A review of the Bovis Calculus’s intervention mechanism and clinical application in ischemic stroke by Ke Xu, Bowen Deng, Tongtong Jia, Mihong Ren, Hai Chen, Jing Zhang, Jinlin Guo, Yong Li, Jian Wang

“…Additionally, the efficacy of BC in treating cerebral ischemia/reperfusion injury (CI/RI) is certain, particularly due to the components of bile pigments, bile acids, and amino acids that can interfere with the enzymatic cascade reaction of CI/RI through multiple components, targets, and pathways. …”
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A realistic human head phantom for electromagnetic detection of brain diseases by Zelin Bai, Diyou Chen, Ke Ma, Gui Jin, Jinlong Qiu, Quanquan Li, Haocheng Li, Mingsheng Chen

“…This article combines high-precision computed tomography (CT) images and magnetic resonance imaging (MRI) images to establish an electromagnetic numerical model of the human head with a real anatomical structure. (1) It had Asian characteristics and encompassed 14 different structures, including skin, muscles, cranial bones, cerebrospinal fluid, cerebral veins, cerebral arteries, gray matter, white matter of the brain, basal ganglia, thalamus, cerebellum, brainstem, eyeballs, and vertebrae. (2) The model used a combination of 0.625 mm-resolution CT and 1 mm-resolution MRI image data for reconstruction, with a smooth surface and high accuracy. (3) Within the simulation environment, this model enabled the generation of various brain disease scenarios, such as different types and degrees of cerebral hemorrhage and cerebral ischemia. It proved valuable for studying the distribution of electromagnetic fields in the human head and for investigating novel electromagnetic detection techniques exploiting brain tissue dielectric properties. (4) The created physical model and the numerical model were derived from the same person, which provided a good continuity between simulation experiments and physical experiments, and provided a realistic verification platform for the research of electromagnetic detection technology for brain diseases, such as differentiating the kind of stroke, monitoring brain edema, brain tumor microwave imaging, and diagnosis of Alzheimer’s disease.…”
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Research progress of clinical intervention for apnea in extremely and very preterm infants (极早和超早产儿呼吸暂停临床干预方法进展) by LU Lijun (陆丽君), FENG Xuemo (冯雪茉), LU Yunhong (卢运红)

“…Influenced by a variety of comprehensive factors such as hypoplasia of receptors, electrolyte disorder, bacterial and viral infection, it is easy to lead to cerebral ischemia and hypoxia and other complications in neonates, which is the main cause of neonatal death. …”
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A comprehensive review on alpha-lipoic acid delivery by nanoparticles by Navid Mosallaei, Amirhossein Malaekeh-Nikouei, Setayesh Sarraf Shirazi, Javad Behmadi, Bizhan Malaekeh-Nikouei

“…ALA encapsulated in niosomes showed potential for treating cerebral ischemia, a condition largely linked to stroke. …”
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Cerebrovascular stenosis related to tyrosine kinase inhibitor for chronic myeloid leukemia: two illustrative cases by Nozomi Sasaki, Yukiko Enomoto, Takamitsu Hori, Hirofumi Matsubara, Yusuke Egashira, Tsuyoshi Izumo

“…He was diagnosed with hemodynamic cerebral ischemia due to severe intracranial ICA stenosis and underwent superficial temporal artery (STA)-MCA bypass surgery. …”
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Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats by Tongxia Zhang, Tao Zhang, Han Yu, Lingyi Chi

“…In previous studies, Isosteviol sodium (STVNa) has been shown to protect rats against acute focal cerebral ischemia; however, the effects of STVNa on SCI recovery in rats remain unknown. …”
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Prognostic analysis of endovascular mechanical thrombectomy in stroke patients with acute internal carotid artery obstruction based on circle of Willis variation by Tianlun Qiu, Huagang Luo, Wuqiao Bao

“…The prognosis and mortality rates at 90 days post-stroke were evaluated for the different grades and within each grade, patients were further categorized into two subtypes based on vascular compensation and occluded vessels.ResultsSignificant differences were observed among the four grades of Willis compensation concerning etiologic classification (p = 0.008), postoperative modified treatment in cerebral ischemia (mTICI, p = 0.017), postoperative symptomatic intracranial hemorrhage (sICH, p = 0.007), NIHSS score at admission (p = 0.001), and favorable outcomes at 90 days (modified Rankin Score 0–2) (p = 0.003). …”
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Construction of an lncRNA-mediated ceRNA network to investigate the inflammatory regulatory mechanisms of ischemic stroke. by Meimei Xu, Shan Yuan, Xing Luo, Mengsi Xu, Guangze Hu, Zhe He, Xinyuan Yang, Rui Gao

“…In this study, we established a cerebral ischemia-reperfusion injury model using middle cerebral artery occlusion (MCAO) in male Sprague-Dawley rats. …”
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Detection of Neuroinflammation in a Rat Model of Subarachnoid Hemorrhage Using [F]DPA-714 PET Imaging by Clément Thomas MD, Johnny Vercouillie PhD, Aurélie Doméné, Clovis Tauber PhD, Michael Kassiou PhD, Denis Guilloteau PhD, Christophe Destrieux MD, PhD, Sophie Sérrière PhD, Sylvie Chalon PhD

“…Subarachnoid hemorrhage (SAH) can lead to delayed cerebral ischemia, which increases the rate of morbidity and mortality. …”
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Dose Effect Evaluation and Therapeutic Window of the Neuro-EPO Nasal Application for the Treatment of the Focal Ischemia Model in the Mongolian Gerbil by Iliana Sosa Teste, Yuneidys Mengana Tamos, Yamila Rodríguez Cruz, Adriana Muñoz Cernada, Janette Cruz Rodríguez, Nelvis Subirós Martínez, Rosa Maria Coro Antich, Alina González-Quevedo, Julio Cesar García Rodríguez

“…The aim of this study was to determine the Neuro-EPO delivery into the central nervous system (CNS) to exert a neuroprotective effect in cerebral ischemia model of the Mongolian gerbil. The Neuro-EPO in a rate of 249.4 UI every 8 hours for 4 days showed 25% higher viability efficacy (𝑃>0.01), improving neurological score and behavior of the spontaneous exploratory activity, the preservation of CA3 areas of the hippocampus, the cortex, and thalamic nuclei in the focal ischemia model of the Mongolian gerbil. …”
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PET Quantification of Cerebral Oxygen Metabolism in Small Animals by Takashi Temma, Kazuhiro Koshino, Tetsuaki Moriguchi, Jun-ichiro Enmi, Hidehiro Iida

“…Since small animals such as rats are widely used to study various diseases including cerebral ischemia, cerebrovascular diseases, and neurodegenerative diseases, the development of a noninvasive in vivo measurement method of cerebral oxygen metabolic parameters such as oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) as well as cerebral blood flow (CBF) and cerebral blood volume (CBV) has been a priority. …”
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Effect of Acupoint Catgut-embedding on the Expression of GABA_Band mGluR1 in the Brain Stem of Rats with Spasticity after Ischemic Stroke by Xiaodong FENG, Ruiqing LI, Xiaolei SONG, Chengmei LIU

“…The rats in both the model group and the treatment group were administratered with middle cerebral artery occlusion (MCAO) to establish the model of focal cerebral ischemia. Only the left carotid artery was dissected in sham group rats. …”
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The Long-Term Outcome Comparison of Different Time-Delayed Kallikrein Treatments in a Mouse Cerebral Ischemic Model by Yaohui Ni, Kefu Cai, Yujie Hu, Chuan-hui Wang, Yuanyuan Zhang, Hua Huang, Xing Su, Jin-hua Gu

“…In this study, we compared the long-term outcome among three kallikrein therapeutic regimens starting at different time points following mouse cerebral ischemia. Furthermore, the protective mechanisms involving neurogenesis, angiogenesis, and AKT-GSK3β-VEGF signaling pathway were analyzed. …”
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Chlorpromazine and Promethazine (C+P) Reduce Brain Injury after Ischemic Stroke through the PKC-δ/NOX/MnSOD Pathway by Sichao Guo, Fengwu Li, Melissa Wills, James Yip, Alexandra Wehbe, Changya Peng, Xiaokun Geng, Yuchuan Ding

“…Cerebral ischemia-reperfusion (I/R) incites neurologic damage through a myriad of complex pathophysiological mechanisms, most notably, inflammation and oxidative stress. …”
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Gallic acid: a dietary metabolite’s therapeutic potential in the management of atherosclerotic cardiovascular disease by Xiao-Lan Zhao, Zhang-Jing Cao, Ke-Di Li, Fei Tang, Li-Yue Xu, Jing-Nan Zhang, Dong Liu, Cheng Peng, Hui Ao, Hui Ao

“…Additionally, GA can treat ASCVD-related diseases, such as coronary heart disease (CHD) and cerebral ischemia. However, the pharmacological actions of GA in the prevention and treatment of ASCVD have not been comprehensively reviewed, which limits its clinical development. …”
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Inclusion of hypocretin-1 improved performance of poor sleep quality prediction for elderly patients with acute ischemic stroke: a prospective cohort study by Ting Fu, Weiwei Zhang, Rongrong Guo, Shuang He, Saiying Yu, Huiying Wang, Yunfeng Zhang, Ying Wu

“…BackgroundHypocretin-1 is a vital neurotransmitter in regulating the sleep–wake cycle and provides neuroprotection against cerebral ischemia. We aims to develop a poor sleep quality predictive model for elderly population with acute ischemic stroke.MethodsA total of 183 consecutively elderly patients were included in the prospective cohort study. …”
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Temporal Trends in Serum Homer1 Levels and Their Prognostic Implications in Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study by Dai J, Lin Q, Ye L, Chen X, Li Z, Lu C, Chen M, Ba H, Sun J, Cai J

“…Serum homer1 levels were linearly and independently correlated with WFNS scores, mFisher scores, continuous GOS scores, ordinal GOS scores, poor prognosis risk and delayed cerebral ischemia (DCI) likelihood. DCI partially mediated association of serum homer1 levels with poor prognosis. …”
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Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability by Lipeng Dong, Huimin Qiao, Xiangjian Zhang, Xiaolin Zhang, Chaohui Wang, Lina Wang, Lili Cui, Jingru Zhao, Yinxue Xing, Yanhua Li, Zongjie Liu, Chunhua Zhu

“…PN administered intraperitoneally immediately after cerebral ischemia and once daily on the following days. …”
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Complement inhibition targets a rich-club within the neuroinflammatory network after stroke to improve radiographic and functional outcomes by Youssef M. Zohdy, Tomas Garzon-Muvdi, Jonathan A. Grossberg, Daniel L. Barrow, Brian M. Howard, Gustavo Pradilla, Firas H. Kobeissy, Stephen Tomlinson, Ali M. Alawieh

“…The neuroinflammatory response in cerebral ischemia is robust and multifactorial, complicating therapeutic approaches targeting single pathways. …”
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Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage by Yoichiro Nakagawa, Takashi Kusayama, Sho Tamai, Yuta Nagamori, Kazutaka Takeuchi, Shuhei Iwaisako, Taishi Tsutsui, Tomoya Kamide, Kouichi Misaki, Soichiro Usui, Kenji Sakata, Mitsutoshi Nakada, Masayuki Takamura

“…Although these abnormalities gradually normalized, delayed cerebral ischemia episodes were associated with increased HF oscillation. …”
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