Chemical catalyst manipulating cancer epigenome and transcription by Yuki Yamanashi, Shinpei Takamaru, Atsushi Okabe, Satoshi Kaito, Yuto Azumaya, Yugo R. Kamimura, Kenzo Yamatsugu, Tomoya Kujirai, Hitoshi Kurumizaka, Atsushi Iwama, Atsushi Kaneda, Shigehiro A. Kawashima, Motomu Kanai

“…Therefore, this histone acetylation catalyst provides a unique tool for elucidating the time-resolved consequences of histone PTMs and may offer a modality for cancer chemotherapy.…”
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Immunological differences between monophasic and biphasic synovial sarcoma with implications for immunotherapy by S. J. Luk, M. E. IJsselsteijn, A. Somarakis, I. Acem, I. Briaire de Bruijn, K. Szuhai, J. V. M. G. Bovee, N. F. C. C. de Miranda, J. H. F. Falkenburg, M. H. M. Heemskerk

“…The immune composition of synovial sarcoma was dominated by CD68+ myeloid cells of which a substantial part was of the CD163+ immunosuppressive phenotype, which increased after chemotherapy or radiotherapy. Biphasic synovial sarcomas were more densely infiltrated by both T cells and myeloid cells than monophasic synovial sarcomas. …”
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Metastatic Urothelial Carcinoma from Transplanted Kidney with Complete Response to an Immune Checkpoint Inhibitor by Ryan S. Chiang, Ashton A. Connor, Brant A. Inman, Wen-Chi Foo, David N. Howell, John F. Madden, Matthew J. Ellis, Aparna S. Rege, Michael R. Harrison

“…Approaches to treatment have largely been individualized based on clinical circumstances given the lack of evidence-based guidelines, with therapeutic options ranging from discontinuation of immunosuppression and transplantectomy to the addition of chemotherapy or radiotherapy. Case Presentation. Herein, we describe a 60-year-old woman with metastatic donor-derived upper tract urothelial carcinoma (UTUC) discovered nine years postrenal transplant. …”
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Treatment Patterns and Outcomes Among Patients With Advanced or Recurrent Endometrial Cancer Initiating First-Line Therapy in the United States by Robert L. Coleman, Jamie Garside, Jean Hurteau, Joehl Nguyen, Monica Kobayashi

“…**Discussion:** The use of platinum-based chemotherapy for first-line treatment of advanced or recurrent EC predominates in the real-world setting, despite the poor long-term survival outcomes associated with most of these regimens. …”
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Novel Pt (II) Complexes With Anticancer Activity Against Pancreatic Ductal Adenocarcinoma Cells by Erika Stefàno, Gianluca Rovito, Luca G. Cossa, Federica De Castro, Viviana Vergaro, Asjad Ali, Giulia My, Danilo Migoni, Antonella Muscella, Santo Marsigliante, Michele Benedetti, Francesco Paolo Fanizzi

“…However, the development of resistance to chemotherapy drugs has created a need for the synthesis of new anticancer agents. …”
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Case report: Transarterial chemoembolization for nasal hemangiosarcoma in a dog by Keunho Kim, Changgyu Lim, Songyi Kim, Hearang Lim, Sang-Hwan Hyun, Byeong-Teck Kang, Dongwoo Chang, Namsoon Lee

“…Although initial treatments with radiotherapy and chemotherapy provided temporary relief, the symptoms reappeared 11 months later. …”
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Determinants of Demoralization Syndrome and Social Support Among Patients with Breast Cancer: A Cross-Sectional Study by Yang L, Song LX, Zhang L, Yang Y, Zhang YM

“…Among patients with BC, demographic variables such as age, education level, residential address, monthly income, occupation, and receipt of chemotherapy were the main influencing factors (P < 0.05), whereas factors such as current status of children, and surgical methods were not the main influencing factors (P < 0.05). …”
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TIM‐4 increases the proportion of CD4+CD25+FOXP3+ regulatory T cells in the pancreatic ductal adenocarcinoma microenvironment by inhibiting IL‐6 secretion by Ziyao Wang, Zerong Xie, Yu Mou, Ruiman Geng, Chen Chen, Nengwen Ke

“…Conclusion TIM‐4 has the potential to be an immunotherapeutic target or to improve the efficacy of chemotherapy for PDAC.…”
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Synchronous Bilateral Testicular Tumors with Different Histopathology by Ioannis Anastasiou, Dimitrios Deligiannis, Ioannis Katafigiotis, Ioannis Skarmoutsos, Georgios Karaolanis, Viktoria-Varvara Palla, Afrodite Nonni, Dionysios Mitropoulos, Constantinos A. Constantinides

“…He received two cycles of adjuvant combination chemotherapy with bleomycin, etoposide, and cisplatin. …”
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Recent advances in bacterial outer membrane vesicles: Effects on the immune system, mechanisms and their usage for tumor treatment by Shuo Xiang, Qiufang Yao, Arshad Khan, Dong Wang

“…This dual capability enhances the effectiveness of immunotherapy combined with chemotherapy or phototherapy, thereby improving anticancer drug efficacy. …”
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Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer by Mikito Inokuchi, Yoshitaka Fujimori, Sho Otsuki, Yuya Sato, Masatoshi Nakagawa, Kazuyuki Kojima

“…Chemotherapy has become the global standard treatment for patients with metastatic or unresectable gastric cancer (GC), although outcomes remain unfavorable. …”
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Adjuvant Radiotherapy for Synchronous Bilateral Testicular Seminoma: A Case Report and a Review of the Pertinent Literature by Daniel A. Jones, Elizabeth C. Ester, David Leavitt, Robert Sweet, Badrinath Konety, Gautam Jha, L. Chinsoo Cho

“…Organ preservation remains investigational. Chemotherapy is probably a reasonable option. We propose that patients with bilateral stage I synchronous GCT, with concordant seminoma histology, should be managed with bilateral orchiectomy, followed by paraaortic radiotherapy.…”
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Trace elements‐based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapy by Hadil M. Alahdal, Sumya Ayad Abdullrezzaq, Hawraz Ibrahim M. Amin, Sitah F. Alanazi, Abduladheem Turki Jalil, Mehrdad Khatami, Marwan Mahmood Saleh

“…Abstract Hyperthermia is an additional treatment method to radiation therapy/chemotherapy, which increases the survival rate of patients without side effects. …”
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BRAF inhibitor monotherapy in BRAFV600E-mutated pediatric low-grade glioma: a single center’s experience by S. S. McThenia, S. S. McThenia, S. S. McThenia, K. M. Reddy, K. M. Reddy, E. Damaraju, E. Castellino, Z. He, R. Beer, F. Chien, F. Chien, F. Chien, R. C. Castellino, R. C. Castellino, R. C. Castellino, A. E. Goldman-Yassen, A. E. Goldman-Yassen, J. R. Fangusaro, J. R. Fangusaro, J. R. Fangusaro, T. MacDonald, T. MacDonald, T. MacDonald

“…BackgroundPediatric low-grade gliomas (pLGGs) have an overall survival of over 90%; however, patients harboring a BRAFV600E alteration may have worse outcomes, particularly when treated with classic chemotherapy. Combined BRAF/MEK inhibition following incomplete resection demonstrated improved outcome in BRAFV600E altered pLGG compared to combined carboplatin/vincristine chemotherapy and is now considered the standard FDA-approved treatment for this group of tumors. …”
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Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H2O2 by C.F. Pulliam, M.A. Fath, S. Sho, S.T. Johnson, B.A. Wagner, M. Singhania, A.L. Kalen, K. Bayanbold, S.R. Solst, B.G. Allen, B.N. George, J.M. Caster, G.R. Buettner, D.P. Riley, J.L. Keene, R.A. Beardsley, D.R. Spitz

“…Most importantly, the combination of RUC + P-AscH‾ was found to sensitize both H1299T and A549 cell types to radio-chemotherapy with cisplatin (CIS) + etoposide (ETOP). …”
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Recent progress on anti-cancer activity of thiadiazoles: A review by C.R. Santhosh, Sampath Chinnam, Nagaraju Kottam, S Amreen, Guddekoppa S. Ananthnag, G.M. Madhu, Samata Gadde, Viola Tressa Fernandes, Haritha Arnipalli

“…Thiadiazoles exhibit beneficial synergistic effects when used with other anticancer treatments like chemotherapy or targeted therapy. They have shown considerable anti-cancer action against various cancer cell lines. …”
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Endometrial Cancer Cells Promote M2-Like Macrophage Polarization by Delivering Exosomal miRNA-21 under Hypoxia Condition by Li Xiao, Yumin He, Fan Peng, Jianlin Yang, Chengfu Yuan

“…Increasing evidence has demonstrated that hypoxia was an aggressive feature in endometrial cancer (EC), which is significantly associated with the tumor grade, lymph node metastasis, and tumor resistance to chemotherapy. However, the relationship between hypoxia and the immune microenvironment in EC is not very clear. …”
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The combination of a tyrosine kinase inhibitor and blinatumomab in patients with Philadelphia chromosome–positive acute lymphoblastic leukemia or Philadelphia chromosome‐like acute... by Xiaoxia Wu, Shenqi Lu, Xinhui Zhang, Zhen Yang, Aining Sun, Depei Wu, Huifen Zhou, Miao Miao

“…The combination of blinatumomab and a TKI in the frontline setting has shown the safety and efficacy of the chemotherapy‐free treatment approach in patients with Ph + ALL. …”
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Pembrolizumab in a Patient with Treatment-Naïve Unresectable BRAF-Mutation Negative Anaplastic Thyroid Cancer by Fadi Nabhan, Elizabeth Kander, Rulong Shen, Amit Agrawal, Vineeth Sukrithan, Ye Zhou, Ashima Goyal, Katie Roll, Manisha Shah, Bhavana Konda

“…The disease was declared surgically inoperable, and the patient declined chemotherapy/radiation therapy (XRT), but agreed to ICI therapy with intravenous pembrolizumab 200 mg every three weeks. …”
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Clinicopathologic Significance of CXCL12 and CXCR4 Expressions in Patients with Colorectal Cancer by Naomi Yoshuantari, Didik Setyo Heriyanto, Susanna Hilda Hutajulu, Johan Kurnianda, Ahmad Ghozali

“…There was no difference in the expression of CXCL12 and CXCR4 according to the patients’ ages, gender, tumour differentiation, or response to chemotherapy. Conclusion. Our study demonstrated that the mRNA expression of CXCL12 was significantly correlated with rectal location. …”
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