Development and approval of a Lasso score based on nutritional and inflammatory parameters to predict prognosis in patients with glioma by Huixian Li, Hui Hong, Jinling Zhang

“…This nomogram incorporated the Lasso score, age, pathological type, chemotherapy status, and Ki67 expression to predict overall survival (OS). …”
Get full text

Increased Co-Expression of PD-L1 and CTLA-4 Predicts Poor Overall Survival in Patients with Acute Myeloid Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation by Chen C, Qiu K, Chen J, Wang S, Zhang Y, Wang C, Li Y

“…This study aims to investigate the significance of the alteration of IC co-expression for evaluating the prognosis of AML patients following allogeneic hematopoietic stem cell transplantation (allo-HSCT).Patients and Methods: Quantitative real-time PCR (qRT-PCR) data of bone marrow (BM) samples from 62 de novo AML patients, including 37 patients who received allo-HSCT and 25 patients who received chemotherapy only, were used for prognostic analysis.Results: High expression of PD-1, PD-L1, PD-L2, CTLA-4, and LAG-3 was associated with poor overall survival (OS) in AML patients receiving allo-HSCT, while the expression levels of PD-1, PD-L2, CTLA-4, and LAG-3, other than PD-L1, were not significantly correlated with OS in AML patients receiving chemotherapy. …”
Get full text

Primary Neuroendocrine Carcinoma of Ocular Adnexa by Daisuke Yamanouchi, Toshiyuki Oshitari, Yosuke Nakamura, Jiro Yotsukura, Kaoru Asanagi, Takayuki Baba, Tomohiro Nizawa, Takashi Kishimoto, Yoko Yonemori, Satoshi Ota, Shuichi Yamamoto

“…Thus, combined therapy including surgery, radiotherapy, and/or chemotherapy is needed for complete management of NEC.…”
Get full text

Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research by Foteini Stefania Koumpa, Diamantis Xylas, Maciej Konopka, Dieter Galea, Kirill Veselkov, Anthony Antoniou, Akash Mehta, Reza Mirnezami

“…In patients with CPM, radical multimodality treatment consisting of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has demonstrated oncological superiority over systemic chemotherapy alone. …”
Get full text

Molecular Detection of EMT Markers in Circulating Tumor Cells from Metastatic Non-Small Cell Lung Cancer Patients: Potential Role in Clinical Practice by Annalisa Milano, Francesca Mazzetta, Sabatino Valente, Danilo Ranieri, Laura Leone, Andrea Botticelli, Concetta Elisa Onesti, Salvatore Lauro, Salvatore Raffa, Maria Rosaria Torrisi, Paolo Marchetti

“…Blood samples from ten metastatic NSCLC patients before starting treatment and during chemotherapy were used to test this approach by longitudinal monitoring. …”
Get full text

Effect of probiotics combined with immune checkpoint suppressors and chemotherapeutic agents on digestive system function, intestinal immunity and prognosis in patients with metast... by Xiaolei Wang, Yuxia Huang, Zhen Yang, Yang Yang, Fenfen Wei, Min Yan, Fanfan Li, Chenghao Wang

“…The control group received only immune checkpoint inhibitors or chemotherapy, while the intervention group received immune checkpoint inhibitors or chemotherapy, plus probiotic therapy. …”
Get full text

Efficacy and safety of immune checkpoint inhibitors in elderly patients with advanced non-small cell lung cancer: a systematic review and meta-analysisResearch in context by Jiacheng Yao, Sihan Li, Lu Bai, Jun Chen, Chengbo Ren, Tingting Liu, Jingping Qiu, Jun Dang

“…Interpretation: ICIs are associated with a significant improvement in OS and PFS compared to chemotherapy in elderly patients with advanced NSCLC. …”
Get full text

miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells by Yong Li, Ping Gong, Ji-xue Hou, Wei Huang, Xiao-ping Ma, Yu-li Wang, Jing Li, Xiao-bin Cui, Na Li

“…Collectively, our combined analysis reveals a critical role of miR-34a/OAZ2 cascade in conferring a proper cellular response to CCa chemotherapy.…”
Get full text

Comparison of prophylactic topical application of Cryptomphalus aspersa secretion versus betamethasone for telecobalt radiation-induced skin reactions in locally advanced head and... by Ramashish Kumar, Ashok Chauhan, Sovan Sarang Dhar, Nitish Kumar

“…Background: External beam radiation therapy (EBRT) with or without concurrent chemotherapy is practiced as backbone of treatment across sites and subsites of head and neck cancer (HNC) when the intent is definitive. …”
Get full text

Residual transmission of schistosomiasis in Ndikinimeki Health District (Centre Region, Cameroon) despite implementation of complementary control strategies: Prospects for eliminat... by Hervé Kengne Fogang, Hugues C. Nana Djeunga, Alvine C. Kengne-Fokam, Murielle C. Tchami Mbagnia, Flobert Njiokou, Dickson S. Nsagha, Emmanuel Yenshu, Joseph Kamgno

“…Schistosomiasis control currently relies on school-based preventive chemotherapy (PC) with praziquantel, which has been proven, unfortunately, insufficient to interrupt disease transmission in areas with persistent transmission. …”
Get full text

Metastatic Uterine Leiomyosarcoma in the Upper Buccal Gingiva Misdiagnosed as an Epulis by Andrea Cassoni, Valentina Terenzi, Davina Bartoli, Oriana Rajabtork Zadeh, Andrea Battisti, Mario Pagnoni, Davide Conte, Alessandro Lembo, Sandro Bosco, Francesco Alesini, Valentino Valentini

“…The treatment of choice is surgery and the use of adjuvant chemotherapy and radiation has limited impact on clinical outcome. …”
Get full text

Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma by Li Zhang, Matthew Crocker, Lawrence Fong, Lisa M Coussens, Charles D Lopez, Shamilene Sivagnanam, Meenal Sinha, Brandon Chen, Jaqueline Marquez, Alexander Cheung, Whitney Tamaki, Jacob Stultz, Kendra Todd, Courtney Betts, Madeline J Griffith, Isabelle Solman, Eric Liu, Denise Pener, Anne Fahlman, Erin Taber, Kimberly Lerner, Brindha Rajagopalan, Clarisha Ware, Mark Bridge, Johnson Vo, Hannah Dragomanovich, Julie Sudduth-Klinger, Gina Vaccaro, Margaret Tempero

“…When ibrutinib was combined with chemotherapy, most of these immune changes were not observed. …”
Get full text

Identification of Two Novel Immune Subtypes Characterized by Distinct Prognosis and Tumor Microenvironment in Osteosarcoma by Shunhan Yao, Meiling Deng, Xiaojing Du, Qingfeng Chen, Rongzhi Huang

“…Further, the two immune subtypes are shown to differ in immunotherapy and chemotherapy. The results would be helpful for clinical decision in osteosarcoma.…”
Get full text

Successful Treatment of Disseminated Subcutaneous Panniculitis-Like T-Cell Lymphoma with Single Agent Oral Cyclosporine as a First Line Therapy by Nida Iqbal, Vinod Raina

“…Currently there are no standardized therapies for SPTL; however good responses have been seen with chemotherapy regimens generally employed for B-cell lymphomas. …”
Get full text

Primary orbital yolk sac tumor in an infant: A rare entity by Varsha Mishra, Sandeep Jain, Payal Malhotra, Garima Durga, Gauri Kapoor

“…She was started on infant bleomycin etoposide cisplatin (BEP) chemotherapy protocol. There was a good clinical and radiological response. …”
Get full text

Brain Metastasis as an Initial Manifestation of Ovarian Carcinoma: A Case Report by Zafer Selçuk Tuncer, Gokhan Boyraz, Aslıhan Yazıcıoğlu, İlker Selcuk, Senem Özge Yücel

“…Following a surgical staging laparotomy procedure, the patient received brain irradiation and systemic chemotherapy.…”
Get full text

Supraglottic Neuroendocrine Carcinoma: A Case Report and Literature Review by Renda Alhabib, Chaker Zaidi, Abdulrahman Alfryyan, Hanan Albenayyan, Ibrahim Alotain

“…Treatment typically involves a combination of surgery, chemotherapy, and radiotherapy. We present a case of supraglottic laryngeal NEC in a 61-year-old female nonsmoker. …”
Get full text

Female Urethral Diverticulum Carcinoma: A Case Report and Literature Review by Ryo Kasahara, Tadashi Tabei, Yukio Tsuura, Kazuki Kobayashi

“…The patient received adjuvant gemcitabine and cisplatin chemotherapy. She is alive at 5 months since the operation.…”
Get full text

Bilateral Multifocal Central Serous-Like Chorioretinopathy due to MEK Inhibition for Metastatic Cutaneous Melanoma by Scott D. Schoenberger, Stephen J. Kim

“…Recognition of this side effect is important with this new class of chemotherapy.…”
Get full text

Raoultella Planticola Bacteremia Following Consumption of Seafood by Philip W Lam, Irving E Salit

“…She was successfully treated with intravenous ceftriaxone followed by oral ciprofloxacin. Recent chemotherapy, proton pump inhibitor use and altered biliary flow secondary to hepatic metastases may have been contributing factors to the pathogenesis of disease.…”
Get full text