Complexed Crystal Structure of Saccharomyces cerevisiae Dihydroorotase with Inhibitor 5-Fluoroorotate Reveals a New Binding Mode by Hong-Hsiang Guan, Yen-Hua Huang, En-Shyh Lin, Chun-Jung Chen, Cheng-Yang Huang

“…DHOase catalyzes the reversible cyclization of N-carbamoyl aspartate (CA-asp) to dihydroorotate (DHO) in the third step of the pathway for the biosynthesis of pyrimidine nucleotides and is an attractive target for potential anticancer and antimalarial chemotherapy. Crystal structures of ligand-bound DHOase show that the flexible loop extends toward the active site when CA-asp is bound (loop-in mode) or moves away from the active site, facilitating the product DHO release (loop-out mode). …”
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Focused ultrasound for treatment of peripheral brain tumors by Phillip Mitchell Johansen, Payton Yerke Hansen, Ali A. Mohamed, Sarah J. Girshfeld, Marc Feldmann, Brandon Lucke-Wold

“…Central nervous system (CNS) tumors are classically treated with surgical resection and radiotherapy in addition to adjuvant chemotherapy. However, the therapeutic efficacy of chemotherapeutic agents is limited due to the blood-brain barrier (BBB). …”
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Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes by Zongheng Wang, Zhipeng Hou, Shuguang Zhang, Shuangyi Ren, Liqun Yang, Qianshi Zhang

“…These findings suggested that the 5-FU-loaded PTMC membranes hold great potential for application in cancer patients, offering benefits in chemotherapy treatment.…”
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Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling by Cheng-Hung Chuang, Yu-An Tai, Ting-Jing Wu, Ying-Jui Ho, Shu-Lan Yeh, Shu-Lan Yeh

“…IntroductionCancer-related fatigue (CRF) is a common symptom induced by chemotherapy. The main objective of the present study was to investigate whether quercetin regulates the hypothalamic-pituitary-adrenal (HPA) axis and chemoattractant protein-1 (MCP-1) signaling, two factors contributing to CRF in mice exposed to cisplatin.MethodsMale BALB/c mice were randomly assigned to the following five groups for 15 weeks: Control, CDDP, CDDP+TAK779 (an antagonist of MCP-1 receptor, human CC chemokine receptor R2 (CCR2)), CDDP+OQ (a diet containing 1% quercetin) and CDDP+IQ (quercetin given by ip, 10 mg/kg, 3 times/week).ResultsThe results first showed that OQ and IQ significantly increased grip strength and locomotor activity, decreased plasma cortisol/corticosterone levels, and decreased the corticotropin releasing hormone (CRH) mRNA level in the brain tissues in mice exposed to CDDP. …”
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Case report: Multi-organ injuries induced by tislelizumab by Man Yuan, Man Yuan, Ning Han, Ning Han, Li Shu, Libo Yan, Libo Yan, Hong Tang, Hong Tang

“…A 68-year-old man had undergone neoadjuvant chemotherapy with paclitaxel, carboplatin, and tislelizumab. …”
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Bone Marrow-Liver-Spleen Type of Large B-Cell Lymphoma Associated with Hemophagocytic Syndrome: A Rare Aggressive Extranodal Lymphoma by Kirill A. Lyapichev, Jennifer R. Chapman, Oleksii Iakymenko, Offiong F. Ikpatt, Uygar Teomete, Sandra Patricia Sanchez, Francisco Vega

“…The patient underwent treatment with chemotherapy (R-CHOP) but unfortunately passed away 2 months after initial presentation. …”
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Hypothyroidism Due to Thyroid Amyloidosis Simultaneously With AL Renal Amyloidosis to Give Better Idea of Association of the Two Conditions by Guan C, Liu Y, Chen R, Zhu Y

“…The patient received levothyroxine sodium tablets as replacement therapy and received chemotherapy in the hematology department. At the same time, we monitored the improvement in thyroid function and reduction in thyroid volume.Keywords: thyroid amyloidosis, hypothyroidism, renal amyloidosis, nephrotic syndrome, macroalbuminuria…”
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Antianemic Treatment of Cancer Patients in German Routine Practice: Data from a Prospective Cohort Study—The Tumor Anemia Registry by Tilman Steinmetz, Jan Schröder, Margarete Plath, Hartmut Link, Michèle Vogt, Melanie Frank, Norbert Marschner

“…Over 85% received chemotherapy. Median age was 67 years; 48% were male. …”
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Targeted therapy for cisplatin‐resistant lung cancer via aptamer‐guided nano‐zinc carriers containing USP14 siRNA by Xinmin Zhao, Xianghua Wu, Huijie Wang, Songtao Lai, Jialei Wang

“…However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. …”
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Serum Levels of Irisin and Omentin-1 in Breast Neoplasms and Their Association with Tumor Histology by Grigorios Panagiotou, Sofia Triantafyllidou, Basil C. Tarlatzis, Eleni Papakonstantinou

“…Disease-free individuals (N = 56) and patients with histologically proven benign (N = 61) or malignant tumor (N = 96; subdivided into recently diagnosed/treatment-naïve (N = 72) and chemotherapy-treated (N = 24) subgroups) were enrolled in this study. …”
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Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation by Michela Staderini, Lara Mannelli, Elisabetta Antonioli, Benedetta Puccini, Valentina Berti, Francesco Mungai, Federica Vergoni, Valentina Carrai, Luigi Rigacci, Alberto Bosi

“…The therapeutic program initially included chemotherapy (cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone; CHOEP), radiotherapy on the leg, bortezomib, and then consolidation with autologous hematopoietic stem cell transplantation. …”
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Synergistic anticancer effects of cisplatin and phenolic aglycones of the aerial part of Rumex dentatus L. in tongue squamous cell carcinoma: insights from network pharmacology and... by Amany E. Ragab, Ghada M. Al-Ashmawy, Sherin R. El Afify, Ola A. El-Feky, Amera O. Ibrahim

“…Cisplatin is the standard chemotherapy for OSCC, but resistance often reduces its efficacy, necessitating new treatments with fewer side effects. …”
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Infantile Extracranial Rhabdoid Tumor of the Scalp by Sura Al Rawabdeh, Deifallah Alsharari, Hayat Khasawneh, Ola M. Al Waqfi, Qamar Yaser Malabeh, Hiathem Abu Alhaija, Raed Mohammad Aljubour, Hamzeh M. Alkhawaldeh

“…After tumor excision, the patient was referred to pediatric oncology to receive chemotherapy. Experience with scalp extracranial rhabdoid tumors is limited. …”
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Retroperitoneal Soft Tissue Sarcoma and Kidney Autotransplantation: A Case Report by S. N. Hakkesteegt, C. A. J. Oudmaijer, L. J. Jeletich, J. Sprakel, H. J. A. N. Kimenai, D. J. Grünhagen

“…After unsuccessful neoadjuvant chemotherapy, she underwent an en‐bloc resection and subsequent autotransplantation. …”
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Transferrin receptor-1 and ferritin heavy and light chains in astrocytic brain tumors: Expression and prognostic value. by Ann Mari Rosager, Mia D Sørensen, Rikke H Dahlrot, Steinbjørn Hansen, David L Schonberg, Jeremy N Rich, Justin D Lathia, Bjarne W Kristensen

“…Treatment with radio- and chemotherapy has increased survival making prognostic biomarkers increasingly important. …”
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Expression of MxA in esophageal cancer cell lines can influence sensitivity to chemotherapeutic agents but this does not require apoptosis by R. M. Hayes, T. R. O'Donovan, S. L. McKenna

“…Collectively these data indicate that MxA can promote resistance to chemotherapy, but this does not always correspond with effects on apoptosis. …”
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Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases by Ajit A. Kulkarni, Collynn F. Woeller, Thomas H. Thatcher, Sesquile Ramon, Richard P. Phipps, Patricia J. Sime

“…PPARγ ligands show great promise in moderating lung inflammation, as antiproliferative agents in combination to enhance standard chemotherapy in lung cancer and as treatments for pulmonary fibrosis, a progressive fatal disease with no effective therapy. …”
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Review: performance of jujube and its extracts in cancer: therapeutic, toxicity-reducing and potentiating effects by Boyun Gou, Guoqing Chen, Shicong Huang, Na Ning, Qian Gu, Shuai Duan, Yuhua Du, Yi Nan, Ling Yuan

“…Although there are effective treatments such as radiotherapy and chemotherapy for cancers, they are often accompanied by serious side effects. …”
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Association of JMJD2B and Hypoxia-Inducible Factor 1 Expressions with Poor Prognosis in Osteosarcoma by Xujian Liu, Qianqian Zhang, Yi Zhao, Jianjun Xun, Hongzeng Wu, Helin Feng

“…JMJD2B and HIF1 expression levels were both significantly associated with Enneking stage, distant metastasis, and neoadjuvant chemotherapy, and the JMJD2B and HIF1 expressions were positively correlated (p<0.001, R=0.752). …”
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Correlation of Oncotype DX Recurrence Score with Histomorphology and Immunohistochemistry in over 500 Patients by Matthew G. Hanna, Ira J. Bleiweiss, Anupma Nayak, Shabnam Jaffer

“…The RR is divided into low (0–17), intermediate (18–30), and high (31) to predict chemotherapy benefit. Our goal was to determine the association between histomorphology, immunohistochemistry, and RR. …”
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