Lactic Acid Regulation: A Potential Therapeutic Option in Rheumatoid Arthritis by Qianlei Wang, James Asenso, Ning Xiao, Jinzhang Gao, Feng Xiao, Jiajie Kuai, Wei Wei, Chun Wang

“…Moreover, LA contributes to the migration and activation of immune cells. Immune cells proliferate and secrete interleukins (IL) including IL-1, IL-2, IL-13, IL-17, and other inflammatory factors. …”
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NLRP12/C1qA positive feedback in tumor-associated macrophages regulates immunosuppression through LILRB4/NF-κB pathway in lung adenocarcinoma by Jiaxin Yin, Yuxiao Song, Yang Fu, Jun Wang, Zhimin Zhang, Shasha Ruan, Gaoli Liu, Bicheng Zhang

“…NLRP12-overexpressing TAMs promoted tumor cells’ malignant progression and inhibited T cells’ proliferation and cytotoxic function. Lastly, NLRP12 knockout (NLRP12−/−) reversed macrophage polarization, enhanced T-cell anti-tumor immunity, and suppressed tumor growth. …”
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Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W. I. Cox, Mattia Chiesa, Yuri D’Alessandra, Michela Garofalo, Caroline H. Topham, Gianpiero Di Leva

“…Herein, we identified the pan-CDKi dinaciclib as a promising alternative to palbociclib for the suppression of MB cells proliferation. We present evidence supporting dinaciclib’s ability to inhibit MB cells in vitro proliferation at considerably lower doses than palbociclib. …”
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Solitary Fibrous Tumor Arising in the Buccal Space by Tatsuo Okui, Soichiro Ibaragi, Hotaka Kawai, Akira Sasaki

“…The tumor was composed of bland spindle cells proliferating in a patternless arrangement with a collagenous background. …”
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In Silico Design of a Trans-Amplifying RNA-Based Vaccine against SARS-CoV-2 Structural Proteins by Fatemeh Nafian, Ghazal Soleymani, Zahra Pourmanouchehri, Mahnaz Kiyanjam, Simin Nafian, Sayed Mohammad Mohammadi, Hanie Jeyroudi, Sharareh Berenji Jalaei, Fatemeh Sabzpoushan

“…Macrophages and dendritic cells proliferated continuously, and IFN-γ and cytokines like IL-2 were released highly.…”
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AgNOR Count in Resting Cells (Resting NOR) Is a New Prognostic Marker in Invasive Bladder Tumor by Mitsuro Tomobe, Toru Shimazui, Katsunori Uchida, Hideyuki Akaza

“…Results: The AgNOR count in proliferating cells (proliferating NOR) was significantly higher than that in resting cells (resting NOR) (p < 0.01). …”
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KLF5 promotes esophageal squamous cell carcinoma radioresistance by targeting the Keap1-Nrf2 pathway by Yang Wang, Yue-ying Yang, Abulajiang Kamili, Dilimulati Aishanjiang, Yi Liu

“…The effects of overexpression or downregulation of KLF5 on anti-irradiated cells' proliferation, migration, invasion, and apoptotic activity were studied through colony formation assay, Transwell assay, and flow cytometry. …”
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Clinical Outcomes of Primary Posterior Continuous Curvilinear Capsulorhexis in Postvitrectomy Cataract Eyes by Mengting Yu, Duan Yan, Wenjie Wu, Yingbin Wang, Xinna Wu

“…Lens epithelium cells proliferation was confined to the peripheral capsular bag during a mean follow-up of 12.9 ± 10.5 months (ranging from 3 to 28 months). …”
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Nuclear factor I-C regulates intramembranous bone formation via control of FGF signalling by Jieun Lee, Joo-Cheol Park, Heung‐Joong Kim, Hyun Sook Bae, Dong-Seol Lee

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SLC7A11 is a potential therapeutic target and prognostic biomarker correlated with immune cell infiltration in cervical cancer by Mutangala Muloye Guy, Tingting Bian, Longyun Sun, Yiping Hao, Xinlin Jiao, Wenjing Zhang, Teng Zhang, Baoxia Cui

“…Besides, SLC7A11 was positively regulated cervical cancer cells’ proliferation, migration and invasion. We identified 113 DEGs between two subgroups. …”
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Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice by Minghui Wang, Shangsheng Yao, Dehua He, Mulan Qahar, Jinqing He, Meifang Yin, Jun Wu, Guang Yang

“…T2DM inhibited hair follicle regeneration and skin cells proliferation by inhibiting WNT-dependent Lgr5 HFSC activation. …”
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Fabrication and In Vivo Evaluation of In Situ pH-Sensitive Hydrogel of Sonidegib–Invasomes via Intratumoral Delivery for Basal Cell Skin Cancer Management by Maha M. Ghalwash, Amr Gamal Fouad, Nada H. Mohammed, Marwa M. Nagib, Sherif Faysal Abdelfattah Khalil, Amany Belal, Samar F. Miski, Nisreen Khalid Aref Albezrah, Amani Elsayed, Ahmed H. E. Hassan, Eun Joo Roh, Shaimaa El-Housiny

“…Background/Objectives: Basal cell skin cancer (BCSC) develops when skin cells proliferate uncontrollably. Sonidegib (SDB) is a therapeutic option for the treatment of BCSC by inhibiting hedgehog signaling. …”
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hsa_circ_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p by Shenglan Huang, Kan Liu, Yongkan Xu, Hua Wang, Shumin Fu, Jianbing Wu

“…Functionally, circPKT2 promoted the HCC cells proliferation, migration, and invasion both in vitro and vivo. …”
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The effect of miR-381 on proliferation and prognosis of breast cancer by altering CCNA2 expression by Ming-Gang Cao, Yan Wang, Zhi-Min Yang, Yang Wang, Mei-Qing Wang, Shuai Zhuo, Yan Yang, Chun-Sheng Liu

“…Cox regression analysis showed that miRNA-381 ≥ 1.65 2−ΔΔCt and CCNA ≥ 2.95 2−ΔΔCt were the influence factors of PFS and OS, the hazard ratio (HR) values were 0.553, 2.075, 0.462 and 2.089, respectively.Conclusion miR-381 inhibitors breast cancer cells proliferation and migration by down-regulating the expression of CCNA2, both of them can predict the prognosis of breast cancer.…”
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Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation by Man Wang, Yuechen Han, Weibin An, Xue Wang, Fang Chen, Junze Lu, Yu Meng, Yan Li, Yanqing Wang, Jingxin Li, Chunjie Zhao, Renjie Chai, Haibo Wang, Wenwen Liu, Lei Xu

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Long-term observation of the in vivo safety of a new design of phakic refractive lens by Yinjie Jiang, Xun Chen, Mingrui Cheng, I-Chun Lin, Boliang Li, Xinjie Zhu, Guanghan Xu, Huamao Miao, Xiaoying Wang, Xingtao Zhou

“…Electron microscopy showed that epithelial cells proliferated on the surface of all anterior capsule membranes, with no significant differences between the two groups. …”
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miR-9-5p/HMMR regulates the tumorigenesis and progression of clear cell renal cell carcinoma through EMT and JAK1/STAT1 signaling pathway by Xinyang Niu, Dingheng Lu, Weitao Zhan, Jiazhu Sun, Yuxiao Li, Yuchen Shi, Kai Yu, Suyuelin Huang, Xueyou Ma, Xiaoyan Liu, Ben Liu

“…Furthermore, overexpression of an upstream transcriptional regulator, miR-9-5p, effectively downregulated HMMR expression and thus impeded ccRCC cells proliferation and migration. HMMR might influence ccRCC growth via the Epithelial-Mesenchymal Transition (EMT) pathway and the Janus Kinase 1/Signal Transducer and Activator of Transcription 1 (JAK1/STAT1) pathway. …”
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Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis by Linfeng Sun, Xiangdong Li, Yuhao Xiao, Wenjie Yu, Xuyang Chen, Ziyi Wang, Nan Xia, Xuejiao Chen, Minhao Chen, Haoliang Zhu, Jie Li, Jie Wei, Sheng Han, Liyong Pu

“…Furthermore, function assays demonstrated that Mfsd2a suppresses CRC cells proliferation, migration, invasion, and EMT in vitro, while also delaying tumor growth and liver metastasis in vivo. …”
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Yeast cell wall polysaccharides accelerate yet in-feed antibiotic delays intestinal development and maturation via modulating gut microbiome in chickens by Fangshen Guo, Jianing Qiao, Zeqiong Hu, Jia Huang, Ruichen Bi, Waseem Abbas, Wenrui Zhen, Yuming Guo, Zhong Wang

“…YCWP addition also upregulated gene expression levels of Lgr5, Wnt/β-catenin signaling pathway related gene (Wnt3, β-catenin, d 21; β-catenin, d 42), intestinal cells proliferation marker Ki-67 and barrier function related genes (occludin, d 21 and d 42, P < 0.05). …”
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In vitro functional validation of anti-CD19 chimeric antigen receptor T cells expressing lysine-specific demethylase 1 short hairpin RNA for the treatment of diffuse large B cell l... by Zhi Guo, Zhi Guo, Mingxin He, Ning Liu, Yiqing Yang, Rui Sun, Jianxun Wang, Qiang Wang

“…We further found that LSD1 shRNA anti-CD19 CAR-T cells secreted more IFN-γ and granzyme B than RNAU6 anti-CD19 CAR-T cells. CAR-T cells proliferated after U-2932 cell stimulation and were able to sustain proliferation. …”
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