Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells by Jingwei Liu, Jingwei Liu, Tong Shu, Yiheng Mu, Wanlin Zheng, Xiaohuan Lu, Xiaohuan Lu, Hong Tao, Hong Tao

“…The expression of these inflammatory factors effectively promotes the migration and differentiation of T cells to the site of infection, completing the clearance of infected epithelial cells.ConclusionThe main components of Baofukang suppository, curdione and borneol, inhibit the progression of HPV infection and the occurrence of cervical cancer by modulating the communication between innate and adaptive immunity, promoting the recruitment and recognition of CD8+ T cells to eliminate HPV-infected epithelial cells.…”
Get full text

A bioinformatics approach for identifying the probable cause of the cross-interaction of antibodies to the antigenic protein HPV16 L1 with the HPV6 L1 protein by A. S. Stolbikov, R. K. Salyaev, N. I. Rekoslavskaya

“…In this work, the amino acid sequences of HPV16 L1 and HPV6 L1 used for the development of a binary vaccine against cervical cancer and anogenital papillomatosis have been analyzed. …”
Get full text

Knowledge, attitude, and reasons for non-uptake of human papilloma virus vaccination among nursing students by Soni Chauhan, Surya Kant Tiwari, Vishal Dubey, Pragya Tripathi, Priyanka Pandey, Anuj Singh, Narendra Pal Singh Choudhary

“…Abstract Background Cervical cancer is a significant health issue, especially in low- and middle-income countries like India, where it ranks fourth among women. …”
Get full text

Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway by Jincan Chen, Jie Wang, Yuanyuan Deng, Tao Wang, Tifang Miao, Chengpeng Li, Xianhong Cai, Ying Liu, Justin Henri, Lanmei Chen

“…These complexes were found to exhibit moderate antitumor activity to different types of human cancers, including A549 (human lung carcinoma), MCF-7 (breast cancer), HeLa (human cervical cancer), and HepG2 (human hepatocellular carcinoma) cell lines, but displayed low toxicity to human normal cell lines BEAS-2B (immortalized human bronchial epithelial cells) when compared with that of cisplatin. …”
Get full text

Urinary human papillomavirus DNA as an indicator of gynaecological infection in young women in Schistosoma and HIV endemic South Africa by P. Pillay, H. N. Galappaththi-Arachchige, M. Taylor, B. Roald, B. Roald, E. F. Kjetland, E. F. Kjetland

“…BackgroundGlobally, Africa has the highest HIV, cervical cancer and schistosomiasis prevalence. Female Genital Schistosomiasis (FGS) is hypothesized to be associated with HIV and cervical atypia. …”
Get full text

Effectiveness of HPV vaccination in reducing infection among young Brazilian women by Ana Carolina da Silva Santos, Nayara Nascimento Toledo Silva, Ismael Dale Cotrim Guerreiro da Silva, Mariângela Carneiro, Wendel Coura-Vital, Angélica Alves Lima

“…Abstract Background Globally, cervical cancer is an increasing public health issue, and vaccination against HPV has proven to be an effective strategy to reduce this neoplasia. …”
Get full text

Primary Clear Cell Adenocarcinoma of the Cervix: A Clinical Analysis of 18 Cases without Exposure to Diethylstilbestrol by Dongying Wang, Chunhua Zhao, Li Fu, Yang Liu, Weiyang Zhang, Tianmin Xu

“…Based on the staging criteria of the International Federation of Gynecology and Obstetrics (FIGO) cervical cancer clinical stage in 2018, 55.6% patients were stage I (n=10), 16.7% were stage II (n=3), 22.2% were stage III (n=4), and 5.6% were stage IV (n=1). …”
Get full text

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer by Anne Mills, Leisha A Emens, Mary L Disis, Kunle Odunsi, John B Liao, Tyler Curiel, Margaret Gatti-Mays, Amir Jazaeri, Emese Zsiros, Marcus O Butler, Jyoti Bajpai, Katherine C Kurnit, Haider Mahdi, Laura Doherty, Claire F Friedman, Melissa A Geller, Sarah F Adams, Shelley A Dodt, Veena S John

“…Recently, immune checkpoint inhibitors (ICIs) have been approved by the US Food and Drug Administration for the treatment of cervical cancer and endometrial cancer, offering durable responses for some patients. …”
Get full text

Accuracy of screening tests for cervical precancer in women living with HIV in low-resource settings: a paired prospective study in Lusaka, Zambia by Nicola Low, Partha Basu, Andreas Limacher, Katayoun Taghavi, Misinzo Moono, Mulindi Mwanahamuntu, Herbert Kapesa, Albert Manasyan, Julia Bohlius, Marie Roumet, Thamsanqa Madliwa, Anne Rutjes

“…We assessed the accuracy of screening tests that can be used in low-resource settings and give results at the same visit.Methods and analysis We conducted a paired, prospective study among consecutive eligible WLHIV, aged 18–65 years, receiving cervical cancer screening at one hospital in Lusaka, Zambia. …”
Get full text

The Effect of Guidance regarding Home Exercise and ADL on Adolescent Females Suffering from Adverse Effects after HPV Vaccination in Japanese Multidisciplinary Pain Centers by Takahiro Ushida, Masahiko Shibata, Masaki Kitahara, Shoji Yabuki, Masahiko Sumitani, Takanori Murakami, Masako Iseki, Masako Hosoi, Hiroaki Shiokawa, Tomoko Tetsunaga, Hiroyuki Nishie, Sei Fukui, Motohiro Kawasaki, Sinsuke Inoue, Makoto Nishihara, Shuichi Aono, Tatunori Ikemoto, Takashi Kawai, Young-Chang Arai

“…Two prophylactic papillomavirus (HPV) vaccines have been available for primary prevention of cervical cancer. Although serious adverse effects (AE) were rare, more than 230 women have been suffering from severe AEs such as persistent pain and headache in Japan. …”
Get full text

Predicting the risk of high-grade precancerous cervical lesions based on high-risk HPV typing in Changsha China by Yaling Xiao, Rangjiao Liu, Shaobo Wang, Yuxiang Wang, Weimin Miao, Meiwei Chen, Xiaowen Liu, Yan Chen, Yongchun Wen, Zhongping Deng, Lizhong Dai, Zenghui Mao, Jun He

“…Abstract Background Persistent infection with high-risk human papillomavirus (HPV) is a significant risk factor for cervical cancer. HPV typing and cytology are conducted in women of appropriate age to assess the risk of cervical lesions and to guide the need for further diagnostic procedures such as colposcopy, cervical biopsy, or treatment. …”
Get full text

Oncogenic PIK3CA corrupts growth factor signaling specificity by Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck

“…Dose-dependent expression of PIK3CA H1047R in human cervical cancer and induced pluripotent stem cells corrupted the fidelity of growth factor-induced information transfer, with preferential amplification of epidermal growth factor receptor (EGFR) signaling responses compared to insulin-like growth factor 1 (IGF1) and insulin receptor signaling. …”
Get full text

Human papillomavirus vaccination hesitancy among young girls in Ethiopia: factors and barriers to uptake by Ashenafi Kibret Sendekie, Ashenafi Kibret Sendekie, Biruk Beletew Abate, Biruk Beletew Abate, Betelhem Anteneh Adamu, Aschalew Mulatu Tefera, Kaleab Temelket Mekonnen, Melkam Alemu Ashagrie, Yabibal Berie Tadesse, Abera Dessie Dagnaw, Mequannent Sharew Melaku, Gizachew Kassahun Bizuneh

“…The infection might lead to vaginal cancer, vulvar cancer, genital warts, cervical intraepithelial neoplasia lesions, and cervical cancer. This study assessed hesitancy of HPV vaccination, associated factors, and barriers to vaccination among youth girls in Ethiopia.MethodsAn institutional-based cross-sectional study was conducted among female undergraduate students at the University of Gondar, College of Medicine and Health Sciences, between July and August 2022. …”
Get full text

Classification and diagnosis of cervical lesions based on colposcopy images using deep fully convolutional networks: A man-machine comparison cohort study by Binhua Dong, Huifeng Xue, Ye Li, Ping Li, Jiancui Chen, Tao Zhang, Lihua Chen, Diling Pan, Peizhong Liu, Pengming Sun

“…Colposcopy is an important technique in the diagnosis of cervical cancer. The development of computer-aided diagnosis methods can mitigate the shortage of colposcopists and improve the accuracy and efficiency of colposcopy examinations in China. …”
Get full text

Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy by Coraline Radermecker, Pascale Hubert, Patrick Roncarati, Stephanie Demoulin, Charlotte Pilard, Marie Ancion, Celia Reynders, Thomas Lerho, Diane Bruyere, Alizee Lebeau, Margot Meunier, Marie-Julie Nokin, Elodie Hendrick, Olivier Peulen, Philippe Delvenne, Michael Herfs

“…Regarding its role in cancer development/progression, paradoxical results exist in the literature and it is still unclear whether HMGB1 mainly acts as an oncogene or a tumor suppressor.Methods HMGB1 expression was first assessed in tissue specimens (n=359) of invasive breast, lung and cervical cancer and the two distinct staining patterns detected (nuclear vs cytoplasmic) were correlated to the secretion profile of malignant cells, patient outcomes and the presence of infiltrating immune cells within tumor microenvironment. …”
Get full text

The Role of Human Papilloma Virus in Synchronous Gynecologic Malignancies: A Report of Two Cases and Review of the Literature by Salih Taşkın, Emre Göksan Pabuçcu, Alper Kahraman, İbrahim Yalçın, Uğur Fırat Ortaç

“…Unlike cervical pathologies, HPV does not seem to play active role as etiologic agent in endometrial neoplasms, even detected synchronously with invasive cervical cancers.…”
Get full text

Understanding cultural perceptions of sexuality in China and their influence on human papillomavirus vaccine hesitancy by Jiayuan Jin, Yanchao Han

“…IntroductionThe human papillomavirus (HPV) vaccine prevents infections that may result in precancerous lesions, cervical cancers, genital warts, and many other diseases. …”
Get full text

Osteoclastic Giant Cell Rich Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature by Lucía Alemán-Meza, Gabriela Sofía Gómez-Macías, Oralia Barboza-Quintana, Raquel Garza-Guajardo, Abelardo Loya-Solis

“…Histologically 85 to 90% of cervical cancers are squamous cell carcinoma. Osteoclastic giant cell rich squamous cell carcinoma is an unusual histological variant of which only 4 cases have been reported. …”
Get full text

Malignancies in people living with HIV: A 25-years observational study from a tertiary hospital in Italy by Antonio Anastasia, Walter Mazzucco, Luca Pipitò, Santo Fruscione, Roberta Gaudiano, Marcello Trizzino, Maurizio Zarcone, Antonio Cascio

“…Background: HIV infection has been associated with an increased risk of cancer development and Kaposi’s sarcoma, non-Hodgkin’s lymphoma, and invasive cervical cancers have been a manifestation of AIDS. With the advent of antiretroviral therapy, a collateral appearance of non-AIDS defining cancers (NADC) has been observed in HIV positive patients. …”
Get full text