Case Report: A rare presentation of rapidly progressive moyamoya disease refractory to unilateral surgical revascularization by Daniel Friel Leach, Srivikram Margam S, Aaron Gustin, Paul J. Gustin, Mohamad N. Jajeh, Yhana C. Chavis, Kristin V. Walker, Joshua S. Bentley

“…As such, the most usual presentations are those that occur with cerebral ischemia, specifically transient ischemic attack, acute ischemic stroke, and seizures. …”
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An ultrasonic degraded polysaccharide extracted from Pueraria lobata ameliorate ischemic brain injury in mice by regulating the gut microbiota and LPS-TLR4 pathway by Yulong Zhang, Zuman Dou, Shanshan Li, Huaying Zhang, Shanshui Zeng, Xiangyu Zuo, Yu Xiao, Lingling Zhang, Zhixin Li, Qingfeng Zhu, Wenyang Zhang, Hui Niu, Qingfei Duan, Xiaoxia Chen, Zhuang Li, Hongwei Zhou, Qian Wang

“…The results demonstrated that PLP-3 effectively reduced the infarct area, improves neurological function, and alleviates neuronal damage of cerebral ischemia injury. Mechanistically, PLP-3 significantly reduces serum LPS levels in MCAO mice, inhibiting TLR-4 activation in brain tissue and thereby reducing IL-1β and TNF-α levels. …”
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Effect of Electroacupuncture at Shuigou Acupoint on L-type Voltage-gated Calcium Channels in hippocampal CA1 region of MCAO rats by Da LONG, Ling CHEN, Yu YAO, Mingan ZENG

“…Electroacupuncture at Shuigou acupoint may play an importment role in inhibiting calcium overload in nerve cells, promoting the recovery of nerve function in mice after cerebral ischemia reperfusion and playing a role in brain protection.…”
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Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border by Keke Wang, Hongyan Qu, Ruinan Hu, Bernard Lassègue, Douglas C. Eaton, Chang Song, Jianjun Mu, Kathy K. Griendling, Marina S. Hernandes

“…Methods and Results Cerebral ischemia was induced in endothelial-specific Poldip2 knockout mice and controls. …”
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The clinical impact of recent amphetamine exposure in aneurysmal subarachnoid hemorrhage patients by Jeffrey R. Vitt, Roger C. Cheng, Jason Chung, Travis Caton, Bo Zhou, Nerissa Ko, Karl Meisel, Edilberto Amorim

“…There was no difference in delayed cerebral ischemia incidence, length of hospital stay, need for ventriculoperitoneal shunt placement, functional outcome at discharge or hospital mortality based on amphetamine use.InterpretationRecent amphetamine use was not associated with worse vasospasm severity or delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage patients. …”
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Effects of Electroacupuncture at Zusanli and Quchi on Neurological Function Recovery in Rats with Cerebral Infarction by Jiangcong HONG, Yingzheng WANG, Guangwen WU, Yulong ZOU

“…The staining was the strongest one day after the cerebral ischemia reperfusion, and the staining range was reduced later. …”
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Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model by Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee

“…Abstract Following cerebral ischemia, neutrophil extracellular traps (NETs) contribute significantly to brain damage by exacerbating delayed immune cell infiltration and vascular injury. …”
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Neuroimaging: biochemical principles and its application in the cerebrovascular ischemic disease. by Zenaida Milagros Hernández Díaz, Adnolys Reyes-Berazaín, Miguel Ángel Buergo –Zuaznabar, Marianela Arteche-Prior

“…The present bibliographic review has the objective of supporting the importance of neuroimaging studies in the diagnosis of acute cerebral ischemia.…”
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Posterior Cerebral Infarction following Loss of Guide Wire by Jean-Marc Bugnicourt, Denis Belhomme, Bruno Bonnaire, Jean-Marc Constans, Cécile Manaouil

“…Stroke after internal jugular venous cannulation typically leads to acute carotid or vertebral arteries injury and cerebral ischemia. We report the first case of delayed posterior cerebral infarction following loss of guide wire after left internal jugular venous cannulation in a 46-year-old woman with a history of inflammatory bowel disease. …”
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Aneurysmal Subarachnoid Hemorrhage Models: Do They Need a Fix? by Fatima A. Sehba, Ryszard M. Pluta

“…The discovery of tissue plasminogen activator to treat acute stroke is a success story of research on preventing brain injury following transient cerebral ischemia (TGI). That this discovery depended upon development of embolic animal model reiterates that proper stroke modeling is the key to develop new treatments. …”
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Statins Promote Long-Term Recovery after Ischemic Stroke by Reconnecting Noradrenergic Neuronal Circuitry by Kyoung Joo Cho, So Young Cheon, Gyung Whan Kim

“…This study investigated the effects of statins on the recovery of NA neuron circuitry and its function after transient focal cerebral ischemia (tFCI). Using the wheat germ agglutinin (WGA) transgene technique combined with the recombinant adenoviral vector system, NA-specific neuronal pathways were labeled, and were identified in the locus coeruleus (LC), where NA neurons originate. …”
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Advances in Knowledge Regarding Arterial Curvature and its Relationship to Ischemic Stroke: A Narrative Review by Lin-Han Zhang, Fei Cao

“…The degree of arterial curvature may serve as a risk factor for cerebral ischemia, alongside traditional vascular risk factors. …”
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Candesartan Reduces Neuronal Apoptosis Caused by Ischemic Stroke via Regulating the FFAR1/ITGA4 Pathway by Yubao Ding, Yue Lang, Hui Zhang, Yu Li, Xiao Liu, Minjie Li

“…Ischemic stroke (IS) is a general term for necrosis of brain tissue caused by stenosis, occlusion of arteries supplying blood to the brain (carotid artery and vertebral artery), and insufficient blood supply to the brain. Cerebral ischemia is the main kind of IS causing cell damage. …”
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Evidence-Based Cerebral Vasospasm Surveillance by Heather Kistka, Michael C. Dewan, J. Mocco

“…The most common—and devastating—complication is delayed cerebral ischemia resulting from vasospasm. In this paper, the authors review the various surveillance technologies available to detect cerebral vasospasm in the days following aSAH. …”
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Imaging Gene Expression in Regional Brain Ischemia in Vivo with a Targeted [In]-Antisense Radiopharmaceutical by Toyofumi Suzuki, Yun Zhang, Yu-feng Zhang, Felix Schlachetzki, William M. Pardridge

“…The in vivo imaging of decreased GFAP gene expression in cerebral ischemia was examined in the present studies using a targeted peptide nucleic acid (PNA), which was labeled with 111 In, and which hybridized to nucleotides 20–37 of the rat GFAP mRNA. …”
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Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils by Yixiang Jiang, Ning Wang, Jingyi Liu, Haoran Ren, Wenkang Jiang, Yanting Lei, Xidan Fu, Miao Hao, Xiujuan Lang, Yumei Liu, Xijun Liu, Rui Li, Hulun Li

“…Results TTC staining, behavioral experiments, and pathological assessments reveal intranasal delivery of hMSC-L and hMSC-M significantly reduces the infarct volume of mice with cerebral ischemia, improves neurological function scores, and promotes motor function recovery. …”
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Neurocranial Pharmacodialysis Device for subarachnoid hemorrhage treatment—a perspective by Nandor Ludvig

“…The RESULTS showed the following four facts: (1) high-grade SAH requiring decompressive craniectomy readily offers, as the last step of the neurosurgical procedure, the safe closure of the opened cranium with the NPD while leaving the efficacy of the decompressive intervention intact. (2) The neurocranially attached NPD can automatically execute, as long as it is necessary, subarachnoid polypharmacy to prevent post-SAH vasospasm, reduce the risk of rebleeding, and provide neuroprotection in delayed cerebral ischemia (DCI), bypassing the blood-brain barrier (BBB) via connected subarachnoid strips. (3) These effects of drug delivery can be optimized with NPD-controlled long-term cleaning of the CSF and drainage of cellular debris, hydrocephalus, and interstitial edema accompanied by the subarachnoid dialysis of potentially neurotoxic extracellular molecules. (4) Safety and efficacy of these NPD operations are monitored, and possible epileptiform EEG is detected, via the wireless EEG system of the device. …”
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Diagnosis and treatment of cerebral vasospasm after subarachnoid hemorrhage by Youssef Fardos, Daniel Mattimore, Wesam Andraous, Sofia Geralemou, Sergio Bergese, Ana Costa

“… Cerebral vasospasm after subarachnoid hemorrhage leads to delayed cerebral ischemia and contributes to increased morbidity and mortality. …”
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Rodent Models of Developmental Ischemic Stroke for Translational Research: Strengths and Weaknesses by Mariangela Gennaro, Alessandro Mattiello, Tommaso Pizzorusso

“…Cerebral ischemia can occur at any stage in life, but clinical consequences greatly differ depending on the developmental stage of the affected brain structures. …”
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Dynamic Analysis of the Blood-Brain Barrier Disruption in Experimental Stroke Using Time Domain in Vivo Fluorescence Imaging by Abedelnasser Abulrob, Eric Brunette, Jacqueline Slinn, Ewa Baumann, Danica Stanimirovic

“…The blood-brain barrier (BBB) disruption following cerebral ischemia can be exploited to deliver imaging agents and therapeutics into the brain. …”
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