The Emerging Perspective of Morphine Tolerance: MicroRNAs by Teng J. Zhang, Yong Qiu, Zhen Hua

“…MicroRNAs are noncoding RNAs that have been proposed to regulate gene expression and degradation at the posttranscriptional level, including the MOR, as well as synaptic plasticity and neuroplasticity, in both the peripheral and central nervous systems. This review covers some of the most striking microRNA functions involved in morphine tolerance and presents limitations on our knowledge of their physiological roles.…”
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Rheumatoid Meningoencephalitis: A Feared Condition in the Era of TNF Blockers by Fernando Figueroa Rodriguez, Kwon Minkyung, Sruthi Jinna, Sohail Farshad, Francisco Davila

“…Central nervous system (CNS) involvement in rheumatoid arthritis (RA) is uncommon, and most of the times, it is secondary to vasculitic processes or extra-articular rheumatoid nodules. …”
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Cardiac Dysrhythmias and Neurological Dysregulation: Manifestations of Profound Hypomagnesemia by Sagger Mawri, Edward Gildeh, Namita Joseph, Bobak Rabbani, Bryan Zweig

“…We herein discuss the clinical presentation, pathophysiology, diagnosis, and management of severe hypomagnesemia and emphasize the implications of magnesium deficiency in the cardiovascular and central nervous systems. Furthermore, this case highlights the importance of having high vigilance for hypomagnesemia in the appropriate clinical setting.…”
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Hearing Loss due to Infiltration of the Tympanic Membrane by Chronic Lymphocytic Leukemia by Jonathon B. Cohen, Robert Cavaliere, John C. Byrd, Leslie A. Andritsos

“…Central nervous system (CNS) involvement by chronic lymphocytic leukemia (CLL) can present with dramatic neurologic findings or can be quite subtle, discovered only at the time of autopsy. …”
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Trigeminal Neuralgia, Glossopharyngeal Neuralgia, and Myofascial Pain Dysfunction Syndrome: An Update by Mohammad Khan, Shamima Easmin Nishi, Siti Nazihahasma Hassan, Md. Asiful Islam, Siew Hua Gan

“…The unique functions (masticatory process and facial expression) of the maxillofacial structure require the exquisite organization of both the peripheral and central nervous systems. Neuralgia is painful paroxysmal disorder of the head-neck region characterized by some commonly shared features such as the unilateral pain, transience and recurrence of attacks, and superficial and shock-like pain at a trigger point. …”
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The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases by Margarete Dulce Bagatini, Alessandra Antunes dos Santos, Andréia Machado Cardoso, Aline Mânica, Cristina Ruedell Reschke, Fabiano Barbosa Carvalho

“…This review aims to present the role of purinergic signaling highlighting the ectonucleotidases E-NTPDase, E-NPP, E-5′-nucleotidase, and adenosine deaminase in noncommunicable, neurological, and degenerative diseases associated with the cardiovascular and central nervous systems and cancer. In conclusion, changes in the activity of ectonucleotidases were verified in all reviewed diseases. …”
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A Single Lung Transplant in a Patient with Fabry Disease: Causality or Far-Fetched? A Case Report by Martina Gaggl, Renate Kain, Peter Jaksch, Dominik Haider, Gerald Mundigler, Till Voigtländer, Raute Sunder-Plassmann, Paulus Rommer, Walter Klepetko, Gere Sunder-Plassmann

“…Subsequently, various organ systems are involved, clinically the most important are kidneys, the heart, and the peripheral and central nervous systems. Although obstructive lung disease is a common pathological finding in Fabry disease, pulmonary involvement is a clinically disregarded feature. …”
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Canine distemper outbreak and laryngeal paralysis in captive tigers (Panthera tigris) by Sarin Suwanpakdee, Anuwat Wiratsudakul, Nattarun Chaisilp, Luxsana Prasittichai, Anurux Skulpong, Patarapol Maneeorn, Benjaporn Bhusri, Chalisa Mongkolpan, Ruangrat Buddhirongawatr, Jarupa Taowan, Peerawat Wongluechai, Nlin Arya, Parin Suwannaprapha, Natharin Ngamwongsatit, Witthawat Wiriyarat, Nareerat Sangkachai

“…Therefore, laryngeal paralysis may result from CDV infection and degeneration, potentially affecting the peripheral and central nervous systems. This condition could pose a life-threatening risk to tigers. …”
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Systematic Study of Steroid Drugs’ Ability to Cross Biomembranes—The Possible Environmental Impact and Health Risks Associated with Exposure During Pregnancy by Anna W. Sobańska, Aleksandra Orlikowska, Karolina Famulska, Lovro Bošnjak, Domagoj Bosiljevac, Aleksandra Rasztawicka, Andrzej M. Sobański

“…Over 30% of studied compounds are likely to pass through the blood–brain barrier (although five compounds in this group are likely P-gp substrates, which may reduce their activity in the central nervous systems); they have also very high affinity for both studied enzymes.…”
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Assessing the role of selenium in Minamata disease through reanalysis of historical samples by Mineshi Sakamoto, Masumi Marumoto, Koichi Haraguchi, Takashi Toyama, Yoshiro Saito, Steven J. Balogh, Chiharu Tohyama, Masaaki Nakamura

“…The elevated Hg/Se molar ratio in the brain helps explain the severe neurological damage in patients’ central nervous systems, despite higher Hg levels in the liver and kidney compared to the brain. …”
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The Effects of Noxious Electrical Stimulation and Eccentric Exercise on Mechanical and Thermal Pain Sensitivity in Recreational Runners with Achilles Tendinopathy by Scott K. Stackhouse, Brian J. Eckenrode, Kathleen C. Madara

“…Sensitization of both the peripheral and central nervous systems may contribute to the persistent pain. …”
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