The Timing of Infarction Pain in Patients with Acute Myocardial Infarction after Previous Revascularization by Predrag M. Mitrovic, Branislav Stefanovic, Zorana Vasiljevic, Mina Radovanovic, Nebojsa Radovanovic, Gordana Krljanac, Dubravka Rajic, Predrag Erceg, Vladan Vukcevic, Ivana Nedeljkovic, Miodrag Ostojic

“…This subgroup of patients, together with the subgroups of patients with a dominant evening peak (patients with CHF and those with non-STEMI) and with patients with no peak (patients with previous angina and previous AMI), probably appear to modify characteristic circadian variation of infarction onset, expressing a higher evening peak, respectively to the previous CABG, with adverse consequences for central nervous system functioning.…”
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FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis by David Hunt, Siddharthan Chandran, Peter Connick, Peter Foley, Patrick K A Kearns, Sergio E Baranzini, Adam D Waldman, Sarah J Martin, Elizabeth Freyer, F J Carod-Artal, Lee Murphy, Amy Stenson, Jessie Chang, Rozanna Meijboom, Elizabeth N York, Yingdi Chen, Christine Weaver, Katarzyna Hafezi, Stacey Thomson, Adil Harroud, Margaret McLeod, Jonathon O'Riordan, Niall J J MacDougall

“…Purpose Multiple sclerosis (MS) is an immune-mediated, neuroinflammatory disease of the central nervous system and in industrialised countries is the most common cause of progressive neurological disability in working age persons. …”
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Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan by Jeffrey M. Hord, Sarah Burns, Tobias Willer, Matthew M. Goddeeris, David Venzke, Kevin P. Campbell

“…Genetic defects in post-translational O-mannosylation of DG interfere with its receptor function and result in muscular dystrophy with central nervous system and skeletal muscle pathophysiology. …”
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Brain Iron Deposition Alterations in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment Based on Quantitative Susceptibility Mapping by Qiuyue Zhao, Subinuer Maimaitiaili, Yan Bi, Ming Li, Xin Li, Qian Li, Xinyi Shen, Min Wu, Linqing Fu, Zhengyang Zhu, Xin Zhang, Jiu Chen, Anning Hu, Zhou Zhang, Wen Zhang, Bing Zhang

“…ABSTRACT Background Iron is one of the most important elements in brain that may has a direct impact on the stability of central nervous system. The current study devoted to explore the alterations of iron distribution across the whole brain in type 2 diabetes mellitus (T2DM) patients with mild cognitive impairment (MCI). …”
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Chronic Stress‐Induced and Tumor Derived SP1+ Exosomes Polarizing IL‐1β+ Neutrophils to Increase Lung Metastasis of Breast Cancer by Leyi Zhang, Jun Pan, Meijun Wang, Jini Yang, Sangsang Zhu, Lili Li, Xiaoxiao Hu, Zhen Wang, Liwei Pang, Peng Li, Fang Jia, Guohong Ren, Yi Zhang, Danying Xu, Fuming Qiu, Jian Huang

“…When exposed to chronic stress, exosomes released from neural and neuroendocrine cells in the central nervous system are enhanced and modified. However, whether tumor‐derived exosomes (TDEs) are influenced by chronic stress and participate in chronic stress‐mediated distant metastasis remains unclear. …”
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Early Outcomes from Proton Craniospinal Irradiation for Leptomeningeal Metastasis From Solid Tumors by Keng Lam, MD, Lewis F. Nasr, MD, Clark R. Andersen, MS, Kathryn E. Marqueen, MD, Jing Li, MD, PhD, Chenyang Wang, MD, Thomas H. Beckham, MD, PhD, Nazanin K. Majd, MD, PhD, Ashley E. Aaroe, MD, Monica Loghin, MD, Barbara J. O'Brien, MD, Susan L. McGovern, MD, PhD

“…Median overall survival and median central nervous system progression-free survival from the first day of pCSI were estimated using Kaplan-Meier survival curves. …”
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Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI by Hyeong-Geol Shin, Woojun Kim, Jung Hwan Lee, Hyun-soo Lee, Yoonho Nam, Jiwoong Kim, Xu Li, Peter C.M. van Zijl, Peter A. Calabresi, Jongho Lee, Jinhee Jang

“…Objectives: Susceptibility source-separation (χ-separation) MRI provides in-vivo proxy of myelin (diamagnetic susceptibility, χdia) and iron concentrations (paramagnetic susceptibility, χpara) in the central nervous system, potentially uncovering myelin- and iron-related pathology in multiple sclerosis (MS) lesions (e.g., demyelination, remyelination, and iron-laden microglia/macrophages formation). …”
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Real life outcome analysis of breast cancer brain metastases treated with Trastuzumab Deruxtecan by Alessandra Fabi, Alessandro Rossi, Roberta Caputo, Simona Pisegna, Simone Scagnoli, Francesco Pantano, Giuliana D’Auria, Palma Fedele, Agnese Fabbri, Claudio Vernieri, Michela Palleschi, Luisa Carbognin, Gianluigi Ferretti, Elena Di Monte, Ida Paris, Francesco Pavese, Ornella Garrone, Antonio Franco, Michelino De Laurentiis, Gianluca Franceschini, Giovanni Scambia, Diana Giannarelli, Riccardo Masetti, Andrea Botticelli

“…Abstract Tumor dissemination to the central nervous system (CNS) is almost a rule in the treatment journey of advanced HER2+ breast cancer (BC). …”
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Aluminum-Induced Alterations in Purinergic System Parameters of BV-2 Brain Microglial Cells by Charles Elias Assmann, Vitor Bastianello Mostardeiro, Grazielle Castagna Cezimbra Weis, Karine Paula Reichert, Audrei de Oliveira Alves, Vanessa Valéria Miron, Margarete Dulce Bagatini, Taís Vidal Palma, Cinthia Melazzo de Andrade, Micheli Mainardi Pillat, Fabiano Barbosa Carvalho, Cristina Ruedell Reschke, Ivana Beatrice Mânica da Cruz, Maria Rosa Chitolina Schetinger, Vera Maria Melchiors Morsch

“…The trivalent free Al anion (Al3+) can cross the blood-brain barrier (BBB), accumulate in the brain, and elicit harmful effects to the central nervous system (CNS) cells. Thus, evidence has suggested that Al increases the risk of developing neurodegenerative diseases, particularly Alzheimer’s disease (AD). …”
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European standard clinical practice recommendations for paediatric high-grade gliomas by Elwira Szychot, Géraldine Giraud, Darren Hargrave, Dannis van Vuurden, Jacques Grill, Veronica Biassoni, Maura Massimo, André O. Von Büren, Rejin Kebudi, Maria João Gil-da-Costa, Sophie Veldhuijzen van Zanten, Simon Bailey, Michael Karremann, Stephanie Bolle, Thankamma Ajithkumar, Mechthild Krause, Yasmin Lassen-Ramshad, Geert Janssens, Giovanni Morana, Ulrike Löbel, Shivaram Avula, Brigitte Bison, Maarten Lequin, Kristian Aquilina, Ulrich Thomale, Pelle Nilsson, Sami Bui-Quy Abu Hamdeh, Torsten Pietsch, Pascale Varlet, Thomas S. Jacques, Pieter Wesseling, David Jones, Uri Tabori, Anirban Das, David Mulligan, Francesca Kozmann, Christof M. Kramm

“…Paediatric high-grade gliomas (pedHGGs) are highly invasive brain tumours accounting for approximately 15 % of all central nervous system (CNS) tumours in children and adolescents. …”
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JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation by Shuyan Wu, Jundan Jiang, Danfeng Wang, Daoyi Lin, Mingxue Lin, Pinzhong Chen, Jianghu Chen, Honghong Zhang, Ying Wang, Xiaohui Chen, Xiaochun Zheng

“…Dysregulation of the JAK/STAT3 pathway in the central nervous system is associated with pain and brain inflammatory disorders, but its role in bone cancer pain (BCP) remains unclear. …”
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Characteristic alterations of gut microbiota and serum metabolites in patients with chronic tinnitus: a multi-omics analysis by Jiang Wang, Jia-Hui Xiang, Xu-Yuan Peng, Min Liu, Le-Jia Sun, Min Zhang, Li-Yuan Zhang, Zhi-Bin Chen, Zheng-Quan Tang, Lei Cheng

“…ABSTRACT Chronic tinnitus is a central nervous system disorder. Currently, the effects of gut microbiota on tinnitus remain unexplored. …”
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Increased Early‐Mortality in Children With Solid Tumors During the COVID‐19 Pandemic in a Middle‐Income Country by Oscar Ramirez, Vivian Piedrahita, Santiago Bolivar, Karina Grillo, Adriana Linares, Carlos Pardo, Martha Piña, Amaranto Suarez, Carlos A. Portilla, Jesus Ardila, Viviana Lotero, Luz A. Urcuqui, Angela Trujillo, Patricia Montenegro, Luis E. Bravo, Paula Aristizabal, VIGICANCER Working Group

“…Hematolymphoid, central nervous system, and extracranial solid tumors represented 57%, 15%, and 28% of patients, respectively. …”
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Effect of Different Doses of Intrathecal Nalbuphine as Adjuvant to Hyperbaric Bupivacaine on Characteristics of Subarachnoid Block in Pelvic and Lower Limb Orthopaedic Surgeries: A... by Anupama Kumari, Shraddha Jogani, Nilesh Shah, Sara Mary Thomas

“…It has less affinity and strength of depressant effects on myocardial and Central Nervous System (CNS) vital centers in pharmacodynamic studies, along with a superior pharmacokinetic profile. …”
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Manifestaciones neurológicas asociadas a la vacuna contra COVID-19 by R. Alonso Castillo, J.C. Martínez Castrillo

“…The most frequently reported adverse events were Bell's palsy 4936/13809 (35.7%), headache (4067/13809), cerebrovascular events 2412/13809 (17.47%), Guillain-Barré syndrome 868/13809 (6.28%), central nervous system demyelination 258/13809 (1.86%) and functional neurological disorder 398/13809 (2.88%). …”
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Exploring proteomic immunoprofiles: common neurological and immunological pathways in multiple sclerosis and type 1 diabetes mellitus by Fátima Cano-Cano, Almudena Lara-Barea, Álvaro Javier Cruz-Gómez, Francisco Martín-Loro, Laura Gómez-Jaramillo, María Carmen González-Montelongo, María Mar Roca-Rodríguez, Lucía Beltrán-Camacho, Lucía Forero, Javier J. González-Rosa, Mª Carmen Durán-Ruiz, Ana I. Arroba, Manuel Aguilar-Diosdado

“…Although the clinical symptoms of T1DM differ from those of MS, such as pancreatic β-cell failure in T1DM and demyelination in the central nervous system (CNS) in MS, both pathologies are considered as autoimmune-related diseases with shared pathogenic pathways, which include autophagy, inflammation and degeneration, among others. …”
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Neurological manifestations associated with COVID-19 vaccine by R. Alonso Castillo, J.C. Martínez Castrillo

“…The most frequently reported adverse events were Bell’s palsy 4936/13 809 (35.7%), headache (4067/13 809), cerebrovascular events 2412/13 809 (17.47%), Guillain-Barré syndrome 868/13 809 (6.28%), central nervous system demyelination 258/13 809 (1.86%) and functional neurological disorder 398/13 809 (2.88%). …”
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The role of smell in medical and psychological disorders: An interdisciplinary approach by Giuseppe Riva

“…Finally, central causes of smell alterations result from the damage of the olfactory processing pathways of the central nervous system, such as neurodegenerative diseases [1]. …”

Comparison of Hyperbaric 0.5% Levobupivacaine and Hyperbaric 0.75% Ropivacaine for Intrathecal Use in Infraumbilical Surgeries: A Randomised Clinical Study by Tejash H Sharma, Jagrati Jain, Priya Kishnani, Richa Tailor, Sara Mary Thomas

“…It has less affinity and strength of depressant effects on myocardial and Central Nervous System (CNS) vital centers in pharmacodynamic studies, along with a superior pharmacokinetic profile. …”
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SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors by Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova

“…Growing evidence suggests the significance of hepatic regulatory mechanisms in the neurobiology of central nervous system disorders, supporting the ‘liver-brain’ concept. …”
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