Molecular Imaging to Identify Tumor Recurrence following Chemoradiation in a Hostile Surgical Environment by Olugbenga T. Okusanya, Charuhas Deshpande, Eduardo M. Barbosa, Charu Aggarwal, Charles B. Simone, Jack Jiang, Ryan Judy, Elizabeth DeJesus, Steve Albelda, Shuming Nie, Philip S. Low, Sunil Singhal

“…Imaging modalities have limited ability to accurately detect recurrent cancer in fields affected by previous surgery, chemotherapy, or radiation. However, definitive tissue diagnosis is often needed to initiate treatment and to direct therapy. …”
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A Rare Case of Metastatic Choriocarcinoma of Lung Origin by Parth Rali, Jianwu Xie, Grishma Rali, Mayur Rali, Jan Silverman, Khalid Malik

“…We report a rare case of metastatic primary lung choriocarcinoma in a 69-year-old postmenopausal woman who was treated with combination of surgery, chemotherapy, and radiation. The patient had a good outcome and is doing well after 1-year follow-up.…”
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Trastuzumab Resistance: Role for Notch Signaling by Kinnari Mehta, Clodia Osipo

“…Trastuzumab, the humanized, monoclonal antibody directed against ErbB-2 has shown tremendous efficacy and improved overall survival for women when combined with a taxane-based chemotherapy. However, resistance to trastuzumab remains a major concern, most notably in women with metastatic breast cancer. …”
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Extramedullary Solitary Plasmacytoma with Anaplastic Features of the Nasopharynx by Parikshit Padhi, Radwa El-Behery

“…Given there are no treatment guidelines, we would like to highlight this rare case and discuss different potential management options such as radiation, chemotherapy, surgery, or a combination of different modalities.…”
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Clear Cell Adenocarcinoma Arising from Endometriosis in the Groin: Wide Resection and Reconstruction with a Fascia Lata Tensor Muscle Skin Flap by Shozo Yoshida, Akira Onogi, Masamitsu Kuwahara, Tomoko Uchiyama, Hiroshi Kobayashi

“…The patient received chemotherapy with gemcitabine and carboplatin for 6 cycles and had no evidence of recurrence 7 months after the treatment. …”
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Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis by X. A. Andrade, H. E. Fuentes, D. M. Oramas, H. Mann, P. Kovarik

“…This case report illustrates a case of a patient with long-standing rheumatoid arthritis and an iatrogenic peripheral T-cell lymphoma with secondary hemophagocytic lymphohistiocytosis who achieved a complete response after intensive chemotherapy.…”
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Genetic and Molecular Biology Implications in the Surgical Treatment of Gastric Cancer by Roberto Eduardo Aguirre Fernández, Miguel Ángel Serra Valdés

“…Current clinical practice guidelines offer treatment models that involve surgery, radiotherapy, chemotherapy, immunotherapy and therapy directed at specific growth receptors, however, genetic and molecular biology aspects are not always taken into account in medical practice. …”
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Recurrent Gastrointestinal Hemorrhage in Children with Philadelphia-Positive B-Cell Acute Lymphoblastic Leukemia Treated with Dasatinib: Case Reports by Xin Liao, Yuxia Guo, Yali Shen, Jianwen Xiao

“…We report three Chinese children with Ph + B-ALL who received a combination treatment of chemotherapy and dasatinib and developed gastrointestinal bleeding several months later. …”
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The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia by Majd A. Al-Hamaly, Evelyn Winter, Jessica S. Blackburn

“…Relapse can be attributed to the inability of chemotherapy agents to eradicate leukemia stem cells (LSC), which possess self-renewal capabilities and are responsible for the long-term maintenance of the disease. …”
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Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer by Allison N. Martin, Patrick M. Dillon, David E. Jones, David R. Brenin, David A. Lapides

“…The patient was treated with neoadjuvant chemotherapy, modified radical mastectomy, adjuvant Herceptin, and pertuzumab. …”
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Small Cell Carcinoma of the Larynx Treated by Concurrent Chemoradiotherapy: A Case Report by Susumu Nakahara, Norihiko Takemoto, Hidenori Inohara

“…In spite of intensive chemotherapy using CDDP and irinotecan (CPT-11), the patient died of disease in 34 months after the first interview. …”
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Disulfidptosis as a key regulator of glioblastoma progression and immune cell impairment by Yifu Shu, Jing Li

“…SMC4 inhibition reduced LN299 cell migration and increased chemotherapy sensitivity, decreasing CD4 and CD8 T cell activation.ConclusionsDisulfidptosis-Tex genes are pivotal in glioblastoma progression and immune interactions, offering new avenues for improving anti-glioblastoma therapies through modulation of T cell exhaustion.…”
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Emerging role of exosomes in cancer therapy: progress and challenges by Jiale Li, Jiachong Wang, Zigui Chen

“…This review aims to explore the potential of exosomes in cancer therapy, with a focus on applications in chemotherapy, gene therapy, and immunomodulation. Additionally, challenges related to exosome production and standardization are analyzed, highlighting the importance of addressing these issues for their clinical application. …”
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Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma by Christopher S. Hong, Edwin Partovi, James Clune, Anita Huttner, Henry S. Park, Sacit Bulent Omay

“…Despite first-line treatment with maximal surgical resection, followed by nonstandardized adjuvant chemotherapy/radiation regimens, clinical prognosis remains exceedingly poor. …”
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Involvement of HMGB1 in Resistance to Tumor Vessel-Targeted, Monoclonal Antibody-Based Immunotherapy by Vito Pistoia, Annalisa Pezzolo

“…HMGB1-induced autophagy promotes tumor resistance to chemotherapy, as shown in different models of malignancy, for example, osteosarcoma, leukemia, and gastric cancer. …”
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A Patient Affected with Serous Ovarian/Peritoneal Carcinoma Carrying the FANCM Mutation by Adamantia Nikolaidi, Irene Konstantopoulou, Nikolaos Pistalmantzian, Florentia Fostira, Drakoulis Yannoukakos, Ilias Athanasiadis

“…She received neoadjuvant chemotherapy and after 5 cycles achieved partial response, and then, she underwent a total hysterectomy/bilateral salpingo-oophorectomy. …”
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SURGICAL TECHNIQUES TO INCREASE RESECTABILITY IN LIVER METASTASIS by Orlando Jorge Martins Torres, Guido Torzilli, Marcelo Enne, Rinaldo Gonçalves, Eduardo de Santibanes, Timothy Pawlik, Rene Adam, Olivier Soubrane, Paulo Herman, Ricardo Lemos Cotta-Pereira

“…ABSTRACT The development of surgical techniques, chemotherapy, biological agents, and multidisciplinary approaches have made patients with unresectable colorectal liver metastases eligible for surgery. …”
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A Case of Metastatic Adamantinoma That Responded Well to Sunitinib by Andrew D. Liman, Agnes K. Liman, Jenna Shields, Becky Englert, Rashmikant Shah

“…Metastatic adamantinoma has been reported to be resistant to chemotherapy. We report a case of metastatic adamantinoma to the lung, 10 years after the initial diagnosis of tibial mass. …”
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An Unusual Case of Gastrointestinal Bleeding by Kristin N. Fiorino, Brian Lestini, Kim E. Nichols, Sudha A. Anupindi, Asim Maqbool

“…Subsequent biopsy revealed a paraganglioma that was treated with chemotherapy. This case represents an unusual presentation of a paraganglioma associated with gastrointestinal (GI) bleeding and highlights the utility of CTA and 123MIBG in evaluation and treatment.…”
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Immunotherapy for Extensive-stage Small Cell Lung Cancer: 
Research Progress and Future Perspectives by Yuling ZHONG, Jingyi WANG, Lin WU

“…At present, immunotherapy combined with chemotherapy has become the first-line standard of treatment for extensive-stage small cell lung cancer (ES-SCLC). …”
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