Clinicopathological features of two ultra-rare cases of malignant perivascular epithelioid cell tumors (PEComas) involving the uterus with recent updates by Bharat Rekhi, Santosh Menon

“…She underwent cytoreductive surgery twice with adjuvant chemotherapy for multiple tumors and TAH-BSO for a uterine tumor, 2 years before. …”
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Hypercalcemia in Lung Cancer due to Simultaneously Elevated PTHrP and Ectopic Calcitriol Production: First Case Report by Saed Nemr, Sunitha Alluri, Dhivya Sundaramurthy, Daniel Landry, Gregory Braden

“…A 60-year-old Caucasian male patient with stage IIIB squamous cell lung cancer developed hypercalcemia at 14.8 mg/dL two years after receiving chemotherapy and radiotherapy where labs showed a serum intact PTH: 7 pg/mL, PTHrP: 30 pmol/L, 1,25-hydroxyvitamin D (calcitriol): 76 pg/mL, and 25-hydroxyvitamin D levels: <4 ng/mL. …”
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Rare Encounter Behind the Ear: Unveiling Kimura Disease in the Postaural Region by Divya Nayani, Siddhartha Nyathani, Rahul Kumar Pitale Ashok

“…Treatment options encompass systemic steroids, antihistamines, immunosuppressants, chemotherapy, radiotherapy, and surgical excision. Despite interventions, the disease often locally recurs. …”
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The Role of Gut Microbiota in Tumor Immunotherapy by Miao Wu, Jiawei Bai, Chengtai Ma, Jie Wei, Xianjin Du

“…Tumor immunotherapy is the fourth therapy after surgery, chemotherapy, and radiotherapy. It has made great breakthroughs in the treatment of some epithelial tumors and hematological tumors. …”
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T Cell Histiocyte Rich Large B Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: An Uncommon Presentation of a Rare Disease by Uroosa Ibrahim, Gwenalyn Garcia, Amina Saqib, Shafinaz Hussein, Qun Dai

“…An excisional biopsy of the right inguinal lymph node was consistent with a diagnosis of THRLBCL and the patient subsequently received six cycles of chemotherapy with R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) after which a PET-CT scan showed no evidence of biologically active disease and ferritin was down to 822 ng/mL. …”
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The Effect of SP/NK1R on the Expression and Activity of Catalase and Superoxide Dismutase in Glioblastoma Cancer Cells by Faranak Korfi, Hossein Javid, Reza Assaran Darban, Seyed Isaac Hashemy

“…Glioblastoma is the most malignant brain tumor with different therapeutic protocols, including surgery, radiotherapy, and chemotherapy. Substance P (SP), a peptide released by sensory nerves, increases cellular excitability by activating the neurokinin-1 receptor (NK1R) in several human tumor cells. …”
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A Rare Presentation of Lymphoma of the Cervix with Cross-Sectional Imaging Correlation by Brinda Rao Korivi, Corey T. Jensen, Madhavi Patnana, Keyur P. Patel, Tharakeswara K. Bathala

“…The patient was started on chemotherapy to control the newly diagnosed humeral head lesion, which then regressed. …”
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Evaluating stakeholder coordination and partnerships for NTD elimination in Taraba state, Nigeria: a multi-level analysis by Adeola Onasanya, Oladimeji Oladepo, Gima Humphrey Forje, Eucheria Ekugeni Abua, Uche Veronica Amazigo

“…Control efforts have involved the four levels of governance with programs focused on vector control, preventive chemotherapy, water, sanitation and health education. …”
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A Unique Case of Malignant Pleuropericardial Effusion: HHV-8-Unrelated PEL-Like Lymphoma—A Case Report and Review of the Literature by Farhan Mohammad, Muhammad Neaman Siddique, Faraz Siddiqui, M. Popalzai, Masoud Asgari, Marcel Odaimi

“…We are also presenting a review of relevant literature focused mainly on comparing outcomes in patients treated with and without chemotherapy.…”
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Translocation (6;15)(q12;q15): A Novel Mutation in a Patient with Therapy-Related Myelodysplastic Syndrome by Saba F. Ali, Rebecca J. Sonu, Denis M. Dwyre, Brian A. Jonas, Hooman H. Rashidi

“…The patient was successfully treated with chemotherapy and an autologous bone marrow transplant but subsequently developed a new FLT3-ITD negative t-MDS with a unique translocation, t(6;15)(q12;q15), three years after transplant. …”
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A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in an HIV Patient Treated with CHOP by Jorge Hurtado-Cordovi, Louay Hanna, Vladimir Gotlieb, Alan S. Multz, Anastasia Pigal

“…Patient was treated with 6 cycles of CHOP (cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone) chemotherapy and went into complete remission. Due to the aggressive course that this malignancy follows in HIV patients we suggest prompt treatment with systemic therapy.…”
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Concurrent Malignant Solitary Fibrous Tumor Arising from the Omentum and Grade 3 Endometrial Endometrioid Adenocarcinoma of the Uterus with p53 Immunoreactivity by Naoya Harada, Ichiro Nobuhara, Noriko Haruta, Yumi Higashiura, Hideki Watanabe, Sumire Ohno

“…Interestingly, the tumor cells were immunoreactive for p53. Adjuvant chemotherapy was administered for the uterine corpus cancer and the patient remains healthy 48 months after the surgery. …”
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Two Synchronous Neonatal Tumors: An Extremely Rare Case by M. Rodríguez-Zubieta, K. Albarenque, C. Lagues, A. San Roman, M. Varela, D. Russo, G. Podesta, D. Steinberg, C. Schauvinhold, A. Etchegaray, M. T. G. de Dávila

“…The infant underwent surgery and chemotherapy in different steps. Complete surgical resection with clean margins is considered to be the best treatment option for sialoblastoma. …”
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Enhanced Expression of ABCB1 and Nrf2 in CD133-Positive Cancer Stem Cells Associates with Doxorubicin Resistance by Shinji Goto, Tsuyoshi Kawabata, Tao-Sheng Li

“…Complex mechanisms, including drug excretion and redox regulation, are likely involved in the DXR resistance of CD133-positive cells, suggesting the difficulty of drug resistance problem in cancer chemotherapy.…”
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Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone by Shachar Kenan, Leonard Kahn, Morris Edelman, Arlene Redner, Samuel Kenan

“…The patient thus avoided further surgical intervention and received the appropriate treatment of chemotherapy, with subsequent rapid resolution of the lesion. …”
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circ_ZFR Is Linked to Paclitaxel Resistance in Cervical Cancer via miR-944 Sponging and IL-10 Upregulation by Xiaoqian Long, Meiyun Zheng, Youlin Yang, Yi Chen, Xiahui Zhang, Haiyan Zhang

“…Cervical cancer (CC) has an elevated rate of invasion and death despite surgical treatment, radiotherapy, and chemotherapy. Several studies revealed that circRNAs have a key contribution to the resistance of drugs against different types of carcinomas. …”
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Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application by Ziyuan Liang, Lixian Deng, Xiaoying Zhou, Zhe Zhang, Weilin Zhao

“…The ketogenic diet (KD) may enhance the sensitivity of various cancers to standard therapies, such as chemotherapy and radiotherapy, by exploiting the reprogrammed metabolism of cancer cells and shifting the metabolic state from glucose reliance to KB utilization, rendering it a promising candidate for adjunct cancer therapy. …”
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The Efficacy of Ramucirumab in the Treatment of Gastric or Gastroesophageal Junction Cancer: A Meta-Analysis of RCTs by Hongqiong Yang, Yaojun Zhou, Liangzhi Wang, Tianyi Gu, Mengjia Lv, Jinling Sun, Chao Tu, Junbo He

“…Moreover, compared with the current first-line chemotherapy, the OS (OR=0.93, 95%CI=0.83–1.04, p=0.19) and PFS (OR=0.82, 95%CI=0.64–1.06, p=0.13) results were not significantly higher with RAM. …”
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Preparation of Ca-Mg Double-Doped Mesoporous Silica Nanoparticles and Their Drug-Loading and Drug-Releasing Properties by Qian Zhang, Jiamin Huang, Chao Liu, Ruihua Chen, Tao Jiang, Yusufu Hailili, Telieke Bahetibieke, Xiaohui Tang, Mei Wang

“…Breast cancer is a common clinical malignant tumor that seriously threatens women’s physical and mental health. Chemotherapy, as the first choice of breast cancer treatment, has limited its application in the clinic due to problems of poor stability, short half-life, and serious toxic side effects. …”
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Outcome of spine surgery in the context of spinal metastatic disease: The National Surgical Quality Improvement Program by Salim M. Yakdan, Maya Herrera, Nour Wehbe, Monifa Al Akoum, Muhammad Irfan Kaleem, Miguel A. Ruiz-Cardozo, Karan Joseph, Nada Assaf, Hani Dimassi

“…In addition, 28.6% of patients experienced a prolonged hospital stay, with significant predictors including chemotherapy, surgical urgency, dependent status, preoperative hematocrit, neurological deficits, preoperative albumin levels, and surgical complexity. …”
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