The emerging role of 12/15-lipoxygenase in ischemic stroke by Xuening Wang, Qiuji Shao, Yuan Gao

“…The arachidonic acid metabolic pathway is a classic inflammatory pathway. 12/15-lipoxygenase (LOX), a member of the lipoxygenase family that metabolizes arachidonic acid, has been implicated in the pathogenesis of numerous central nervous system (CNS) diseases. Ischemic stroke is a devastating disease in which the occlusion of cerebral arteries leads to a series of pathophysiological changes in brain tissue, triggering an inflammatory cascade within the brain that results in neuroinflammation. …”
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Cold induces brain region-selective cell activity-dependent lipid metabolism by Hyeonyoung Min, Yale Y Yang, Yunlei Yang

“…It has been well documented that cold is an enhancer of lipid metabolism in peripheral tissues, yet its effect on central nervous system lipid dynamics is underexplored. It is well recognized that cold acclimations enhance adipocyte functions, including white adipose tissue lipid lipolysis and beiging, and brown adipose tissue thermogenesis in mammals. …”
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Comprehensive Update on Rabies: A Neglected Zoonotic Disease of Public Health Concern by Kavitha Guladahalli Manjunatha, Chethana Chandrahasa, Sadanand Dangari Akshay, Akhila Dharnappa Sannejal, Rajeshwari Vittal, Govindaiah Kavitha, Khang Wen Goh, Shrikrishna Isloor, Devananda Devegowda

“…The virus targets the central nervous system of warm-blooded animals and claims the lives of over 60,000 individuals annually. …”
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Early Polytherapy for Probably Benzodiazepine Refractory Naïve Status Epilepticus (Stage 1 Plus) by Giuseppe Magro

“…These cases include not only prolonged SE as previously proposed by the author (SE lasting > 10 min) but also other cases notoriously associated with BDZ refractoriness such as the absence of prominent motor phenomena and acute etiology (especially primary central nervous system etiology). Interestingly, the absence of prominent motor phenomena as is the case of non convulsive SE might implicitly fall in the category of prolonged SE due to the delay in recognition and treatment. …”
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Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation by Adam Aguirre, Carola J. Maturana, Paloma A. Harcha, Juan C. Sáez

“…In the central nervous system (CNS), mastocytes and glial cells (microglia, astrocytes and oligodendrocytes) function as sensors of neuroinflammatory conditions, responding to stress triggers or becoming sensitized to subsequent proinflammatory challenges. …”
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Simultaneous Quantification of γ-Hydroxybutyrate, γ-Butyrolactone, and 1,4-Butanediol in Four Kinds of Beverages by Shaoming Jin, Xiao Ning, Jin Cao, Yaonan Wang

“…γ-Hydroxybutyrate (GHB) is a neurotransmitter, which exhibits a strong central nervous system depressant effect. The abuse of GHB or its precursor substances (γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD)) may cause serious problems. …”
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Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis by Shyi-Jou Chen, Yen-Ling Wang, Hueng-Chuen Fan, Wen-Tsung Lo, Chih-Chien Wang, Huey-Kang Sytwu

“…Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, and CD4+ T cells form the core immunopathogenic cascade leading to chronic inflammation. …”
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Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Alterations in Low-Grade Gliomas: Report of a Novel Gene Fusion Partner in a Pilocytic Astrocytoma and Review of the Literature by Siobhan S. Pattwell, Eric Q. Konnick, Yajuan J. Liu, Rebecca A. Yoda, Laligam N. Sekhar, Patrick J. Cimino

“…Pilocytic astrocytoma is a low-grade glial neoplasm of the central nervous system (CNS) that tends to occur in the pediatric population and less commonly presents in adults. …”
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Research Progress on Biomaterials for Spinal Cord Repair by Liao Z, Bao Q, Saijilahu, Chimedtseren C, Tumurbaatar K, Saijilafu

“…Zhenglie Liao,1,* Qianyi Bao,1,* Saijilahu,2 Chimedragchaa Chimedtseren,3 Khaliunaa Tumurbaatar,3 Saijilafu1 1Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, People’s Republic of China; 2Tongliao Centers for Disease Control and Prevention, Tongliao, Inner Mongolia, People’s Republic of China; 3Institute of Traditional Medicine and Technology of Mongolia, Ulaanbaatar city, Mongolia*These authors contributed equally to this workCorrespondence: Saijilafu, Email saijlf@hzcu.edu.cnAbstract: Spinal cord injury (SCI) is a very destructive disease of the central nervous system that often causes irreversible nerve damage. …”
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Adult ADHD Medications and Their Cardiovascular Implications by A. Sinha, O. Lewis, R. Kumar, S. L. H. Yeruva, B. H. Curry

“…Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurobiological disorder exhibited by difficulty maintaining attention, as well as hyperactivity and impulsive behavior. Central nervous system (CNS) stimulants are the first line of treatment for ADHD. …”
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Nocardia thailandica Brain Abscess in an Immunocompromised Patient by Muhammad Effendi, Samad Tirmizi, Dayna McManus, Anita J. Huttner, David R. Peaper, Jeffrey E. Topal

“…To the best of our knowledge, N. thailandica has not yet been described in the medical literature to cause central nervous system (CNS) infection from brain abscess. …”
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Acute Toxicity and Neuroprotective Effect of “RJ6601”, a Newly Formulated Instant Soup, in Geriatric Rats by Rujikarn Chaisanam, Jintanaporn Wattanathorn

“…Given its antioxidant effects and central nervous system benefits, we hypothesized that RJ6601 should improve neurodegeneration in the hippocampus, a region critical for cognition and the maintenance of quality of life (QoL). …”
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Impact of the Ketogenic Diet on Neurological Diseases: A Review by Carmen Rubio, Alejandro López-Landa, Hector Romo-Parra, Moisés Rubio-Osornio

“…Glial cells play an essential role in the utilization of ketone bodies (KBs) within the central nervous system’s metabolism, particularly during ketosis induced by the KD. …”
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Botanicals as Modulators of Neuroplasticity: Focus on BDNF by Enrico Sangiovanni, Paola Brivio, Mario Dell’Agli, Francesca Calabrese

“…The involvement of brain-derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. …”
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Chronic Fluoxetine Treatment Suppresses Plasticity (Long-Term Potentiation) in the Mature Rodent Primary Auditory Cortex In Vivo by Hans C. Dringenberg, Leora R. Branfield Day, Deanna H. Choi

“…., ocular dominance shifts) in the adult central nervous system. Here, we assessed whether fluoxetine enhances long-term potentiation (LTP) in the thalamocortical auditory system of mature rats, a developmentally regulated form of plasticity that shows a characteristic decline during postnatal life. …”
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Designation of modern management in education by Šormaz Goran, Anđelić Slavica, Marković-Blagojević Marija

“…Education represents the "central nervous system" of every society - the pedagogic, educational, cultural chain that constantly vibrates. …”
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Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons by Eun-Hae Jang, Aeri Sim, Sun-Kyoung Im, Eun-Mi Hur

“…Despite the growing interest of applying MSAs to treat the injured or degenerating central nervous system (CNS), consequences of MSA exposure to neurons in the central and peripheral nervous system (PNS) have not been thoroughly investigated. …”
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The Role of the Innate Immune System in Alzheimer’s Disease and Frontotemporal Lobar Degeneration: An Eye on Microglia by Elisa Ridolfi, Cinzia Barone, Elio Scarpini, Daniela Galimberti

“…A key role is played by microglia, which represent the immune effector cells in the central nervous system (CNS). They are extremely sensitive to the environmental changes in the brain and are activated in response to several pathologic events within the CNS, including altered neuronal function, infection, injury, and inflammation. …”
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Anti-amoebic effects of selected herbal extracts against Acanthamoeba species isolated from different borehole water samples from Budiriro District in Harare, Zimbabwe by Kudzai Fambisai, Petros Muchesa, Farisai Chidzwondo, Rumbidzai Mangoyi

“… Acanthamoeba species are the major cause of Acanthamoeba Keratitis (AK) of eyes, Acanthamoeba meningoencephalitis of the central nervous system, and fatal Granulomatous Amoebic Encephalitis (GAE) of the brain in humans. …”
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EEG Microstate as a Marker of Adolescent Idiopathic Scoliosis by M. Rubega, E. Passarotto, M. Paramento, E. Formaggio, S. Masiero

“…The pathophysiology of Adolescent Idiopathic Scoliosis (AIS) is not yet fully understood, but multifactorial hypotheses have been proposed that include defective central nervous system (CNS) control of posture, biomechanics, and body schema alterations. …”
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