Clinical Manifest X-Linked Recessive Adrenoleukodystrophy in a Female by Gyda Hlin Skuladottir Jack, Karolina Malm-Willadsen, Anja Frederiksen, Dorte Glintborg, Marianne Andersen

“…The intracellular accumulation of VLCFA leads to demyelination in the central nervous system (CNS) and cell destruction in the adrenal glands. …”
Get full text

Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco by Rachad Alnamer, Katim Alaoui, El Houcine Bouidida, Abdelaziz Benjouad, Yahia Cherrah

“…We evaluate the sedative and hypnotic activities of the methanolic and aqueous extract of Lavandula officinalis L. on central nervous system (CNS). In this study, the effect of the methanolic and aqueous extracts of this plant was investigated in a battery of behavioural models in mice. …”
Get full text

Movement disorders in autoimmune encephalitis: Clinical spectrum, prognosis, and outcomes from an Indian cohort by Shreyashi Jha, Netravathi M, Vikram Venkappayya Holla, Nitish Kamble, Anita Mahadevan, Pramod Kumar Pal

“…BACKGROUND: Antibody-mediated autoimmune encephalitis (AE) encompasses inflammatory central nervous system disorders linked etiologically with neuronal autoantibodies. …”
Get full text

Pediatric Extramedullary Epidural Spinal Teratomas: A Case Report and Review of the Literature by David G. Deckey, Andrea Fernandez, Nina J. Lara, Steve Taylor, Jamal McClendon, David M. Bennett

“…Pediatric intraspinal teratomas, however, are an exceedingly rare central nervous system (CNS) neoplasm. The clinical presentation of these intraspinal neoplasms can vary significantly and thus can be difficult to identify in infants less than one year of age where verbal expression and motor development are still lacking. …”
Get full text

Intraventricular Neurilemmoma (Schwannoma): Shall GFAP Immunostaining Be Regarded as a Histogenetical Tag or as a Mere Histomimetical Trait? by Miguel Fdo. Salazar, Martha Lilia Tena Suck, Daniel Rembao Bojórquez, Citlaltepetl Salinas Lara

“…Neurilemmomas are benign neoplasms presumedly derived from Schwann cells which rarely originate within the central nervous system. Moreover, their intraventricular location has been seldom noticed with less than 30 cases reported worldwide. …”
Get full text

Mechanisms of Cancer-Induced Bone Pain by Wang X, Li L, Wang Y

“…When tumor cells produce inflammatory mediators that acidify the microenvironment or damage nerve endings, the spinal cord becomes excessively stimulated, resulting in increased or prolonged pain signals that propagate to the higher central nervous system through the ascending pathway. There are substantial differences in the pain generation mechanisms between CIBP and common inflammatory and neuropathic pain. …”
Get full text

Interaction of the Gut-Liver-Brain Axis and the sterolbiome with sexual dysfunction in patients with cirrhosis by Spencer C. Harris, Jasmohan S. Bajaj

“…There is a complex interplay between the gut microbes, liver, and central nervous system, a gut-liver-brain axis, where the brain impacts intestinal and hepatic function while the gut and liver can impact cognition and mental status. …”
Get full text

Pediatric Multiple Sclerosis—A Challenging Demyelinating Disease: Case Report and Brief Review of the Literature by Regina Célia Ajeje Pires de Albuquerque, Raquel Siqueira Leonel de Paula, Manuelina Mariana Capellari Macruz Brito, José Roberto Lopes Ferraz Filho, Lucas Crociati Meguins

“…Multiple sclerosis (MS) is an inflammatory, demyelinating, neurodegenerative disorder of the central nervous system (CNS) of unknown etiology. The peak onset is between age 20 and 40 years and usually affects more women than men. …”
Get full text

Epidural abscess formation after chemotherapy for breast cancer: a case report and literature review by Youzhi An, Lili Li, Qingning Liu, Zhen Zhang, Xuelin Lin

“…IntroductionSpinal epidural abscess is a rare infectious lesion of the central nervous system. Here, we report a rare case of a thoracic suppurative epidural abscess in a female patient who developed incomplete paralysis of both lower limbs after chemotherapy for breast cancer. …”
Get full text

Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges by Kamran Sheikhi, Salah Ghaderi, Hassan Firouzi, Sarvenaz Rahimibarghani, Ehsan Shabani, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami, Aref Yarahmadi

“…Multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, and cognitive dysfunction. …”
Get full text

Modern approaches to production of safe and effective genetically modified rabies vaccines for animals by M. I. Doronin, A. Mazloum, D. V. Mikhalishin, M. N. Mitrofanova, A. Yu. Sukharkov, V. V. Kiseleva, A. V. Sprygin

“…Rabies is a dangerous zoonoticdisease that affects the central nervous system, causes encephalomyelitis and paralyses and Is almost invariably fatal. …”
Get full text

Incontinentia Pigmenti Misdiagnosed as Neonatal Herpes Simplex Virus Infection by Fahimeh Abdollahimajd, Minoo Fallahi, Mohammad Kazemian, Yalda Nilipour, Mitra Radfar, Sedigheh Tahereh Tehranchi

“…Neonatal herpes simplex virus (HSV) infection can be manifested in 3 forms: localized, disseminated, and central nervous system (CNS) involvement. Timely diagnosis and treatment of neonatal HSV infection is critical. …”
Get full text

Measuring the Effect of Vision on the Synergy of Lower Extremity Muscles during Walking using Nonnegative Matrix Factorization (NNMF) Algorithm Method by Nasim Safari, Mahboubeh Alemzadeh, Mahdi Majlesi, Nader Farahpour, Muharram Mansoorizadeh

“…Lack of visual information in blind people during walking can affect the choice of muscle synergy from among the many incoming messages that reach the central nervous system (CNS). This study aimed to determine the effect of vision on the synergy of lower limb muscles during walking using the nonnegative matrix factorization algorithm (NNMF). …”
Get full text

Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats by Shu Zhu, Dongyu Min, Jianhong Zeng, Yetao Ju, Yao Liu, Xu Chen

“…Since SHED are homologous to the central nervous system, they possess superior capacity to differentiate into neural cells. …”
Get full text

Mechanism of Nerve Regeneration after Ischemic Stroke Induced by Exercise Intervention by TENG Lili, ZHANG Mei, SONG Wenjing, ZHU Luwen

“…Based on the plasticity of the central nervous system, exercise intervention can play a neuroprotective role in the brain through multi-levels, multi-pathways and multi-targets, such as regulating synaptic budding, connection and transmission efficiency, improving the functional connection between regenerative axons and target cells, promoting angiogenesis and protecting the integrity of neurovascular units, regulating related inhibitory nerve regeneration factors, and inducing the expression of various nerve growth factors related to nerve regeneration and promoting the proliferation of neural stem cells, so as to participate in the regulation of central nervous rege-neration environment, and improve the damaged nerve function after ischemia.…”
Get full text

Intrathecal Immunoglobulin A Synthesis in Multiple Sclerosis: From Biological Aspects to Clinical Relevance by Dariia Kliushnikova, Ferdinand Otto, Georg Pilz, Peter Wipfler, Andrea Harrer

“…Recent observations, however, highlight the migration of immune regulatory IgA-producing plasma cells from the gut to the central nervous system (CNS) in experimental autoimmune encephalitis models. …”
Get full text

The effect of space flight on genes expression in brain by A. S. Tsybko, T. V. Ilchibaeva, N. K. Popova

“…Thus, the data obtained from the flight of the Bion-M1 biosatellite for the first time allowed for creating a molecular genetic basis for the currently known neurophysiological mechanisms of adaptation of the central nervous system to the state of weightlessness.…”
Get full text

Cycloastragenol promotes dorsal column axon regeneration in mice by Tao Zihan, Tao Zihan, Teng Wenwen, Teng Wenwen, Ma Yanxia, Saijilafu

“…However, whether CAG can activate axon regeneration central nervous system (CNS) remains unknown.MethodsHere, we established a novel mouse model for visualizing spinal cord dorsal column axon regeneration involving the injection of AAV2/9-Cre into the lumbar 4/5 dorsal root ganglion (DRG) of Rosa-tdTomato reporter mice. …”
Get full text

The putative role of immune-inflammatory mechanisms in nociplastic pain pathways: a narrative review by Mariateresa Giglio, Alberto Corriero, Angela Preziosa, Giustino Varrassi, Filomena Puntillo

“…This type of pain is usually multifocal, more diffuse or intense than expected and it is usually associated with other central nervous system-derived symptoms, such as fatigue, sleep, memory, and mood problems. …”
Get full text

High-Risk Microgranular Acute Promyelocytic Leukemia with a Five-Way Complex Translocation Involving PML-RARA by Benjamin Powers, Diane Persons, Deepthi Rao, Janet Woodroof, Tara L. Lin

“…Given his elevated white blood cell count at presentation, intrathecal chemotherapy for central nervous system prophylaxis was also given. The patient remains on maintenance therapy and remains in remission. …”
Get full text