Advancing the Fight Against Cervical Cancer: The Promise of Therapeutic HPV Vaccines by Qian Zheng, Misi He, Zejia Mao, Yue Huang, Xiuying Li, Ling Long, Mingfang Guo, Dongling Zou

“…This review focuses on clinical studies involving therapeutic HPV vaccines for cervical cancer, specifically in three key areas: the treatment of cervical intraepithelial neoplasia; the treatment of cervical cancer in combination with or without chemotherapy, radiotherapy, or immune checkpoint inhibitors; and the role of prophylaxis following completion of treatment. …”
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A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca <i>Lepidium meyenii</i> by Albert Gabriel Turpo-Peqqueña, Sebastian Luna-Prado, Renato Javier Valencia-Arce, Fabio Leonardo Del-Carpio-Carrazco, Badhin Gómez

“…Current therapeutic strategies, including surgery, chemotherapy, and radiotherapy, often fail due to the tumor’s ability to develop resistance. …”
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High Expression of Ten Eleven Translocation 1 Is Associated with Poor Prognosis in Hepatocellular Carcinoma by Haopeng Wen, Tengfei Ji, Liteng Lin, Nan Cheng, Kangshun Zhu, Liangqi Cao

“…High and low TET1 expression groups had distinct immune cell infiltration and response to immunotherapy and chemotherapy. We identified 90 DEGs related to DNA demethylation in high vs. low TET1 expression groups. …”
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DNA methylation and immune evasion in triple-negative breast cancer: challenges and therapeutic opportunities by Wen-yu Cai, Xin-xian Cai, Yi-ran Fei, Rui Ye, Ding-ming Song, Dan Hu, Wan-wan Zhang, Ming-fei Xia, Xiao-xiao Yang

“…Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Chemotherapy remains the primary treatment option, yet TNBC frequently develops resistance, leading to relapse and metastasis. …”
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Significance of Preoperative Systemic Immune Score for Stage I Gastric Cancer Patients by Jun Lu, Long-long Cao, Ping Li, Jian-wei Xie, Jia-bin Wang, Jian-xian Lin, Qi-yue Chen, Mi Lin, Ru-hong Tu, Chang-ming Huang, Chao-hui Zheng

“…Determining preferences regarding the benefits of adjuvant chemotherapy (AC) for stage I GC is critical. Methods. …”
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Sm10.3, a member of the micro-exon gene 4 (MEG-4) family, induces erythrocyte agglutination in vitro and partially protects vaccinated mice against Schistosoma mansoni infection. by Vicente P Martins, Suellen B Morais, Carina S Pinheiro, Natan R G Assis, Barbara C P Figueiredo, Natasha D Ricci, Juliana Alves-Silva, Marcelo V Caliari, Sergio C Oliveira

“…Current schistosomiasis control strategies are mainly based on chemotherapy, but many researchers believe that the best long-term strategy to control disease is a combination of drug treatment and immunization with an anti-schistosome vaccine. …”
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Matching-Adjusted Indirect Comparison of the Efficacy and Safety of Erdafitinib vs Enfortumab Vedotin in Patients with Locally Advanced Metastatic Urothelial Carcinoma by Suzy Van Sanden, Ayman Youssef, Simona Baculea, Keith Stubbs, Spyros Triantos, Zijiao Yuan, Caitlin Daly

“…**Methods:** An anchored MAIC was conducted according to the National Institute for Health and Care Excellence Decision Support Unit guidance, with physician’s choice of chemotherapy (docetaxel/paclitaxel and vinflunine) as the common comparator. …”
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Clinicopathological and prognostic factor analyses of primary fallopian tube carcinoma and high-grade serous ovarian cancer: a single-institution retrospective study by Mengyan Tu, Xueyan Gao, Tianchen Guo, Weiguo Lu, Junfen Xu

“…OS was significantly related to FIGO stage, the preoperative serum CA 125 level, lymphadenectomy, residual tumor size, appendectomy, and the number of cycles of chemotherapy. However, only FIGO stage was an independent prognostic variable for OS. …”
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Alveolar Rhabdomyosarcoma of Nasopharynx and Paranasal Sinuses in Children Diagnosis and Treatment—Review of the Literature and Case Report by Cristian Mârțu, Ștefan Dragoș Tîrnovanu, Ioana Mârțu, Dan Ferariu, Dan Mârțu, Alexandra Jităreanu, Luminița Rădulescu

“…Combined treatment approaches (surgery, radiotherapy, and chemotherapy) should be tailored to tumor characteristics. …”
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PIVKA-II as a surrogate biomarker for therapeutic response in Non-AFP-secreting hepatocellular carcinoma by San-Chi Chen, Hsiang-Ling Ho, Chien-An Liu, Yi‑Ping Hung, Nai-Jung Chiang, Ming‑Huang Chen, Yee Chao, Muh-Hwa Yang

“…This association held for targeted therapies, immune checkpoint inhibitors, and chemotherapy. Progression-free survival (PFS) for the regression, stable, and progression groups was non-reached, 6.7, and 3.2 months (p = 0.0002), and overall survival (OS) was non-reached, non-reached, and 18.5 months (p = 0.02). …”
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Integrating multiomics analysis and machine learning to refine the molecular subtyping and prognostic analysis of stomach adenocarcinoma by Miaodong Wang, Qin He, Zeshan Chen, Yijue Qin

“…Patients in the high-CMLS group had a significantly poorer prognosis and were less sensitive to immunotherapy but were likely to benefit more from chemotherapy and targeted therapy. In this study, 10 clustering methods and 10 machine learning methods were combined to analyze the multiomics of STAD, classify STAD into three subtypes, and constructed CMLS-related prognostic model features, which are important for accurate management and effective treatment of STAD.…”
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Oncogene mutations in non-small cell lung cancer patients in Iran: a study of their association with programmed death ligand-1 expression by Zahra Abrehdari-Tafreshi, Majid Pirestani, Zahra Mosaferi, Nasser Rakhshani, Ehsan Arefian

“…Therefore, the identification of mutations in crucial cancer-related genes is paramount for guiding optimal chemotherapy strategies. The distribution of EGFR, KRAS, ALK, and ROS1 mutations varies across diverse ethnic populations. …”
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Fungsi Tiroid Pasca Radioterapi Tumor Ganas Kepala- Leher by Ade Chandra, Sukri Rahman

“…</p><p><strong>Kata kunci</strong>: Radioterapi, tumor ganas kepala dan leher, hipotiroid</p><p> </p><p><strong><em>Abstract</em></strong></p><p><em>Background: Radiotherapy is one option of modality in the management of head and neck cancer beside surgery and chemotherapy. Radiotherapy in the head and neck cancer can affect the thyroid gland and stimulates the gland disorders. …”
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Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis by Qiang Li, Ying Liu, Hong-Mei Zhang, Yin-Peng Huang, Tian-Yi Wang, Dong-Sheng Li, Hong-Zhi Sun

“…SNP-stratified analysis indicated that there were remarkable connections of IVS14+1G>A, 464T>A, and 2194G>A polymorphisms with the incidence of marrow suppression in CRC patients receiving 5-FU chemotherapy. Furthermore, we found that IVS14+1G>A, 496A>G, and 2194G>A polymorphisms were correlated with the incidence of gastrointestinal reaction. …”
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Clinical Characteristics and Prognosis of Gastrointestinal Metastases in Solid Tumor Patients: A Retrospective Study and Review of Literatures by Li Lin, Xiangyi Wang, Chuanhao Tang, Jun Liang

“…Ten patients (33.3%) underwent local gastrointestinal treatment, and 20 patients (66.7%) underwent nonlocal treatment (involving chemotherapy alone or best supportive care). For breast cancer patients and gastric cancer patients who underwent local therapy, a significant survival advantage was observed (p=0.001 and p=0.012, respectively). …”
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A case report of successful treatment of advanced thymic squamous cell carcinoma with poor performance status using multimodal therapy by Xianhua Xu, Xiang Yan, Yang Qin, Dan Kou, Qi Huang, Qiongcheng Chen, Yejin Li

“…This experience suggests that combining pembrolizumab with low-dose chemotherapy drugs could be a beneficial treatment option for patients with advanced TSCC, poor PS, and high PD-L1 expression.…”
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Stem Cell Transplantation for Ovarian Cancer Patient with Associated Myelodysplasia After Maintenance Therapy with Olaparib: A Case Report by Linn Z, Gu Z, Wang L, Cai S

“…Following surgery and chemotherapy, the patient commenced maintenance therapy with Olaparib. …”
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Matching plus regression adjustment for the estimation of the average treatment effect on survival outcomes: a case study with mosunetuzumab in relapsed/refractory follicular lymph... by Danilo Di Maio, S. A. Mitchell, S. Batson, E. Keeney, Howard H. Z. Thom

“…As a case study, we compared mosunetuzumab versus rituximab/bendamustine, as a proxy for rituximab/chemotherapy, in 3L+ relapsed/refractory follicular lymphoma. …”
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Case Report: The Versatile Art of Reconstruction: A Decade‐Long Journey With Recurrent Facial Basal Cell Carcinoma by T. H. Pathirana, V. Bandaranayake, A. P. Nellihela, S. Nikeshala, T. Saranga, A. Abegunasekara, S. Gunathilake, N. J. Asanthi

“…Reconstruction was achieved with the help of bilaterally designed Karapandzic flaps for the lip and a bilobed rotational flap for the chin defect. Although no chemotherapy and immunotherapy were given, the functional and aesthetic result were satisfactory. …”
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The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells by Sabrina Bimonte, Antonio Barbieri, Maddalena Leongito, Giuseppe Palma, Vitale del Vecchio, Michela Falco, Raffaele Palaia, Vittorio Albino, Mauro Piccirillo, Alfonso Amore, Antonella Petrillo, Vincenza Granata, Francesco Izzo

“…This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. …”
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