From heparan glycobiology to stem cell therapy: a historical perspective by Victor Nurcombe

“…Translational avenues include the selection and biochemical tuning of heparan sugars as nanoscale scaffolds that support cell signaling for specific applications in tissue engineering and regenerative medicine. …”
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Non-coding RNAs and exosomal ncRNAs in colorectal cancer by Yalda Zhoulideh

“…Abstract Colorectal cancer (CRC) is a complex disease with many genetic and epigenetic changes leading to dysregulation of cell signaling pathways. In recent years, increasing attention has been paid to the role of non-coding RNA (ncRNA) and exogenous ncRNA in the development and progression of CRC. ncRNAs play an essential role in the regulation of gene expression and cell function, and dysregulation of ncRNA expression is associated with the onset and progression of CRC. …”
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The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands: Having the Right Combination by Graham Skelhorne-Gross, Christopher J. B. Nicol

“…In spite of this, several groups reported exciting results with therapeutic regimens that combine PPARγ ligands with other compounds: chemotherapeutic agents, retinoid x receptor (RXR)α agonists, statins, or cell-to-cell signaling molecules in preclinical cancer models and human trials. …”
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Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia by Sirilaksana Kunjara, Patricia McLean, Laurens Rademacher, Thomas W. Rademacher, Fabiana Fascilla, Stefano Bettocchi, Marco Scioscia

“…Inositol second messengers are involved in metabolic and cell signaling pathways and are highly expressed during preeclampsia. …”
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Deciphering the functional roles of PE18 and PPE26 proteins in modulating Mycobacterium tuberculosis pathogenesis and immune response by Aquib Ehtram, Mohd Shariq, Neha Quadir, Neha Quadir, Salma Jamal, Manjunath Pichipalli, Sheeba Zarin, Sheeba Zarin, Javaid Ahmad Sheikh, Nasreen Z. Ehtesham, Seyed E. Hasnain, Seyed E. Hasnain

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Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer by Jackie L. Johnson, Smitha Pillai, Srikumar P. Chellappan

“…It is now clear that heterogeneous cell signaling pathways are disrupted to promote NSCLC, including mutations in critical growth regulatory proteins (K-Ras, EGFR, B-RAF, MEK-1, HER2, MET, EML-4-ALK, KIF5B-RET, and NKX2.1) and inactivation of growth inhibitory pathways (TP53, PTEN, p16, and LKB-1). …”
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The Desmosomal Plaque Proteins of the Plakophilin Family by Steffen Neuber, Mario Mühmer, Denise Wratten, Peter J. Koch, Roland Moll, Ansgar Schmidt

“…These proteins have been implicated in cell signaling, organization of the cytoskeleton, and control of protein biosynthesis under specific cellular circumstances. …”
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Neurobiology of Vascular Dementia by Ana-Maria Enciu, Stefan N. Constantinescu, Laurenţiu M. Popescu, Dafin F. Mureşanu, Bogdan O. Popescu

“…However, in a very large majority of cases, these alterations occur in an already aged brain, characterized by a milieu of cellular and molecular events common for different neurodegenerative diseases. The cell signaling defects and molecular dyshomeostasis might lead to neuronal malfunction prior to the death of neurons and the alteration of neuronal networks. …”
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Synaptic Wnt/GSK3β Signaling Hub in Autism by Mario O. Caracci, Miguel E. Ávila, Giancarlo V. De Ferrari

“…The convergence of these variants in networks of genes associated with synaptic function warrants the study of cell signaling pathways involved in the regulation of the synapse. …”
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GSK-3𝜷: A Bifunctional Role in Cell Death Pathways by Keith M. Jacobs, Sandeep R. Bhave, Daniel J. Ferraro, Jerry J. Jaboin, Dennis E. Hallahan, Dinesh Thotala

“…GSK-3β is involved in modulating a variety of functions including cell signaling, growth metabolism, and various transcription factors that determine the survival or death of the organism. …”
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Inhibition of Src signaling induces autophagic killing of Toxoplasma gondii via PTEN-mediated deactivation of Akt. by Alyssa Hubal, Anusha Vendhoti, Charles N Shaffer, Sarah Vos, Yalitza Lopez Corcino, Carlos S Subauste

“…The intracellular protozoan Toxoplasma gondii manipulates host cell signaling to avoid targeting by autophagosomes and lysosomal degradation. …”
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Design, Expression, and Inhibitory Effects of Antagonistic Single-Chain Platelet-Derived Growth Factor on Lung Cancer Cells by Salim Alhafyan

“…Platelet-derived growth factor (PDGF) plays a pivotal role in numerous physiological and pathological conditions, acting as a dimeric disulfide-bound protein that induces receptor dimerization and subsequently activates cell signaling pathways. Given its involvement in various malignant and benign diseases, targeting the PDGF signaling pathway is a promising therapeutic strategy. …”
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BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets by Jaehwi Lee, Man Hee Rhee, Eunji Kim, Jae Youl Cho

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Oscillatory Shear Stress Induces Oxidative Stress via TLR4 Activation in Endothelial Cells by Zhimei Wang, Feng Wang, Xiangquan Kong, Xiaofei Gao, Yue Gu, Junjie Zhang

“…However, the molecular mechanism by which TLR4 modulates oxidative changes and the cell signaling transudation upon OSS is yet to be determined. …”
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Transcriptomics profiling of Parkinson’s disease progression subtypes reveals distinctive patterns of gene expression by Carlo Fabrizio, Andrea Termine, Carlo Caltagirone

“…All three subtypes showed a significant modulation of pathways related to the regulation of gene expression, metabolism, and cell signaling. ML revealed that the progression subtype with the worst prognosis can be predicted at baseline with 0.877 AUROC, yet the contribution of gene expression was marginal for the prediction of the subtypes. …”
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SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development. by Marissa Baccas, Vanathi Ganesan, Amy Leung, Lucas R Pineiro, Alexandra N McKillop, Jun Liu

“…Development of multicellular organisms requires well-orchestrated interplay between cell-intrinsic transcription factors and cell-cell signaling. One set of highly conserved transcription factors that plays diverse roles in development is the SoxC group. …”
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Resistance to Radiotherapy in Cancer by Almaz A. Akhunzianov, Elvira V. Rozhina, Yuliya V. Filina, Albert A. Rizvanov, Regina R. Miftakhova

“…These biomarkers mainly include proteins involved in metabolism and cell signaling pathways.…”
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Proteomics of the Dark-Ventral-Patch Sexual Signal in Male Red Deer by Camilla Broggini, Paula V. Huertas-Abril, Alberto Membrillo, Eva de la Peña, Nieves Abril, Juan Carranza

“…In this study, we used a shotgun proteomic approach to investigate whether the ventral patch hair retains proteins on its surface that could reveal metabolic and cell-signaling adaptations potentially related to reproductive activity. …”
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Influence of Acute High Glucose on Protein Abundance Changes in Murine Glomerular Mesangial Cells by Michelle T. Barati, James C. Gould, Sarah A. Salyer, Susan Isaacs, Daniel W. Wilkey, Michael L. Merchant

“…These proteins could be broadly grouped into two categories: (1) proteins involved in cell survival/cell signaling and (2) proteins involved in stress response. …”
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Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases by Larry S. Sherman, Steven Matsumoto, Weiping Su, Taasin Srivastava, Stephen A. Back

“…The glycosaminoglycan hyaluronan (HA), a component of the extracellular matrix, has been implicated in regulating neural differentiation, survival, proliferation, migration, and cell signaling in the mammalian central nervous system (CNS). …”
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