Novel Action of FSH on Stem Cells in Adult Mammalian Ovary Induces Postnatal Oogenesis and Primordial Follicle Assembly by Deepa Bhartiya, Seema Parte, Hiren Patel, Kalpana Sriraman, Kusum Zaveri, Indira Hinduja

“…VSELs are relatively quiescent and were recently reported to survive chemotherapy and initiate oogenesis in mice when exposed to FSH. …”
Get full text

Myocarditis Concurrent with Sweet Syndrome: A Presentation of Acute Myeloid Leukemia by Christopher G. Burkeen, David Pottinger, Chaitanya Iragavarapu, Reshma Ramlal, Gerhard Hildebrandt

“…He was treated with an induction chemotherapy regimen of 7 days of cytarabine and 3 days of daunorubicin with resolution of his chest pain and skin lesions. …”
Get full text

Development of prognostic models for HER2-positive metastatic breast cancer in females: a retrospective population-based study by Yan Chen, Yu Qiu, Haoyang Shen, Shuixin Yan, Jiadi Li, Weizhu Wu

“…Independent prognostic factors of BCSS and OS included: age; marital status; race; oestrogen receptor status; surgery; chemotherapy; and bone, brain, liver, and lung metastases. …”
Get full text

Real-Life Report on Chemoembolization Using DEBIRI for Liver Metastases from Colorectal Cancer by M. Stutz, A. Mamo, D. Valenti, A. Hausvater, T. Cabrera, P. Metrakos, P. Chaudhury, G. Steacy, E. Garoufalis, P. Kavan

“…Patients with LMCRC, ECOG 0–2, who failed at least 1 line of systemic chemotherapy, received embolizations with 2 mL of microspheres preloaded with 100 mg of irinotecan. …”
Get full text

Mastectomy, HER2 Receptor Positivity, NPI, Late Stage and Luminal B-Type Tumor as Poor Prognostic Factors in Geriatric Patients with Breast Cancer by Demet Nak, Mehmet Kivrak

“…The effects of the type of surgery; breast cancer types; cellularity; Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status; molecular class; axillary lymph nodes; Nottingham prognostic index (NPI); status of receiving systemic chemotherapy (SCT), hormone therapy (HT), and radiotherapy (RT); tumor size and tumor on overall survival (OS); and progression-free status (PFS) of geriatric patients were investigated. …”
Get full text

Lung Metastasis of Primary Alveolar Soft-Part Sarcoma Occurring 20 Years after Initial Treatment by R. F. Falkenstern-Ge, M. Kimmich, M. Wohlleber, A. Grabner, G. Friedel, G. Ott, I. Leuschner, M. Kohlhäufl

“…Due to pleural and extensive mediastinal infiltration with bilateral lung metastases, a systemic treatment with chemotherapy doxorubicin and ifosfamide was initiated. …”
Get full text

Proton pump inhibitors enhance chemosensitivity, promote apoptosis, and suppress migration of breast cancer cells by Ihraiz Worood G., Ahram Mamoun, Bardaweel Sanaa K.

“…In conclusion, the addition of PPIs to the treatment regimen of breast cancer appears to be a promising strategy to potentiate the efficacy of chemotherapy and may suppress cancer metastasis.…”
Get full text

Use of Magnetic Nanoparticles as Targeted Therapy: Theranostic Approach to Treat and Diagnose Cancer by Arif Malik, Tariq Tahir Butt, Sara Zahid, Fatima Zahid, Sulayman Waquar, Mahmood Rasool, Mahmood Husain Qazi, Aamer Mahmood Qazi

“…In practice, magnetic nanoparticles- (MNPs-) based systems following the application of Fe3O4 bound antitumor drug have shown an enhanced therapeutic index in comparison with conventional chemotherapy ensuring the significant decline in nanosystems’ toxicity. …”
Get full text

Fish-derived hepcidins in cancer treatment: a scoping review by Wan-Atirah Azemin, Syarifah Ab Rashid, Noraini Philip, Abdul Manaf Ali, Mohd Shahir Shamsir

“…Tilapia-derived hepcidins demonstrated notable anticancer properties, including concentration-dependent effects, selective cytotoxicity against cancer cells, and potential enhancement of conventional chemotherapy efficacy through mechanisms involving reactive oxygen species production and mitochondrial apoptosis pathways. …”
Get full text

Immunoprotection of mice against Schistosomiasis mansoni using solubilized membrane antigens. by Guidenn Sulbarán, Oscar Noya, Beatríz Brito, Diana E Ballén, Italo M Cesari

“…The availability of a vaccine could represent an additional component to chemotherapy. Experimental vaccination studies are however necessary to identify parasite molecules that would serve as vaccine candidates. …”
Get full text

Self-Assembly Iron Oxide Nanoclusters for Photothermal-Mediated Synergistic Chemo/Chemodynamic Therapy by Xiang Li, Zhen Wang, Mian Ma, Zhouqing Chen, Xiang-long Tang, Zhong Wang

“…The shell consisted of a human serum albumin- (HSA-) paclitaxel (PTX) layer, which extended the blood circulation time and ensured the effectiveness of the chemotherapy. Arg-Gly-Asp peptides (RGD) were linked to the naked cysteine moieties in HSA to promote the specific targeting of human glioma U87 cells by αvβ3 integrins. …”
Get full text

Complexed Crystal Structure of Saccharomyces cerevisiae Dihydroorotase with Inhibitor 5-Fluoroorotate Reveals a New Binding Mode by Hong-Hsiang Guan, Yen-Hua Huang, En-Shyh Lin, Chun-Jung Chen, Cheng-Yang Huang

“…DHOase catalyzes the reversible cyclization of N-carbamoyl aspartate (CA-asp) to dihydroorotate (DHO) in the third step of the pathway for the biosynthesis of pyrimidine nucleotides and is an attractive target for potential anticancer and antimalarial chemotherapy. Crystal structures of ligand-bound DHOase show that the flexible loop extends toward the active site when CA-asp is bound (loop-in mode) or moves away from the active site, facilitating the product DHO release (loop-out mode). …”
Get full text

Immunotherapy versus targeted therapy in management of recurrent squamous cell carcinoma of oral tongue by Nadimul Hoda, Aastha Moza, K.P. Amith, K.S. Sabitha

“…Conclusion: This newer modality of the cancer treatment forms the fourth pillar supporting surgery, chemotherapy, and radiotherapy. Therefore careful selection of patient is the key for success rate of immunotherapy, which is based on patient's immunological contexture. …”
Get full text

Percutaneous transhepatic arterial access for coil embolization of hepatic artery infusion pump-associated bleeding by Anuj K. Dutta, Vishal Shankar, Ernesto G. Santos, Brett Marinelli, Erica S. Alexander, Vlasios S. Sotirchos, Ken Zhao

“…Abstract Background Hepatic artery infusion pump (HAIP) chemotherapy is a locoregional treatment for intrahepatic malignancies. …”
Get full text

mRNA vaccines as cancer therapies by Shaoxiong Huang, Haiying Que, Manni Wang, Xiawei Wei, Yanjie Yin

“…Cancer remains a major global health challenge, with conventional treatments like chemotherapy and radiotherapy often hindered by significant side effects, lack of specificity, and limited efficacy in advanced cases. …”
Get full text

Focused ultrasound for treatment of peripheral brain tumors by Phillip Mitchell Johansen, Payton Yerke Hansen, Ali A. Mohamed, Sarah J. Girshfeld, Marc Feldmann, Brandon Lucke-Wold

“…Central nervous system (CNS) tumors are classically treated with surgical resection and radiotherapy in addition to adjuvant chemotherapy. However, the therapeutic efficacy of chemotherapeutic agents is limited due to the blood-brain barrier (BBB). …”
Get full text

Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes by Zongheng Wang, Zhipeng Hou, Shuguang Zhang, Shuangyi Ren, Liqun Yang, Qianshi Zhang

“…These findings suggested that the 5-FU-loaded PTMC membranes hold great potential for application in cancer patients, offering benefits in chemotherapy treatment.…”
Get full text

Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling by Cheng-Hung Chuang, Yu-An Tai, Ting-Jing Wu, Ying-Jui Ho, Shu-Lan Yeh, Shu-Lan Yeh

“…IntroductionCancer-related fatigue (CRF) is a common symptom induced by chemotherapy. The main objective of the present study was to investigate whether quercetin regulates the hypothalamic-pituitary-adrenal (HPA) axis and chemoattractant protein-1 (MCP-1) signaling, two factors contributing to CRF in mice exposed to cisplatin.MethodsMale BALB/c mice were randomly assigned to the following five groups for 15 weeks: Control, CDDP, CDDP+TAK779 (an antagonist of MCP-1 receptor, human CC chemokine receptor R2 (CCR2)), CDDP+OQ (a diet containing 1% quercetin) and CDDP+IQ (quercetin given by ip, 10 mg/kg, 3 times/week).ResultsThe results first showed that OQ and IQ significantly increased grip strength and locomotor activity, decreased plasma cortisol/corticosterone levels, and decreased the corticotropin releasing hormone (CRH) mRNA level in the brain tissues in mice exposed to CDDP. …”
Get full text

Case report: Multi-organ injuries induced by tislelizumab by Man Yuan, Man Yuan, Ning Han, Ning Han, Li Shu, Libo Yan, Libo Yan, Hong Tang, Hong Tang

“…A 68-year-old man had undergone neoadjuvant chemotherapy with paclitaxel, carboplatin, and tislelizumab. …”
Get full text

Bone Marrow-Liver-Spleen Type of Large B-Cell Lymphoma Associated with Hemophagocytic Syndrome: A Rare Aggressive Extranodal Lymphoma by Kirill A. Lyapichev, Jennifer R. Chapman, Oleksii Iakymenko, Offiong F. Ikpatt, Uygar Teomete, Sandra Patricia Sanchez, Francisco Vega

“…The patient underwent treatment with chemotherapy (R-CHOP) but unfortunately passed away 2 months after initial presentation. …”
Get full text