Interleukin-22 Plays a Protective Role by Regulating the JAK2-STAT3 Pathway to Improve Inflammation, Oxidative Stress, and Neuronal Apoptosis following Cerebral Ischemia-Reperfusion Injury by Yongfei Dong, Chengyun Hu, Chunxia Huang, Jie Gao, Wanxiang Niu, Di Wang, Yang Wang, Chaoshi Niu

“…The interleukins (ILs) are a pluripotent cytokine family that have been reported to regulate ischemic stroke and cerebral ischemia/reperfusion (I/R) injury. IL-22 is a member of the IL-10 superfamily and plays important roles in tissue injury and repair. …”
Get full text

Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications by Fang Du, Tao Tang, Qingzhu Li, Jiaxin Liu

“…This paper reviews the role of Fyn in the pathological process of cerebral ischemia-reperfusion, including neuroexcitotoxicity and neuroinflammation, to explore how Fyn affects specific signal cascades and leads to cerebral ischemia-reperfusion injury. …”
Get full text

Role of microRNAs in Stroke and Poststroke Depression by Han Yan, Min Fang, Xue-Yuan Liu

“…Herein, studies on the role of miRNAs in the cerebral ischemia and PSD were reviewed, and results may be helpful for the diagnosis and prognosis of cerebral ischemia and PSD with miRNAs in clinical practice.…”
Get full text

Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective by Mario Di Napoli, Imtiaz M. Shah

“…However, the pathophysiological mechanisms of brain response to cerebral ischemia in old age are currently poorly understood. …”
Get full text

Comparative Effects of Glenzocimab and Eptifibatide on Bleeding Severity in 2 Mouse Models of Intracranial Hemorrhage by Sébastien Dupont, Héloïse Lebas, Sabrina Mavouna, Eloïse Pascal, Astride Perrot, Adrien Cogo, Marie‐Charlotte Bourrienne, Carine Farkh, Mialitiana Solo Nomenjanahary, Véronique Ollivier, Fatima Zemali, Bernhard Nieswandt, Stéphane Loyau, Martine Jandrot‐Perrus, Eric Camerer, Jean‐Philippe Desilles, Mikael Mazighi, Yacine Boulaftali, Benoît Ho‐Tin‐Noé

“…Background Antiplatelet drugs represent potential candidates for protecting the penumbral microcirculation during cerebral ischemia and improving the benefits of arterial recanalization in ischemic stroke. …”
Get full text

The E3-ligase Siah2 activates mitochondrial quality control in neurons to maintain energy metabolism during ischemic brain tolerance by Maria Josè Sisalli, Elena D’Apolito, Ornella Cuomo, Giovanna Lombardi, Michele Tufano, Lucio Annunziato, Antonella Scorziello

“…The balance between mitophagy and biogenesis is needed to reduce cerebral ischemia-induced cell death. Ischemic preconditioning (IPC) represents an adaptation mechanism of CNS that increases tolerance to lethal cerebral ischemia. …”
Get full text

Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model by Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee

“…Abstract Following cerebral ischemia, neutrophil extracellular traps (NETs) contribute significantly to brain damage by exacerbating delayed immune cell infiltration and vascular injury. …”
Get full text

Neuroimaging: biochemical principles and its application in the cerebrovascular ischemic disease. by Zenaida Milagros Hernández Díaz, Adnolys Reyes-Berazaín, Miguel Ángel Buergo –Zuaznabar, Marianela Arteche-Prior

“…The present bibliographic review has the objective of supporting the importance of neuroimaging studies in the diagnosis of acute cerebral ischemia.…”
Get full text

Posterior Cerebral Infarction following Loss of Guide Wire by Jean-Marc Bugnicourt, Denis Belhomme, Bruno Bonnaire, Jean-Marc Constans, Cécile Manaouil

“…Stroke after internal jugular venous cannulation typically leads to acute carotid or vertebral arteries injury and cerebral ischemia. We report the first case of delayed posterior cerebral infarction following loss of guide wire after left internal jugular venous cannulation in a 46-year-old woman with a history of inflammatory bowel disease. …”
Get full text

Aneurysmal Subarachnoid Hemorrhage Models: Do They Need a Fix? by Fatima A. Sehba, Ryszard M. Pluta

“…The discovery of tissue plasminogen activator to treat acute stroke is a success story of research on preventing brain injury following transient cerebral ischemia (TGI). That this discovery depended upon development of embolic animal model reiterates that proper stroke modeling is the key to develop new treatments. …”
Get full text

Advances in Knowledge Regarding Arterial Curvature and its Relationship to Ischemic Stroke: A Narrative Review by Lin-Han Zhang, Fei Cao

“…The degree of arterial curvature may serve as a risk factor for cerebral ischemia, alongside traditional vascular risk factors. …”
Get full text

Candesartan Reduces Neuronal Apoptosis Caused by Ischemic Stroke via Regulating the FFAR1/ITGA4 Pathway by Yubao Ding, Yue Lang, Hui Zhang, Yu Li, Xiao Liu, Minjie Li

“…Ischemic stroke (IS) is a general term for necrosis of brain tissue caused by stenosis, occlusion of arteries supplying blood to the brain (carotid artery and vertebral artery), and insufficient blood supply to the brain. Cerebral ischemia is the main kind of IS causing cell damage. …”
Get full text

Evidence-Based Cerebral Vasospasm Surveillance by Heather Kistka, Michael C. Dewan, J. Mocco

“…The most common—and devastating—complication is delayed cerebral ischemia resulting from vasospasm. In this paper, the authors review the various surveillance technologies available to detect cerebral vasospasm in the days following aSAH. …”
Get full text

Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils by Yixiang Jiang, Ning Wang, Jingyi Liu, Haoran Ren, Wenkang Jiang, Yanting Lei, Xidan Fu, Miao Hao, Xiujuan Lang, Yumei Liu, Xijun Liu, Rui Li, Hulun Li

“…Results TTC staining, behavioral experiments, and pathological assessments reveal intranasal delivery of hMSC-L and hMSC-M significantly reduces the infarct volume of mice with cerebral ischemia, improves neurological function scores, and promotes motor function recovery. …”
Get full text

Neurocranial Pharmacodialysis Device for subarachnoid hemorrhage treatment—a perspective by Nandor Ludvig

“…The RESULTS showed the following four facts: (1) high-grade SAH requiring decompressive craniectomy readily offers, as the last step of the neurosurgical procedure, the safe closure of the opened cranium with the NPD while leaving the efficacy of the decompressive intervention intact. (2) The neurocranially attached NPD can automatically execute, as long as it is necessary, subarachnoid polypharmacy to prevent post-SAH vasospasm, reduce the risk of rebleeding, and provide neuroprotection in delayed cerebral ischemia (DCI), bypassing the blood-brain barrier (BBB) via connected subarachnoid strips. (3) These effects of drug delivery can be optimized with NPD-controlled long-term cleaning of the CSF and drainage of cellular debris, hydrocephalus, and interstitial edema accompanied by the subarachnoid dialysis of potentially neurotoxic extracellular molecules. (4) Safety and efficacy of these NPD operations are monitored, and possible epileptiform EEG is detected, via the wireless EEG system of the device. …”
Get full text

Diagnosis and treatment of cerebral vasospasm after subarachnoid hemorrhage by Youssef Fardos, Daniel Mattimore, Wesam Andraous, Sofia Geralemou, Sergio Bergese, Ana Costa

“… Cerebral vasospasm after subarachnoid hemorrhage leads to delayed cerebral ischemia and contributes to increased morbidity and mortality. …”
Get full text

Rodent Models of Developmental Ischemic Stroke for Translational Research: Strengths and Weaknesses by Mariangela Gennaro, Alessandro Mattiello, Tommaso Pizzorusso

“…Cerebral ischemia can occur at any stage in life, but clinical consequences greatly differ depending on the developmental stage of the affected brain structures. …”
Get full text

Current Controversies in the Prediction, Diagnosis, and Management of Cerebral Vasospasm: Where Do We Stand? by Young Lee, Scott L. Zuckerman, J. Mocco

“…Around 30 percent of patients with aneurysmal subarachnoid hemorrhage suffer from cerebral ischemia and infarction due to cerebral vasospasm, a leading cause of treatable death and disability following aneurysmal subarachnoid hemorrhage. …”
Get full text

Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic Perspectives by Marjan Talebi, Alireza Ghassempour, Afsoon Feizi, Seyed Abdulmajid Ayatollahi, Mehrdad Faizi

“…The role of the genus Dracocephalum was investigated in relation to various neurological conditions such as Alzheimer's disease, insomnia, Parkinson's disease, vascular dementia, cerebral ischemia, pain, depression, and glioblastoma. …”
Get full text

Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases by Longxiao Zhang, Yunfei Zhou, Zhongbo Yang, Liangchao Jiang, Xinyang Yan, Wenkai Zhu, Yi Shen, Bolong Wang, Jiaxi Li, Jinning Song

“…Additionally, we also emphasize the paradoxical role of LDs in post-cerebral ischemia inflammation and explore potential underlying mechanisms, aiming to identify novel therapeutic targets for this disease.…”
Get full text