Metformin in the treatment of colorectal cancer and neuroendocrine tumours by Karolina Daniłowska, Natalia Picheta, Barbara I. Krupska, Anna Rudzińska, Oliwia Burdan, Katarzyna Szklener

“…Metformin, a drug commonly used in the treatment of type 2 diabetes, has demonstrated its ability to reduce the incidence and increase the efficacy of chemotherapy in colorectal cancer and neuroendocrine tumors. …”
Get full text

Laryngeal Synovial Sarcoma: A Rare Clinical Entity by Clair Saxby, Ron Bova, Melanie Edwards

“…The patient received adjuvant chemotherapy followed by a course of radiotherapy and remains alive and disease free at 18 months after treatment. …”
Get full text

Gompertz model with delays and treatment: Mathematical analysis by Marek Bodnar, Monika Joanna Piotrowska, Urszula Foryś

“…In this paper we study the delayed Gompertz model, as a typical model of tumor growth, with a term describing external interference that can reflect a treatment, e.g. chemotherapy. We mainly consider two types of delayed models, the one with the delay introduced in the per capita growth rate (we call it the single delayed model) and the other with the delay introduced in the net growth rate (the double delayed model).We focus on stability and possible stability switches with increasing delay for the positive steady state. …”
Get full text

Primary Cardiac Lymphoma Presenting with Thrombocytopenia, Right Heart Failure, and Cardiogenic Shock by Samantha Kurniawan, Gita Mathur, Yvonne Bogun, Giselle Kidson-Gerber

“…The patient stabilised with initiation of high dose steroids prior to tissue diagnosis and platelet counts normalised following chemotherapy. This case demonstrates the importance of considering PCL as a diagnosis and preemptive initiation of high dose steroids to improve outcomes in PCL associated with cardiogenic shock. …”
Get full text

Desmoplastic reaction in the microenvironment of head and neck and other solid tumors: the therapeutic barrier by Kohei Okuyama, Maiko Tsuchiya, Kala Chand Debnath, Shajedul Islam, Souichi Yanamoto

“…DR also affects bone invasion and chemotherapy resistance by modulating stromal responses. …”
Get full text

A Review on the Application of PD-1 Blockade in EBV-Associated Nasopharyngeal Carcinoma Immunotherapy by Jin Bian, Yan Niu, Yanli Ma, Fuhua Chen, Ning Ma

“…Although radiotherapy and chemotherapy are effective treatments for NPC, they have immunosuppressive effects. …”
Get full text

Neoadjuvant Radiation with Concurrent 5-FU Resulting in Complete Pathologic Response in Stage IIIB Squamous Cell Carcinoma of the Urethra by Krishna H. Suthar, Meghana Kesireddy, Mark Sides, Amit Correa, Aijan Ukudeyva, Rohit Venkatesan

“…Here, we present the case of a 47-year-old man with stage IIIB urethral squamous cell cancer that showed complete clinical and pathologic response to neoadjuvant chemoradiation with only 5-flurouracil after incomplete response to traditional chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP).…”
Get full text

Adaptive Treatment of Metastatic Prostate Cancer Using Generative Artificial Intelligence by Youcef Derbal

“…Testosterone and prostate-specific antigen (PSA) are assumed to be repeatedly monitored while treatment may involve a combination of androgen deprivation therapy (ADT), androgen receptor-signalling inhibitors (ARSI), chemotherapy, and radiotherapy. The analysis covers various questions relevant to the configuration, training, and inferencing of GPTs for the case of mPC treatment with a particular attention to risk mitigation regarding the hallucination problem and its implications to clinical integration of GenAI technologies. …”
Get full text

Biclonal IgD and IgM Plasma Cell Myeloma: A Report of Two Cases and a Literature Review by Zhongchuan W. Chen, Ioanna Kotsikogianni, Jay S. Raval, Christine G. Roth, Marian A. Rollins-Raval

“…Both cases reported herein demonstrated chemotherapy-resistant clinical courses.…”
Get full text

A Diagnostic Dilemma: Waldenström's Macroglobulinemia/Plasma Cell Leukemia by Bhawna Sethi, K. S. Butola, Yogesh Kumar

“…The patient was referred for chemotherapy but expired on 10th day of admission. The suspected cause of death was cardiorespiratory failure.…”
Get full text

Castleman's Disease and Neutropenic Enterocolitis Presenting as Crohn’s Disease by Kelly W Burak, Ronald J Bridges, Walter B Blahey

“…Biopsies confirmed reactive hyperplasia, consistent with the plasma cell variant of Castleman's disease. Chemotherapy has resulted in improvement of symptoms and decrease in mass size, but cecal ulceration persisted. …”
Get full text

Superficial Bladder Cancer Therapy by Emmanuel Schenkman, Donald L. Lamm

“…Prostatic urethral mucosal involvement with bladder cancer can be effectively treated with Bacillus Calmette-Guerin (BCG) intravesical immunotherapy. Intravesical chemotherapy reduces short-term tumor recurrence by about 20%, and long-term recurrence by about 7%, but has not reduced progression or mortality. …”
Get full text

Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants by Emily E. Miller, Leigh Christopher Reardon

“…Neutropenic enterocolitis (NE) historically primarily affects pediatric patients with leukemia who are undergoing chemotherapy or who have recently received bone marrow transplants. …”
Get full text

First Description of a Primitive Neuroectodermal Tumor Arising in the Nose by Habib Rizk, Aline Khazzaka, Amer Sebaaly, Maguy Cherfan, Roland Tomb, Riad Sarkis

“…After a second resection, our patient was referred to chemotherapy and has already undergone 9 cycles out of 14. …”
Get full text

Fludarabine Treatment of Patient with Chronic Lymphocytic Leukemia Induces a Digital Ischemia by Utku Erdem Soyaltin, Deniz Yuce Yildirim, Mustafa Yildirim, Mehmet Can Ugur, Ferhat Ekinci, Cengiz Ceylan, Harun Akar

“…These symptoms began approximately one week after the fourth cycle of fludarabine and cyclophosphamide chemotherapy and were accompanied by pain, numbness, and cyanosis in the fingers of his right hand except the first finger. …”
Get full text

Advancements in targeted and immunotherapy strategies for glioma: toward precision treatment by Guangyuan Gong, Lang Jiang, Jing Zhou, Yuanchao Su

“…High-grade gliomas (HGGs), characterized by their high malignancy, remain challenging to treat despite standard treatment regimens, including surgery, radiotherapy, chemotherapy, and tumor treating fields (TTF). These therapies provide limited efficacy, highlighting the need for novel treatment strategies. …”
Get full text

Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs by Torić Jelena, Marković Ana Karković, Brala Cvijeta Jakobušić, Barbarić Monika

“…Current treatment includes the administration of one or more anticancer drugs, commonly known as chemotherapy. The biggest issue concerning the chemotherapeutics is their toxicity on normal cells and persisting side effects. …”
Get full text

Diencephalic Syndrome: A Rare Entity with Its Anaesthetic Management and Post-operative Complications of Diabetes Insipidus and Thrombocytopenia by Sakshi Kadian, Sarin John, Siddharth Chakraborty, Sanjay Agrawal

“…The treatment options vary from endoscopic biopsy followed by chemotherapy to definitive surgical resection of the tumour. …”
Get full text

Anti-Retroviral Strategies for AIDS and Related Diseases by Mark A Wainberg, Andre Dascal, Jack Mendelson

“…Each of these steps represents a potential target for antiviral chemotherapy. Combinations of drugs which act against different steps in the viral replication cycle might be expected to have synergistic potential. …”
Get full text

Primary Hepatic Lymphoma Presenting as an Acute Abdomen in a Young Female Patient: A Case Report and Literature Review by Walid E. Abdelrahim, Kamal E. Mohamed, Salwa O. Mekki, Eltaib A. Saad

“…She received adjuvant combination chemotherapy and remained disease-free with normal serial radiology over a 2-year follow-up period.…”
Get full text