Real‐World Prevalence, Treatment Patterns, and Outcomes for Patients With HER2 (ERBB2)‐Mutant Metastatic Non‐Small Cell Lung Cancer, From a US‐Based Clinico‐Genomic Database... by Sarah Waliany, Misako Nagasaka, Leah Park, Clara Lam, Zoe Jiang, Feng Lin, Joel W. Neal

“…Results Among 9206 patients with mNSCLC, 164 (1.78%) met the eligibility criteria (mean age: 67.3 years, 63.4% White, 56.7% female, and 53.0% with a smoking history). 132/164 (80.5%) had at least one line of treatment. Platinum‐based chemotherapy (45.5%) and immune checkpoint inhibitor (ICI) with chemotherapy (28.0%) were the most frequently used first‐line treatments. …”
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A remarkable and durable response to tislelizumab treatment of an anaplastic thyroid carcinoma without targetable genomic alterations: a case report by Jingjing Chai, Jiaqi Lv, Jian Xiong, Xiuwen Chen, Senyuan Luo, Zhiguo Luo, Zhiguo Luo, Ming Luo

“…The patient was unable to tolerate chemotherapy; therefore, radiotherapy was administered initially to prevent airway compression resulting from disease progression. …”
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Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer: 70-Month Analysis of the REMAGUS02 Study by François-Clément Bidard, Lisa Belin, Suzette Delaloge, Florence Lerebours, Charlotte Ngo, Fabien Reyal, Séverine Alran, Sylvie Giacchetti, Michel Marty, Ronald Lebofsky, Jean-Yves Pierga

“…CTC count was performed before and after neoadjuvant chemotherapy in 118 patients and correlated to survival. …”
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RNA-seq and In Vitro Experiments Reveal the Protective Effect of Curcumin against 5-Fluorouracil-Induced Intestinal Mucositis via IL-6/STAT3 Signaling Pathway by Xuan-ying Wang, Bo Zhang, Yi Lu, Lu Xu, Yi-jie Wang, Bi-yu Cai, Qing-hua Yao

“…IM-induced gastrointestinal adverse reactions become frequent reason to postpone chemotherapy and have negative impacts on therapeutic outcomes and prognosis. …”
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EMA/CO Combination Chemotheraphy in Gestational Trophoblastic Neoplasia: Update of Our Results by Tolga Taşçı, Işın Üreyen, Günsu Kimyon, Alper Karalök, Sevgi Koç, M. Faruk Köse, Gökhan Tulunay, Taner Turan

“… OBJECTIVE: In this study, we aimed updating our experience about the treatment success of EMA-CO (etoposide, methotrexate, actinomycin-D, cyclophosphamide, vincristine) chemotherapy in high-risk gestational trophoblastic neoplasia (GTN). …”
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The Impact of Chronic Pelvic Pain and Bowel Morbidity on Quality of Life in Cervical Cancer Patients Treated With Radio (Chemo) Therapy. A Systematic Literature Review by Natuhwera G, Ellis P

“…Studies reported disruptions in nearly all domains of quality-of-life, including global, physical, emotional/psychological, financial, sexual, social, role functioning as a result of being treated with radiotherapy or radio-chemotherapy.Conclusion: Chronic pelvic pain and bowel morbidity are common adverse events experienced by cervical cancer patients receiving, or who have received, pelvic radiotherapy or radio-chemotherapy. …”
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Irinotecan Plus S-1 Followed by Hepatectomy for a Patient with Initially Unresectable Colorectal Liver Metastases, Who Showed Severe Drug Rash with Oxaliplatin Plus 5-FU and Leucov... by Hiroyuki Komori, Toru Beppu, Yasuo Sakamoto, Yuji Miyamoto, Hiromitsu Hayashi, Katsunori Imai, Hidetoshi Nitta, Masayuki Watanabe, Hideo Baba

“…For unresectable colorectal liver metastases (CRLM), hepatic resection with or without chemotherapy is the only curative treatment that sufficiently achieves long-term survival. …”
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Efficacy and safety of PD-1 inhibitors as second-line treatment for advanced squamous esophageal cancer: a systematic review and network meta-analysis with a focus on PD-L1 express... by Fei Yang, Min Dan, Jindan Shi, Ling Fan, Haoluo Zhang, Tiantian Jian, Kelu Lei, Yue Wang, Juan Xin, Zhigang Yu, Wei Chen

“…In terms of safety, Nivolumab (OR = 0.10, 95% CI: 0.05-0.19) and Tislelizumab (OR = 0.18, 95% CI: 0.10-0.33) exhibited significant safety advantages over chemotherapy concerning AEs. Moreover, Nivolumab (OR = 0.13, 95% CI: 0.08-0.20) was associated with a markedly lower risk of Grade ≥ 3 AEs compared to chemotherapy. …”
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Retrospective analysis of disease characteristics and treatment patterns among patients with esophageal cancer across 14 surgically represented centers by Zhihao Lu, Mingfei Geng, Yongtao Han, Jianzhong Cao, Jun Wang, Tianshu Liu, Xianglin Yuan, Xue Meng, Yanqiao Zhang, Rong Zhao, Lixin Wan, Enxiao Li, Wenran Wang, Zhijie Li, Danfeng Shi, Jing Qian, Si Shi, Fengshi Dong, Lin Shen

“…Among patients with advanced EC, 84.6% received systemic therapy as an initial treatment, primarily chemotherapy (61.5% platinum-taxane). Conclusions: Before the approval of immunotherapy in China, most patients with resectable early or locally advanced EC underwent radical surgery without preoperative treatment, whereas most patients with advanced EC received platinum-taxane chemotherapy. …”
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Granulocytic Sarcoma by AML M4eo (inv16) after Allogeneic Stem Cell Transplantation without Bone Marrow Involvement by Stephan Zaenker, Stefan Schweyer, Justin Hasenkamp, Lorenz Truemper, Gerald Wulf

“…The patient underwent the withdrawal of immunosuppression, hysterectomy, and local irradiation at first relapse, as well as systemic chemotherapy and donor lymphocyte infusions at second recurrence, inducing a second and third complete remission, respectively. …”
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Iodine-131 Metaiodobenzylguanidine Therapy for Neuroblastoma: Reports So Far and Future Perspective by Daiki Kayano, Seigo Kinuya

“…The combination therapy with I-131 MIBG and other modalities such as nonmyeloablative chemotherapy and myeloablative chemotherapy with HCT improved the therapeutic response in patients with refractory or relapsed neuroblastoma. …”
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Bilateral Facial Paralysis and Deafness in a Child Treated for Acute Lymphoblastic Leukemia by Rafael V. Lucena, Yuri C. F. Fernandes, Débora B. Pazinatto, Rebecca C. K. Maunsell

“…A 20-month-old male child was diagnosed with ALL and developed otorrhea unresponsive to antimicrobial treatment during the first week of chemotherapy followed by hearing loss, loss of balance, and bilateral facial paralysis. …”
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Current Molecular Targeted Therapy in Advanced Gastric Cancer: A Comprehensive Review of Therapeutic Mechanism, Clinical Trials, and Practical Application by Kaichun Li, Jin Li

“…Compared to best supportive care, chemotherapy can improve quality of life and prolong survival time, but the overall survival is often short. …”
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Metastatic Melanoma of Uncertain Primary with 5-Year Durable Response after Conventional Therapy: A Case Report with Literature Review by Jomjit Chantharasamee, Jitsupa Treetipsatit

“…The previous data reported the median overall survival among the patients who were treated with conventional chemotherapy ranging from 9.1 to 9.3 months and whose 5-year survival was less than 10%. …”
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The Ameliorative Role of Probiotics in 5-fluorouracil Induced Intestinal Mucositis by Alexandra Arcilla Xin Hui Sim, Jia Ying Cheam, Jodi Woan-Fei Law, Vengadesh Letchumanan, Yatinesh Kumari, Satoshi Ogawa, Sunny Hei Wong, Kok-Gan Chan, Loh Teng-Hern Tan

“…Although early detection improves the survival rate to around 90%, late detection would mean the need to use chemotherapy or radiotherapy, especially if surgery is not feasible. 5-fluorouracil (5-FU) is one of the common anti-cancer drugs used in treating CRC. …”
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Long-Term Survival in Locally Advanced KRAS Wild-Type Pancreatic Adenocarcinoma by Marion Alhenc-Gelas, Romain Cohen, Pascale Cervera, Jean-Christophe Vaillant, Thierry André

“…Here we report the case of a 52-year-old LAPC patient treated with chemotherapy followed by chemoradiotherapy that was associated with a 14-year complete remission. …”
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Isolated Langerhans Cell Histiocytosis of Orbit: A Case Report and Review of the Literature by Mayuresh Naik, Anuj Mehta, Neha Mehrotra, Anil Solanki

“…On completion of three cycles of chemotherapy, a reduction in size of the mass was noticed. …”
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Late Prevertebral and Spinal Abscess following Chemoradiation for Laryngeal Squamous Cell Carcinoma by Jawad Hindy, Ilan Shelef, Yuval Slovik, Ben-Zion Joshua

“…Prevertebral and spinal abscess may result from chemotherapy and radiotherapy to the head and neck. Physicians caring for head and neck cancer patients treated with chemotherapy and radiation should be aware of this rare severe complication.…”
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Conservative Management of Muscle Invasive Bladder Cancer in Kidney-Pancreas Transplant Patient by Logan D. Glosser, Brandon S. Zakeri, Conner V. Lombardi, Obi O. Ekwenna

“…The first-line treatment for MIBC is radical cystectomy (RC) with neoadjuvant chemotherapy. For patients that are medically unfit or unwilling to undergo RC, trimodal therapy (TMT) is an alternative. …”
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Advanced Alveolar Soft Part Sarcoma Treated with Pazopanib over Three Years by Yoji Shido, Yukihiro Matsuyama

“…We initially treated this patient by systemic chemotherapy with combination use of ifosfamide and doxorubicin. …”
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