Propionate metabolism in a human pathogenic fungus: proteomic and biochemical analyses by Luiz Paulo Araújo Santos, Leandro do Prado Assunção, Patrícia de Souza Lima, Gabriel Brum Tristão, Matthias Brock, Clayton Luiz Borges, Mirelle Garcia Silva-Bailão, Célia Maria de Almeida Soares, Alexandre Melo Bailão

“…Propionyl-CoA is a toxic compound formed during the degradation of odd-chain fatty acids, branched chain amino acids and cholesterol. Therefore, fungi require a functional MCC for full virulence and the ability to metabolize propionyl-CoA is related to the virulence traits in Paracoccidioides spp. …”
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Retrospective evaluation of risk factors for worsening renal function after angiotensin‐converting enzyme inhibitor treatment in dogs by Yelim Lee, Minju Baek, Dongseop Lee, Jinyeong Park, Yeon Chae, Byeong‐Teck Kang, Taesik Yun, Hakhyun Kim

“…Demographic and serum chemistry data, such as total protein, albumin, blood urea nitrogen, creatinine, symmetric dimethylarginine, glucose, triglyceride, total cholesterol concentrations, and serum electrolyte concentrations at first presentation, were evaluated. …”
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Utility of Visceral Adiposity Index and Lipid Accumulation Products to Define Metabolically-Unhealthy Polycystic Ovary Syndrome in Asian Indian Women - A Cross Sectional Study by R. A. Shreenidhi, Reeta Mahey, Monika Rajput, Rohitha Cheluvaraju, Ashish D. Upadhyay, Jai Bhagwan Sharma, Garima Kachhawa, Neerja Bhatla

“…The cohort was divided into MH-PCOS and MU-PCOS by the modified National Cholesterol Education Programme criteria. VAI and LAP were calculated and correlated with clinical, endocrine and metabolic parameters. …”
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<i>In Vitro</i> and <i>In Vivo</i> Interventions Reveal the Health Benefits of Levan-Type Exopolysaccharide Produced by a Fish Gut Isolate <i>Lactobacillus reuteri</i> FW2 by Waqar Ahmad, Anam Nasir, Satya Prakash, Azam Hayat, Mujaddad ur Rehman, Shazia Khaliq, Kalsoom Akhtar, Munir Ahmad Anwar, Nayla Munawar

“…In the in vivo experiments, mice fed with levan-supplemented feed exhibited low body weight gain, blood glucose, and serum cholesterol levels compared to the control group. These findings highlight the biotherapeutic potential of <i>L. reuteri</i> FW2-derived levan for improving metabolic syndrome and its associated aspects. …”
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Response to Statin Therapy in Obstructive Sleep Apnea Syndrome: A Multicenter Randomized Controlled Trial by Marie Joyeux-Faure, Renaud Tamisier, Jean-Philippe Baguet, Sonia Dias-Domingos, Stephen Perrig, Georges Leftheriotis, Jean-Paul Janssens, Wojciech Trzepizur, Sandrine H. Launois, Françoise Stanke-Labesque, Patrick A. Lévy, Frédéric Gagnadoux, Jean-Louis Pepin

“…In intention to treat analysis, mean PAT difference between atorvastatin and placebo groups was 0.008 (−0.29; 0.28), P=0.979. Total and LDL cholesterol significantly improved with atorvastatin. …”
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Effects of dietary bile acid on the growth performance, intestinal health, blood biochemistry, and antioxidative response of Nile tilapia (Oreochromus niloticus) fed high-fat diets by Mahmoud A.O. Dawood, Sameh El-Dahan, Samy Elsaadawy, Ahmed E. Noreldin, Hani Sewilam

“…Fish-fed HF diet also showed increased total cholesterol, triglycerides, glucose, ALP, and AST levels as well as the malondialdehyde level (MDA). …”
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Short-term effects of follicle-stimulating hormone on immune function, lipid, and vitamin metabolism in transiently castrated men by Jéssica Guedes, Indira Pla, Aniel Sanchez, Gyorgy Marko-Varga, Gilberto Barbosa Domont, K Barbara Sahlin, Berk Hazir, Aleksander Giwercman, Fábio César Sousa Nogueira, Johan Malm, Yvonne Lundberg Giwercman

“…Results: FSH significantly upregulates key proteins involved in the modulation of inflammatory response and innate immune system (P ≤ 0.03) and dysregulates lipid metabolism, evidenced by downregulation of multiple apolipoproteins (P ≤ 0.04) and increased levels of cholesterol and glycerophospholipids (P ≤ 0.03). In addition, low FSH levels were correlated with a reduction in the active form of vitamin D (P < 0.02). …”
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HDL proteome and apolipoproteins concentrations in severe ICU COVID-19 patients by Floran Begue, Bryan Veeren, Philippe Rondeau, Aline-Marie Florence, Simon Jamard, Philippe Montravers, Sébastien Tanaka, Olivier Meilhac, on behalf of French COVID Study Group

“…The severity of the disease has been associated with reduced levels of both high-density lipoprotein (HDL) and low-density lipoprotein cholesterol. Despite the crucial role that these nanoparticles play in SARS-CoV-2 infection, few studies have examined their structure during COVID-19 beyond HDL quantity. …”
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Improving the physiological status of broiler chickens using rosemary leaf meal and sodium bentonite as ammonia gas control agents by Mercy Chisara Ogwuegbu, Fredrick Ugochukwu Udeh, Josephine Chinenye Ugwuozor, Precious Ezinne Okoye, Joy Chimela Kalu, Emmanuel Chinonso Arum, Doctor Mziwenkosi Nhlanhla Mthiyane

“…Broilers fed 6 g RLM + 15 g SB/kg diet exhibited significantly (P < 0.05) enhanced antioxidant enzyme activities (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase), reduced malondialdehyde and cholesterol levels, and improved mineral composition (potassium, calcium, magnesium, zinc, iron, and phosphorus). …”
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Chicken C4BPM facilitates replication of H5N1 and H9N2 Avian Influenza Viruses by inhibiting the production of type I interferons by Huizi Li, Shishi Wang, Ruihong Guo, Xijiao Chen, Yuanyuan Huang, Weixin Jia, Zhangyong Ning

“…Replication of H5N1 and H9N2 AIVs were promoted in C4BPM-overexpressing DF-1 cells with inhibited expression of type I IFNs (IFN-α, IFN-β), protein kinase R (PKR), cholesterol 25-hydroxylase (CH25H), interferon regulatory factor (IRF) 3, and mitochondrial antiviral signaling protein (MAVS) compared to that of the DF-1 cells. …”
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The Impact of Atorvastatin on Intraprostatic Biomarkers – Prognostic Value of 3LS-score – Follow-up of ESTO1-Trial by Eemil Lehtonen, Maiju Vertanen, Heimo Syvälä, Teemu Tolonen, Seppo Auriola, Teuvo Tammela, Aino Siltari, Teemu Murtola

“…Statins have been associated with survival benefits in advanced Pca, potentially by modulating cholesterol metabolism and tumor biology. However, the causal mechanisms are not well understood. …”
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Associations between lipid-lowering drugs and urate and gout outcomes: a Mendelian randomization study by Min Liu, Na Yin, Yuhang Zhu, Aili Du, Chunyuan Cai, Pengyuan Leng

“…The aim of this study was to investigate the genetic association between lipid-lowering drugs and urate and gout.MethodsIn this study, two genetic proxies were employed to approximate lipid-lowering drug exposure: expression quantitative trait loci (eQTL) associated with drug-target genes and genetic variations proximal to or within genes targeted by these drugs, which are linked to low-density lipoprotein cholesterol (LDL-C) levels. The study’s exposures encompassed genetic variants within drug target genes (HMGCR, PCSK9, NPC1L1), each representing distinct lipid-lowering mechanisms. …”
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Preterm Birth and Cardiometabolic Health Trajectories From Birth to Adulthood: The Avon Longitudinal Study of Parents and Children by Gemma L. Clayton, Laura D. Howe, Linda M. O'Keeffe, Adam J. Lewandowski, Deborah A. Lawlor, Abigail Fraser

“…High‐density lipoprotein cholesterol was higher and triglycerides lower at birth, in those born preterm, but this difference also disappeared by age 25 years. …”
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Prospective study of the association between chronotype and cardiometabolic risk among Chinese young adults by Tingting Li, Yang Xie, Shuman Tao, Liwei Zou, Yajuan Yang, Fangbiao Tao, Xiaoyan Wu

“…The cardiometabolic (CM)-risk score was the sum of standardized Z scores based on gender for the 5 indicators: waist circumference (WC), mean arterial pressure (MAP), triglyceride (TG), homeostasis model assessment for insulin resistance (HOMA-IR), and high-density lipoprotein cholesterol (HDL-C), where the HDL-C is multiplied by-1. …”
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The impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic review by Junwen Yu, Yue Wu, Zheng Zhu, Hongzhou Lu

“…Plant-rich diets showed a significant decrease in total cholesterol (TC) with a mean difference of -6.77 (95% CI, -12.36 to -2.58; I 2  = 84.7%), while restrictive diets showed a significant decrease in triglycerides (TG) of -22.12 (95% CI, -36.05 to -8.19; I 2  = 98.4%). …”
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Risk of Atherosclerosis and Helicobacter pylori Infection according to CD14 Promotor Polymorphism in Healthy Korean Population by Sung-Goo Kang, Woo Chul Chung, Sang-Wook Song, Kyu Re Joo, Hyewon Lee, Donghoon Kang, Joune Seup Lee, Kang-Moon Lee

“…There were no differences between specific genotypes of CD14 gene and H. pylori infection rate. As for HDL cholesterol level, there were significant differences among the three genotypes (P<0.01). …”
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Identification of core biomarkers for tuberculosis progression through bioinformatics analysis and in vitro research by Zhanpeng Chen, Qiong Wang, Quan Ma, Jinyun Chen, Xingxing Kong, Yuqin Zeng, Lanlan Liu, Shuihua Lu, Xiaomin Wang

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis indicated that these genes are primarily associated with fatty acid degradation, pyruvate metabolism, arginine and proline metabolism, as well as cholesterol metabolism signaling pathways. Subsequent Protein-protein interaction (PPI) analysis and Receiver Operating Characteristic (ROC) curve analysis identified four core genes closely associated with TB progression, namely Rac Family Small GTPase 1 (RAC1), Ring-Box 1 (RBX1), Mitochondrial Ribosomal Protein L33 (MRPL33), and ELAV Like RNA Binding Protein 1 (ELAVL1). …”
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Exploring the impact of genetic factors and fatty acid quality on visceral and overall Fat levels in overweight and obese women: a genetic risk score study by Niloufar Rasaei, Atefeh Tavakoli, Saba Mohammadpour, Mehdi Karimi, Alireza Khadem, Azam Mohamadi, Seyedeh Fatemeh Fatemi, Fatemeh Gholami, Khadijeh Mirzaei

“…CSI provides information on cholesterol and saturated fats. However, there was a notable interaction between the GRS and the N6/N3 score on VAI, suggesting that obese women with high obesity-related SNPs who consumed foods with a higher ratio of N6/N3 fatty acids tended to have an increased VAI. …”
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Per1/Per2 double knockout transcriptome analysis reveals circadian regulation of hepatic lipid metabolism by Yiran Bu, Si Chen, Mengcheng Ruan, Libang Wu, Hualin Wang, Na Li, Xiuju Zhao, Xiaoli Yu, Zhiguo Liu

“…HFD had greater effects on fatty acid oxidation and cholesterol synthesis and metabolism in Per1-/-Per2-/- mice, which was improved by DHA substitution. …”
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Correlation of irisin with lipid profile in type 2 diabetes mellitus by Wahengbam Diana Devi, Oinam Prabita Devi, Ursula Khwairakpam, Takhelmayum Paras Singh

“…In T2DM cases, serum irisin was inversely correlated with FBS levels (r=−0.32, P=0.04), FBS was correlated directly with total cholesterol (T-Chol) (r=0.216, P=0.180), triglyceride (TG) (r=0.289, P=0.071), and low-density lipoprotein (LDL) (r=0.325, P=0.041) and negatively correlated (r=−0.269, P=0.094) with high-density lipoprotein (HDL) levels. …”
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