Hemophagocytic Syndrome-Associated Variant of Methotrexate-Associated Intravascular Large B-Cell Lymphoma in a Rheumatoid Arthritis Patient by Yukiko Komeno, Minako Akiyama, Yasumi Okochi, Hitoshi Tokuda, Keiko Abe, Kuniko Iihara, Tomiko Ryu

“…Magnetic resonance imaging revealed focal infarctions in the cerebellum and around the left lateral ventricle. Central nervous system relapse was suspected. Although salvage chemotherapy (CHASER), whole brain irradiation, and intrathecal injection of cytarabine and prednisolone were temporarily effective, he died. …”
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Genetic Variations of Gene Associated with Adverse Drug Reactions to Valproic Acid in Korean Epileptic Patients by Ji Hyun Yi, Yang-Je Cho, Won-Joo Kim, Min Goo Lee, Ji Hyun Lee

“…The multidrug resistance protein 2 (MRP2, ABCC2) gene may determine individual susceptibility to adverse drug reactions (ADRs) in the central nervous system (CNS) by limiting brain access of antiepileptic drugs, especially valproic acid (VPA). …”
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Effect of Zbtb33 gene knockout and bacterial lipopolysaccharide on home cage behavior in mice by N. V. Khotskin, I. E. Sorokin, E. A. Kulikova, A. V.  Kulikov

“…Despite the fact that Kaiso is intensively expressed in the central nervous system, its participation in the regulation of behavior is still poorly understood. …”
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A Role of Fluoride on Free Radical Generation and Oxidative Stress in BV-2 Microglia Cells by Xi Shuhua, Liu Ziyou, Yan Ling, Wang Fei, Guifan Sun

“…Our present study demonstrated that toxic effects of fluoride on the central nervous system possibly partly ascribed to activiting of microglia, which enhanced oxidative stress induced by ROS and reactive nitrogen species.…”
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COVID-19 encephalopathy with severe neurological symptoms: a clinical case presentation with literature review by G. Baranauskienė, N. Tutlienė, G. Kaubrys

“…Encephalopathy is singled out as one of the most severe complications of the central nervous system caused by SARS-CoV-2 virus and associated with longer duration of the disease, increased disability, and mortality. …”
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Aspects of Growth Hormone and Insulin-Like Growth Factor-I Related to Neuroprotection, Regeneration, and Functional Plasticity in the Adult Brain by N. David Åberg, Katarina Gustafson Brywe, Jörgen Isgaard

“…Plasticity in the central nervous system (CNS) may be viewed as changes in the functional interplay between the major cell types, neurons, astrocytes, and oligodendrocytes. …”
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A machine learning approach for predicting treatment response of hyponatremia by Tamaki Kinoshita, Shintaro Oyama, Daisuke Hagiwara, Yoshinori Azuma, Hiroshi Arima

“…Hyponatremia leads to severe central nervous system disorders and requires immediate treatment in some cases. …”
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[18F]FDG PET-Based Radiomics and Machine Learning for the Assessment of Gliomas and Glioblastomas: A Systematic Review by Francesco Dondi, Roberto Gatta, Maria Gazzilli, Pietro Bellini, Gian Luca Viganò, Cristina Ferrari, Antonio Rosario Pisani, Giuseppe Rubini, Francesco Bertagna

“…Signatures, including radiomics analysis and ML, generally demonstrated a possible diagnostic value to assess different characteristics of gliomas and GBMs, such as the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter, the isocitrate dehydrogenase (IDH) genotype, alpha thalassemia/mental retardation X-linked (ATRX) mutation status, proliferative activity, differential diagnosis with solitary brain metastases or primary central nervous system lymphoma, and prognosis of these patients. …”
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Adrenal Disorders and the Paediatric Brain: Pathophysiological Considerations and Clinical Implications by Vincenzo Salpietro, Agata Polizzi, Gabriella Di Rosa, Anna Claudia Romeo, Valeria Dipasquale, Paolo Morabito, Valeria Chirico, Teresa Arrigo, Martino Ruggieri

“…The development and maturation of the central nervous system (CNS) through childhood is tightly regulated by intrinsic, paracrine, endocrine, and external modulators, and perturbations in any of these factors, including those related to adrenal hormone imbalance, could result in consequences that affect the structure and function of the paediatric brain. …”
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Therapeutic Drug Monitoring-Guided Linezolid Therapy for the Treatment of Multiple Staphylococcal Brain Abscesses in a 3-Month-Old Infant by Anna Cascone, Maia De Luca, Raffaele Simeoli, Bianca Maria Goffredo, Laura Cursi, Costanza Tripiciano, Lorenza Romani, Stefania Mercadante, Martina Di Giuseppe, Francesca Ippolita Calo Carducci, Davide Luglietto, Paola Bernaschi, Laura Lancella

“…Brain abscesses are invasive infections of the central nervous system with a high level of treatment complexity especially in pediatric patients. …”
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Cost-effectiveness of oral versus injectable disease modifying therapies in relapsing multiple sclerosis: a systematic review analysis by Mehdi Rezaee, Ramin Ravangard, Seyyed Morteza Mojtabaeian, Abdosaleh Jafari

“…Abstract Background Multiple sclerosis (MS) is a chronic and progressive neurological autoimmune disease that affects the central nervous system. There are two types of drugs used to treat this disease: injectable and oral drugs. …”
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Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents by Lili Wen, Yang Huang, Xianbiao Xie, Wan Huang, Junqiang Yin, Wenqian Lin, Qiang Jia, Weian Zeng

“…The antinociceptive activities were evaluated by acetic acid-induced writhing, formalin, and hot-plate tests; open-field test investigated effects on the central nervous system. Our data showed that bufalin (0.3 and 0.6 mg/kg, i.p.) potently decreased carrageenan-induced paw edema. …”
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Antimicrobial Properties of α-MSH and Related Synthetic Melanocortins by A. Catania, G. Colombo, C. Rossi, A. Carlin, A. Sordi, C. Lonati, F. Turcatti, P. Leonardi, P. Grieco, S. Gatti

“…Several properties of α-melanocyte stimulating hormone (α-MSH) suggested that it could be a natural antimicrobial peptide. α-MSH is a primordial peptide that appeared during the Paleozoic era, long before adaptive immunity developed and, like natural antimicrobial molecules, is produced by barrier epithelia, immunocytes, and within the central nervous system. α-MSH was discovered to have antimicrobial activity against two representative pathogens, Staphylococcus aureus and Candida albicans. …”
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Kejadian Gangguan Depresi pada Penderita HIV/AIDS yang Mengunjungi Poli VCT RSUP Dr. M. Djamil Padang Periode Januari - September 2013 by Yaslinda Yaunin, Rudi Afriant, Nurul Maulidya Hidayat

“…Etiology may be cause of psychososcial factor or the effect of HIV agent that infected central nervous system. In order to prevent depression disorders is by the utilization VCT (Voluntary Counseling and Testing) Clinic This study aims to describe the incident rate of depressive disorder among people living with HIV/AIDS visited VCT clinic at RSUP DR. …”
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Actin Alpha 2 (ACTA2) Downregulation Inhibits Neural Stem Cell Migration through Rho GTPase Activation by Ji Zhang, Xuheng Jiang, Chao Zhang, Jun Zhong, Xuanyu Fang, Huanhuan Li, Fangke Xie, Xiaofei Huang, Xiaojun Zhang, Quan Hu, Hongfei Ge, Anyong Yu

“…Although neural stem cells (NSCs) could migrate towards lesions after central nervous system (CNS) injury, the migration ability always is restricted due to the disturbed composition and density of the adhesion ligands and extracellular matrix (ECM) gradient after CNS injury. …”
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SDF-1/CXCR4 Signaling Maintains Stemness Signature in Mouse Neural Stem/Progenitor Cells by Shih-Yin Ho, Thai-Yen Ling, Hsing-Yu Lin, Jeffrey Tsai-Jui Liou, Fei-Chih Liu, I-Chun Chen, Sue-Wei Lee, Yu Hsu, Dar-Ming Lai, Horng-Huei Liou

“…SDF-1 and its primary receptor, CXCR4, are highly expressed in the embryonic central nervous system (CNS) and play a crucial role in brain architecture. …”
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Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection by Thais F. C. Fraga-Silva, Luiza A. N. Mimura, Camila M. Marchetti, Fernanda Chiuso-Minicucci, Thais G. D. França, Sofia F. G. Zorzella-Pezavento, James Venturini, Maria S. P. Arruda, Alexandrina Sartori

“…Multiple sclerosis (MS) is an inflammatory/autoimmune disease of the central nervous system (CNS) mainly mediated by myelin specific T cells. …”
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Sindrom Koroner Akut dengan Komplikasi Udem Paru Akut dan Henti Jantung by Eka Fithra Elfi

“…Disorders of the central nervous system iss the cause of high<br />mortality in patients who survived cardiac arrest and resuscitation. …”
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Gut Microbiota and Its Impact on Brain Function and Mental Health by Zofia Martyna Wójcik, Katarzyna Kamińska-Omasta, Bartosz Omasta, Olga Krupa, Paulina Dorota Pietrukaniec, Kuba Borys Romańczuk, Kinga Furtak, Szymon Przemysław Stolarczyk, Magdalena Agata Czerska, Daria Rybak

“…Recent research reveals that microbiota not only supports metabolic and immune functions but also influences central nervous system (CNS) regulation via the gut-brain axis, a two-way communication system. …”
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Assessing the antiproliferative effect of biogenic silver chloride nanoparticles on glioblastoma cell lines by quantitative image‐based analysis by Nathalia Müller, Mateus Eugenio, Luciana F. Romão, Jorge Marcondes de Souza, Soniza V. Alves‐Leon, Loraine Campanati, Celso Sant’Anna

“…Abstract Glioblastoma is the most life‐threatening tumour of the central nervous system. Temozolomide (TMZ) is the first‐choice oral drug for the treatment of glioblastoma, although it shows low efficacy. …”
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