Stromal Expression of Hypoxia Regulated Proteins Is an Adverse Prognostic Factor in Colorectal Carcinomas by Arjen H. G. Cleven, Manon van Engeland, Bradly G. Wouters, Adriaan P. de Bruïne

“…Background: Hypoxia modifies the phenotype of tumors in a way that promotes tumor aggressiveness and resistance towards chemotherapy and radiotherapy. However, the expression and influence of hypoxia-regulated proteins on tumor biology are not well characterized in colorectal tumors. …”
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Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma by H. Auge, C. Yguel, E. Schmitt, B. Frotscher, H. Busby-Venner, R. Morizot, C. Moulin, P. Feugier, A. Perrot, L. Filliatre-Clement

“…The patient received induction therapy with bortezomib, thalidomide, and dexamethasone (VTD), followed by high-dose melphalan chemotherapy and autologous stem cell transplantation, and then VTD consolidation, and finally maintenance with lenalidomide. …”
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Clinical efficacy of Methylene Blue mediated antimicrobial Photodynamic Therapy (PDT) using 680 nm Diode Laser in patients undergoing Open Flap Debridement: An Original Research by Soundarya Singh, Manisha Rout, Mayur Kaushik, Shilpa Sharma, Aprajita Srivastava

“…Antimicrobial photodynamic therapy may hold promise as a substitute for currently available chemotherapy in the treatment of periodontal and peri-implant disease and in endodontic therapy.…”
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Trastuzumab in Esophagogastric Cancer: HER2-Testing and Treatment Reality outside Clinical Studies in Germany by Kirsten Merx, Manuel Barreto Miranda, Lenka Kellermann, Ulrich Mahlknecht, Oliver Lange, Michael Gonnermann, Ralf-Dieter Hofheinz

“…We analysed trends over time in palliative first-line chemotherapy in patients with locally advanced or metastatic esophagogastric cancer. …”
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Improved outcomes of children with Wilms’ tumor in a low-middle-income nation: The contribution of a pediatric oncologist to successful management by Usama Al-Jumaily, Hamid D. Habeeb Rjeib, Mohammed Fawzi Alqanbar, Safa Faraj, Dheyaa Aldeen Al-Khateeb

“…Initially, patients were treated with a pretreatment biopsy, preoperative chemotherapy, or upfront nephrectomy. Results: In this study, 54 patients were enrolled. …”
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IMPACT OF COVID-19 PANDEMIC ON THE SURGICAL TREATMENT OF GASTRIC CANCER: A 3-YEAR ANALYSIS by Amanda Juliani ARNEIRO, Marina Alessandra PEREIRA, André Roncon DIAS, Ulysses RIBEIRO JUNIOR, Marcus Fernando Kodama Pertille RAMOS

“…In patients undergoing curative surgery, there was a greater indication for postoperative ICU (p=0.022) and neoadjuvant chemotherapy (p<0.001). There was no difference in 30- and 90-day mortality. …”
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Extensive Growth of an Anaplastic Meningioma by Hajrullah Ahmeti, Homajoun Maslehaty, Athanasios K. Petridis, Alexandros Doukas, Mehran Mahvash, Harald Barth, H. M. Mehdorn

“…With the presented case, we would like to show the aggressive behavior of anaplastic meningiomas in a very illustrative way. Chemotherapy, radiotherapy, and surgery reach their limits in this tumor entity.…”
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LINC02389/miR-7-5p Regulated Cisplatin Resistance of Non-Small-Cell Lung Cancer via Promoting Oxidative Stress by Peng Ma, Wen Han, Cunying Meng, Xiaohong Tan, Pengfei Liu, Lei Dong

“…Non-small-cell lung cancer (NSCLC) is one of the most common malignancies worldwide, and cisplatin-based chemotherapy is the main treatment for NSCLC. However, cisplatin resistance of NSCLC cells is a major challenge for NSCLC treatment. …”
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Expression of O6-Alkylguanine-DNA Alkyltransferase in Normal and Malignant Bladder Tissue of Egyptian Patients by Abir A. Saad, Heba Sh. Kassem, Andrew C. Povey, Geoffrey P. Margison

“…Based on this, bladder cancers would be expected to be relatively resistant to chemotherapy which involved O6-guanine alkylating antitumour agents.…”
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A Rare Case of Large-Vessel Vasculitis following Checkpoint Inhibitor Therapy and Pegfilgrastim by Joseph Mort, Shipra Maheshwari, Nayanika Basu, Patrick Dillon, Kevin Brady, Harry Bear, Trish Millard

“…We present a 59-year-old female with left stage IIA (cT2N0M0) triple-negative breast cancer receiving neoadjuvant decitabine and pembrolizumab prior to neoadjuvant chemotherapy (NAC). NAC included standard-of-care dose dense doxorubicin and cyclophosphamide (ddAC) supported with pegfilgrastim use followed by weekly carboplatin and paclitaxel. …”
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OSTEOSARCOMA HAS NOT BECOME ATTENTION TO SOCIETY PROFILE OF OSTEOSARCOMA PATIENTS AT DR. SOETOMO GENERAL HOSPITAL SURABAYA "A RETROSPECTIVE STUDY” by Ferdiansyah Mahyudin, Mouli Edward, Muhammad Hardian Basuki, Yunus Abdul Bari, Yesa Suwandani

“…Osteosarcoma treated mostly by amputation, either with or without chemotherapy. The survival rate in the first, second, or the fifth year was found lower than other references. …”
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Nanoparticles assisted drug delivery for effective management of Glioblastoma by Mansi Damani, Nagesh Nilawar, Munira Momin, Raghumani Singh Ningthoujham, Tabassum Khan

“…Standard treatments, including surgery, radiotherapy, and chemotherapy with temozolomide (TMZ), are often limited by the ability of the tumor to circumvent therapeutic effects and by the physiological barriers that restrict drug delivery to the brain parenchyma. …”
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circRNA_101277 Influences Cisplatin Resistance of Colorectal Cancer Cells by Modulating the miR-370/IL-6 Axis by Qing Lv, Qinghua Xia, Anshu Li, Zhiyong Wang

“…However, in those where the disease progresses to an advanced stage, chemotherapy remains the primary available treatment option, and the associated 5-year survival rate remains low. …”
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Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose by Nao Iguchi, Ali Teimouri, Duncan T. Wilcox, Anna P. Malykhina, Nicholas G. Cost

“…Abstract Vincristine (VCR) is one of the most widely used chemotherapy agents in treating pediatric cancer. Nonetheless, it is known to cause dose-dependent neurotoxicity which can impact virtually every organ system. …”
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Topical Mitomycin C and Radiation Induce Conjunctival DNA-Polyploidy by Olaf Cartsburg, Christopher Kallen, Jost Hillenkamp, Rainer Sundmacher, Natalia Pomjanski, Alfred Böcking

“…Conclusion: Measurements of DNA‐content revealed euploid polyploidisation of morphological suspicious but benign squamous cells which is the biologic correlate of well known secondary morphologic changes following topical chemotherapy and/or radiation. DNA‐image‐cytometry is a useful tool in the differention of euploid polyploidization as a sign of reactive cell changes following treatment and tumor recurrences.…”
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Effect of “Time To Surgery” on the Endometrial Cancer Prognosis by Engin Celik, Harika Yumru Celiksoy, Hamdullah Sozen, Hale Goksever Celik, Semen Onder, Mehmet Yavuz Salihoglu, Samet Topuz

“…STUDY DESIGN: Patients who were diagnosed with epithelial type endometrial cancer and did not receive preoperative chemotherapy, radiotherapy, or hormonal therapy were included in the study. …”
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Application of clown care in hospitalized children: A scoping review. by Guo Xin, Fu Yingping, Chen Yue, Wu Jiaming, Hu Xue

“…Clown care can be used with children who have burns, perioperative care, fracture rehabilitation, autism, puncture therapy, chemotherapy, respiratory pathologies and disabled children, according to a review of the literature. …”
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Case report: Near-complete response to neratinib-based treatment in HR-positive HER2-amplified metastatic breast cancer refractory to trastuzumab deruxtecan by Ünal Metin Tokat, Ashkan Adibi, Ashkan Adibi, Esranur Aydın, Şevval Nur Bilgiç, Eylül Özgü, Onur Tutar, Mutlu Demiray

“…The backbone of first-line treatment in HR+/HER2+ BC is dual anti-HER2 blockade combined with taxane chemotherapy. Although this regimen exhibits high rates of response and disease control in both HR+ and HR− cohorts, some patients could have intrinsic or develop acquired resistance to trastuzumab and/or pertuzumab. …”
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Predictive and Prognostic Factors of Synchronous Colorectal Lung-Limited Metastasis by Yuqiang Li, Zhongyi Zhou, Da Liu, Ming Zhou, Fengbo Tan, Wenxue Liu, Hong Zhu

“…A multivariate regression analysis discriminated 9 independent prognostic factors, including age, race, marital status, pathological grade, T stage, colectomy/proctectomy, chemotherapy, CEA, and TD. The prognostic nomogram illustrated that nonresection/NOS played as the poorest prognostic factor, followed by nonchemotherapy, ≥75-year old and T4 stage. …”
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The Impact of Radiation Dose on Preoperative Neoadjuvant Chemoradiotherapy Effects for Patients with Locally Advanced Squamous Cell Esophageal Carcinoma: A Propensity Score-Matched... by Yanru Mu, Hui Wang, Tao He, Li Xu

“…The patients with LASCEC received either low dose radiotherapy (50.4Gy/23f/1.8Gy) or a high dose (64.8Gy/25f/1.8Gy) followed by neoadjuvant chemotherapy preoperatively were included in this study. …”
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