In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species by M. Karkhane Yousefi, M. Seyed Hashtroudi, A. Mashinchian Moradi, A.R. Ghasempour

“…Breast cancer is the most common cancer type among women all over the world. Chemotherapy is the use of anticancer medicines for treating cancer but it has many side effects and cells may become resistant to these chemical medicines. …”
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Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma by Erin E. Crotty, Aimee A. Sato, Aimee A. Sato, Mohamed S. Abdelbaki

“…Recent biologic insights and therapeutic targeting of MAPK-alterations have dramatically shifted the treatment approach in pLGG. While chemotherapy remains front-line therapy for unresectable pLGG in most scenarios (with the notable exception of BRAFV600E-altered tumors), many patients recur following cytotoxic agents and require further treatment. …”
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Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer by Xinhang Xia, Wenhu Pi, Yanli Lan, Xiaomai Wu, Dongqing Lv, Yinnan Meng, Haihua Yang, Wei Wang

“…Our data revealed that the treatment of combination of antitumor angiogenesis agent anlotinib with chemotherapy drug 5-FU may have synergistic cytotoxicity to SCLC in vitro and in vivo. …”
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First Account of Primary Leiomyosarcoma of the Lesser Omentum since Establishment of c-Kit Mutations in Gastrointestinal Stromal Tumors by Fumito Saijo, Kaoru Sato, Tomoko Handa, Yoichi Narushima, Naoki Matsumura, Noriyuki Iwama, Fumie Nakayama, Hiromi Tokumura

“…No recurrence had been observed 1 year after surgery without adjuvant chemotherapy. Conclusions. Primary lesser omental leiomyosarcoma, which is difficult to diagnose before surgery given the location of the primary tumor in the lesser omentum, has rarely been reported. …”
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Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets by Ding Nan, Weiping Yao, Luanluan Huang, Ruiqi Liu, Xiaoyan Chen, Wenjie Xia, Hailong Sheng, Haibo Zhang, Xiaodong Liang, Yanwei Lu

“…Oral supplementation with glutamine also enhances the immune capabilities of cancer patients, improves the sensitivity to chemotherapy and radiotherapy, and improves prognosis. …”
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Integrating AI into Cancer Immunotherapy—A Narrative Review of Current Applications and Future Directions by David B. Olawade, Aanuoluwapo Clement David-Olawade, Temitope Adereni, Eghosasere Egbon, Jennifer Teke, Stergios Boussios

“…Traditional treatments like chemotherapy and radiation often result in significant side effects and varied patient outcomes. …”
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High Serum Alkaline Phosphatase Flare after First-Line Androgen Deprivation Therapy Predicts Poor Prognosis in Metastatic Prostate Cancer Patients Treated with Second-Generation An... by Satoko Kojima, Hiroshi Masuda, Takahito Suyama, Kyokushin Hou, Kousuke Mikami, Kazuhiro Araki, Yukio Naya

“…A higher ALP flare ratio after first-line ADT was a significant prognostic factor in metastatic PCa, especially in patients treated with second-generation ART for CRPC. Chemotherapy for patients with a higher ALP flare ratio 1 month after induction of ADT may be a clinically relevant decision.…”
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Incidence, risk factors, and outcomes of the transition of HIPEC-induced acute kidney injury to acute kidney disease: a retrospective study by Yunwei Lu, Ziyan Xiao, Xiujuan Zhao, Yingjiang Ye, Shu Li, Fuzheng Guo, Haiyan Xue, Fengxue Zhu

“…Background Acute kidney injury (AKI) is recognized as a common complication following cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). Characterized by prolonged renal function impairment, acute kidney disease (AKD) is associated with a higher risk of chronic kidney disease (CKD) and mortality.Methods From January 2018 to December 2021, 158 patients undergoing CRS-HIPEC were retrospectively reviewed. …”
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MicroRNA-155 modulates methotrexate-induced spatial memory impairment by disruption of the blood-brain barrier integrity by Yu-Chieh Chen, Li-Tung Huang, Hong-Ren Yu, Jiunn-Ming Sheen

“…Aim: Methotrexate (MTX) is a commonly used chemotherapy drug, yet its late neurotoxic side effects are gaining attention. …”
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Targeted Therapies Compared to Dacarbazine for Treatment of BRAFV600E Metastatic Melanoma: A Cost-Effectiveness Analysis by Vanessa Shih, Renske M. ten Ham, Christine T. Bui, Dan N. Tran, Jie Ting, Leslie Wilson

“…We evaluated the cost-effectiveness of BRAF inhibitors and traditional chemotherapy for treatment of metastatic melanoma. Methods. …”
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Current attitudes to testicular prosthesis insertion during radical orchidectomy—An international perspective by Anthony Emmanuel, Abi Kanthabalan, Cameron Alexander, Nikita Bhatt, Vinson Chan, Odunayo Kalejaiye, Krishna Narahari, Veeru Kasivisvanathan, Majed Shabbir

“…The most frequently selected reasons for not offering testicular prosthesis implantation included concerns about delaying chemotherapy (41%), infection (33%), impaired cosmesis (17%) and lack of availability (17%). …”
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Immunotherapy as a neoadjuvant preoperative treatment for locally advanced pulmonary sarcomatoid carcinoma: a case report of clinical efficacy by Hanhan Li, Hanhan Li, Ruilian Chen, Wei Guo, Shang Xiang, Shang Xiang, Jiayang Huang, Jiayang Huang, Hanrui Chen

“…Postoperative pathology confirmed that the neoadjuvant chemotherapy in this regimen achieved pathological complete remission (pCR). …”
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Advancing the Fight Against Cervical Cancer: The Promise of Therapeutic HPV Vaccines by Qian Zheng, Misi He, Zejia Mao, Yue Huang, Xiuying Li, Ling Long, Mingfang Guo, Dongling Zou

“…This review focuses on clinical studies involving therapeutic HPV vaccines for cervical cancer, specifically in three key areas: the treatment of cervical intraepithelial neoplasia; the treatment of cervical cancer in combination with or without chemotherapy, radiotherapy, or immune checkpoint inhibitors; and the role of prophylaxis following completion of treatment. …”
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A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca <i>Lepidium meyenii</i> by Albert Gabriel Turpo-Peqqueña, Sebastian Luna-Prado, Renato Javier Valencia-Arce, Fabio Leonardo Del-Carpio-Carrazco, Badhin Gómez

“…Current therapeutic strategies, including surgery, chemotherapy, and radiotherapy, often fail due to the tumor’s ability to develop resistance. …”
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High Expression of Ten Eleven Translocation 1 Is Associated with Poor Prognosis in Hepatocellular Carcinoma by Haopeng Wen, Tengfei Ji, Liteng Lin, Nan Cheng, Kangshun Zhu, Liangqi Cao

“…High and low TET1 expression groups had distinct immune cell infiltration and response to immunotherapy and chemotherapy. We identified 90 DEGs related to DNA demethylation in high vs. low TET1 expression groups. …”
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DNA methylation and immune evasion in triple-negative breast cancer: challenges and therapeutic opportunities by Wen-yu Cai, Xin-xian Cai, Yi-ran Fei, Rui Ye, Ding-ming Song, Dan Hu, Wan-wan Zhang, Ming-fei Xia, Xiao-xiao Yang

“…Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Chemotherapy remains the primary treatment option, yet TNBC frequently develops resistance, leading to relapse and metastasis. …”
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Significance of Preoperative Systemic Immune Score for Stage I Gastric Cancer Patients by Jun Lu, Long-long Cao, Ping Li, Jian-wei Xie, Jia-bin Wang, Jian-xian Lin, Qi-yue Chen, Mi Lin, Ru-hong Tu, Chang-ming Huang, Chao-hui Zheng

“…Determining preferences regarding the benefits of adjuvant chemotherapy (AC) for stage I GC is critical. Methods. …”
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Matching-Adjusted Indirect Comparison of the Efficacy and Safety of Erdafitinib vs Enfortumab Vedotin in Patients with Locally Advanced Metastatic Urothelial Carcinoma by Suzy Van Sanden, Ayman Youssef, Simona Baculea, Keith Stubbs, Spyros Triantos, Zijiao Yuan, Caitlin Daly

“…**Methods:** An anchored MAIC was conducted according to the National Institute for Health and Care Excellence Decision Support Unit guidance, with physician’s choice of chemotherapy (docetaxel/paclitaxel and vinflunine) as the common comparator. …”
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Alveolar Rhabdomyosarcoma of Nasopharynx and Paranasal Sinuses in Children Diagnosis and Treatment—Review of the Literature and Case Report by Cristian Mârțu, Ștefan Dragoș Tîrnovanu, Ioana Mârțu, Dan Ferariu, Dan Mârțu, Alexandra Jităreanu, Luminița Rădulescu

“…Combined treatment approaches (surgery, radiotherapy, and chemotherapy) should be tailored to tumor characteristics. …”
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PIVKA-II as a surrogate biomarker for therapeutic response in Non-AFP-secreting hepatocellular carcinoma by San-Chi Chen, Hsiang-Ling Ho, Chien-An Liu, Yi‑Ping Hung, Nai-Jung Chiang, Ming‑Huang Chen, Yee Chao, Muh-Hwa Yang

“…This association held for targeted therapies, immune checkpoint inhibitors, and chemotherapy. Progression-free survival (PFS) for the regression, stable, and progression groups was non-reached, 6.7, and 3.2 months (p = 0.0002), and overall survival (OS) was non-reached, non-reached, and 18.5 months (p = 0.02). …”
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