Neurobiology of Vascular Dementia by Ana-Maria Enciu, Stefan N. Constantinescu, Laurenţiu M. Popescu, Dafin F. Mureşanu, Bogdan O. Popescu

“…However, in a very large majority of cases, these alterations occur in an already aged brain, characterized by a milieu of cellular and molecular events common for different neurodegenerative diseases. The cell signaling defects and molecular dyshomeostasis might lead to neuronal malfunction prior to the death of neurons and the alteration of neuronal networks. …”
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Synaptic Wnt/GSK3β Signaling Hub in Autism by Mario O. Caracci, Miguel E. Ávila, Giancarlo V. De Ferrari

“…The convergence of these variants in networks of genes associated with synaptic function warrants the study of cell signaling pathways involved in the regulation of the synapse. …”
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Research Progress in Diseases Caused by STAT1 Gain-of-Function Mutations by LI Linpeng, MA Jing, GU Hao, SHU Zhou, MAO Huawei

“…Gain-of-function mutations in STAT1 (STAT1-GOF) impaired the dephosphorylation of STAT1 protein, mediated the enhancement of cell signaling pathways such as type Ⅰ, Ⅱ, and Ⅲ interferon(IFN) and interleukins-27 (IL-27), IL-6, IL-10, and IL-17, and inhibited Th17 cells. …”
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GSK-3𝜷: A Bifunctional Role in Cell Death Pathways by Keith M. Jacobs, Sandeep R. Bhave, Daniel J. Ferraro, Jerry J. Jaboin, Dennis E. Hallahan, Dinesh Thotala

“…GSK-3β is involved in modulating a variety of functions including cell signaling, growth metabolism, and various transcription factors that determine the survival or death of the organism. …”
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Inhibition of Src signaling induces autophagic killing of Toxoplasma gondii via PTEN-mediated deactivation of Akt. by Alyssa Hubal, Anusha Vendhoti, Charles N Shaffer, Sarah Vos, Yalitza Lopez Corcino, Carlos S Subauste

“…The intracellular protozoan Toxoplasma gondii manipulates host cell signaling to avoid targeting by autophagosomes and lysosomal degradation. …”
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Design, Expression, and Inhibitory Effects of Antagonistic Single-Chain Platelet-Derived Growth Factor on Lung Cancer Cells by Salim Alhafyan

“…Platelet-derived growth factor (PDGF) plays a pivotal role in numerous physiological and pathological conditions, acting as a dimeric disulfide-bound protein that induces receptor dimerization and subsequently activates cell signaling pathways. Given its involvement in various malignant and benign diseases, targeting the PDGF signaling pathway is a promising therapeutic strategy. …”
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BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets by Jaehwi Lee, Man Hee Rhee, Eunji Kim, Jae Youl Cho

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Oscillatory Shear Stress Induces Oxidative Stress via TLR4 Activation in Endothelial Cells by Zhimei Wang, Feng Wang, Xiangquan Kong, Xiaofei Gao, Yue Gu, Junjie Zhang

“…However, the molecular mechanism by which TLR4 modulates oxidative changes and the cell signaling transudation upon OSS is yet to be determined. …”
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Transcriptomics profiling of Parkinson’s disease progression subtypes reveals distinctive patterns of gene expression by Carlo Fabrizio, Andrea Termine, Carlo Caltagirone

“…All three subtypes showed a significant modulation of pathways related to the regulation of gene expression, metabolism, and cell signaling. ML revealed that the progression subtype with the worst prognosis can be predicted at baseline with 0.877 AUROC, yet the contribution of gene expression was marginal for the prediction of the subtypes. …”
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Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps by Drake W. Phelps, Ashley M. Connors, Giuliano Ferrero, Jamie C. DeWitt, Jeffrey A. Yoder

“…Known mechanisms by which PFASs modulate innate immune function are also reviewed, including disruption of cell signaling, metabolism, and tissue-level effects. …”
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Caveolin-Mediated Endocytosis: Bacterial Pathogen Exploitation and Host–Pathogen Interaction by Dibyasri Barman, Rishi Drolia

“…Caveolae are specialized microdomains on cell surfaces that impact cell signaling. Caveolin proteins facilitate the creation of caveolae and have three members in vertebrates: caveolin-1, caveolin-2, and caveolin-3. …”
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SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development. by Marissa Baccas, Vanathi Ganesan, Amy Leung, Lucas R Pineiro, Alexandra N McKillop, Jun Liu

“…Development of multicellular organisms requires well-orchestrated interplay between cell-intrinsic transcription factors and cell-cell signaling. One set of highly conserved transcription factors that plays diverse roles in development is the SoxC group. …”
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Resistance to Radiotherapy in Cancer by Almaz A. Akhunzianov, Elvira V. Rozhina, Yuliya V. Filina, Albert A. Rizvanov, Regina R. Miftakhova

“…These biomarkers mainly include proteins involved in metabolism and cell signaling pathways.…”
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Proteomics of the Dark-Ventral-Patch Sexual Signal in Male Red Deer by Camilla Broggini, Paula V. Huertas-Abril, Alberto Membrillo, Eva de la Peña, Nieves Abril, Juan Carranza

“…In this study, we used a shotgun proteomic approach to investigate whether the ventral patch hair retains proteins on its surface that could reveal metabolic and cell-signaling adaptations potentially related to reproductive activity. …”
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Influence of Acute High Glucose on Protein Abundance Changes in Murine Glomerular Mesangial Cells by Michelle T. Barati, James C. Gould, Sarah A. Salyer, Susan Isaacs, Daniel W. Wilkey, Michael L. Merchant

“…These proteins could be broadly grouped into two categories: (1) proteins involved in cell survival/cell signaling and (2) proteins involved in stress response. …”
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Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases by Larry S. Sherman, Steven Matsumoto, Weiping Su, Taasin Srivastava, Stephen A. Back

“…The glycosaminoglycan hyaluronan (HA), a component of the extracellular matrix, has been implicated in regulating neural differentiation, survival, proliferation, migration, and cell signaling in the mammalian central nervous system (CNS). …”
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Research progress on the antiviral immune regulation of ubiquitin ligase F-box family by MENG Xiangbo, LI Tianqi, ZHANG Tong

“…They specifically recognize substrate proteins via the ubiquitin-proteasome pathway and participate in various biological activities, such as cell cycle regulation, transcriptional regulation, apoptosis, and cell signaling transduction. Numerous studies have shown that FBPs play important roles in host-virus interactions. …”
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Dysregulation of Metabolic Peptides in the Gut–Brain Axis Promotes Hyperinsulinemia, Obesity, and Neurodegeneration by Camille Green, Vandana Zaman, Kayce Blumenstock, Narendra L. Banik, Azizul Haque

“…These peptides are crucial for regulating many different processes like metabolism and cell signaling, as they bind to receptors on various cells. …”
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The Effect of Endotoxin-Induced Inflammation on the Activity of the Somatotropic Axis in Sheep by Maciej Wójcik, Dorota Anna Zieba, Joanna Bochenek, Agata Krawczyńska, Marcin Barszcz, Alina Gajewska, Hanna Antushevich, Andrzej Przemysław Herman

“…Our study suggests that disruption of the GH cell signaling pathway may be one of the important elements of the pathophysiology of inflammation. …”
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Free radicals and their impact on health and antioxidant defenses: a review by Nisansala Chandimali, Seon Gyeong Bak, Eun Hyun Park, Hyung-Jin Lim, Yeong-Seon Won, Eun-Kyung Kim, Sang-Ik Park, Seung Jae Lee

“…While free radicals are essential for certain physiological processes, such as cell signaling and immune defense, their overproduction can disrupt the delicate balance between oxidants and antioxidants, leading to oxidative stress. …”
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