Adaptive Evolution Coupled with Retrotransposon Exaptation Allowed for the Generation of a Human-Protein-Specific Coding Gene That Promotes Cancer Cell Proliferation and Metastasis in Both Haematological Malignancies and Solid Tumours: The Extraordinary Case of MYEOV Gene by Spyros I. Papamichos, Dimitrios Margaritis, Ioannis Kotsianidis

“…This study focuses on MYEOV, an oncogene encoding for two protein isoforms, reported as causally involved in promoting cancer cell proliferation and metastasis in both haematological malignancies and solid tumours. …”
Get full text

Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A—or Exchange Protein Activated by cAMP-Dependent Signal Pathway by Takekatsu Saito, Naotoshi Sugimoto, Kunio Ohta, Tohru Shimizu, Kaori Ohtani, Yuko Nakayama, Taichi Nakamura, Yashiaki Hitomi, Hiroyuki Nakamura, Shoichi Koizumi, Akihiro Yachie

“…LCWE was shown to induce phosphorylation of the nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways and cell proliferation in mice fibroblast cells. Theophylline and phosphodiesterase inhibitor increased intracellular cAMP and inhibited LCWE-induced cell proliferation as well as phosphorylation of NF-κB and MAPK. …”
Get full text

Piezo1-directed neutrophil extracellular traps regulate macrophage differentiation during influenza virus infection by Yuexin Wang, Qiuli Yang, Yingjie Dong, Likun Wang, Zhiyuan Zhang, Ruiying Niu, Yufei Wang, Yujing Bi, Guangwei Liu

Get full text

Dynamics and regulatory roles of RNA m6A methylation in unbalanced genomes by Shuai Zhang, Ruixue Wang, Kun Luo, Shipeng Gu, Xinyu Liu, Junhan Wang, Ludan Zhang, Lin Sun

Get full text

lncRNA RUNDC3A-AS1 Regulates Proliferation and Apoptosis of Thyroid Cancer Cells via the miR-151b/SNRPB Axis by Yan Deng, Jie Wu, Xin Li

“…RUNDC3A-AS1 knockdown suppressed cell proliferation but induced cell apoptosis. Importantly, RUNDC3A-AS1 targeted miR-151b to regulate the SNRPB expression. …”
Get full text

Hypoxia-Induced GST1 Exerts Protective Effects on Trophoblasts via Inhibiting Reactive Oxygen Species (ROS) Accumulation by Lingjuan Chen, Gaoli Chen, Lixuan Guo, Yaping Wang, Chengjin Ai

“…The inhibitory effects of hypoxia exposure on cell proliferation, migration, and invasion induced by hypoxia exposure were obviously reversed by overexpression of GSTP1. …”
Get full text

PAX6 enhances Nanog expression by inhibiting NOTCH signaling to promote malignant properties in small cell lung cancer cells by Xiao-Fang Guo, Ling-Ling Wang, Fei-Meng Zheng, He-Ping Li

“…Here, we find that PAX6 overexpression promotes SCLC cell proliferation and cell cycle progression, while downregulation of PAX6 expression suppresses SCLC cell proliferation and cell cycle progression. …”
Get full text

Delta-Like-1 Changes the Immunomodulatory Property of OP9 Cells by Lei Zhang, Rui-Jie Dang, Yan-Mei Yang, Dian-Chao Cui, Ping Li, Yan-Li Ni, Tong Hao, Changyong Wang, Xiao-Xia Jiang, Nan-Zhu Fang

“…Both OP9 and OP9DL1 inhibited mature B and T cell proliferation. Furthermore, OP9 showed stronger inhibition on B cell proliferation and OP9DL1 exhibited stronger inhibition on T cell proliferation. …”
Get full text

The Long Noncoding RNA LOXL1-AS1 Promotes the Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Jiang Liu, Chengtong Zhai, Degan Liu, Jianhua Liu

“…In addition, in the Hep-G2 cell line, LOXL1-AS1 downregulation significantly inhibited cell proliferation in the light of the MTT and colony formation assays in vitro, which was consistent with animal experiment in vivo. …”
Get full text

High FGF18 expression levels predict poor prognosis in endometrial carcinoma patients and promote tumor growth and metastasis by Zheng-Yao Lei, Jian Wu, Bao-Hua Zhang, Wei Xiang, Min Wang, Bin-bin Li, Ming-Cheng Dai

“…FGF18 expression was stably knocked down in EC cell lines. Changes in cell proliferation, migration, and invasion rates were examined via cell behavior experiments. …”
Get full text

Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway by Chuan Lv, Can Wu, Yue-hong Zhou, Ying Shao, Guan Wang, Qiu-yue Wang

“…The aim of this study was to investigate whether alpha lipoic acid (LA) regulates high glucose-induced mesangial cell proliferation and extracellular matrix production via mTOR/p70S6K/4E-BP1 signaling. …”
Get full text

Exosomal miR-543 Inhibits the Proliferation of Ovarian Cancer by Targeting IGF2 by Shupei Zhang, Diling Pan, Shaoyu Zhang, Qiumei Wu, Lan Zhen, Shihuang Liu, Jingjing Chen, Rong Lin, Qiuhua Hong, Xiangqin Zheng, Huan Yi

“…Exosomal miR-543 participates in the proteoglycan pathway to suppress cell proliferation by targeting IGF2 in OvCa.…”
Get full text

Z-Guggulsterone Induces Apoptosis in Gastric Cancer Cells through the Intrinsic Mitochondria-Dependent Pathway by Ruxi Lv, Min Zhu, Kun Chen, Haitao Xie, Hongxia Bai, Qingfa Chen

“…MTT assay was applied to evaluate cell proliferation. Flow cytometry and Hoechst staining were used to assess cell apoptosis. …”
Get full text

Effects of Hyaluronic Acid on Three Different Cell Types of the Periodontium in a Novel Multi-Culture Cell Plate: An Exploratory Study by Alessio Barbieri, Luciano Pitzurra, Bruno Loos, Ineke D. C. Jansen

“…HA has been proposed to play a role in cell proliferation, differentiation, migration, and cell–matrix as well as cell–cell interactions. …”
Get full text

The Role of Bovine Amniotic Membrane and Hydroxyapatite for the Ridge Preservation by Octarina Octarina, Elly Munadziroh, Fathilah Abdul Razak, Ekowati Handharyani, Meircurius Dwi Condro Surboyo

“…Additionally, a histological examination was conducted to analyse collagen thickness and osteoblast cell proliferation. The results demonstrated that the application of BAM-HA significantly increased collagen density, osteoblast cell proliferation, and the expression of BMP2, RUNX2, and osteoclacin compared to the control group (p<0.05) on both days 14 and 28. …”
Get full text

Overexpression of PAX8-AS1 Inhibits Malignant Phenotypes of Papillary Thyroid Carcinoma Cells via miR-96-5p/PKN2 Axis by Ping Zhou, Tongdao Xu, Hao Hu, Fei Hua

“…EdU assay was used to detect cell proliferation. Western blot assay was employed to examine protein expression. …”
Get full text

AEBP1 Promotes Glioblastoma Progression and Activates the Classical NF-κB Pathway by Kai Guo, Lei Song, Jianyong Chang, Peicheng Cao, Qi Liu

“…Upregulated AEBP1 in GBM promotes GBM cell proliferation, migration, and invasion and facilitates tumor growth in vivo by activating the classical NF-κB pathway.…”
Get full text

SHP2 is essential for the progesterone-promoted proliferation and migration in breast cancer cell lines by Hui-Chen Wang, Hui-Chen Wang, Wen-Sen Lee, Wen-Sen Lee, Wen-Sen Lee, Wen-Sen Lee

“…IntroductionWe previously demonstrated that progesterone (P4) can promote breast cancer cell proliferation and migration through activating the P4 receptor (PR)/cSrc-mediated signaling pathway. …”
Get full text

In situ Apoptotic and Proliferation Index in Laryngeal Squamous Cell Carcinomas by Hjalmar G. Hagedorn, Jutta Tübel, Irmgard Wiest, Andreas G. Nerlich

“…We applied the TUNEL end labelling technique for the investigation of apoptosis and immunohistochemistry (Ki‐67 antigen) for the determination of the cell proliferation.…”
Get full text

Rare Presentation of Primary Extramedullary Plasmacytoma as Lip Lesion by Mali Him, Maggie Meier, Vikas Mehta

“…Malignant plasma cell proliferation can be presented as part of disseminated disease of multiple myeloma, as solitary plasmacytoma of bone, or in soft tissue as extramedullary plasmacytoma. …”
Get full text