Fatty Liver and Insulin Resistance in the Liver-Specific Knockout Mice of Mitogen Inducible Gene-6 by Byung Kil Park, Eun-Ah Lee, Hee-Youn Kim, Jun Choul Lee, Koon Soon Kim, Won Hoon Jeong, Ki Young Kim, Bon Jeong Ku, Sang Dal Rhee

“…The fasting plasma cholesterol and glucose concentration were higher in the Mig-6d/d mice than the Mig-6f/f mice with increased fat deposition in the liver. …”
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Livogrit mitigates ANIT-induced cholestasis-like symptoms in an in vivo model by curbing hepatic inflammation and regulating BAX, TGF-β, MMP-9 and α-SMA gene expression by Acharya Balkrishna, Ritu Paliwal, Surjeet Singh, Rani Singh, Vivek Gohel, Rishabh Dev, Kunal Bhattacharya, Sandeep Sinha, Anurag Varshney

“…Livogrit treatment protect the rats against ANIT-induced increase in blood serum markers (total bile acids, ALT, AST, GGT, ALP, total cholesterol, and total bilirubin) and reduced manifestation of liver necrosis, inflammation, and periportal fibrosis. …”
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Square-Stepping HIIT Combined With 'Phyllanthus amarus' Supplementation Alleviates Fasting Blood Glucose and Oxidative Stress in Overweight and Obese Individuals by Surachat Buddhisa, Nattaphol Prakobkaew, Piyapong Prasertsri, Sudarat Boonpitak, Puttipong Poncumhak, Orachorn Boonla

“…Venous blood was collected for measurements of the glucose, total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein concentrations, the serum proinflammatory cytokines interleukin (IL)–6 and anti-inflammatory cytokine IL-10. …”
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Effect of Genetic Predisposition on Blood Lipid Traits Using Cumulative Risk Assessment in the Korean Population by Min Jin Go, Joo-Yeon Hwang, Dong-Joon Kim, Hye-Ja Lee, Han Byul Jang, Kyung-Hee Park, Jihyun Song, Jong-Young Lee

“…Dyslipidemia, mainly characterized by high triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, is an important etiological factor in the development of cardiovascular disease (CVD). …”
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Diabetic retinopathy further increases risk of cardiovascular disease mortality in a high-risk cohort by Richard Kha, Yasemin Kapucu, Mayuri Indrakumar, George Burlutsky, Aravinda Thiagalingam, Pramesh Kovoor, Paul Mitchell, Gerald Liew

“…After controlling for age, sex, BMI, diabetes, total cholesterol, smoking status, hypertension, previous myocardial infarction and stroke, any DR was associated with 1.8-fold higher risk of CVD mortality (Hazard Ratio [HR] 1.84, 95% Confidence Interval [95% CI: 1.30–2.61]). …”
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New insights into the effects of Aspergillus oryzae administration during the transition period in Bubalus bubalis by Sameh A. Abdelnour, Walaa M. Essawi, Nasser Ghanem, Ibrahim T. El-Ratel, Abdel-Wahab A. Abdel-Warith, Elsayed M. Younis, Ahmed N. F. Neamat-Allah, Shimaa A. Amer, Simon J. Davies, Ali Ali El-Raghi

“…Regarding energy metabolism, the ASG supplementation significantly increased total cholesterol, triglycerides, and high-density lipoprotein compared to the control group. …”
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β-Caryophyllene and Statins in Bone Fracture Healing – A Narrative Review by Marom H, Khan MA, Darvish N, Tornetta III P, Khoury A, Weil YA, Skelley NW, Allison DC, Meiron S, Ehrmann Barr T

“…Statins, known for their cholesterol-lowering effects, also promote bone formation and reduce bone resorption through multiple biochemical pathways. …”
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Evaluating the association between lipidome and female reproductive diseases through comprehensive Mendelian randomization analyses by Ye Ma, Fang Wu, Zeming Yu, Lu Yang

“…The results indicated a close association between specific lipidomes, particularly sphingomyelin, lysophosphatidylethanolamine, cholesterol ester, and phosphatidylcholines, with FRDs. …”
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Functional Status of Pancreatic α and β Cells in Type 2 Diabetes Mellitus Patients with Different Plasma Triglyceride Levels: A Retrospective Analysis by Hang Guo, Chunlei Ma, Xiaoming Wu, Congqing Pan

“…Glucagon was negatively correlated with ΔI30/ΔG30, high-density lipoprotein (HDL), HOMA-β, body mass index (BMI), ISI, and AUCI (P<0.05) and positively correlated with fasting blood glucose (FPG), AUCG, HOMA-IR, HbA1c, duration, TG, low-density lipoprotein (LDL), and total cholesterol (TC) (P<0.05). Conclusion. Hypertriglyceridemia aggravated the dysfunction of pancreatic α and β cells. …”
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Prevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern Taiwan by Chien-An Tu, Chien-Feng Kuo, Chun-Ming Lee, Chang-Pan Liu, Hsiang-Kuang Tseng, Tseng-Yu Huang, Chih-Chen Lin, Hsun Chang, Winter Yu-Ning Lee, Fang-Ju Sun, Zu-Yi Sun, Pei-Ching Lian, Ming-Wei Cheng, Alice Ying-Jung Wu

“…A modified National Cholesterol Education Program ATP III definition of metabolic syndrome was used to define metabolic syndrome and body mass index was used as surrogate for waist circumference. 809 PLWH participated in the study, in which 81.3% of patients were on integrase inhibitor-based HAART regimen. …”
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Xiaohua Funing decoction ameliorates non-alcoholic fatty liver disease by modulating the gut microbiota and bile acids by Jindong Zhao, Jindong Zhao, Yan Li

“…Furthermore, metagenomic sequencing and BA metabolomic analyses were performed.ResultsCompared to the Con group, the Mod group presented significant differences in body and liver weights; serum total cholesterol (TC) and triglyceride (TG) levels; and liver TG, TC, and bile salt hydrolase levels (p &lt; 0.05 or p &lt; 0.01). …”
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Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease by Giuseppe Verdile, Kevin N. Keane, Vinicius F. Cruzat, Sandra Medic, Miheer Sabale, Joanne Rowles, Nadeeja Wijesekara, Ralph N. Martins, Paul E. Fraser, Philip Newsholme

“…Insulin resistance affects many tissues and organs, either through impaired insulin signalling or through aberrant changes in both glucose and lipid (cholesterol and triacylglycerol) metabolism and concentrations in the blood. …”
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Changes induced in mouse lipid metabolism by simultaneous impact of antisense oligonucleotide derivatives to <i>apoB</i>, <i>PCSK9</i>, and <i>apoCIII</i> mRNAs by S. I. Oshevski, Y. I. Ragino, E. V. Kashtanova, Y. V. Polonskaya, E. M. Stakhneva, V. P. Nikolin, N. A. Popova, N. A. Kolchanov, M. I. Voevoda

“…Development of new drugs able to decrease the level of “bad” cholesterol, in particular, based on antisense oligonucleotide derivatives (ASOs), remains relevant for the patients with familial hypercholesterolemia and/or intolerant to statins. …”
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Effects of a high-fat diet on the lipid profile of oocytes in mice by E. Yu. Brusentsev, E. A. Chuyko, K. A. Okotrub, T. N. Igonina, I. N. Rozhkova, D. S. Ragaeva, S. V. Ranneva, V. A. Naprimerov, S. Ya. Amstislavsky

“…A high-fat diet caused larger body weight in female mice compared with the control (p &lt; 0.001; 44.77±1.46 and 35.22±1.57, respectively), and increased the blood levels of cholesterol (p &lt; 0.05; 2.06±0.10 and 1.78±0.10, respectively) and triglycerides (p &lt; 0.05; 2.13±0.23 and 1.49±0.21, respectively). …”
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Prevalence, Awareness, and Treatment of Hypertension in Patients with Type 1 Diabetes: A Nationwide Multicenter Study in Brazil by Marilia B. Gomes, Lucianne Righeti Monteiro Tannus, Alessandra Saldanha de Mattos Matheus, Roberta Arnoldi Cobas, Catia C. Sousa Palma, Aline Tiemi Kano Silva, Carlos Antonio Negrato, Sergio Atala Dib, Melanie Rodacki, João Soares Felício, Luis Henrique Canani

“…Hypertensive patients were older, exhibited longer duration of diabetes, and had higher body mass index (BMI), total cholesterol, triglycerides, and LDL-C values (P<0.001, for all comparisons), but only 370 (53.7%) received treatment. …”
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Reducing the dietary starch:protein ratios in low-protein diets enhanced the growth performance of goslings from 1 to 28 days of age by Xucheng Zheng, Qian Lu, Chunhui Huang, Usman Nazir, Zhi Yang, Haiming Yang, Zhiyue Wang

“…Protein at 18% level, minimized serum total cholesterol (TC) in goslings. Reducing the dietary S: P ratio elevated serum lipid concentration. …”
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Combination of autoimmune hepatitis to non-alcoholic steatohepatitis (Clinical case) by A. A. Driga, M. V. Mayevskaya, V. T. Ivashkin

“…According to international classifications the 1-st type AIH of high activity (triggered by medicinal factor) in combination to NASH on a background of morbid obesity (dyslipidemia: cholesterol – 198 mg/dl, very low and high-density lipoproteins 38,2 and 31,3 mg/dl respectively) was diagnosed. …”
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Structure elucidation and in vitro rat intestinal fermentation properties of a novel sulfated glucogalactan from Porphyra haitanensis by Peilin Chen, Lu Liu, Zirun Cheng, Yi Zhang, Baodong Zheng, Xiaoke Hu, Hongliang Zeng

“…Prediction of metabolic function suggested that PHP2 could modulate cholesterol metabolism. The sulfated glucogalactan fermentation behavior may be associated with its monosaccharide composition, chain branching and chain conformation. …”
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Determinants of Change in Glycemic Status in Individuals with Prediabetes: Results from a Nationwide Cohort Study in Germany by Rebecca Paprott, Christa Scheidt-Nave, Christin Heidemann

“…Determinants of a regression to normoglycemia were female sex (male vs. female: 0.67 (0.46; 0.98)) and higher HDL cholesterol levels (1.17 (1.02; 1.35) per 10 mg/dl). …”
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60-month follow-up of Long Limb vs. Standard Limb Roux-en-Y gastric bypass for type 2 diabetes and obesity: the LONG LIMB RCT by Saleem Ansari, Anna Kamocka, Tina Mazaheri, Ibiyemi Ilesanmi, Lara Jimenez-Pacheco, Kleopatra Alexiadou, Joanna Tan, Harvinder Chahal, Krishna Moorthy, Sanjay Purkayastha, Anne Margot Umpleby, Stephen Robert Bloom, Francesco Rubino, Alexander Dimitri Miras, Ahmed Rashid Ahmed, Tricia Tan

“…Clinical outcomes, including HbA1c, number of glucose-lowering medications, weight loss, blood pressure and low-density lipoprotein cholesterol, and adverse events, were collected up to 60 months postoperatively to assess the durability of postoperative weight and glycaemic improvements. …”
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