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501
miRNA changes associated with differentiation of human embryonic stem cells into human retinal ganglion cells
Published 2024-12-01“…Retinal ganglion cells (RGC), whose axons connect the eye to the brain, are central nervous system cells of great interest, yet their study is largely restricted to animals due to the difficulty in obtaining healthy human RGC. …”
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502
Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models
Published 2016-01-01“…Epigenetic mechanisms play a role in human disease but their involvement in pathologies from the central nervous system has been hampered by the complexity of the brain together with its unique cellular architecture and diversity. …”
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503
The Optimal Management of Acute Febrile Encephalopathy in the Aged Patient: A Systematic Review
Published 2016-01-01“…Acute change in mental status from baseline is commonly seen among the elderly even when the main process does not involve the central nervous system. The term “geriatric syndrome” is used to capture those clinical conditions in older people that do not fit into discrete disease categories, including delirium, falls, frailty, dizziness, syncope, and urinary incontinence. …”
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504
The Extracellular Environment of the CNS: Influence on Plasticity, Sprouting, and Axonal Regeneration after Spinal Cord Injury
Published 2018-01-01“…The extracellular environment of the central nervous system (CNS) becomes highly structured and organized as the nervous system matures. …”
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505
HIV-Associated Neurotoxicity: The Interplay of Host and Viral Proteins
Published 2021-01-01“…HIV-associated neurocognitive disorder (HAND) is being observed since the beginning of the AIDS epidemic due to a change in the functional integrity of cells from the central nervous system (CNS). Even with the presence of antiretroviral therapy, there is a decline in the functioning of the brain especially movement skills, noticeable swings in mood, and routine performance activities. …”
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506
Cerebral Wegener’s Granuloma: Surgery Mandatory for Diagnosis and Treatment
Published 2013-01-01“…The involvement of the central nervous system in case of Wegener granulomatosis (WG) is infrequent and usually leads to cranial nerve abnormalities, cerebrovascular events, and seizures. …”
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507
Mimicking Neural Stem Cell Niche by Biocompatible Substrates
Published 2016-01-01“…Neural stem cells (NSCs) participate in the maintenance, repair, and regeneration of the central nervous system. During development, the primary NSCs are distributed along the ventricular zone of the neural tube, while, in adults, NSCs are mainly restricted to the subependymal layer of the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. …”
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508
Regeneration of Zebrafish CNS: Adult Neurogenesis
Published 2016-01-01“…Unlike mammals, zebrafish retains radial glia, a nonneuronal cell type in their adult central nervous system. Injury induced proliferation involves radial glia which proliferate, transcribe embryonic genes, and can give rise to new neurons. …”
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509
Gut microbiota on anxiety and depression in primary Sjogren's syndrome: A novel insight
Published 2025-02-01“…Recent theories on the gut-brain axis have elucidated that the gut microbiota considered the second brain of humans, can modulate the central nervous system and behavior by mediating bidirectional response systems, including immunity, vagus nerve, and neuroendocrine pathways. …”
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510
Biography of Prof. Dr. Albert Eckstein and His Studies in Türkiye
Published 2025-01-01“…Eckstein excelled as a clinician, educator, and researcher, specializing in infectious diseases, disorders of the central nervous system, the biology of premature and newborn infants, and preventive pediatric care. …”
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511
Homozygous mice with mutant protein FUS[1-359] overexpression: Innovative possibilities for ALS treatment
Published 2024-12-01“…Differences in the copy number of the transgenic insertion were also identified, revealing that homozygous animals exhibited increased expression of the mutant FUS protein in various structures of the central nervous system, consistent with existing literature on ALS pathogenesis. …”
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512
The Nasal Route as a Potential Pathway for Delivery of Erythropoietin in the Treatment of Acute Ischemic Stroke in Humans
Published 2009-01-01“…This method allows drugs that do not cross the BBB to be delivered to the central nervous system in a few minutes. With this technology, it will be possible to eliminate systemic administration and its potential side effects. …”
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513
Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication
Published 2017-01-01“…However, GABA and the most clinically applicable GABA-R ligands may be suboptimal for the long-term treatment of diabetes due to their pharmacological properties or potential side-effects on the central nervous system (CNS). Lesogaberan (AZD3355) is a peripherally restricted high-affinity GABAB-R-specific agonist, originally developed for the treatment of gastroesophageal reflux disease (GERD) that appears to be safe for human use. …”
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514
Rare Association of Anti-Hu Antibody Positive Paraneoplastic Neurological Syndrome and Transitional Cell Bladder Carcinoma
Published 2012-01-01“…A 76-year-old female presented with bilateral muscle weakness and paraesthesia of the upper and lower limbs in a length-dependent “glove and stocking” distribution. Central nervous system symptoms included cognitive problems, personality change, and truncal ataxia. …”
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515
Nocardiose disseminada
Published 2025-01-01“…Extensive investigations revealed an ischemic lesion in the central nervous system (CNS) attributed to vasculitis. Two months later, she returned with literal paraphasia, ocular symptoms (red eye and retro-orbital pain), and fever. …”
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516
Brain lateralisation feature extraction and ant colony optimisation‐bidirectional LSTM network model for emotion recognition
Published 2022-02-01“…Furthermore, it extracts valid features using peripheral nervous system signals PPG, GSR, and EOG as well as the central nervous system signals EEG, simultaneously. The authors reinforce feature performance by adding brain lateralisation for emotion recognition. …”
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517
Comprehensive Insight of Neurodegenerative Diseases and The Role of Neurotoxin Agents — Glutamate
Published 2020-04-01“…It causes neuronal dysfunction and degeneration in the central nervous system (CNS). Glutamate neurotoxicity can be categorized into two forms, which are receptor-mediated glutamate excitotoxicity and non-receptor mediated glutamate oxidative toxicity. …”
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518
Transcranial Magnetic Stimulation as a Potential Biomarker in Multiple Sclerosis: A Systematic Review with Recommendations for Future Research
Published 2019-01-01“…Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system. Disease progression is variable and unpredictable, warranting the development of biomarkers of disease status. …”
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519
A bicycle can be balanced by stochastic optimal feedback control but only with accurate speed estimates.
Published 2023-01-01“…The physics component pertains to the laws that govern the movements of the rider and his bicycle, and the neurobiological component pertains to the mechanisms via which the central nervous system (CNS) uses these laws for balance control. …”
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520
Neuroendocrine Cell Carcinoma of Unknown Primary Arising in Long Standing History of Multiple Sclerosis
Published 2015-01-01“…Multiple sclerosis (MS) is a chronic autoimmune disease that targets myelinated axons in the central nervous system (CNS). Cancer of unknown primary site (CUP) is a well-recognised clinical disorder, accounting for 3–5% of all malignant epithelial tumors. …”
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