The impact of architectural modifications on relative resistance to fluid flow in ventricular catheters by Rajesh Kumar Madhavan, Ahmad Faryami, Nathan Tappen, Pranav Gopalakrishnan, Shaheer H. Ajaz, Carolyn A. Harris

“…This study represents the in-vitro assessment of various architectural modifications on catheter flow rate and pressure, focusing on bulk outflow dynamics and occlusion with whole blood-inoculated cerebrospinal fluid.MethodsCatheters were manufactured utilizing a novel catheter production setup with 16 variations from standard catheters, including but not limited to changes in: hole number, hole dimensions, catheter lumen dimension, and catheter lumen impingement. …”
Get full text

Identification of potential druggable targets for endometriosis through Mendelian randomization analysis by Peng Chen, Xin Wei, Xiao-Ke Li, Yi-Hang Zhou, Yi-Hang Zhou, Qi-Fang Liu, Ling Ou-Yang

“…This study aimed to identify both cerebrospinal fluid (CSF) and plasma protein markers as promising therapeutic targets for EM.MethodsWe utilized Mendelian randomization (MR) analysis to explore potential disease-causing proteins, utilizing genetic datasets from genome-wide association studies (GWAS) and protein quantitative trait loci (pQTL) analyses. …”
Get full text

Immunology and Oxidative Stress in Multiple Sclerosis: Clinical and Basic Approach by Genaro G. Ortiz, Fermín P. Pacheco-Moisés, Oscar K. Bitzer-Quintero, Ana C. Ramírez-Anguiano, Luis J. Flores-Alvarado, Viridiana Ramírez-Ramírez, Miguel A. Macias-Islas, Erandis D. Torres-Sánchez

“…Multiple sclerosis (MS) exhibits many of the hallmarks of an inflammatory autoimmune disorder including breakdown of the blood-brain barrier (BBB), the recruitment of lymphocytes, microglia, and macrophages to lesion sites, the presence of multiple lesions, generally being more pronounced in the brain stem and spinal cord, the predominantly perivascular location of lesions, the temporal maturation of lesions from inflammation through demyelination, to gliosis and partial remyelination, and the presence of immunoglobulin in the central nervous system and cerebrospinal fluid. Lymphocytes activated in the periphery infiltrate the central nervous system to trigger a local immune response that ultimately damages myelin and axons. …”
Get full text

A novel virulent core genome multilocus sequence type CT 11424 of Listeria monocytogenes isolate causing stillbirth in Bangladesh by Muntasir Alam, Md Saiful Islam, M. Ishrat Jahan, Arpita Shyama Deb, Afruna Rahman, Zahidul Islam, Atique Iqbal Chowdhury, Kazi Munisul Islam, Mohammad Zahid Hossain, Dilruba Ahmed, Shams El Arifeen, Emily S. Gurley, Mustafizur Rahman

“…The Lm-BD-CHAMPS-01 isolate was recovered from the blood and cerebrospinal fluid (CSF) of a male stillborn. Maternal history, clinical, and demographic data were collected by the CHAMPS surveillance platform. …”
Get full text

The regulatory role of cystatin C in autophagy and neurodegeneration by T. A. Korolenko, A. B. Shintyapina, A. B. Pupyshev, A. A. Akopyan, G. S. Russkikh, M. A. Dikovskaya, V. A. Vavilin, E. L Zavjalov, M. A. Tikhonova, T. G. Amstislavskaya

“…In our study on humans, a higher concentration of cystatin C was noted in cerebrospinal fluid than in serum; much lower concentrations were observed in other biological fluids (intraocular fluid, bile, and sweat). …”
Get full text

Cryptococcal Meningitis: A Retrospective Cohort of a Brazilian Reference Hospital in the Post-HAART Era of Universal Access by Aline Z. de Azambuja, Gustavo Wissmann Neto, Guilherme Watte, Luciana Antoniolli, Luciano Z. Goldani

“…Most of the patients presented positive CSF (cerebrospinal fluid) cultures for Cryptococcus neoformans (96%). …”
Get full text

The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases by Aleksandra Pogoda-Wesołowska, Nina Sługocka, Agnieszka Synowiec, Klaudia Brodaczewska, Marcin Mejer-Zahorowski, Maciej Ziękiewicz, Wojciech Szypowski, Piotr Szymański, Adam Stępień

“…The main tests used to support the diagnosis are magnetic resonance imaging (MRI) examination and cerebrospinal fluid (CSF) analysis. Nonetheless, to date, no sensitive or specific marker has been identified for the detection of the disease at its initial stage. …”
Get full text

Five-year Survey of Bacterial Culture Isolates and Their Antibiogram in Pediatric Patients of Rural Tertiary Care Hospital of Central Gujarat by Krutika R Tandon, Prachi Vani, Rahul Tandon, Nirav Thakar, Swati Kamani, Amit Kumar

“…Among positive culture isolates, 30.9, 24.8, 17.3, 16.1, 1.6, and 8.9% were from blood, pus, urine, endotracheal tube/tracheostomy tube (ET/TT), cerebrospinal fluid (CSF), and others, respectively. The median (IQR) hospital stay was 10 (4, 22) days. …”
Get full text

Clinical Characteristics of COVID-19 in Neonates and Infants Younger Than 3 Months by Fatemeh Varshoei, Mohammad Sadegh Rezai, Roya Farhadi, Azin Hajialibeig, Saeid Mohammadi, Masoud Moradi, Fatemeh Hosseinzadeh

“…Sepsis workup was performed in 82.9% of patients, and none had a positive cerebrospinal fluid culture. Conclusions: Although this study showed a 5% vertical transmission rate, only delivery from a mother with COVID-19 or having a positive COVID-19 reverse transcription polymerase chain reaction (RT-PCR) test result without symptoms is not a reason for a sepsis workup. …”
Get full text

Impaired Sphenoparietal Venous Drainage Is Associated With Increased Risk of Vasospasm in Aneurysmal Subarachnoid Hemorrhage by Kyle A. Lyman, Gautam Adusumilli, Hera A. Kamdar, Joanna Yang, Guy A. Rordorf, Daniel B. Rubin, Robert W. Regenhardt, Christopher J. Stapleton, Aman B. Patel, Joseph J. Locascio, William Taylor Kimberly, Brian L. Edlow, Jeremy J. Heit, David Y. Chung

“…Background Adequate venous drainage of brain parenchyma is essential to maintain cerebral perfusion and clearance of cerebrospinal fluid. The cortical vein opacification score (COVES) is a radiographic metric calculated from a computed tomography angiogram that provides a measure of venous drainage using 3 cortical veins in each hemisphere. …”
Get full text

Serological Diagnosis of <i>Brucella</i> Infection in Cetaceans by Rapid Serum Agglutination Test and Competitive ELISA with <i>Brucella abortus</i> and <i>Brucella ceti</i> as Ant... by Tiziana Di Febo, Gabriella Di Francesco, Carla Grattarola, Luigina Sonsini, Ludovica Di Renzo, Giuseppe Lucifora, Roberto Puleio, Cristina Esmeralda Di Francesco, Camilla Smoglica, Giovanni Di Guardo, Manuela Tittarelli

“…“Homologous” and “heterologous” antigens were used in a rapid serum agglutination test (Rose Bengal test, RBT) and a competitive ELISA assay (c-ELISA) to test a panel of sera, blood, and other body fluids (cerebrospinal fluid, pericardial fluid, tracheal fluid, and aqueous humor) collected from 71 individuals belonging to five cetacean species (<i>Stenella coeruleoalba</i>; <i>Tursiops truncatus</i>; <i>Grampus griseus</i>; <i>Globicephala melas</i>; and <i>Ziphius cavirostris</i>), which were found stranded on the Italian coastline. …”
Get full text

Exploring the shared gene signatures and mechanism among three autoimmune diseases by bulk RNA sequencing integrated with single-cell RNA sequencing analysis by Xiaofang Liu, Bin Li, Yuxi Lin, Xueying Ma, Yingying Liu, Lili Ma, Xiaomeng Ma, Xia Wang, Nanjing Li, Xiaoyun Liu, Xiaohong Chen

“…Immune cell infiltration pattern analysis showed significant differences in the expression of various immune cells in MS patients. scRNA-seq analysis revealed clusters of genes that were significantly upregulated in the single cells of cerebrospinal fluid in MS patients. The expression of shared genes was validated in the EAE mose model. …”
Get full text

Evaluation of the association between bevacizumab concentration and clinical outcomes in patients with breast cancer brain metastasis by Chih-Ning Cheng, Yun-Jung Tsai, Huai-Hsuan Chiu, Tom Wei-Wu Chen, Ching-Hung Lin, Yen-Sheng Lu, Ching-Hua Kuo

“…For LM patients, plasma and cerebrospinal fluid (CSF) concentrations of bevacizumab and etoposide were measured to investigate the enhancement of etoposide penetration provided by bevacizumab. …”
Get full text

Microvascular decompression: a contemporary update by Inibehe Ime Okon, Sidharth Sunil Menon, Mahmoud Osama, Maidan Aiman, Luis F. Fabrini Paleare, Don Lucero-Prisno Eliseo, Muhammad Danish Shafqat, Chizowa Okwuchukwu Ezeaku, Márcio Yuri Ferreira, Youssef Razouqi, Marianna Kapsetaki, Jovy Dia Remolino Saniel, Naneta M. Panit, Asad Gul Rao, Umer Iqbal, Daniel David Otobo, Ibraheem M. Alkhawaldeh, Felipe Salvagni Pereira, Imad Akbar, Omar Kasimieh, Bipin Chaurasia

“…Despite these advancements, complications such as hearing loss (1–2%) and cerebrospinal fluid leakage (2–4%) persist, highlighting the need for continuous refinement of techniques. …”
Get full text

Inflammatory and Redox Blood Gene Expression Fingerprint of Severe Obstructive Sleep Apnoea in Patients With Mild Alzheimer&rsquo;s Disease by Romero-ElKhayat L, Dakterzada F, Huerto R, Carnes-Vendrell A, Mínguez O, Pujol Sabaté M, Targa A, Barbé F, Milanesi E, Dobre M, Manda G, Cuadrado A, Piñol-Ripoll G

“…We aimed to identify inflammatory and redox genes differentially expressed in the blood from AD patients with severe OSA compared with those with nonsevere OSA.Methods: We included 40 AD patients diagnosed based on clinical manifestations and AD biomarker levels in cerebrospinal fluid (CSF). Severe or nonsevere OSA (apnoea–hypopnea index ≥ 30/h and < 30/h, respectively) was diagnosed through overnight polysomnography (PSG). …”
Get full text

A Test-Retest Study of Single- and Multi-Delay pCASL for Choroid Plexus Perfusion Imaging in Healthy Subjects Aged 19 to 87 Years by Zixuan Liu, Qinyang Shou, Kay Jann, Chenyang Zhao, Danny JJ Wang, Xingfeng Shao

“…There is a growing interest in the choroid plexus (ChP) due to its critical role in cerebrospinal fluid (CSF) production and its involvement in neurodegenerative and cerebrovascular diseases. …”
Get full text

Genome-wide association study unravels mechanisms of brain glymphatic activity by Shu-Yi Huang, Yi-Jun Ge, Peng Ren, Bang-Sheng Wu, Weikang Gong, Jing Du, Shi-Dong Chen, Ju-Jiao Kang, Qing Ma, Arun L. W. Bokde, Sylvane Desrivières, Hugh Garavan, Antoine Grigis, Herve Lemaitre, Michael N. Smolka, Sarah Hohmann, IMAGEN Consortium, Jian-Feng Feng, Ya-Ru Zhang, Wei Cheng, Jin-Tai Yu

“…Genetic correlation and polygenic overlap analyses indicate a common underlying genetic mechanism between the ALPS-index, ventricular volumes, and cerebrospinal fluid tau levels, with GMNC (3q28) and C16orf95 (16q24.2) as the shared genetic basis. …”
Get full text

Case report: A severe myositis mimicking bulbar palsy after administration of immune checkpoint inhibitors by Philippe Rochigneux, Philippe Rochigneux, Alexandre Bertucci, Elika Loir, Alexia Mattei, Danielle Robert, Michael Dassa, Brice Chanez, Mikael Ebbo, Lea Gaigne, Anne Sophie Chretien, Giovanni Corazza, Giovanni Corazza, Nicolas Schleinitz

“…We also discussed the elimination of differential diagnoses (notably with normal MRI and cerebrospinal fluid analysis) and finally the clinical management of this severe irAE.ResultsA 57 years woman presented multiple sub-diaphragmatic adenopathies related with an advanced melanoma of unknown primary. …”
Get full text

Autoimmune glial fibrillary acidic protein astrocytopathy misdiagnosed as intracranial infectious diseases: case reports and literature review by Runhua Bai, Runhua Bai, Li An, Wei Du, Zhiwei Wang, Xiaokun Qi, Jianguo Liu, Ming Ren, Yingxin Yu

“…Their diagnoses of A-GFAP-A were confirmed with positive GFAP-IgG in cerebrospinal fluid (CSF). We searched the PubMed database with the key words of “GFAP astrocytopathy”, “GFAP autoimmunity”, “GFAP autoantibody”, “intracranial infection”, “meningitis”, “misdiagnose”, and within the literature from Jan 1, 2015 to Mar 15, 2024, 40 cases with A-GFAP-A with positive GFAP-IgG in CSF who were previously misdiagnosed with intracranial infection were reported. …”
Get full text

Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms by Marc Dörner, Malte Pfister, Anthony Tyndall, Roland von Känel, Katja Neumann, Frank Schreiber, Philipp Arndt, Erelle Fuchs, Cornelia Garz, Wenzel Glanz, Michaela Butryn, Anna-Charlotte John, Annkatrin Hildebrand, Sebastian Euler, Andreas B. Hofmann, Lena Machetanz, Johannes Kirchebner, Pawel Tacik, Alexander Grimm, Robin Jansen, Marc Pawlitzki, Solveig Henneicke, Valentina Perosa, Bendix Labeit, Emrah Düzel, Sven G. Meuth, Stefan Vielhaber, Hendrik Mattern, Jose Bernal, Stefanie Schreiber

“…Abstract Inferior frontal sulcal hyperintensities (IFSH) observed on fluid-attenuated inversion recovery (FLAIR) MRI have been proposed as indicators of elevated cerebrospinal fluid waste accumulation in cerebral small vessel disease (CSVD). …”
Get full text