The Economic and Humanistic Burden of Pediatric-Onset Multiple Sclerosis by Nupur Greene, Lita Araujo, Cynthia Campos, Hannah Dalglish, Sarah Gibbs, Irina Yermilov

“…**Background:** Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system. Pediatric-onset MS (POMS), defined as onset of MS before 18 years of age, is estimated to account for 2% to 5% of the MS population worldwide. …”
Get full text

Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons by Anne-Emilie Allain, Hervé Le Corronc, Alain Delpy, William Cazenave, Pierre Meyrand, Pascal Legendre, Pascal Branchereau

“…γ-aminobutyric acid (GABA) acting on Cl−-permeable ionotropic type A (GABAA) receptors (GABAAR) is the major inhibitory neurotransmitter in the adult central nervous system of vertebrates. In immature brain structures, GABA exerts depolarizing effects mostly contributing to the expression of spontaneous activities that are instructive for the construction of neural networks but GABA also acts as a potent trophic factor. …”
Get full text

Coordinated human-exoskeleton locomotion emerges from regulating virtual energy. by Rezvan Nasiri, Hannah Dinovitzer, Nirosh Manohara, Arash Arami

“…These findings may have implications for understanding how the central nervous system controls our locomotion.…”
Get full text

Tppp3 is a novel molecule for retinal ganglion cell identification and optic nerve regeneration by Mishal Rao, Ziming Luo, Chia-Chun Liu, Chi-Yu Chen, Shining Wang, Michael Nahmou, Bogdan Tanasa, Aman Virmani, Leah Byrne, Jeffrey L. Goldberg, José-Alain Sahel, Kun-Che Chang

“…Abstract Mammalian central nervous system (CNS) axons cannot spontaneously regenerate after injury, creating an unmet need to identify molecular regulators to promote axon regeneration and reduce the lasting impact of CNS injuries. …”
Get full text

Extracellular Vesicles as Tools for Crossing the Blood–Brain Barrier to Treat Lysosomal Storage Diseases by Giovanni Lerussi, Verónica Villagrasa-Araya, Marc Moltó-Abad, Mireia del Toro, Guillem Pintos-Morell, Joaquin Seras-Franzoso, Ibane Abasolo

“…Extracellular vesicles (EVs) are nanosized, membrane-bound structures that have emerged as promising tools for drug delivery, especially in the treatment of lysosomal storage disorders (LSDs) with central nervous system (CNS) involvement. This review highlights the unique properties of EVs, such as their biocompatibility, capacity to cross the blood–brain barrier (BBB), and potential for therapeutic cargo loading, including that of enzymes and genetic material. …”
Get full text

Predictors of recurrent febrile seizure in children aged from 6 months to 5 years: A cross-sectional study by Anand Muttath, Thomas Antony, Rati Santhakumar, Rose Xavier, Jassal Mathew

“…Clinical evaluations ruled out central nervous system infections and fever causes were diagnosed per ICD-10 at discharge. …”
Get full text

Mycobacterium spp. exposure, childhood vaccinations, and early childhood brain and CNS cancers by Samer Singh, Rakesh K. Singh

“…Globally, with improvements in general hygiene, the incidence of early childhood (0-4Y-olds/<5Y-olds) brain and central nervous system (BCNS) cancers is increasing. Although immunological underpinning is suspected, the identification of protective variables for the majority of BCNS cancer cases remains elusive. …”
Get full text

Task-Driven Neurophysiological qEEG Baseline Performance Capabilities in Healthy, Uninjured Division-I College Athletes. by Robert E. Mangine, Thomas G. Palmer, James A. Tersak, Michael Mark, Joseph F Clark, Marsha Eifert-Mangine, Audrey Hill-Lindsay, Brian M Grawe

“…Orthopedic functional assessments used to monitor the neuroplastic properties of the central nervous system lack objectivity and/or pertinent functionality specific to sport. …”
Get full text

Case report: Dysphonia associated with high-dose cytarabine therapy by Ling Ma, Niya Huang, Haixi Zhang, Jia Liu, Zhiqing Zhang

“…Additionally, it can cause central nervous system (CNS) symptoms, which include hoarseness, ataxic tremor, ataxic gait, nystagmus, dysmetria, and dysdiadochokinesia. …”
Get full text

NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation by Agata Habas, Srinivasa Reddy Natala, Jon K. Bowden-Verhoek, Emily M. Stocking, Diana L. Price, Wolfgang Wrasidlo, Douglas W. Bonhaus, Martin B. Gill

“…Among TLR subtypes, both TLR2 and TLR9 have been implicated in neurodegenerative disorders with increased expression of these receptors in the central nervous system being associated with pro-inflammatory signaling and increased burdens of pathologic aggregated proteins. …”
Get full text

Dose Effect Evaluation and Therapeutic Window of the Neuro-EPO Nasal Application for the Treatment of the Focal Ischemia Model in the Mongolian Gerbil by Iliana Sosa Teste, Yuneidys Mengana Tamos, Yamila Rodríguez Cruz, Adriana Muñoz Cernada, Janette Cruz Rodríguez, Nelvis Subirós Martínez, Rosa Maria Coro Antich, Alina González-Quevedo, Julio Cesar García Rodríguez

“…The aim of this study was to determine the Neuro-EPO delivery into the central nervous system (CNS) to exert a neuroprotective effect in cerebral ischemia model of the Mongolian gerbil. …”
Get full text

Evaluation of GABAergic Transmission Modulation as a Novel Functional Target for Management of Multiple Sclerosis: Exploring Inhibitory Effect of GABA on Glutamate-Mediated Excitot... by Ankit A. Gilani, Ranjeet Prasad Dash, Mehul N. Jivrajani, Sandeep Kumar Thakur, Manish Nivsarkar

“…Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS) where the communication ability of nerve cells in the brain and spinal cord with each other gets impaired. …”
Get full text

Lipidopathy disrupts peripheral and central amyloid clearance in Alzheimer's disease: Where are our knowledge by Shahram Darabi, Enam Alhagh Charkhat Gorgich, Fatemeh Moradi, Auob Rustamzadeh

“…Disruptions in these processes contribute to the accumulation of Aβ in the central nervous system (CNS) and the progression of AD. Recent research emphasizes the need for a broader focus on the systemic effects of organs outside the brain, particularly in the context of AD prevention and treatment. …”
Get full text

ANALYSIS OF FRACTIONAL ANISOTROPY (FA) VALUES AND APPARENT DIFFUSION COEFFICIENT (ADC) VALUES IN ISCHEMIC STROKE DISEASES OF MRI GE 3 TESLA by Ali Mustofa, Anggraini Dwi Sensusiati, Muhaimin Muhaimin, Sri Andreani Utomo, Risalatul Latifah

“…Whereas, Diffusion Tensor Imaging (DTI) shows connectivity’s of central nervous system that cannot be seen by using conventional MRI. …”
Get full text

Unmasking the Area Postrema on MRI: Utility of 3D FLAIR, 3D-T2, and 3D-DIR Sequences in a Case–Control Study by Javier Lara-García, Jessica Romo-Martínez, Jonathan Javier De-La-Cruz-Cisneros, Marco Antonio Olvera-Olvera, Luis Jesús Márquez-Bejarano

“…A case–control study included 35 patients with MS and 35 with other non-demyelinating central nervous system diseases (ND-CNSD). MRI images were acquired employing 3D DIR, 3D FSE Cube FLAIR, and 3D FSE Cube T2WI sequences. …”
Get full text

Improvement in Impaired Social Cognition but Not Seizures by Everolimus in a Child with Tuberous Sclerosis-Associated Autism through Increased Serum Antioxidant Proteins and Oxidan... by Kunio Yui, George Imataka, Hitomi Sasaki, Yohei Kawasaki, Tohru Okanshi, Ryoichi Shiroki, Shigemi Yoshihara

“…Everolimus had no effect on TSC-related epileptiform discharges, and thus, the autistic symptoms and epileptic activity may be two independent end results of a common central nervous system disorder including mTOR hyperactivity. …”
Get full text

The Angiotensin-Melatonin Axis by Luciana A. Campos, Jose Cipolla-Neto, Fernanda G. Amaral, Lisete C. Michelini, Michael Bader, Ovidiu C. Baltatu

“…Angiotensin production in the central nervous system may not only influence hypertension but also appears to affect the circadian rhythm of blood pressure. …”
Get full text

Clothianidin and Thiacloprid Mixture Administration Induces Degenerative Damage in the Dentate Gyrus and Alteration in Short-Term Memory in Rats by Alejandra Mora-Gutiérrez, Jorge Guevara, Carmen Rubio, Minerva Calvillo-Velasco, Daniela Silva-Adaya, Socorro Retana-Márquez, Blanca Espinosa, Carmen Martínez-Valenzuela, Moisés Rubio-Osornio

“…Neonicotinoids are pesticides that act as agonists of nicotinic receptors for acetylcholine in insects’ central nervous system (CNS). Chronic exposure to neonicotinoids in humans is related to autism, memory loss, and finger tremor. …”
Get full text

MeHg Causes Ultrastructural Changes in Mitochondria and Autophagy in the Spinal Cord Cells of Chicken Embryo by Fabiana F. Ferreira, Evelise M. Nazari, Yara M. R. Müller

“…Methylmercury (MeHg) is a known neurodevelopmental toxicant, which causes changes in various structures of the central nervous system (CNS). However, ultrastructural studies of its effects on the developing CNS are still scarce. …”
Get full text

The case of Kinsburn’s Encephalopathy in a child with neuroblastoma of posterior mediastinum by T.I. Stetsenko, H.M. Fedushka, S.O. Rebenkov, T.P. Ivanova

“…Opsoclonus-myoclonus-ataxia syndrome (OMAS) is an autoimmune rare disease of the central nervous system with lesion of the cerebellum and its ligaments. …”
Get full text