The role of olfactory transport in the penetration of manganese oxide nanoparticles from blood into the brain by A. V. Romashchenko, M. B. Sharapova, К. N. Morozova, E. V. Kiseleva, K. E. Kuper, D. V. Petrovskii

“…It is assumed that NPs can penetrate from blood into the central nervous system (CNS) only by breaking the blood–brain barrier (BBB). …”
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NRBF2 plays a crucial role in the acquisition process of learning and memory, independent of the Vps34 complex by Songfen Wu, Songfen Wu, Songfen Wu, Haicai Zhuang, Haicai Zhuang, Haicai Zhuang, Xidan Zhou, Kuan Li, Kuan Li, Kuan Li

“…Our results suggested that NRBF2 deletion impaired memory acquisition through an autophagy-independent pathway and provided novel insights into the role of NRBF2 in the central nervous system.DiscussionThis study offer new insights into the role of NRBF2 and highlight the potential of targeting NRBF2 as a therapeutic strategy for addressing cognitive deficits associated with various disorders.…”
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Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2/TLR4 Signaling Pathway by Chun Yang, Shengnan Sun, Qi Zhang, Jia Guo, Tengfei Wu, Ying Liu, Min Yang, Yan Zhang, Yinghua Peng

“…Exosomes are one of the important paracrine factors and have been reported as potential cell-free therapy for the treatment of autoimmune and central nervous system disorders. In this study, we examined exosomes derived from antler MSCs (AMSCs) of POCD rats after CPB and evaluated their potential regulatory mechanisms. …”
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The potential of stem cell therapy in Multiple Sclerosis treatment: a review by Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham

“…Multiple Sclerosis is an autoimmune and neurodegenerative disease of the central nervous system. There are currently 2.8 million people living with Multiple Sclerosis worldwide, including 9000 people in Ireland, with a prevalence of 193 per 100,000 people. …”
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Unraveling the heterogeneity of WHO grade 4 gliomas: insights from clinical, imaging, and molecular characterization by Haihui Jiang, Xijie Wang, Xiaodong Chen, Shouzan Zhang, Qingsen Ren, Mingxiao Li, Ming Li, Xiaohui Ren, Song Lin, Yong Cui

“…Abstract Purpose The 2021 WHO classification of central nervous system tumors introduced molecular criteria to stratify Grade 4 gliomas, which remain heterogeneous. …”
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Does Clostridium Perfringens Epsilon Toxin Mimic an Auto-Antigen Involved in Multiple Sclerosis? by Marie-Lise Gougeon, Valérie Seffer, Cezarela Hoxha, Elisabeth Maillart, Michel R. Popoff

“…Multiple sclerosis (MS) is a chronic immune-mediated neurological disorder, characterized by progressive demyelination and neuronal cell loss in the central nervous system. Many possible causes of MS have been proposed, including genetic factors, environmental triggers, and infectious agents. …”
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Infection with Toxoplasma gondii triggers coagulation at the blood-brain barrier and a reduction in cerebral blood flow by Evelyn M. Hoover, Christine A. Schneider, Christian Crouzet, Tatiane S. Lima, Dario X. Figueroa Velez, Cuong J. Tran, Dritan Agalliu, Sunil P. Gandhi, Bernard Choi, Melissa B. Lodoen

“…Recent work has demonstrated that Toxoplasma gondii infects and lyses central nervous system (CNS) endothelial cells that form the blood-brain barrier (BBB). …”
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Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential by Mi-bo Tang, Yi-xuan Liu, Zheng-wei Hu, Hai-yang Luo, Shuo Zhang, Chang-he Shi, Yu-ming Xu, Yu-ming Xu, Yu-ming Xu

“…Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), which is highly expressed in the central nervous system, is known to be involved in the regulation of mitochondrial biosynthesis, metabolic regulation, neuroinflammation, autophagy, and oxidative stress. …”
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68Ga-NOTA-RM26 PET/CT in the evaluation of glioma: a pilot prospective study by Yilin Li, Rongxi Wang, Jingci Chen, Zhaohui Zhu, Yu Wang, Wenbin Ma

“…Abstract Background Gliomas are the most common malignant primary tumors of the central nervous system. There is an urgent need for new convenient, targeted and specific imaging agents for gliomas. …”
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Impact of fluoxetine exposure on Lymnaea stagnalis and its developing eggs: integrating untargeted lipidomics, targeted metabolomics, and classical risk assessment by Diana Ilyaskina, Yumi Nakadera, Yumi Nakadera, Marja H. Lamoree, Joris M. Koene, Pim E. G. Leonards

“…Snails were exposed to a range of 51–434 µg fluoxetine L⁻1 for 7 days, followed by analysis of survival, feeding behaviour, reproduction, and metabolomic changes in the central nervous system (CNS), albumen gland, and eggs. Although no significant effects were observed on survival or fecundity, fluoxetine exposure significantly impaired egg development in a dose-dependent manner, reducing hatching rates with an EC50 of 126 µg fluoxetine L⁻1. …”
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Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice by Wei Song, Zi-ming Zhou, Le-le Zhang, Hai-feng Shu, Jin-ru Xia, Xia Qin, Rong Hua, Yong-mei Zhang

“…Activated microglia in the central nervous system (CNS) and infiltration of peripheral immune cells contribute to dopaminergic neuron loss. …”
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Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations by Ru Bai, Shuang Liu, Yueyin Zhao, Yuqi Cheng, Shu Li, Aiyun Lai, Zhongqi Xie, Xinyu Xu, Zhaoping Lu, Jian Xu

“…We concluded that the high prevalence of depression and anxiety and the association between depression and SLE disease activity might reveal the covert damage of central nervous system in SLE. The role of anti-P0 antibody in SLE patients with emotional disorders warrants more researches.…”
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Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice by Yinshan Tang, Shujun Shao, Yu Guo, You Zhou, Jin Cao, Anping Xu, Jihong Wu, Zhigang Li, Dulian Xiang

“…Excessive expression of BACE1 might cause overproduction of neurotoxins in the central nervous system. Previous studies indicated that BACE1 initially cleaves the amyloid precursor protein (APP) and may subsequently interfere with physiological functions of proteins such as PKA, which is recognized to be closely associated with long-term potentiation (LTP) level and can effectively ameliorate cognitive impairments. …”
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Pretreatment of Ascorbic Acid Inhibits MPTP-Induced Astrocytic Oxidative Stress through Suppressing NF-κB Signaling by Xiaokang Zeng, Kai Xu, Ji Wang, Yunqi Xu, Shaogang Qu

“…Astrocytes are a major constituent of the central nervous system (CNS). Astrocytic oxidative stress contributes to the development of Parkinson’s disease (PD). …”
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Advances in tissue engineering of peripheral nerve and tissue innervation – a systematic review by Jayson Sueters, Rowan van Heiningen, Ralph de Vries, Zeliha Guler, Judith Huirne, Theo Smit

“…Original in vivo or in vitro studies meeting the inclusion criteria (tissue-engineered peripheral nerve/innervation of tissue) and no exclusion criteria (no full text available; written in foreign language; nonoriginal article; tissue-engineering of central nervous system; publication before 2012; insufficient study quality or reproducibility) were assessed. …”
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Age-related aspects of glioma: current understanding. Literature review by Serhii P. Luhovskyi, Tetiana Y. Kvitnytska-Ryzhova

“… The updated 2021 WHO Classification of Central Nervous System (CNS) Tumors introduces, for the first time, an age-based approach to glioma classification, leveraging advances in molecular biology and epigenetics of CNS tumors. …”
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Diabetes insipidus and Guillain-Barré-like syndrome following CAR-T cell therapy: a case report by Christian Koch, Patrick Roth, Juliane Fleischer, Todor Popov, Karl Frontzek, Bettina Schreiner, Markus G. Manz, Simone Unseld, Antonia M. S. Müller, Norman F. Russkamp

“…Furthermore, safety data on CAR-T cell therapy in patients with central nervous system (CNS) lymphoma remain limited.Main body We here report occurrence of a Guillain-Barré-like syndrome (GBS) and central diabetes insipidus (cDI) following tisagenlecleucel therapy for relapsed high-grade lymphoma with CNS involvement. …”
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Transcription factor DREF regulates expression of the microRNA gene <i>bantam in Drosophila melanogaster</i> by M. B.  Schwartz, M. M. Prudnikova, O. V. Andreenkov, E. I. Volkova, I. F. Zhimulev, O. V. Antonenko, S.  A. Demakov

“…This microRNA is involved in the control of normal development of the ocu lar and wing imaginal discs, the central nervous system, and also in maintaining the undifferentiated state of stem cells in the ovaries of adult females. …”
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Alexithymia in multiple sclerosis: past, present and future by Samar S. Ayache, Samar S. Ayache, Samar S. Ayache, Samar S. Ayache, Moussa A. Chalah, Moussa A. Chalah, Moussa A. Chalah

“…In multiple sclerosis (MS), an autoimmune disease of the central nervous system, alexithymia seems to occur in up to 53% of patients. …”
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Comparative transcriptome analysis reveals a serotype-specific immune response in Nile tilapia (Oreochromis niloticus) infected with Streptococcus agalactiae by Renan José Casarotto Appel, Renan José Casarotto Appel, Karine Nicole Siqueira, Ioannis Konstantinidis, Maria Isabel Mello Martins, Rajesh Joshi, Lucienne Garcia Pretto-Giordano, Laurival Antônio Vilas-Boas, Jorge Manuel de Oliveira Fernandes, Jorge Manuel de Oliveira Fernandes

“…The serotype Ib strain seems promptly recognized by the host, triggering a potent inflammatory response, whereas the serotype III strain elicited a less immediate response, resulting in more pronounced central nervous system (CNS) symptoms and behavioral effects. …”
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