Paraneoplastic Autoimmunity Associated with Testicular Myeloid Sarcoma and Chronic Myelomonocytic Leukemia by Jeffrey W. Craig, Richard J. Lin

“…Treatment with both radical orchiectomy and leukemia-directed chemotherapy led to immediate reductions in symptom severity, suggesting that these early symptoms were paraneoplastic in origin. …”
Get full text

Advances in Immunotherapy and Targeted Therapy of Malignant Melanoma by Xue Wang, Shanshan Ma, Shuting Zhu, Liucun Zhu, Wenna Guo

“…Traditional treatments such as surgery, chemotherapy, and radiotherapy are unable to achieve the expected results due to MM’s low sensitivity, high drug resistance, and toxic side effects. …”
Get full text

The Potential Role of Liver Transplantation as a Treatment Option in Colorectal Liver Metastases by Pål-Dag Line, Morten Hagness, Svein Dueland

“…Strict selection criteria have not yet been well defined, but tumor load, response to chemotherapy, pretransplant carcinoembryonic antigen level, and time interval from resection of the primary tumor to transplant are all factors related to outcome. …”
Get full text

Towards Curative Therapy in Burkitt Lymphoma: The Role of Early African Studies in Demonstrating the Value of Combination Therapy and CNS Prophylaxis by Ian Magrath

“…Pioneer investigators explored the value of chemotherapy since surgery and radiation were not effective modalities. …”
Get full text

Traditional Chinese Medicine Protects against Cytokine Production as the Potential Immunosuppressive Agents in Atherosclerosis by Yan Ren, Wei Qiao, Dongliang Fu, Zhiwei Han, Wei Liu, Weijie Ye, Zunjing Liu

“…Accordingly, strategies to inhibit immune activation and impede immune responses towards anti-inflammatory activity are an alternative therapeutic strategy to conventional chemotherapy on cardiocerebrovascular outcomes. Since a number of Chinese medicinal plants have been used traditionally to prevent and treat atherosclerosis, it is reasonable to assume that the plants used for such disease may suppress the immune responses and the resultant inflammation. …”
Get full text

Sintilimab for the treatment of lung adenocarcinoma-induced immune-related hypophysitis: a case report by Ming-xing Wang, Ai-xin Liu, Qing-ming Sun, Wan-hui Dong

“…This report describes a case of a lung cancer patient who, after receiving chemotherapy in combination with the programmed death-1 (PD-1) inhibitor sintilimab, presented with systemic fatigue, alterations in mental and behavioral patterns, somnolence, and symptoms of diabetes insipidus, leading to a diagnosis of grade 4 immune-related hypophysitis. …”
Get full text

Lung Cancer Associated with Neurofibromatosis Type I by Anastasia Oikonomou, Dimitrios Mikroulis, Paraskevi Mintzopoulou, Lawal Lukman, Panos Prassopoulos

“…The patient did not receive systemic chemotherapy or radiotherapy. She was free of disease on 18-month followup.…”
Get full text

Melittin: A Natural Component of Honeybee Venom as a Potential Anti-Cancer Therapy by Niamh Donnellan, Anne M Friel

“…Cancer is a major cause of death worldwide and while chemotherapy is the main approach there are many negative associations in current treatment procedures. …”
Get full text

Benign Multicystic Peritoneal Mesothelioma: A Rare Condition in an Uncommon Gender by Muhammad S. Khurram, Hamadullah Shaikh, Uqba Khan, Jacob Edens, Warda Ibrar, Ameer Hamza, Awais Zaka, Roohi Bano, Tarik Hadid

“…We report a case series of three male patients who were diagnosed with BMPM and were treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC).…”
Get full text

Malignant Mesothelioma of the Pericardium: A Report of Two Different Presentations by Pattarapong Makarawate, Narumol Chaosuwannakit, Jarin Chindaprasirt, Piti Ungarreevittaya, Surachat Chaiwiriyakul, Kosin Wirasorn, Chusak Kuptarnond, Kittisak Sawanyawisuth

“…Both patients: may have indirect exposure to asbestos. Despite chemotherapy, both patients died at 2 weeks and 3 months after the diagnosis. …”
Get full text

Review of Small Cell Carcinomas of the Prostate by P. Furtado, M. V. A. Lima, C. Nogueira, M. Franco, F. Tavora

“…Treatment consists mainly of chemotherapy associated with surgery. Radiation therapy is reserved for selected cases. …”
Get full text

Myokines as Possible Therapeutic Targets in Cancer Cachexia by Emilia Manole, Laura C. Ceafalan, Bogdan O. Popescu, Carmen Dumitru, Alexandra E. Bastian

“…This syndrome has a dramatic impact on the patient’s quality of life, and it is also associated with a low response to chemotherapy leading to a decrease in survival. Despite this, cachexia is still underestimated and often untreated. …”
Get full text

Adolescent and Young Adult Testicular Germ Cell Tumors: Special Considerations by Amanda F. Saltzman, Nicholas G. Cost

“…Similar to T-GCTs of all ages, surgical excision with orchiectomy is the standard initial step in treatment. Chemotherapy, retroperitoneal lymph node dissection, and targeted treatment of distant metastases make even widely disseminated disease treatable and curable. …”
Get full text

Metastatic Squamous Cell Carcinoma of the Anus to the Lung Confirmed with Allelotyping by Rachel Roth, Susan Moffatt-Bruce, Marino E. Leon

“…The patient was treated with palliative chemotherapy instead of additional surgical treatment. …”
Get full text

Primary Bilateral Non-Hodgkin’s Lymphoma of the Adrenal Gland Presenting as Incidental Adrenal Masses by Christopher Rizzo, David James Camilleri, Alexandra Betts, Andre’ Gatt, Stephen Fava

“…The patient was started on systemic chemotherapy, but her disease progressed with neurological involvement which responded to second-line therapy. …”
Get full text

NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance by Shaoyan Shi, Xuehai Ou, Chao Liu, Rui Li, Qianjin Zheng, Leiming Hu

“…It also enhances tumor cell resistance to chemotherapy and radiotherapy by activating anti-apoptotic signaling pathways and exacerbating treatment-induced inflammation. …”
Get full text

A review on the potential of Bruton’s tyrosine kinase (Btk) inhibitor – Ibrutinib for treatment of Multiple Myeloma (MM) by Sze-Ting Bong, Lydia Ngiik-Shiew Law, Jodi Woan-Fei Law

“…MM remains as an incurable cancer, but it can be treated through chemotherapy. Nonetheless, research on novel therapies for effective treatment of MM is ongoing and in this case the involvement of Bruton’s tyrosine kinase (Btk) in B-cell malignancies has made it one of the new therapeutic targets. …”
Get full text

“Dead Cells Talking”: The Silent Form of Cell Death Is Not so Quiet by Richard Jäger, Howard O. Fearnhead

“…In this time the ideas that apoptosis protects us from tumourigenesis and that cancer chemotherapy works by inducing apoptosis also emerged. …”
Get full text

Leiomyosarcoma of the Renal Vein Mimicking a Primitive Renal Cell Carcinoma: Case Report of an Unusual Presentation by Amal Fekkar, Hafsa Elouazzani, Ahmed Jahid, Kaoutar Znati, Fouad Zouaidia, Zakia Bernoussi

“…Standard treatment consists of radical nephrectomy followed by chemotherapy and/or radiotherapy. Because of insufficient histological data and follow-up, the prognosis factors are not well identified. …”
Get full text

Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy by Nataliya Kutsevol, Yuliia Kuziv, Tetiana Bezugla, Vasyl Chumachenko, Vasyl Chekhun

“…The water-soluble star-like dextran-graft-polyacrylamide copolymer was used as a nanoplatform for the creation of polymer-based multicomponent drug delivery systems for photodynamic and combined (photodynamic+chemotherapy) antitumor therapy. The three-component nanocomposites with incorporated gold nanoparticles and photosensitizer and the four-component ones additionally loaded by Doxorubicin into polymer nanoplatform were studied at 25 and 37°C by transmission electron microscopy and dynamic light scattering. …”
Get full text