Construction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma by Huai-Yu Wu, Shu-Ya Cao, Zheng-Gang Xu, Tian- Wang, Gu-Wei Ji, Ke Wang

“…HCC single-cell data obtained from Gene Expression Omnibus (GEO) were used to map gene signatures and explore inter-cellular signaling communications. Finally, a radiogenomic signature was used to predict the objective response rate (ORR) and overall survival (OS). …”
Get full text

Design, synthesis, SAR and ADMET analyses of the novel class of synthetic 7-amino[1,2,5]oxadiazolo[3,4-b]pyridine-6-carboxylate derivatives with vasorelaxant activity by Anatolii Varenyk, Roman Vydzhak, Svitlana Panchishin, Irina Ivanova, Victor Zhirnov, Volodymyr Brovarets

Get full text

Health promoting activities and corresponding mechanism of (–)-epicatechin-3-gallate by Zhiliang Li, Changchun Feng, Hongjin Dong, Weibin Jin, Wenying Zhang, Jianfeng Zhan, Shuzhen Wang

“…This review has summarized recent studies on pharmacological properties of ECG, and discussed corresponding mechanism on modulation of cellular signaling events by ECG, hoping to broaden its multiple usage.…”
Get full text

Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor by Elias Leiva-Salcedo, Claudio Coddou, Felipe E. Rodríguez, Antonello Penna, Ximena Lopez, Tanya Neira, Ricardo Fernández, Mónica Imarai, Miguel Rios, Jorge Escobar, Margarita Montoya, J. Pablo Huidobro-Toro, Alejandro Escobar, Claudio Acuña-Castillo

Get full text

Body donor reperfusion and re-ventilation in medical training: an Italian study testing SimLife® by Irene Neri, Giulio Vara, Antonietta Fazio, Maria Vittoria Marvi, Foteini-Dionysia Koufi, Elisa Boschetti, Simone Lodi, Giulia Adalgisa Mariani, Marilisa Quaranta, Anna Maria Billi, Alessandra Ruggeri, Carlo Barausse, Cyril Brèque, Annalisa Plava, Veronica Moretti, Lucia Manzoli, Stefano Ratti

Get full text

Corrigendum: Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysacc... by Kirstine Mejlstrup Hymøller, Kirstine Mejlstrup Hymøller, Stig Hill Christiansen, Stig Hill Christiansen, Anders Grønnegaard Schlosser, Uffe B. Skov Sørensen, Jean C. Lee, Steffen Thiel, Steffen Thiel

Get full text

Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and w... by Kirstine Mejlstrup Hymøller, Kirstine Mejlstrup Hymøller, Stig Hill Christiansen, Stig Hill Christiansen, Anders Grønnegaard Schlosser, Uffe B. Skov Sørensen, Jean C. Lee, Steffen Thiel, Steffen Thiel

Get full text

In vivo evidence for cell body loss in cortical lesions in people with multiple sclerosis by Eva A. Krijnen, Hansol Lee, Samantha Noteboom, Florence L. Chiang, Martijn D. Steenwijk, Menno M. Schoonheim, Eric C. Klawiter, Susie Y. Huang

“…Compared to healthy controls (mean 0.58 ± 0.028), normal‐appearing cortex in multiple sclerosis (0.57 ± 0.034) showed lower intra‐cellular signal fraction. Cortical lesions (0.49 ± 0.089) exhibited lower intra‐cellular signal fractions compared to perilesional (“inner”: 0.55 ± 0.049, “outer”: 0.55 ± 0.039) and normal‐appearing cortex, demonstrating a gradation of change. …”
Get full text

The Redox System in C. elegans, a Phylogenetic Approach by Andrew D. Johnston, Paul R. Ebert

“…This hypothesis suggests that the primary effect of changes to the redox state is modified cellular signalling rather than simply oxidative damage. …”
Get full text

The role of laminins in cancer pathobiology: a comprehensive review by Elena Nonnast, Emilia Mira, Santos Mañes

“…By acting as molecular bridges between cells and the extracellular matrix (ECM) through integrins and other surface receptors, they regulate key cellular signals that influence cell behavior and tissue architecture. …”
Get full text

Methylation Marks of Blood Leukocytes of Native Hucul Mares Differentiated in Age by T. Ząbek, E. Semik-Gurgul, T. Szmatoła, A. Gurgul, A. Fornal, M. Bugno-Poniewierska

“…Genes colocated with age-related differentially methylated regions (age DMRs) are the members of pathways involved in cellular signal transduction, immune response, neurogenesis, differentiation, development, and cancer progression. …”
Get full text

A sensitive ERK fluorescent probe reveals the significance of minimal EGF-induced transcription by Zhang Weisheng, Jun Nakayama, Yukino Inomata, Shigeki Higashiyama, Toru Hiratsuka

“…Our study highlights the significance of sensitive fluorescent probes to understand cellular signal dynamics and the role of minimal ERK activation in regulating transcription. …”
Get full text

p38δ MAPK: Emerging Roles of a Neglected Isoform by Carol O’Callaghan, Liam J. Fanning, Orla P. Barry

“…While the p38 MAPK family as a whole has been implicated in a wide variety of biological processes, a specific role for p38δ MAPK in cellular signalling and its contribution to both physiological and pathological conditions are presently lacking. …”
Get full text

Fitting and comparison of calcium-calmodulin kinetic schemes to a common data set using non-linear mixed effects modelling. by Domas Linkevicius, Angus Chadwick, Guido C Faas, Melanie I Stefan, David C Sterratt

“…Our results support two hypotheses: (1) partially bound calmodulin is important in cellular signalling; and (2) calcium binding sites within a calmodulin lobe are kinetically distinct rather than identical. …”
Get full text

Multiple Myeloma and B Cell Lymphoma. Investigation of IL-6, IL-6 Receptor Antagonist (IL-6RA), and GP130 Antagonist (GP130A) Using Various Parameters in an In Vitro Model by Eva Kovacs

“…This means that gp130 is not absolutely necessary for the cellular signalling cascade via JAK/STAT and RAS/MAPK pathways involved in proliferation and viability. …”
Get full text

Site-selective photo-crosslinking for the characterisation of transient ubiquitin-like protein-protein interactions. by Zac Sandy, Zijuan Wang, Deepak Behera, Benjamin M Foster, Finlay A Martin, Kira Brüninghoff, Kathleen M Cain, Wolfgang Dörner, Maria Jose Cabello-Lobato, Josep V Forment, Matthew J Cliff, Igor Larrosa, Perdita Barran, Duncan L Smith, Henning D Mootz, Christine K Schmidt

“…Non-covalent protein-protein interactions are one of the most fundamental building blocks in cellular signalling pathways. Despite this, they have been historically hard to identify using conventional methods due to their often weak and transient nature. …”
Get full text