR = 1.69, p = 0.083). …”
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Evolocumab safety and efficacy in hypercholesteremia patients with or without diabetes: a retrospective real-world analysis by Sultan Ibrahim Alraddadi, Hind Almodaimegh, Abdullah Kharbosh, Hadeel Alharbi, Ahmed Ibrahim Fathelrahman, Mona Yaser Alsheikh, Lama Alfehaid

“…Abstract Background Proprotein convertase subtilisin/kexin type 9 inhibitors effectively reduce LDL cholesterol and adverse cardiovascular events with a safety profile comparable to a placebo. …”
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The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the... by Mengyuan Zhu, Xingqiang Wang, Zining Peng, Weitian Yan, Qian Deng, Meihui Li, Nian Liu, Ling Zhang

“…Objective To explore the risk factors for uric acid-lowering therapy-resistant gout (UALT-RG) and its relationships with the estimated glomerular filtration rate (eGFR), body roundness index (BRI), and visceral adiposity index (VAI) via 2007–2018 National Health and Nutrition Examination Survey (NHANES) data.Methods We calculated the BRI using waist circumference and standing height; the VAI using triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and body mass index (BMI); and the eGFR from serum creatinine levels. …”
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Effects of Omega-3 Fatty Acid in Nonalcoholic Fatty Liver Disease: A Meta-Analysis by Wenxia Lu, Sainan Li, Jingjing Li, Jianrong Wang, Rong Zhang, Yuqing Zhou, Qin Yin, Yuanyuan Zheng, Fan Wang, Yujing Xia, Kan Chen, Tong Liu, Jie Lu, Yingqun Zhou, Chuanyong Guo

“…A meta-analysis was conducted to assess the effect of omega-3 fatty acid supplementation (n-3 PUFAs) in lowering liver fat, liver enzyme (alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) levels), and blood lipids (triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), and low density lipoprotein (LDL)) in patients with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH). …”
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Transcriptome analysis of jejunal mucosal tissue in breeder hens exposed to acute heat stress by Yongcai Zhu, Satoshi Kubota, Phocharapon Pasri, Sitthipong Rakngam, Supattra Okrathok, Chayanan Pukkung, Shenglin Yang, Sutisa Khempaka

“…Functional analysis through gene ontology classification, pathway mapping via the Kyoto encyclopedia of genes and genomes, and protein interaction networks identified several important regulatory genes in thermal response (HSPA8 and HSPA2), energy homeostasis and fat metabolism (PDK4, PPARA, and CD36), glucose transport (SLC2A5), and cholesterol synthesis pathway (SQLE, CYP51A1, and HSD17B7). …”
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The atherogenic index of plasma is associated with an increased risk of diabetes in non-obese adults: a cohort study by Jun Cao, Zhaohai Su, Jiangyong Yang, Bilong Zhang, Rengui Jiang, Weiling Lu, Zhenhua Huang, Zhenhua Huang, Zheng Xie

“…Lowering triglycerides (TG) or increasing high-density lipoprotein cholesterol (HDL-C) levels may help reduce this risk.…”
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Prevalence of communicable, non-communicable diseases, disabilities and related risk factors in Khyber Pakhtunkhwa Pakistan: Findings from the Khyber Pakhtunkhwa Integrated Populat... by Ziaul Haq, Saima Afaq, Muhammad Ibrahim, Zala, Muhammad Asim

“…<h4>Objectives</h4>The objective of this study was to present the demographic characteristics and the burden of locally-specific CDs (hepatitis B and C, TB, AIDS), NCDs (diabetes, renal diseases, asthma, epilepsy, coronary heart diseases, cancer, hypertension, cholesterol, thalassemia), and disabilities (congenital, post-disease, post-injury, paralysis) stratified by sex, age and setting in the Khyber Pakhtunkhwa province of Pakistan.…”
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The Role of Matrix Metalloproteinases (MMP-2 and MMP-9) in Ageing and Longevity: Focus on Sicilian Long-Living Individuals (LLIs) by Patrizia Cancemi, Anna Aiello, Giulia Accardi, Rosalia Caldarella, Giuseppina Candore, Calogero Caruso, Marcello Ciaccio, Laura Cristaldi, Francesca Di Gaudio, Valentina Siino, Sonya Vasto

“…Finally, in LLIs MMP-9 values correlated directly both with cholesterol and with low-density lipoproteins. On the whole, our data suggest that the observed increase of MMP-2 in LLIs might play a positive role in the attainment of longevity. …”
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